EKS-ORN-00551

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00551

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	393.5	6.4E-118	9	271	263

Status

Unreviewed

Ensembl Protein

ENSONIP00000004697

UniProt Accession

I3J758;

Protein Name

Protein Synonyms/Alias

Gene Name

ULK1 (1 of 2)

Gene Synonyms/Alias

ULK1 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000003736	ENSONIP00000004698	ENSONIT00000004701
ENSONIG00000003736	ENSONIP00000004697	ENSONIT00000004700

Organism

Oreochromis niloticus

Functional Description

Protein Length

1025

Protein Sequence
(FASTA)

METVGKFEFS RKDLIGHGAF AVVFKGRHRE KHDWEVAVKC INKKNLAKSQ TLLGKEIKIL 60

KELKHENIVA LLDFQETASS VYLVMEYCNG GDLADYLHSK GTLSEDTIRV FLQQIAGAMR 120

VLQSKGIIHR DLKPQNILLS YPPGCKSHSN NTCIKIADFG FARYLQNNMM AATLCGSPMY 180

MAPEVIMSQN YDAKADLWSI GTIVFQCLTG KAPFQASSPQ DLRLFYEKNK NLSPNIPRET 240

SSHLRQLLLG LLQRNHKDRM DFDDFFCHPF LEASSSVKKT TPTVTMTCLP SSASASSCSS 300

SSTSHLASPP QSLAEIQQLR AKALASPTQE ATGFLLKDSS GGGGSSKNSS SCDTDDFVIV 360

PAHFTTGELT SESKVLQDSL MNSGSLLASA GLCSQAKTPP HSPSYSGSPS PVRPSEFSGS 420

SYGNHGQSLP IPVPTQVQNY QRMEQNLHST KQDGSPRLST PVHRCSSGSL LGCARTGPSP 480

PYGQGAVTTT TTRRFSLGGA RTFQLSPQAL QHTEPRLNSQ QHPQRAGLGT RLHSAPCLLD 540

CATGGGRQKI RKQHSDPLGT PSAGLMAVRP LHSSPRLSEL MQRNPLPTIL GSPSRAIPPF 600

EFPKTPSSPN LVTFLTQQGM VIGSPCSRTA PAELRDLVHQ APTPVTHSPH CIHRRNDDAK 660

SFGRSQSAGG LSDVLLMAAF GPGGPAGDRG STENLTSEKA IDITGSPGGG GGFAPSSGSP 720

AQVVFTVGSP PSGSTPPFTS RQRKYSGSFT SGSPAGSLTS RHPPTGTCLD GFEVSSSPRY 780

SFPDPITANM GGRVTFEAPE LPEETLMEQE HTDTVQRLRF TLDFALCLME VAAARGATVT 840

GEQGDFSHLS LLQQQSLVAD QISSLSREWS HAEQLVLYLK TAELLSNALH TAMEQVKQGK 900

LYPSATVKQV VRKLNELYKS SVASCRSLNS RLEHFFTRKH RLMDQITSIT AERLLFSHTV 960

QMVQAAALDE MFHQGEASVL RYHKALLLME GLSLLLTEQD DIISVSKCKE CIERRLTALQ 1020

AGLCI 1025

Nucleotide Sequence
(FASTA)

ATGGAGACGG TGGGAAAATT TGAGTTCAGT CGGAAGGACC TGATAGGACA TGGCGCATTT 60

GCTGTGGTCT TTAAAGGTAG ACATCGAGAG AAACATGACT GGGAGGTGGC AGTAAAATGC 120

ATCAACAAGA AGAACCTAGC CAAATCTCAG ACTCTGCTGG GGAAGGAGAT CAAAATACTG 180

AAGGAACTCA AACATGAGAA CATTGTTGCT TTACTGGACT TTCAGGAAAC TGCCAGCTCA 240

GTGTACCTGG TAATGGAGTA CTGCAACGGC GGCGATCTCG CTGACTACTT ACACTCTAAG 300

GGCACACTGA GTGAGGACAC TATTCGGGTT TTCCTGCAGC AGATTGCAGG GGCCATGAGG 360

GTCCTACAAT CCAAAGGAAT AATCCACAGG GACCTCAAGC CACAGAACAT CCTGCTTTCT 420

TACCCACCAG GATGCAAGTC ACACTCCAAC AACACCTGCA TCAAGATTGC GGACTTTGGG 480

TTTGCGAGGT ACCTTCAGAA CAACATGATG GCAGCCACGC TCTGTGGCTC CCCTATGTAC 540

ATGGCTCCTG AAGTAATTAT GTCCCAAAAC TATGATGCCA AGGCTGACTT GTGGAGTATA 600

GGAACAATAG TGTTTCAGTG CCTGACTGGA AAAGCTCCTT TTCAGGCCAG CAGTCCCCAA 660

GATCTCCGGC TGTTCTATGA AAAAAACAAG AACCTCAGCC CCAACATTCC CAGAGAGACT 720

TCAAGCCACC TGAGGCAGCT GCTGCTGGGT CTGCTGCAGC GCAACCACAA AGACCGCATG 780

GACTTTGATG ACTTTTTTTG TCATCCTTTC CTGGAGGCTA GCTCATCTGT GAAAAAGACA 840

ACTCCTACTG TGACCATGAC TTGTTTGCCC AGCTCTGCAT CAGCCAGCTC TTGTAGCAGC 900

TCTTCCACCT CTCACCTCGC CTCACCACCG CAGTCTCTTG CTGAGATTCA GCAGTTGCGA 960

GCCAAAGCTC TGGCCTCTCC CACCCAGGAG GCCACTGGTT TTCTCCTTAA GGACTCATCT 1020

GGAGGTGGCG GCAGCAGCAA GAACTCGTCC TCCTGTGACA CAGATGACTT TGTGATAGTG 1080

CCTGCTCACT TCACCACAGG TGAGCTGACA AGTGAGAGTA AAGTGCTGCA GGACAGCCTA 1140

ATGAACAGCG GCTCTCTTTT AGCTTCTGCT GGTCTGTGTA GCCAAGCCAA AACACCGCCA 1200

CACTCGCCTT CCTACAGTGG ATCACCTAGT CCTGTCAGGC CCAGCGAGTT CTCGGGAAGT 1260

AGCTATGGAA ACCATGGTCA GTCATTGCCT ATTCCAGTCC CCACTCAGGT CCAGAATTAC 1320

CAGCGCATGG AGCAAAACCT CCATTCTACC AAACAGGATG GTTCACCACG GCTGTCAACA 1380

CCTGTGCACC GCTGCAGCAG TGGAAGCTTG TTGGGCTGTG CTAGGACTGG ACCTTCACCA 1440

CCCTATGGGC AGGGGGCTGT CACCACCACC ACCACCCGCA GGTTCTCCCT GGGAGGTGCC 1500

AGAACTTTCC AGCTTTCTCC TCAAGCTCTG CAGCACACTG AACCCAGGCT GAATTCTCAG 1560

CAGCACCCAC AGAGGGCAGG ACTCGGCACA AGGCTCCACA GTGCCCCCTG TCTGTTGGAC 1620

TGTGCCACTG GTGGTGGCAG GCAAAAAATC CGAAAGCAGC ACTCGGACCC TCTGGGTACT 1680

CCCTCAGCCG GACTCATGGC TGTCCGCCCC TTACACTCTT CTCCCAGACT GAGTGAGCTG 1740

ATGCAGCGTA ATCCCCTCCC CACTATCCTG GGCTCCCCCT CCAGGGCCAT CCCACCATTT 1800

GAATTCCCCA AGACTCCGAG TTCTCCAAAT CTGGTGACTT TCCTGACACA GCAGGGTATG 1860

GTCATAGGCT CTCCTTGCAG CAGGACTGCC CCAGCAGAGC TCAGAGACCT GGTACACCAA 1920

GCACCCACAC CTGTCACCCA TTCTCCTCAT TGCATCCACA GACGGAATGA TGATGCCAAG 1980

AGCTTTGGAA GGTCTCAAAG TGCCGGTGGT CTGTCCGACG TGCTGCTGAT GGCTGCGTTT 2040

GGACCCGGTG GACCTGCAGG TGACCGAGGC AGTACAGAGA ACCTGACCTC TGAAAAAGCC 2100

ATAGACATAA CAGGATCCCC AGGTGGCGGG GGAGGCTTTG CACCGAGCTC TGGCAGCCCA 2160

GCACAGGTGG TTTTCACTGT AGGATCTCCA CCTAGTGGCA GCACTCCACC CTTTACCTCC 2220

AGACAAAGAA AATACTCAGG CTCATTCACT TCAGGCAGCC CTGCAGGCTC CTTAACCAGC 2280

CGTCACCCTC CGACAGGCAC CTGTTTGGAT GGCTTTGAGG TTTCTTCCAG TCCTCGTTAC 2340

AGTTTCCCCG ATCCCATCAC AGCCAACATG GGCGGTCGCG TCACCTTCGA GGCTCCCGAG 2400

CTGCCCGAAG AGACGCTGAT GGAGCAGGAG CATACAGACA CTGTGCAAAG GCTGCGCTTC 2460

ACATTGGATT TTGCTCTGTG TCTAATGGAG GTGGCTGCTG CCCGTGGTGC TACAGTGACA 2520

GGGGAGCAGG GGGACTTTTC TCATCTCTCT CTCCTTCAGC AGCAGAGCCT GGTAGCAGAT 2580

CAGATAAGCT CACTGAGCCG AGAGTGGAGT CATGCAGAAC AGCTGGTTCT CTACCTTAAA 2640

ACTGCAGAAC TCTTGTCCAA TGCCTTACAC ACAGCCATGG AGCAAGTTAA ACAGGGCAAG 2700

CTCTACCCAT CTGCTACTGT CAAACAAGTC GTGAGAAAAC TGAATGAGCT GTACAAGTCC 2760

AGCGTGGCAT CCTGCCGCTC ACTCAACAGC CGTCTGGAGC ATTTCTTTAC CCGGAAGCAT 2820

CGCCTAATGG ACCAAATCAC CTCCATCACA GCGGAACGGC TGCTGTTCAG CCACACTGTG 2880

CAGATGGTTC AGGCTGCTGC ACTAGATGAG ATGTTCCACC AGGGGGAAGC ATCAGTCCTG 2940

CGCTACCACA AAGCTCTCTT ACTGATGGAG GGCCTGTCTC TGCTGCTCAC TGAACAGGAT 3000

GACATCATCA GTGTTAGCAA ATGTAAAGAG TGCATTGAAC GGCGCCTCAC AGCTTTACAG 3060

GCAGGGCTCT GTATATGA 3078

Domain Profile

S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkklkkslenlekeikilkelkheni  60

         +s ++ iG+G+favv+kgr+r+k++++vA+k+++kk+l+ks++ l keikilkelkheni

Q: 9     FSRKDLIGHGAFAVVFKGRHREKHDWEVAVKCINKKNLAKSQTLLGKEIKILKELKHENI  68

         7889********************************************************

S: 61    valldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskkiv  120

         valld++et+++vylvmeyc+ggdLa++l++k++Lsedt+r+flqq+a a+++L+sk+i+

Q: 69    VALLDFQETASSVYLVMEYCNGGDLADYLHSKGTLSEDTIRVFLQQIAGAMRVLQSKGII  128

         ************************************************************

S: 121   hrDlkPqniLlsyadakk.elkkvtlkladFglarvlkeesmaatlkGsplYmaPEvvke  179

         hrDlkPqniLlsy  + k + +++++k+adFg+ar+l++++maatl+Gsp+YmaPEv+++

Q: 129   HRDLKPQNILLSYPPGCKsHSNNTCIKIADFGFARYLQNNMMAATLCGSPMYMAPEVIMS  188

         *************98877699***************************************

S: 180   qqydakaDlWSiGtilyellvGkpPfaaesiseLvekiekndvleppipkeisselkdll  239

         q+ydakaDlWSiGti++++l+Gk+Pf+a+s+++L+ ++ekn++l+p+ip+e+ss+l++ll

Q: 189   QNYDAKADLWSIGTIVFQCLTGKAPFQASSPQDLRLFYEKNKNLSPNIPRETSSHLRQLL  248

         ************************************************************

S: 240   qsLLqrdpkkRisfeelfahpfl  262

          +LLqr++k+R++f+++f+hpfl

Q: 249   LGLLQRNHKDRMDFDDFFCHPFL  271

         *********************96

Domain Sequence
(FASTA)

FSRKDLIGHG AFAVVFKGRH REKHDWEVAV KCINKKNLAK SQTLLGKEIK ILKELKHENI 60

VALLDFQETA SSVYLVMEYC NGGDLADYLH SKGTLSEDTI RVFLQQIAGA MRVLQSKGII 120

HRDLKPQNIL LSYPPGCKSH SNNTCIKIAD FGFARYLQNN MMAATLCGSP MYMAPEVIMS 180

QNYDAKADLW SIGTIVFQCL TGKAPFQASS PQDLRLFYEK NKNLSPNIPR ETSSHLRQLL 240

LGLLQRNHKD RMDFDDFFCH PFL 263

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR022708	; Ser/Thr_kinase_C.

Pfam

PF12063	; DUF3543; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013