EKS-ORN-00047
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00047
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak322.82.5E-968541125272
StatusUnreviewed
Ensembl ProteinENSONIP00000004987
UniProt AccessionI3J7Z7;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameJAK2 (2 of 2)
Gene Synonyms/Alias JAK2 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000003957ENSONIP00000004987ENSONIT00000004990
OrganismOreochromis niloticus
Functional Description
Protein Length1136
Protein Sequence
(FASTA)
MSIFKRHMAC ILLTNMDPPT TENQNGLPPN LDLATGPKRD TKATCLSVYQ YCEKKEGGEG 60
GASYSEIVLT FPPGEYVAEE LCISAAKACG ICPVFCSLFG LMRESDRTWF APNHVFKVDH 120
SSCEKLHFRI RYYFPGWYNS NNSSYAHRYG LSKGMESPVM DDCVMAYQFF QWRSDFLNGW 180
VDIPVSHEAQ EECLGMAVLD MMRLAKERGQ SAVDIYNDKS YKSFLPVSMR SRIQEYNILT 240
RKRIRYRFRK FIQQFSECKA TVCNLKLKYL MSLEMLLPSL YSERFQVTDT SSNEVTIIVT 300
GNKGIQWSKG KEEDRAEEEL QTYCDFPEVI DISIKQGNKE GSAESRIVTL TKQDNQIMEL 360
EFRSLSVAVS FVSLIDGYYR LVADAHHYLC KEVAPPRLLE CIQSYCHGPV SMEFTVSKLR 420
RSGNHQGLYM LRCSPRDYDK YFMSFVVGYE TMVDYKHCQI TKTESGEYIL SGAKRSFGSL 480
RELLNCYQKE ALRTDGYTFQ LIRCCPPSHK DKSNLLVCRN NQGAEMPTSP TLHNQNISQM 540
VFHKIRKEDL IIKESLGQGT FTKIFCGVRK ELGDYGEIHQ MDVVVKILDK AHRSYSESFF 600
EAASIMSQLS HKHLLLTYGV CVCGDENMMV QEYGKFGSLD TYLKKNKSCV NITWKLEVAK 660
QLSWAMHYLE DKNVIHGNVC AKNVLLIREE DRKTGSLPFI KLSDPGISIT VLPREVLVER 720
IPWVPPECIE NPQNLSLATD KWSFGTTLWE ICSGGDKPLS TLDCSKKNLF YEDRHQLPAP 780
KWTELANLIN SCMDYEPLHR PSFRTIIRDL NSLFTPDYEL LVESDMVPNR ARGFGFPWAS 840
ENQDPSQFEE RHLIFLKQLG KGNFGSVEMC RYDPLQDSTG EVVAVKKLQH STAEHLRDFE 900
REIEILKSLQ HENIVKYKGV CYSAGRRNLR LIMEYLPYGS LRDYLIKHKD RFDSKKLLHY 960
ASQICKGMDY LGTKRYIHRD LATRNILVES EMRVKIGDFG LTKVLPQDKD YYTVREPGES 1020
PIFWYAPESL TESKFSVASD VWSFGVVLYE LFTYSDKNCS PPVVFMNKMG NEKQGQMIVY 1080
HLIDLLRNGY RLPAPDMCPT QIHKIMMECW SNDPKLRPTF KTLIHSVETV RDSEDR 1136
Nucleotide Sequence
(FASTA)
ATGTCTATTT TTAAGCGGCA CATGGCCTGC ATTCTGCTGA CAAACATGGA CCCACCCACC 60
ACAGAAAATC AGAACGGCCT CCCGCCAAAT CTCGACTTGG CCACTGGACC GAAGCGAGAC 120
ACAAAGGCCA CCTGTCTGAG CGTCTACCAG TACTGCGAGA AGAAGGAGGG AGGAGAGGGC 180
GGGGCAAGTT ATTCAGAAAT TGTCCTCACG TTTCCACCTG GAGAGTACGT AGCAGAGGAA 240
CTTTGCATCT CTGCAGCGAA AGCGTGTGGG ATTTGTCCAG TGTTCTGCAG CTTGTTTGGC 300
CTAATGAGGG AAAGTGACCG GACATGGTTC GCCCCAAATC ATGTCTTTAA AGTGGACCAC 360
TCATCCTGTG AGAAACTGCA CTTCAGAATC AGATACTATT TTCCTGGCTG GTACAACAGC 420
AACAATTCAT CATACGCTCA TCGCTATGGT TTGTCTAAAG GGATGGAAAG CCCTGTGATG 480
GATGACTGTG TCATGGCATA CCAGTTTTTT CAGTGGCGTA GTGACTTTCT GAATGGCTGG 540
GTTGATATTC CAGTTAGCCA TGAAGCGCAG GAGGAGTGTC TGGGCATGGC CGTGCTGGAC 600
ATGATGAGGC TCGCCAAAGA GAGGGGGCAA TCAGCAGTGG ACATCTACAA TGACAAAAGC 660
TACAAGTCCT TCCTCCCAGT GTCCATGCGA AGCCGCATCC AGGAATATAA CATTTTGACT 720
CGGAAGAGAA TCCGCTATCG CTTCAGGAAG TTCATCCAGC AGTTCAGTGA ATGCAAGGCC 780
ACTGTGTGTA ACCTCAAGCT CAAATACTTA ATGAGCCTTG AGATGCTGTT GCCCTCTCTC 840
TACTCCGAGC GCTTCCAAGT CACAGACACC TCCTCAAATG AGGTTACCAT CATTGTCACG 900
GGAAATAAGG GCATCCAGTG GTCTAAAGGG AAAGAGGAGG ACAGAGCAGA GGAGGAGCTG 960
CAGACATACT GTGATTTTCC AGAGGTGATT GACATCAGTA TCAAACAAGG CAATAAGGAA 1020
GGATCTGCAG AGAGCCGCAT AGTTACACTC ACCAAACAGG ATAACCAGAT CATGGAGCTG 1080
GAATTTCGCT CGCTCTCAGT GGCCGTGTCA TTCGTGTCAC TGATTGATGG ATACTACAGG 1140
CTGGTGGCCG ATGCCCATCA TTACCTGTGC AAAGAGGTAG CGCCGCCACG GCTTCTGGAG 1200
TGCATTCAGA GCTACTGCCA CGGCCCTGTG TCGATGGAGT TTACAGTCAG TAAATTGCGG 1260
CGCTCCGGTA ACCACCAAGG CCTGTACATG CTTCGCTGCA GCCCCAGGGA TTATGATAAA 1320
TACTTCATGT CTTTTGTGGT GGGGTATGAA ACGATGGTGG ACTATAAGCA CTGCCAGATC 1380
ACAAAGACCG AGTCAGGAGA GTACATTCTA AGTGGAGCCA AGAGGAGCTT TGGTTCACTC 1440
AGGGAACTTC TGAATTGCTA TCAGAAGGAG GCGCTCCGCA CTGATGGGTA CACATTTCAG 1500
CTGATCAGGT GCTGCCCGCC CAGCCACAAA GATAAGTCCA ACCTGCTGGT GTGTAGAAAC 1560
AATCAAGGGG CCGAGATGCC CACATCTCCC ACGCTCCACA ACCAAAACAT CAGCCAGATG 1620
GTCTTTCACA AGATTCGAAA GGAGGATCTC ATCATCAAAG AGAGTCTGGG TCAAGGAACG 1680
TTCACCAAGA TCTTTTGCGG TGTGAGGAAG GAGCTTGGAG ACTATGGGGA GATCCATCAG 1740
ATGGACGTTG TTGTCAAGAT TCTGGATAAG GCGCATCGCA GCTATTCAGA GTCATTTTTT 1800
GAAGCCGCAA GCATAATGAG CCAGCTCTCT CACAAACACT TACTTCTCAC TTATGGCGTG 1860
TGTGTTTGTG GAGATGAAAA CATGATGGTG CAGGAGTATG GTAAATTTGG TTCACTGGAC 1920
ACCTACCTGA AGAAGAACAA AAGCTGTGTT AACATCACCT GGAAACTGGA AGTGGCCAAG 1980
CAGCTCTCCT GGGCTATGCA CTATCTGGAG GATAAAAACG TCATTCATGG GAATGTTTGT 2040
GCTAAGAATG TCCTTCTGAT TCGAGAGGAG GATCGGAAAA CAGGCAGTCT TCCTTTCATC 2100
AAGCTCAGTG ACCCCGGTAT CAGCATCACC GTGCTGCCCA GAGAAGTGCT AGTGGAGCGT 2160
ATCCCATGGG TGCCTCCTGA GTGCATTGAA AACCCTCAAA ACCTGAGTTT AGCTACAGAC 2220
AAGTGGAGCT TCGGGACCAC GCTTTGGGAG ATCTGCAGCG GTGGAGACAA ACCTCTCAGC 2280
ACACTGGACT GCTCAAAGAA AAACTTGTTC TATGAGGACA GACACCAGCT GCCGGCTCCT 2340
AAATGGACAG AGCTGGCCAA CCTGATAAAC AGCTGTATGG ACTATGAGCC TTTACACCGG 2400
CCCTCCTTCA GAACAATAAT CCGAGATCTC AACAGTCTCT TCACACCAGA CTATGAGCTG 2460
CTGGTGGAGA GCGACATGGT GCCCAACAGA GCACGAGGCT TCGGCTTCCC GTGGGCCTCC 2520
GAGAACCAAG ATCCGTCACA GTTCGAGGAG CGGCACCTCA TTTTTCTCAA GCAGCTGGGC 2580
AAAGGGAACT TTGGCAGCGT GGAGATGTGC CGGTACGACC CGCTGCAGGA CAGCACAGGG 2640
GAGGTGGTGG CTGTGAAGAA ACTCCAGCAC AGTACAGCTG AGCACCTCAG GGACTTTGAG 2700
CGGGAAATTG AGATCCTTAA ATCACTTCAG CATGAAAACA TTGTCAAATA CAAGGGAGTG 2760
TGCTACAGTG CAGGACGAAG AAACCTACGG TTGATCATGG AATATCTCCC CTATGGCAGC 2820
TTGAGAGATT ATCTCATCAA ACACAAGGAC AGATTTGATT CCAAGAAACT GTTGCACTAC 2880
GCGTCACAGA TTTGCAAGGG AATGGACTAC CTTGGCACTA AGCGTTACAT TCACAGAGAC 2940
CTGGCCACAA GAAACATTCT GGTGGAGAGC GAGATGAGGG TTAAGATCGG TGACTTTGGT 3000
CTGACCAAGG TGCTTCCTCA GGACAAAGAC TACTACACTG TCAGAGAGCC TGGGGAAAGC 3060
CCCATCTTCT GGTATGCTCC TGAGTCGCTG ACAGAGAGCA AATTCTCTGT GGCTTCAGAC 3120
GTTTGGAGTT TTGGGGTCGT CCTCTATGAA CTCTTCACTT ACAGCGACAA GAACTGCAGC 3180
CCACCAGTGG TCTTTATGAA TAAAATGGGC AATGAAAAGC AGGGCCAGAT GATTGTCTAC 3240
CATTTGATTG ACCTCCTAAG AAATGGCTAT AGGCTGCCTG CACCTGATAT GTGTCCTACA 3300
CAGATTCACA AGATTATGAT GGAGTGCTGG AGCAATGACC CTAAACTGCG GCCTACTTTC 3360
AAGACATTAA TCCATAGTGT GGAGACTGTA CGAGACAGCG AGGATAGATG A 3411
Domain Profile
S: 2     kqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlsheh  61
          ++++Lgkg+f++v+++r+d+ +dst+e va+k L++s+ ++ rdf+re+eil++l+he+
Q: 854   IFLKQLGKGNFGSVEMCRYDPLQDSTGEVVAVKKLQHSTAEHLRDFEREIEILKSLQHEN  913
         6789********************************************************
S: 62    ivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLed  119
         ivk+kgvc++ g++  rl+mey+++GsL++yL k+k++ + ++ll++a+q++k+m+YL++
Q: 914   IVKYKGVCYSAGRRnlRLIMEYLPYGSLRDYLIKHKDRFDSKKLLHYASQICKGMDYLGT  973
         *********999888*********************************************
S: 120   kklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwlap  178
         k+++hrd+a+rn+Lve+e +      vk++d+gl+k+++qd +Yy+vre+++s+i+w+ap
Q: 974   KRYIHRDLATRNILVESEMR------VKIGDFGLTKVLPQDkDYYTVREPGESPIFWYAP  1027
         ********************......**********************************
S: 179   eclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklell  225
         e+l+e+k +s+asdvWsFgv+lyel+t  +k++sp    ++++++e        +++ ll
Q: 1028  ESLTESK-FSVASDVWSFGVVLYELFTySDKNCSPpvvfMNKMGNEkqgqmivyHLIDLL  1086
         *******.*******************9999*****9987777777899999********
S: 226   eekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263
          ++ rlp+p+ cp++++++m++c+s++p+ rp+F+++++
Q: 1087  RNGYRLPAPDmCPTQIHKIMMECWSNDPKLRPTFKTLIH  1125
         ***********************************9976
Domain Sequence
(FASTA)
IFLKQLGKGN FGSVEMCRYD PLQDSTGEVV AVKKLQHSTA EHLRDFEREI EILKSLQHEN 60
IVKYKGVCYS AGRRNLRLIM EYLPYGSLRD YLIKHKDRFD SKKLLHYASQ ICKGMDYLGT 120
KRYIHRDLAT RNILVESEMR VKIGDFGLTK VLPQDKDYYT VREPGESPIF WYAPESLTES 180
KFSVASDVWS FGVVLYELFT YSDKNCSPPV VFMNKMGNEK QGQMIVYHLI DLLRNGYRLP 240
APDMCPTQIH KIMMECWSND PKLRPTFKTL IH 272
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Danio rerio"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Oryzias latipes"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-DAR-00041
EKS-GAA-00047
EKS-ICT-00030
EKS-ORL-00044
EKS-SUS-00027
EKS-TEN-00052
EKS-XIM-00045
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR019749; Band_41_domain.
IPR019748; FERM_central.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
Pfam
PF07714; Pkinase_Tyr; 2.
PF00017; SH2; 1.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
Prints
PR01823; JANUSKINASE.
PR00109; TYRKINASE.
Created Date20-Feb-2013