EKS-ORN-00150

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00150

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	457.7	1.4E-137	1079	1338	260

Status

Unreviewed

Ensembl Protein

ENSONIP00000004911

UniProt Accession

I3J7S1;

Protein Name

Protein Synonyms/Alias

Gene Name

MET

Gene Synonyms/Alias

MET;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000003898	ENSONIP00000004910	ENSONIT00000004913
ENSONIG00000003898	ENSONIP00000004911	ENSONIT00000004914

Organism

Oreochromis niloticus

Functional Description

Protein Length

1381

Protein Sequence
(FASTA)

MNLCLLHAIM LLWAIRSSVQ GQCDRSSEDT KLNLSVTYEL PSFTAEFPIQ NMVILDGVIY 60

VGAVNRIYAL APNLRKLSEY HTGPLRANET CGQKLNGTSS SGRVDNHNIA LVAENIYDKG 120

LYSCGSADNG VCRRHVLDDG VSAKSVDEEV YCFADKKKLE TGQPDDSDVV VSPLGSQVLN 180

VESNVIQFFV GKRNISSSAK HPHTLSLRKM KTSQNGFTFF SNRSYMDLIP SLRGNYYLRY 240

VYSFQSGPFT YFLTVQQVSK DSQAYHSRIV RMCSADSVIR RYVEMPLECI STDKRRRRRR 300

SGTGVKVFNI LQAAYVTKAG IDPEIQKHLK VEEDDDVLFA AFAKGKPNSK DPTPNSAVCV 360

IALKQINSMF KTYMEKCNTI EPYHFTGLDK KSCYNVKTFL QRATSHCSGY INNYRVQVTQ 420

FFQRLEYWHK DLTNTLVTSI TVVPVHGRAV VYLGTADGRQ IQVLLSRFAS PHVNIHLDSR 480

PVTTSVALLD ADRSDGAILM ATGNKITKVP LIGPGCGQLT TCISCLLSSR VTECGWCDGR 540

CTRASECTSS IWTQDYCTPE ITKVSPASGP IRGSTVVTIC GKNFGFDKTE NFKASMVTVE 600

VAGASCKLSR QENSNRYACV LVKSVFWGWE GDVVKVTSGQ NVTMFKGFNF VDPVIRDIFP 660

TFGPKSGNTM LTITGANLDT GSKREVTIGK GICNVQSWSS KKVTCKTPPY AALSSQTVKL 720

TVDSVERRAP MQFTYNQDPI INNIQPSRSF VSGGCTVSAH GLYLKSGLQP MMLVSIGENT 780

ETFHVSCVYG ENQTSIQCTT PSLVKLGMQP PVITKVSFVL DGYSTKQMDM IYVEDPLFQD 840

PKLTSKDNKS IVELKGDRMD REAMNCQVLT VSNHSCESLT LVGNTLECIV PTELQVATAK 900

ELQVEWRQAD SIRHLGKVTL AQEQDYTGLI VGCVCVSLLL LLLGSLLMWK KNKHIDDLSE 960

VWYDGRGHIQ HLDRLANARS VSPTNEMVSH ESVDYRTTLL EVTIYKNQCH GQSCFPAAKI 1020

LGALGGGIGM GLGMGMGIDG DLVSPLLMAP VHIDPSCLHP DLLTEVQHVV IARERLLLHL 1080

NQVIGRGHFG CVFHGTLLEP DGQKLHCAVK SLNRITDLEE VSQFLKEGII MKDFSHPNVL 1140

SLLGICLPPE GSPLVVLPYM KHGDLRNFIR DEGHNPTVKD LMGFGLQVAR GMEYLASKKF 1200

VHRDLAARNC MLDESYTVKV ADFGLARDVY DKEYYSVHNK SGVKLPVKWM ALESLQTHKF 1260

TTKSDVWSFG VLLWELMTRG APPYSDVNSF DITVFLLQGR RLLQPEFCPD ALYTVMIECW 1320

HPKPERRPSF SELVSRISAI FSSFSGEHYV LLNTTYVNID KMSPYPSLLS STASSSSSSS 1380

E 1381

Nucleotide Sequence
(FASTA)

ATGAATCTCT GTTTGCTTCA TGCCATCATG TTGCTGTGGG CCATTCGCTC CAGCGTGCAG 60

GGCCAGTGCG ATAGATCATC AGAGGATACC AAACTCAACC TCTCTGTCAC CTATGAGCTC 120

CCATCGTTTA CCGCAGAATT CCCAATCCAG AACATGGTGA TACTGGATGG AGTCATCTAT 180

GTTGGTGCTG TAAACAGAAT ATATGCCCTG GCCCCAAACT TGAGAAAGCT GTCAGAGTAC 240

CACACAGGTC CGCTGCGTGC CAACGAGACC TGTGGCCAGA AGCTGAACGG AACAAGCAGC 300

AGTGGAAGAG TAGACAACCA CAACATTGCC TTAGTGGCGG AGAACATTTA CGACAAGGGG 360

TTGTACAGCT GTGGCTCAGC AGATAACGGT GTTTGCCGCC GTCACGTCCT GGATGATGGC 420

GTGAGCGCAA AAAGTGTAGA TGAAGAAGTC TACTGCTTTG CCGACAAGAA GAAACTGGAA 480

ACCGGGCAAC CCGATGACTC AGATGTTGTA GTCAGCCCTT TGGGCTCCCA AGTGCTGAAT 540

GTGGAGAGCA ATGTCATCCA ATTTTTTGTT GGGAAAAGAA ACATCTCAAG CAGTGCAAAA 600

CATCCCCACA CCCTTTCTCT GCGGAAAATG AAGACAAGCC AGAATGGTTT TACTTTCTTC 660

TCAAACAGAT CATACATGGA CCTGATTCCA TCTCTACGTG GAAATTACTA CCTGCGCTAC 720

GTTTACTCCT TCCAGAGTGG ACCCTTCACC TACTTCCTGA CCGTGCAGCA GGTGAGCAAG 780

GACTCTCAGG CCTACCACTC CCGCATAGTC CGCATGTGCT CCGCAGACTC TGTGATTCGT 840

CGCTACGTGG AAATGCCCCT TGAATGCATC AGCACCGATA AGCGGCGGCG ACGGCGGCGC 900

TCTGGGACAG GTGTGAAAGT GTTTAATATC TTGCAGGCAG CCTATGTCAC TAAAGCGGGA 960

ATTGACCCGG AAATCCAGAA GCACCTGAAG GTGGAAGAGG ACGATGATGT GCTGTTTGCT 1020

GCCTTTGCCA AAGGAAAGCC AAACTCTAAA GACCCAACAC CTAATTCAGC GGTTTGTGTG 1080

ATTGCCCTGA AACAAATCAA CAGCATGTTC AAAACCTACA TGGAGAAGTG CAACACCATA 1140

GAGCCATACC ACTTCACTGG TTTAGACAAG AAGTCCTGCT ACAATGTGAA AACATTCCTC 1200

CAACGTGCTA CAAGTCACTG TAGTGGCTAT ATTAATAATT ACAGAGTACA GGTGACCCAG 1260

TTTTTCCAGA GGTTAGAATA CTGGCACAAA GACTTGACAA ACACCTTGGT GACCTCAATT 1320

ACTGTGGTGC CAGTCCACGG TCGTGCTGTG GTATACCTAG GGACTGCTGA TGGACGTCAA 1380

ATACAGGTGT TGCTCTCCCG ATTTGCCTCT CCCCATGTCA ACATCCACCT GGACTCCAGA 1440

CCTGTCACCA CCAGTGTAGC ACTGCTCGAT GCTGACCGTT CAGATGGAGC CATTCTGATG 1500

GCCACAGGAA ACAAGATCAC TAAGGTCCCT TTAATTGGCC CAGGCTGTGG TCAGCTGACC 1560

ACATGCATTT CGTGTTTGTT GTCGTCAAGA GTGACCGAAT GTGGCTGGTG TGATGGACGC 1620

TGTACAAGAG CAAGCGAGTG CACCTCCTCC ATCTGGACCC AGGACTACTG CACACCTGAG 1680

ATCACCAAGG TTAGTCCAGC CTCTGGACCA ATACGAGGCT CTACTGTAGT GACGATTTGT 1740

GGCAAGAACT TTGGCTTCGA CAAGACAGAG AACTTCAAGG CTTCCATGGT AACCGTGGAG 1800

GTGGCAGGGG CTTCCTGTAA ACTGTCCAGG CAAGAAAACT CCAACAGGTA TGCTTGTGTT 1860

TTGGTAAAGA GTGTTTTTTG GGGATGGGAG GGAGACGTTG TGAAGGTCAC CAGTGGCCAA 1920

AATGTGACCA TGTTCAAGGG TTTCAATTTT GTGGACCCTG TGATCAGGGA CATCTTCCCA 1980

ACATTTGGGC CAAAGTCAGG AAACACCATG CTGACCATTA CAGGAGCAAA CCTGGATACA 2040

GGAAGCAAGC GAGAGGTGAC AATAGGGAAG GGTATCTGCA ACGTTCAGAG CTGGTCCTCC 2100

AAAAAGGTGA CCTGTAAGAC GCCACCATAT GCTGCTCTCT CAAGCCAAAC TGTGAAGCTG 2160

ACAGTGGATT CGGTGGAGCG CCGCGCCCCT ATGCAGTTCA CCTACAACCA AGACCCGATC 2220

ATCAACAACA TCCAGCCCTC ACGCTCCTTT GTGAGCGGAG GCTGCACAGT GTCGGCTCAT 2280

GGTTTATACC TTAAGTCCGG CCTTCAACCC ATGATGCTTG TCTCCATTGG TGAGAATACT 2340

GAGACCTTCC ATGTAAGCTG TGTGTATGGT GAAAATCAGA CTTCCATCCA GTGCACAACA 2400

CCCTCTCTGG TCAAACTGGG CATGCAGCCG CCGGTCATCA CCAAGGTGTC ATTTGTCCTG 2460

GACGGCTATT CAACTAAACA GATGGATATG ATCTATGTGG AAGACCCGCT ATTCCAGGAC 2520

CCTAAGCTCA CTTCTAAGGA CAACAAGAGC ATAGTGGAGC TCAAAGGCGA TCGGATGGAC 2580

AGGGAAGCAA TGAACTGTCA GGTCCTCACC GTTTCCAACC ACAGCTGTGA AAGTCTGACT 2640

CTAGTCGGAA ACACTCTGGA GTGCATCGTA CCCACTGAGC TACAGGTTGC CACAGCCAAG 2700

GAGCTGCAGG TGGAGTGGCG TCAGGCGGAC TCCATCAGAC ATCTTGGCAA GGTGACGCTG 2760

GCACAGGAGC AGGACTACAC GGGCCTCATT GTGGGCTGCG TGTGCGTCAG CCTGCTGTTG 2820

CTGCTGCTGG GATCGCTGCT GATGTGGAAG AAGAACAAAC ACATTGATGA TCTGTCTGAG 2880

GTGTGGTATG ATGGCCGGGG TCACATCCAG CATCTGGACA GGCTGGCTAA CGCGAGGAGT 2940

GTCAGCCCCA CTAACGAAAT GGTCTCCCAC GAGTCAGTCG ACTATAGAAC AACCCTGCTG 3000

GAGGTTACTA TCTATAAAAA TCAATGTCAT GGTCAAAGCT GTTTTCCAGC TGCTAAAATA 3060

TTGGGGGCCT TAGGAGGTGG GATAGGGATG GGTCTGGGAA TGGGAATGGG AATTGATGGT 3120

GATTTGGTAT CACCCCTGCT AATGGCCCCG GTCCACATTG ACCCATCCTG CCTCCACCCA 3180

GACCTACTTA CTGAAGTTCA GCACGTGGTG ATCGCCAGGG AGCGGCTGCT TCTCCATCTC 3240

AACCAGGTCA TCGGCAGAGG CCATTTCGGC TGTGTTTTTC ACGGAACGCT GCTTGAGCCA 3300

GACGGCCAGA AGCTACACTG TGCCGTCAAG TCCCTGAACC GCATCACAGA CTTGGAAGAG 3360

GTGTCTCAGT TCCTGAAGGA GGGGATCATC ATGAAGGACT TCAGCCACCC CAACGTTCTC 3420

TCCCTGTTGG GTATCTGCCT TCCGCCCGAG GGCTCACCCC TGGTGGTTCT TCCGTATATG 3480

AAACACGGTG ACCTGCGCAA CTTCATCCGT GATGAGGGAC ATAACCCAAC AGTTAAGGAC 3540

CTGATGGGCT TTGGGCTGCA GGTGGCCAGA GGGATGGAGT ATCTGGCCAG CAAAAAGTTT 3600

GTCCACCGAG ACCTGGCTGC CAGGAACTGC ATGCTGGATG AGAGCTACAC AGTAAAGGTG 3660

GCAGACTTCG GCTTGGCCAG AGATGTTTAT GACAAAGAAT ATTACAGCGT TCACAACAAG 3720

AGCGGAGTCA AGCTGCCCGT TAAATGGATG GCTCTGGAGA GTCTGCAGAC GCACAAGTTT 3780

ACCACCAAAT CAGACGTGTG GTCTTTTGGC GTATTGCTAT GGGAACTCAT GACCCGCGGA 3840

GCTCCGCCGT ATTCTGATGT GAACTCCTTC GACATCACCG TGTTCCTCCT GCAGGGGAGG 3900

AGGCTGCTGC AGCCTGAGTT CTGCCCTGAT GCCCTCTACA CGGTCATGAT CGAGTGTTGG 3960

CACCCAAAGC CTGAACGACG GCCCTCATTC TCTGAGCTGG TTTCCCGCAT CTCTGCCATC 4020

TTCTCCAGCT TCAGCGGCGA GCACTACGTC CTGCTCAACA CCACGTATGT CAACATAGAC 4080

AAGATGAGCC CCTACCCCTC CCTCCTCTCC TCCACCGCTT CCTCCTCCTC ATCCTCTTCT 4140

GAG 4143

Domain Profile

S: 2     dkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhpn  61

         + ++viG+GhfG+v++g+l++++++k ++avksl+ritd+e+v++fl+eg++mk+++hpn

Q: 1079  HLNQVIGRGHFGCVFHGTLLEPDGQKLHCAVKSLNRITDLEEVSQFLKEGIIMKDFSHPN  1138

         789*********************************************************

S: 62    vlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylask  121

         vlsllGi+l++eg+plvvlpymk+Gdl++fir+e +n+tvkdl++f+lqva+gmeylask

Q: 1139  VLSLLGICLPPEGSPLVVLPYMKHGDLRNFIRDEGHNPTVKDLMGFGLQVARGMEYLASK  1198

         ************************************************************

S: 122   kfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqtf  181

         kfvhrdlaarnc+lde++tvkvadfGlardv+dke+y+v+++ + +lpvkw+aleslqt+

Q: 1199  KFVHRDLAARNCMLDESYTVKVADFGLARDVYDKEYYSVHNKSGVKLPVKWMALESLQTH  1258

         ************************************************************

S: 182   kqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvml  241

         k fttksdvwsfGvllwel+trga+pys+v+sfd+t++l +grrl +pe+cpd+ly vm+

Q: 1259  K-FTTKSDVWSFGVLLWELMTRGAPPYSDVNSFDITVFLLQGRRLLQPEFCPDALYTVMI  1317

         *.**********************************************************

S: 242   kcwkakpaerpqfsdlvsiis  262

         +cw++kp++rp+fs+lvs+is

Q: 1318  ECWHPKPERRPSFSELVSRIS  1338

         *******************98

Domain Sequence
(FASTA)

HLNQVIGRGH FGCVFHGTLL EPDGQKLHCA VKSLNRITDL EEVSQFLKEG IIMKDFSHPN 60

VLSLLGICLP PEGSPLVVLP YMKHGDLRNF IRDEGHNPTV KDLMGFGLQV ARGMEYLASK 120

KFVHRDLAAR NCMLDESYTV KVADFGLARD VYDKEYYSVH NKSGVKLPVK WMALESLQTH 180

KFTTKSDVWS FGVLLWELMT RGAPPYSDVN SFDITVFLLQ GRRLLQPEFC PDALYTVMIE 240

CWHPKPERRP SFSELVSRIS 260

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0004872	; F:receptor activity
GO:0007275	; P:multicellular organismal development

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 3.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013