EKS-ORN-00149

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00149

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LRRK	306.4	1.9E-91	1873	2123	251

Status

Unreviewed

Ensembl Protein

ENSONIP00000004815

UniProt Accession

I3J7H6;

Protein Name

Protein Synonyms/Alias

Gene Name

LRRK2

Gene Synonyms/Alias

LRRK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000003823	ENSONIP00000004815	ENSONIT00000004818
ENSONIG00000003823	ENSONIP00000004816	ENSONIT00000004819

Organism

Oreochromis niloticus

Functional Description

Protein Length

2533

Protein Sequence
(FASTA)

MVNKEELEER LKKLLVRLKT PQEDRQLCTL IQIIQDLLFL AHTDYAAELF EDKDVHVPLV 60

LVLSTHISSR GVQQVGWSLL CQLIEICPTT LDQLTRPLDE AQEWEVEGVH QQILKVLSQY 120

SADCRVTMVA LRALALLLRS AKIPLLVLLE EEEDVFGLVV YAMKAFPTSE EVQLQGCTAL 180

QLLLEEVSDD HLVEFVENQD HAVVLAALKR FPDNSEMQLQ ALKALLPLAH PGSNVEVLMS 240

GGTRCYSTII AAMDAFPEVE ELQEKACSLF KRFTSESYND ILVRNGVHRV AVRACQTFPN 300

NAKLQAAALS CLANLTATIV QNKAVAEQGL EEGEEEENRG NGQVEDMELS WMKECFTALE 360

LHADEPGVQE AACWAIHSLL LHGAALNHLE EEQDERTPVY RQLMAAMLLH FASPNVFNAA 420

TSAIATLITN NSKMRSLLLS SGLHVNLVEM MKRHSDSAEV SISACKLLNL LFQGRTASLD 480

ELTMAMNQIL STMKFHNFNL EVQLEALQAS LVFLCPDRSL REHGNSVADP DMADVSLKVL 540

KNQCVVEGAH ILYLEALNRF ISSSAIQTCG LKVLSALADC SGAVDLLCQQ GAIDTVLHTL 600

QMFPQEREIH YWGLTLLTYV VSKKKLSRMI VPVLASVVVT ALIQYREDSE MLLKCLQVAL 660

RMLDACSGAA AELQKEDFDR HIFQCLREET DQSISPLRKS VCLALSKMWC DSELHYSMLE 720

KACMDGDTTM AECLIELGAD INKKTKNESL IYQVCERGGP LELVELLLSR GCHEQHLRRA 780

LAVSVKRGDG PTVIQLLGRL GLDLNNNALC LGGFRLGRLD AAWLSPLLGE RSRTYSLRYN 840

NTKGPSLAKY IQFLQRAKSV NCPPRSVTDP CLTSGYISDE SDDSSFSFTS LEDGLFFNDD 900

MESDGSDSLS GALSPKSYNN SSEELRGESL RRKQGRRRHA SAESGQTESE HTEPLHRRYG 960

RNSSSQKVLG SAENSAALPK EKERIHLLDL SGNELNSLSC LNDGFVQQQL WHIHRLDLSY 1020

NCLLEFPSEL CLSLKNLTRL DLQGNQLQSL PQELLSLPSL SMLNASRNCV GPQLTFDPEV 1080

TCPKLKQLNL SFNKITTFPF ELGRTMHTLE ELYMEGNCIT ELCTPLCLPE IKLLDVSKNG 1140

VENISADFLR SCPKLETLNV SMNKLCSLSR LPSKIMTLKL ANNSFASIPE AVLELPVLRS 1200

VDMRTNSIVV LPGPASWVSS IIRELMFSQN CIQTLDLSGP IHKWTRLEKL HLSANRLTEI 1260

PPQIGLLEGL TSLDVSHNTN LRSFPDEMGK LSRLWDLPLD GLQLQLDLKL TGSKTKDIVR 1320

FLQQRLKKAV PYYRMKLIVV GNAGSGKTSL IQQLMKLKRS QLNSKQTSFG IDVRDWTVRE 1380

RDKKKMVLNV WDFSGGEEFS GSHPHFLTSR ALYLVVYNIS KGTSQVDALK PWLFNIKAVA 1440

PLSPVILVGT HTDVSEDSQL QNCLSKIRQE ILIHQGFPVI RDYYMVSVCE DSDAIARLRK 1500

AIVREVTSFK IQDQPVMGQL VPDSYVELER RILQERARVP PEFPVLRHHE LLQLIQESQL 1560

QLEEAELPHA IHFLSEVGVL LHFDDPALEL QELYFIDPQW LCSVISQKLT LKSCGYWEHP 1620

KGVVQRSVVE KFLSETKCFP KSHLTQFLKL LEKFQIALPF GEDQLLVPSS LSKHRPVIEL 1680

PHCENSEVIV RLYEMPYFPM DYWSRQISRL LEASSYLLCG REKMVRPNRI YWRRGIYLNW 1740

SQEAYCLVEE NPSSCVRITV PASCKGRLLL GQVVDHIDSL LEEWFPGLLN TDMHGSGEAL 1800

LKKWALYSPE DGQEWRKIPL EDIFTDFLGA SAENRPCTLP VFQTAPDLLL SDQPAGTTLD 1860

SEELDIDLSL ENRLGDGGFG TVYRGVYKNE DVAVKIFNKH ASELYIYRLL RQELVVLGRL 1920

RHPSLVSLLA AGSTPQVLVM ELALRGSLDS LFQKKNVSFN QKLQHRIALQ VADGLRYLHS 1980

AMIIYRDLKP HNILLFNLKT DSDIIAKITD YGIAQYCCSM GVRSSEGTAG FRAPEVARGN 2040

VIYNQQADVF SFGLLLYDLM TRGERISDGM KFPSEFDEIA VQGKLPDPVK HYGCSPWPSF 2100

QVLIKECLQE SPQDRPTSAQ VFDRLNSGEM LCLMRELVVP GVLSAECFIL SSGADSNSSS 2160

HRVWLGGGSR TQKKGSITAV DLNTNTVATQ AGSFEVDTSP VLCLVTVQIP NEDSDWLVAG 2220

TQSGSLVVIN SRDTSTWHHL QRVTDAVTSL YFHVHPRRTQ RKNYLLVGTA DGILSIYEDS 2280

VLKQENGQPV KTLSVGNVNT PVMCLGQSVH SLDSRSVWAG CGPKILSFTA DYDVCKSIDT 2340

RPNLFSHQQR SLGSEACVYR MVVDKYVYLS KARTTTVEVW DKRSERMVDC IDCAQIIRRD 2400

RGGDGREAEL PSEASPSWAT VKALLLPNAA MLWIGTRRGH LLLLELPKHQ ILQVMESHCD 2460

SLRCMASALI QTLNRENVVL VLGRRQTQHK NPNDEESVLT VWNSMLPVEV KDLKKHCEKR 2520

EQIAAKMREQ LHQ 2533

Nucleotide Sequence
(FASTA)

ATGGTTAACA AAGAGGAGCT GGAAGAAAGG CTGAAAAAAC TTTTGGTGAG GCTGAAAACT 60

CCCCAGGAAG ACAGGCAACT GTGCACGCTG ATTCAAATCA TCCAGGATCT GCTTTTCCTG 120

GCGCACACCG ACTATGCAGC TGAACTGTTT GAAGACAAAG ATGTCCACGT GCCCCTCGTG 180

CTGGTTCTGT CTACCCACAT CAGCAGCAGA GGAGTCCAGC AGGTTGGCTG GTCATTGCTG 240

TGTCAGCTGA TTGAAATATG CCCCACTACA CTGGACCAGT TAACCAGACC TTTGGATGAA 300

GCCCAAGAGT GGGAGGTAGA GGGAGTGCAC CAGCAGATCC TCAAGGTGTT ATCTCAGTAC 360

AGCGCAGATT GTCGAGTGAC CATGGTTGCA CTCAGAGCCT TGGCACTGCT GCTCAGATCA 420

GCCAAGATTC CTCTGCTGGT GCTGCTGGAG GAGGAGGAGG ACGTGTTTGG CCTTGTGGTG 480

TACGCCATGA AGGCGTTTCC TACAAGTGAA GAAGTGCAAC TCCAAGGCTG CACAGCTCTG 540

CAGCTGCTTC TGGAGGAAGT CAGTGATGAC CACCTTGTGG AGTTTGTGGA GAACCAGGAT 600

CACGCTGTGG TTCTGGCAGC ACTCAAGAGG TTTCCGGACA ACTCAGAGAT GCAGCTGCAG 660

GCTTTAAAAG CGCTGCTTCC TCTGGCTCAC CCTGGCAGTA ATGTGGAGGT GTTGATGTCA 720

GGGGGCACTC GGTGCTACAG CACCATCATC GCTGCCATGG ATGCTTTCCC TGAGGTGGAG 780

GAGCTGCAGG AGAAAGCCTG CTCCCTGTTC AAAAGGTTTA CTTCAGAGAG TTACAACGAC 840

ATCCTGGTGA GGAATGGTGT CCACAGAGTC GCAGTCAGAG CCTGCCAGAC TTTCCCTAAC 900

AACGCCAAGC TGCAAGCCGC TGCTCTGTCC TGCCTGGCTA ACCTCACTGC AACCATCGTG 960

CAGAACAAAG CGGTGGCCGA GCAGGGTCTG GAGGAAGGAG AGGAGGAGGA GAACAGGGGT 1020

AACGGGCAGG TGGAGGACAT GGAGCTGAGC TGGATGAAGG AATGCTTTAC TGCACTGGAG 1080

CTCCACGCAG ATGAGCCAGG TGTTCAGGAA GCTGCGTGCT GGGCCATTCA CAGTCTGTTA 1140

CTGCACGGAG CTGCACTGAA CCATCTAGAA GAAGAGCAGG ATGAAAGGAC TCCTGTTTAT 1200

AGACAGCTGA TGGCGGCCAT GCTGCTCCAC TTCGCCTCTC CTAATGTGTT TAATGCTGCT 1260

ACCAGCGCCA TCGCCACACT CATCACAAAC AACAGTAAAA TGCGTTCTTT GCTGCTGTCA 1320

AGTGGCCTTC ATGTGAATTT GGTGGAGATG ATGAAGAGAC ATTCAGACTC AGCCGAGGTT 1380

TCCATCAGTG CCTGCAAACT GTTAAACCTG CTCTTCCAGG GAAGGACAGC CAGTCTGGAT 1440

GAGTTGACCA TGGCCATGAA CCAGATCCTC AGCACCATGA AGTTTCATAA CTTTAATCTT 1500

GAGGTTCAGC TGGAGGCTCT GCAAGCCAGC TTGGTCTTCC TTTGCCCGGA CAGGAGTTTA 1560

AGGGAGCACG GCAACTCGGT CGCAGATCCC GACATGGCCG ACGTGTCTCT GAAGGTCCTG 1620

AAAAACCAGT GTGTGGTGGA AGGAGCTCAC ATCCTCTACC TGGAGGCTCT CAACAGGTTC 1680

ATCAGCAGCT CAGCCATTCA AACGTGTGGT TTGAAGGTGC TGTCTGCTCT GGCTGACTGC 1740

TCTGGTGCGG TGGATCTTCT GTGCCAGCAG GGGGCGATAG ACACAGTGCT GCATACACTA 1800

CAAATGTTCC CACAGGAACG AGAGATACAC TACTGGGGGC TGACCCTACT CACCTACGTT 1860

GTGTCCAAGA AGAAGCTCTC GAGGATGATC GTACCTGTAC TGGCCTCCGT TGTGGTTACC 1920

GCTCTAATTC AGTACAGAGA AGACTCTGAG ATGCTGCTAA AGTGTTTACA GGTGGCATTG 1980

AGGATGCTAG ACGCCTGTTC AGGAGCAGCT GCTGAACTGC AGAAAGAAGA CTTTGACAGG 2040

CATATCTTCC AGTGCCTTAG AGAAGAGACT GACCAGAGCA TCAGTCCACT GCGGAAGTCG 2100

GTGTGCCTGG CTCTGTCTAA AATGTGGTGC GACTCAGAGC TGCACTACAG CATGCTGGAA 2160

AAGGCCTGCA TGGATGGAGA TACGACAATG GCCGAGTGTC TGATCGAGCT GGGAGCTGAC 2220

ATCAACAAGA AGACCAAAAA TGAGTCTCTC ATTTACCAGG TCTGTGAGAG AGGTGGACCT 2280

CTGGAACTGG TGGAACTCTT GTTAAGCCGA GGCTGCCACG AGCAGCACCT CCGCAGGGCT 2340

CTGGCCGTGA GCGTGAAGAG GGGTGACGGG CCCACAGTCA TCCAGTTACT TGGCCGTCTG 2400

GGTCTGGACC TCAACAACAA TGCCCTGTGC CTGGGCGGCT TCAGGCTAGG CCGTCTGGAT 2460

GCCGCTTGGC TGAGCCCCCT GCTGGGTGAA AGAAGCAGAA CTTACAGTCT ACGCTACAAC 2520

AACACTAAGG GCCCGAGTCT GGCAAAGTAC ATCCAGTTTC TCCAGAGGGC CAAAAGTGTG 2580

AACTGTCCCC CTCGGTCAGT GACTGACCCA TGTTTGACCT CTGGCTACAT TTCTGATGAG 2640

AGCGACGACT CCAGCTTCAG CTTTACCTCT TTGGAAGACG GCCTGTTTTT CAACGATGAC 2700

ATGGAGAGTG ATGGAAGTGA TTCGCTGTCT GGTGCTCTTT CTCCAAAGTC GTACAACAAT 2760

TCATCAGAGG AGCTGAGGGG GGAATCCTTA AGGAGGAAGC AGGGCCGTCG CAGACATGCC 2820

AGCGCAGAGA GTGGTCAGAC TGAGAGCGAG CACACTGAGC CTCTTCACAG AAGATATGGA 2880

CGGAATAGCT CGAGTCAAAA AGTGCTGGGG TCTGCCGAGA ACTCTGCTGC TCTGCCCAAA 2940

GAGAAAGAGA GGATCCACCT GCTGGACCTA TCTGGGAATG AGCTGAACTC CCTGTCCTGT 3000

CTCAACGATG GCTTTGTCCA GCAGCAGCTG TGGCATATCC ACCGTCTGGA CCTGAGCTAT 3060

AATTGTCTGC TCGAGTTTCC CTCTGAGCTC TGCCTGAGTT TGAAGAATTT GACTCGACTA 3120

GACCTGCAGG GGAATCAGCT CCAGTCGCTG CCACAGGAGC TGCTGTCTCT GCCCTCGCTG 3180

AGCATGCTGA ACGCCTCTCG TAACTGCGTT GGCCCCCAGC TGACCTTTGA CCCTGAAGTT 3240

ACCTGTCCAA AACTGAAGCA GCTCAACCTT TCATTCAACA AAATCACCAC ATTCCCTTTC 3300

GAGCTGGGCC GCACCATGCA TACACTGGAG GAGCTTTATA TGGAAGGAAA CTGTATCACT 3360

GAGCTGTGCA CACCTCTTTG TCTGCCTGAG ATTAAGTTGC TTGATGTGAG CAAGAACGGT 3420

GTGGAGAATA TTTCTGCAGA TTTCCTGAGA AGCTGCCCCA AACTGGAAAC TTTGAATGTC 3480

TCTATGAACA AACTCTGTTC CCTGTCCCGG CTGCCATCAA AGATTATGAC ACTAAAACTT 3540

GCAAACAATA GCTTTGCATC AATTCCCGAG GCTGTACTTG AACTTCCAGT GTTGCGGTCA 3600

GTAGATATGA GAACCAACAG CATCGTTGTT CTGCCTGGCC CGGCGTCCTG GGTGTCCAGC 3660

ATCATCAGAG AGCTGATGTT CAGTCAGAAC TGCATACAGA CTCTGGATCT GAGTGGACCT 3720

ATCCACAAAT GGACCAGACT GGAGAAACTC CACCTTAGTG CCAATAGGCT CACTGAGATC 3780

CCTCCCCAGA TTGGCTTGTT GGAAGGCCTG ACTTCCCTGG ATGTGAGTCA TAACACTAAC 3840

CTGCGCTCAT TCCCAGATGA AATGGGAAAA CTGAGCAGAC TGTGGGACCT GCCACTAGAT 3900

GGCCTTCAGC TGCAGCTGGA CCTCAAACTC ACTGGCAGCA AGACAAAAGA CATAGTCAGG 3960

TTCCTTCAGC AGCGGCTGAA GAAGGCAGTG CCATACTATC GGATGAAGCT CATCGTGGTG 4020

GGGAACGCAG GCAGTGGAAA GACCAGCCTG ATCCAGCAGC TGATGAAGCT AAAACGCTCG 4080

CAGCTGAACT CAAAACAGAC GTCTTTTGGC ATTGACGTCC GCGACTGGAC CGTCAGGGAA 4140

CGAGACAAGA AGAAAATGGT GCTGAATGTC TGGGACTTTT CAGGAGGAGA GGAGTTCAGT 4200

GGTTCTCACC CTCACTTCCT GACGTCCAGA GCTCTCTACC TGGTAGTTTA CAACATCAGC 4260

AAGGGAACTA GTCAAGTGGA CGCTCTCAAA CCTTGGCTCT TCAACATCAA AGCAGTAGCA 4320

CCGCTGTCTC CAGTCATTCT GGTGGGCACC CACACAGATG TGAGTGAGGA CTCACAGCTG 4380

CAGAACTGCC TGAGCAAAAT CAGACAGGAG ATCCTGATCC ACCAAGGCTT CCCTGTTATC 4440

AGGGATTATT ACATGGTCTC AGTCTGTGAG GACTCGGATG CCATCGCCAG ACTCCGTAAG 4500

GCCATTGTCC GGGAGGTCAC CAGCTTCAAG ATACAAGACC AGCCCGTGAT GGGTCAGCTG 4560

GTGCCAGACA GCTACGTGGA GCTGGAGCGC CGGATTCTTC AGGAAAGAGC CAGGGTTCCT 4620

CCAGAGTTCC CTGTCCTCAG GCACCATGAG CTCCTGCAGC TCATCCAAGA GAGTCAGCTG 4680

CAGCTGGAGG AAGCTGAGCT CCCTCATGCC ATCCACTTCC TCAGCGAAGT CGGGGTTCTA 4740

TTGCACTTCG ATGATCCTGC ACTTGAGCTT CAGGAGCTTT ACTTTATTGA CCCACAGTGG 4800

CTATGCAGTG TCATCTCACA GAAACTGACC TTAAAGAGCT GTGGCTACTG GGAGCATCCT 4860

AAAGGAGTGG TCCAGCGCTC TGTCGTGGAA AAGTTTCTGT CTGAGACTAA GTGTTTCCCA 4920

AAGAGTCACC TGACACAGTT CTTGAAGCTG CTGGAGAAGT TTCAGATTGC TCTTCCGTTT 4980

GGCGAGGACC AGCTGCTGGT ACCCAGCAGT TTGTCCAAAC ACAGACCCGT AATAGAACTG 5040

CCTCACTGTG AGAACTCTGA GGTGATCGTC CGACTGTATG AGATGCCGTA CTTCCCCATG 5100

GATTACTGGT CTCGGCAGAT CAGCCGCCTG CTAGAGGCAT CCTCCTACTT GCTTTGTGGA 5160

AGGGAAAAAA TGGTCCGACC CAACCGGATC TACTGGAGGA GAGGAATTTA CCTAAACTGG 5220

TCCCAGGAGG CGTACTGTCT GGTGGAGGAA AACCCCTCCA GCTGTGTCAG AATAACCGTG 5280

CCTGCATCAT GCAAAGGCCG GCTGCTGCTG GGTCAGGTGG TGGATCACAT TGACTCCCTG 5340

CTGGAGGAAT GGTTTCCCGG CCTGCTAAAC ACCGACATGC ACGGCAGTGG AGAAGCTCTG 5400

CTGAAGAAGT GGGCTCTGTA CAGCCCAGAG GATGGGCAGG AGTGGAGGAA GATTCCCCTG 5460

GAAGACATTT TTACAGATTT TTTGGGAGCG AGTGCAGAAA ATCGGCCCTG CACTCTTCCC 5520

GTCTTTCAAA CAGCCCCTGA TCTGTTATTG AGTGACCAGC CTGCAGGAAC AACACTGGAC 5580

AGTGAAGAAC TGGATATAGA TCTGTCTTTA GAGAACCGAC TGGGGGACGG TGGCTTTGGA 5640

ACTGTCTATC GAGGCGTCTA TAAGAACGAA GATGTAGCTG TGAAGATATT CAACAAGCAT 5700

GCTTCTGAGC TTTACATCTA CAGACTCCTC AGACAGGAAT TAGTCGTTTT GGGTCGCCTC 5760

CGTCACCCCA GCCTGGTGAG CCTGCTGGCA GCCGGCTCGA CTCCTCAGGT CCTGGTGATG 5820

GAGCTGGCTC TGCGCGGCTC TCTGGATTCC CTTTTCCAAA AGAAGAATGT TAGCTTCAAC 5880

CAAAAGCTCC AGCACAGGAT TGCCCTGCAG GTGGCAGATG GGCTCAGGTA CCTTCACTCA 5940

GCCATGATCA TCTATCGGGA TCTGAAGCCT CACAACATCC TCCTGTTCAA CCTGAAGACC 6000

GACTCTGACA TCATCGCCAA GATCACAGAC TACGGCATCG CTCAGTACTG CTGCAGCATG 6060

GGAGTAAGAA GCTCCGAGGG GACAGCAGGT TTCCGAGCTC CAGAGGTTGC CCGAGGTAAT 6120

GTGATTTATA ATCAGCAGGC TGATGTGTTC TCGTTCGGCC TGCTGCTCTA CGACCTGATG 6180

ACGCGTGGCG AGCGCATTTC AGACGGCATG AAGTTTCCCA GCGAGTTTGA TGAAATTGCA 6240

GTTCAGGGAA AGCTGCCAGA TCCAGTTAAA CACTACGGTT GCTCACCTTG GCCCAGCTTT 6300

CAGGTTCTAA TAAAGGAGTG TCTGCAGGAG AGCCCACAGG ATCGACCCAC TTCTGCTCAG 6360

GTGTTTGACA GGTTGAATTC AGGTGAAATG CTGTGTCTTA TGAGGGAGCT TGTGGTTCCC 6420

GGGGTTTTGA GCGCTGAGTG CTTCATTCTG AGCTCTGGCG CCGACAGCAA TTCTTCCAGC 6480

CACCGGGTCT GGCTTGGTGG AGGCAGCAGG ACCCAGAAGA AGGGATCCAT CACAGCTGTG 6540

GACCTGAACA CCAACACGGT CGCTACACAG GCTGGTTCTT TCGAGGTCGA CACCAGTCCC 6600

GTCCTGTGCC TCGTGACCGT CCAAATCCCA AACGAGGACA GCGATTGGCT GGTGGCAGGC 6660

ACCCAGTCTG GCTCTTTAGT GGTCATCAAC AGTCGGGACA CGTCGACTTG GCACCACCTG 6720

CAGAGGGTCA CCGACGCCGT CACATCACTG TACTTCCATG TACACCCTCG ACGCACTCAA 6780

AGAAAGAATT ATTTGCTGGT TGGGACAGCA GATGGAATTC TTAGCATTTA TGAGGACTCT 6840

GTGCTCAAGC AGGAGAATGG CCAACCGGTT AAAACGCTCA GTGTGGGCAA CGTCAACACT 6900

CCGGTCATGT GTTTGGGCCA GTCGGTGCAT TCACTGGACA GCAGGTCTGT GTGGGCCGGC 6960

TGCGGACCCA AGATCCTTTC CTTCACTGCT GACTATGATG TCTGCAAGTC CATCGACACA 7020

AGACCGAACC TCTTTTCCCA CCAGCAGCGG TCACTGGGGA GCGAGGCGTG TGTGTATCGT 7080

ATGGTTGTGG ATAAGTACGT GTACCTCAGC AAAGCCAGGA CAACAACTGT TGAGGTTTGG 7140

GACAAGAGGA GCGAGAGGAT GGTGGACTGT ATTGACTGTG CTCAGATTAT TAGACGTGAC 7200

AGAGGCGGGG ACGGCAGAGA AGCTGAGCTG CCCTCTGAGG CGTCGCCCTC CTGGGCCACA 7260

GTGAAGGCCC TGCTCTTGCC AAACGCCGCC ATGCTCTGGA TCGGCACTAG AAGGGGCCAC 7320

CTGCTGCTAC TGGAGCTCCC CAAACACCAA ATTCTGCAGG TCATGGAGTC CCACTGTGAT 7380

TCTCTCCGCT GCATGGCATC TGCACTCATA CAAACACTTA ACAGGGAGAA TGTGGTGCTG 7440

GTTTTGGGCC GAAGACAAAC TCAGCACAAG AATCCAAATG ATGAGGAGTC TGTGCTTACG 7500

GTGTGGAACA GCATGCTCCC GGTGGAGGTC AAAGACCTGA AAAAGCACTG CGAGAAGAGA 7560

GAGCAGATCG CAGCCAAAAT GAGAGAGCAG CTCCACCAGT GA 7602

Domain Profile

S: 6     llGrGafGsvyraavkGeevavkafkiaadklkrdslelalkayselrqelsvLlalkhP  65

          lG+G+fG+vyr  +k e+vavk+f+      k+ s  +    y  lrqel+vL +l+hP

Q: 1873  RLGDGGFGTVYRGVYKNEDVAVKIFN------KHASELY---IYRLLRQELVVLGRLRHP  1923

         69************************......7776555...7999**************

S: 66    sivsLvgisikPlalvleLaplgsLdrlLsedkksssklgrtltkkialqvargleyLhk  125

         s+vsL++++ +P +lv+eLa +gsLd l+++++ s   + ++l+++ialqva+gl+yLh+

Q: 1924  SLVSLLAAGSTPQVLVMELALRGSLDSLFQKKNVS---FNQKLQHRIALQVADGLRYLHS  1980

         *****************************999888...9*********************

S: 126   kkiiyrdLksenvLvwslspkeailikladyGisrqslrsGakgveGteGfraPeivrge  185

         ++iiyrdLk++n+L+++l++ ++i++k++dyGi+++++ +G++++eGt GfraPe++rg+

Q: 1981  AMIIYRDLKPHNILLFNLKTDSDIIAKITDYGIAQYCCSMGVRSSEGTAGFRAPEVARGN  2040

         ************************************************************

S: 186   vvydekvdvfsfGlllyell.sgkrpvegeeqlkivekl.lkGkrPvlvkeeevlptpll  243

         v+y++++dvfsfGllly+l+  g+r+ +g +++ +++++ ++Gk+P++vk++++ p+p

Q: 2041  VIYNQQADVFSFGLLLYDLMtRGERISDGMKFPSEFDEIaVQGKLPDPVKHYGCSPWPSF  2100

         ********************6699***************9******************98

S: 244   d.LlveCwkekPekrPtasqvvs  265

         + L++eC++e P++rPt++qv++

Q: 2101  QvLIKECLQESPQDRPTSAQVFD  2123

         889******************97

Domain Sequence
(FASTA)

RLGDGGFGTV YRGVYKNEDV AVKIFNKHAS ELYIYRLLRQ ELVVLGRLRH PSLVSLLAAG 60

STPQVLVMEL ALRGSLDSLF QKKNVSFNQK LQHRIALQVA DGLRYLHSAM IIYRDLKPHN 120

ILLFNLKTDS DIIAKITDYG IAQYCCSMGV RSSEGTAGFR APEVARGNVI YNQQADVFSF 180

GLLLYDLMTR GERISDGMKF PSEFDEIAVQ GKLPDPVKHY GCSPWPSFQV LIKECLQESP 240

QDRPTSAQVF D 251

Keyword

Complete proteome; GTP-binding; Leucine-rich repeat; Nucleotide-binding; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0005525	; F:GTP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007264	; P:small GTPase mediated signal transduction

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR011009	; Kinase-like_dom.
IPR001611	; Leu-rich_rpt.
IPR003591	; Leu-rich_rpt_typical-subtyp.
IPR013684	; MIRO-like.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020859	; ROC_GTPase.
IPR008271	; Ser/Thr_kinase_AS.
IPR005225	; Small_GTP-bd_dom.
IPR001806	; Small_GTPase.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR017986	; WD40_repeat_dom.

Pfam

PF00560	; LRR_1; 1.
PF08477	; Miro; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00248	; ANK; 2.
SM00369	; LRR_TYP; 1.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS51450	; LRR; 8.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS51424	; ROC; 1.

Prints

PR00449

; RASTRNSFRMNG.

Created Date

20-Feb-2013