EKS-ORN-00418

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00418

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	337.1	9.2E-101	15	272	258

Status

Unreviewed

Ensembl Protein

ENSONIP00000004786

UniProt Accession

I3J7E5;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

MAP4K2

Gene Synonyms/Alias

MAP4K2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000003805	ENSONIP00000004785	ENSONIT00000004788
ENSONIG00000003805	ENSONIP00000004786	ENSONIT00000004789

Organism

Oreochromis niloticus

Functional Description

Protein Length

863

Protein Sequence
(FASTA)

MDRIGVSFLD PLDDYELIHR IGCGTYGDVF KARNIRTSEL AAIKIVKLDS GDDITPIQQE 60

ITMMKECKHK NIVAYFGSYH RNTKLWICME YCGGGSLQDI YHVTGPLKEK QIAFVCRETL 120

QGLYHLHETG KMHRDIKGAN ILLTERGDVK LADFGIAAEI SASVAKRKSF IGTPYWMAPE 180

VAAVEKKGGY NHLCDIWAVG ITAIELAELQ PPMFDLHPMR ALMLMSKSSF QPPKLKDKSK 240

WSASFHSFVK MALIKSTRKR PSAETLLQHS FVTQLLTRNL IIELLDMANN PELHAPHTNT 300

MDDIELEVGV MGPDKIQSAG KHLSVERTLS EQQFDQVKFG PPLRKVTEPY PDLACYDDWS 360

LSGDEGTSPS LLECVEQALE LRSLTIKRAP CADGGRKSSV FSPSTASLPA FSSLTPNTED 420

KDLTPRPTCT LGPDSAVTAD STTALARCSA TQDITKGCSE TCRPAEGAVT AELVTTASSP 480

KRETPLSPEW STLRRKTKDD SADCHGLPPT PQVHMGACFS KVFNGCPLKI NCAVTWIFPK 540

TRDQYLILGA EEGIYTLNLN ELHEDTLEKL LPQRCIWLYV MNNVLMSVSG KSSQLYSHSL 600

PALFEQKGHL HKKHSSLSLS TNRLTERMSL RKFAISVKIP DTKGCRRCSV ARNPYTDSTF 660

LCGAVPSGLV LLLWYEPLQK FMHLKQLAIR LPDSLPIFEL LVLATDEFPQ LCVGVRDCSN 720

DKPPTGQQLR FDIIELNGAP VPVPGDSGAL RAVQVTQLDR DTVLITLERT VKIVNLQGLP 780

SRQLAAEIVF DFPIETLVCL QDSVLAFWKH GLKGRSFHSD EVTQEITDES RVFRVLGTNR 840

YVNSMLTRVI NHCEKLVILV QQK 863

Nucleotide Sequence
(FASTA)

ATGGACCGGA TAGGAGTGTC ATTCCTGGAC CCGCTGGATG ACTACGAGCT AATCCACAGG 60

ATTGGGTGCG GCACCTACGG AGATGTTTTC AAGGCTCGCA ACATCCGGAC GTCTGAACTG 120

GCAGCTATCA AGATTGTCAA GCTCGACTCA GGTGATGACA TCACCCCCAT CCAGCAGGAG 180

ATTACCATGA TGAAGGAGTG CAAGCACAAA AACATCGTGG CCTACTTTGG GAGCTACCAC 240

AGAAACACCA AGCTGTGGAT CTGCATGGAG TACTGCGGTG GAGGCTCCCT GCAGGATATC 300

TACCATGTGA CGGGCCCACT GAAGGAGAAG CAGATAGCAT TTGTGTGCAG GGAAACTCTC 360

CAGGGCCTGT ATCACTTGCA CGAAACTGGC AAAATGCACA GGGACATAAA GGGAGCCAAT 420

ATCCTTTTGA CCGAGCGTGG AGATGTGAAA CTGGCTGATT TTGGGATCGC AGCAGAGATC 480

AGTGCCTCTG TGGCCAAGAG GAAGTCCTTT ATTGGAACTC CTTACTGGAT GGCTCCAGAG 540

GTTGCTGCGG TGGAGAAGAA GGGTGGCTAT AATCACCTGT GTGATATCTG GGCCGTCGGC 600

ATCACTGCCA TCGAGCTGGC AGAGCTGCAG CCGCCCATGT TTGACCTGCA CCCAATGAGA 660

GCACTGATGC TGATGTCCAA GAGCAGCTTC CAGCCTCCAA AACTTAAGGA TAAATCCAAG 720

TGGTCTGCTA GCTTCCATAG CTTTGTGAAG ATGGCTCTCA TTAAAAGCAC TCGTAAGCGG 780

CCCTCAGCTG AGACACTGCT GCAGCATTCG TTTGTGACAC AGCTGTTGAC CCGTAACTTG 840

ATCATTGAGC TGCTGGACAT GGCCAACAAC CCCGAGCTCC ACGCTCCCCA CACAAACACC 900

ATGGATGACA TTGAGCTGGA GGTTGGGGTA ATGGGTCCTG ACAAGATCCA GTCAGCAGGG 960

AAACACCTGT CTGTGGAAAG GACCCTGTCT GAACAACAAT TTGACCAGGT GAAGTTTGGG 1020

CCTCCACTGA GGAAAGTGAC AGAGCCTTAT CCTGACTTGG CCTGTTATGA TGACTGGAGT 1080

CTGTCTGGAG ATGAAGGAAC CTCACCGAGC CTGTTGGAAT GTGTGGAGCA AGCTCTCGAG 1140

CTGAGGAGTT TAACCATCAA AAGAGCGCCA TGTGCTGATG GAGGCAGAAA GAGCAGTGTG 1200

TTCAGTCCGT CTACAGCCTC ACTGCCAGCC TTCAGCTCAT TGACTCCCAA CACAGAGGAC 1260

AAAGATCTTA CACCGAGACC GACCTGTACA CTGGGCCCAG ACAGCGCTGT CACGGCTGAC 1320

TCCACCACAG CCTTGGCCAG GTGCTCGGCC ACTCAGGACA TCACAAAGGG CTGCAGTGAA 1380

ACGTGTCGGC CAGCGGAGGG CGCTGTCACA GCAGAGTTGG TGACTACTGC TTCCTCACCC 1440

AAACGAGAGA CTCCACTATC ACCAGAGTGG AGCACACTGA GGAGGAAGAC GAAGGACGAT 1500

AGCGCTGATT GTCATGGCCT TCCTCCCACC CCTCAAGTCC ATATGGGAGC CTGCTTCTCT 1560

AAAGTCTTCA ATGGCTGCCC TCTAAAAATC AACTGCGCCG TCACCTGGAT TTTTCCCAAA 1620

ACAAGAGATC AGTATCTTAT TCTTGGGGCA GAAGAAGGCA TCTACACGCT GAACCTTAAT 1680

GAACTTCATG AAGATACATT AGAGAAGCTC CTCCCTCAGC GATGTATATG GCTATATGTT 1740

ATGAACAACG TGCTGATGTC CGTATCAGGG AAGTCGTCCC AGCTTTACTC GCACAGCCTG 1800

CCAGCTCTGT TTGAACAGAA AGGACATCTG CACAAGAAAC ACAGCAGCCT GTCGCTCAGC 1860

ACCAACCGCC TCACGGAGCG GATGAGTCTC AGAAAGTTTG CCATATCTGT AAAGATTCCT 1920

GACACTAAAG GTTGTAGGAG GTGCAGTGTA GCAAGAAACC CATACACAGA TAGCACATTT 1980

CTGTGCGGGG CCGTCCCATC TGGCCTGGTT TTACTCTTGT GGTACGAGCC TCTTCAGAAG 2040

TTCATGCATC TAAAGCAACT CGCCATCAGG CTCCCAGATT CTCTTCCGAT ATTTGAACTG 2100

CTGGTGTTGG CAACAGATGA GTTTCCTCAG CTGTGTGTTG GAGTGAGAGA CTGTAGTAAT 2160

GATAAACCAC CAACCGGCCA ACAGCTCAGG TTTGATATTA TAGAGCTGAA CGGCGCTCCT 2220

GTTCCAGTGC CAGGAGATAG TGGAGCACTC AGAGCCGTGC AGGTAACCCA GCTGGACCGA 2280

GACACTGTTC TCATCACCTT GGAAAGAACT GTAAAGATCG TGAACCTGCA AGGCCTTCCA 2340

TCCAGGCAGC TGGCTGCAGA AATAGTCTTT GACTTCCCCA TTGAAACACT AGTCTGCTTG 2400

CAGGACAGTG TGCTGGCATT CTGGAAGCAT GGCCTCAAAG GGAGGAGTTT CCATTCAGAT 2460

GAGGTAACAC AAGAAATTAC AGATGAGAGT CGTGTGTTCA GAGTTCTGGG AACAAACAGG 2520

TATGTTAACA GTATGCTGAC AAGAGTTATC AATCACTGTG AGAAACTAGT AATCCTAGTA 2580

CAGCAGAAGT AA 2592

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         yel+++ig G++g+v++ar+++t+el+aik+++l++ ++++ +q+ei+++k++kh+niv+

Q: 15    YELIHRIGCGTYGDVFKARNIRTSELAAIKIVKLDSGDDITPIQQEITMMKECKHKNIVA  74

         99**********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         y++s+ ++++lw++mey+ gGsl+d+++  ++ +lkE+qia ++re+l++L +lH+ +++

Q: 75    YFGSYHRNTKLWICMEYCGGGSLQDIYH--VTGPLKEKQIAFVCRETLQGLYHLHETGKM  132

         ****************************..******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179

         Hrdik++niLlte+g+VkL+dfg+aa+++++++krk+++gtpywmAPEv a+e + gY++

Q: 133   HRDIKGANILLTERGDVKLADFGIAAEISASVAKRKSFIGTPYWMAPEVAAVEkKGGYNH  192

         ****************************************************98889***

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237

          +Diw++GItaielae +pP++dl+p++al++++k++  ppklk+k+k+s +f++fv+ +

Q: 193   LCDIWAVGITAIELAELQPPMFDLHPMRALMLMSKSSfqPPKLKDKSKWSASFHSFVKMA  252

         **********************************99988*********************

S: 238   lqknpekRpsasellkhkFl  257

         l k+ +kRpsa++ll+h+F+

Q: 253   LIKSTRKRPSAETLLQHSFV  272

         *******************7

Domain Sequence
(FASTA)

YELIHRIGCG TYGDVFKARN IRTSELAAIK IVKLDSGDDI TPIQQEITMM KECKHKNIVA 60

YFGSYHRNTK LWICMEYCGG GSLQDIYHVT GPLKEKQIAF VCRETLQGLY HLHETGKMHR 120

DIKGANILLT ERGDVKLADF GIAAEISASV AKRKSFIGTP YWMAPEVAAV EKKGGYNHLC 180

DIWAVGITAI ELAELQPPMF DLHPMRALML MSKSSFQPPK LKDKSKWSAS FHSFVKMALI 240

KSTRKRPSAE TLLQHSFV 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Mus musculus"; ?>Oryzias latipes"; ?>Pteropus vampyrus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013