EKS-ORN-00019
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00019
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph457.21.4E-137614867254
StatusUnreviewed
Ensembl ProteinENSONIP00000005086
UniProt AccessionI3J896;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA2 (2 of 2)
Gene Synonyms/Alias EPHA2 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000004035ENSONIP00000005086ENSONIT00000005090
OrganismOreochromis niloticus
Functional Description
Protein Length974
Protein Sequence
(FASTA)
MELRGLNLFL FLFINRVFLS LQSKEQVLLD MRASGSELGW LTSPYENGWE IVQTVVNGTL 60
FYTYSVCSIE TTEQDNWLRT TFIQRRPGTS RVSVELSFVV RDCNTFGGAS VACKETFNLF 120
ISEADADVGT NFRKGQFRKV ATIAPDEVTQ GRVLKVNTET KTVGPLSKKG FYLGFQDVGA 180
CVALLSVRVY YKTCPSTVQS LAVFPETVAD ALREVEGACI ENAVSQATPR IYCTAEGKWV 240
VPMVQCQCLA GYEATGDSCQ ACKPGYFKPS VSNDLCQVCP DNTKPSASGA SECLCEEGFF 300
RAPSDPPTSA CSAPPSAPRD LTSMTLPGEG KLQLFWSPPL VTGGRSDLMY SVVCKLCDEA 360
SCIPCGEKIR FEPGPTNLQD PTVVVSDLDS HLNYTFTVEA QSGVSQFSAE RPTATITTAL 420
DYTDPPKVTE IHLADRSPTS LSLSWTPTRR PPAHINHRYE LMYRRKDDST EGDVTTYKVL 480
ILDKSFVQID GLLPATTYTF RVHALGPEGN PGSYSADHEF ITSPLAAPQF GNKPTMVMVA 540
VFGVAVILLV VVAGLLLRKR RLNARRRGGP EDPYFSSDQH KPLKMYIDPH TYEDPNIAIH 600
KFVTEIDPSV IGKQKVIGVG EFGEVFRGVM KIPGRGEVPV AIKTLKPGYS EKQRQDFLSE 660
ATIMGQFSHP NIIHLEGVIT KFKHAMIVTE YMENGALDTH LKGRDGEIPP YQLVGMLRGI 720
AAGMKYLSDM NYVHRDLAAR NVLVNGNLEC KVSDFGLSRV LEDDAEGTYT TRGGKIPIRW 780
TAPEAIAYRK FTSASDVWSF GIVMWEVMAF GERPYWDMSN HEVMKAINEN FRLPAPMDCP 840
STIYQLMLQC WLHERLKRPR FLDIVNFLDK LLKSPESLKT IADFDPRVSI RLPSTSGGDG 900
TMFRSVAEWL ESIKMSQYKE SFARAGITTM EQVLALRHED IRNIGVRLPG HMKRIAYSIL 960
GLKDETSSLS VFAV 974
Nucleotide Sequence
(FASTA)
ATGGAGCTGC GTGGACTCAA CTTATTCTTG TTTTTATTTA TTAACCGAGT ATTTCTCAGC 60
CTCCAGTCGA AAGAACAAGT ATTGCTGGAT ATGAGAGCTT CGGGATCAGA GTTGGGATGG 120
TTGACATCGC CATATGAGAA CGGATGGGAG ATCGTCCAGA CGGTGGTGAA TGGCACACTT 180
TTCTACACTT ACAGTGTTTG TAGCATAGAG ACTACAGAAC AGGATAACTG GCTGCGCACA 240
ACGTTTATTC AGCGGCGCCC GGGCACAAGC CGTGTCTCTG TGGAGCTCAG TTTTGTCGTG 300
CGAGACTGCA ACACTTTTGG TGGTGCGTCT GTTGCCTGCA AAGAAACCTT CAACCTATTC 360
ATCTCAGAGG CTGATGCCGA CGTGGGAACG AACTTCCGTA AAGGACAGTT CCGCAAAGTG 420
GCCACCATTG CTCCCGACGA GGTCACTCAG GGCCGGGTGC TAAAGGTGAA CACAGAGACA 480
AAGACTGTGG GGCCGCTGTC AAAGAAGGGC TTCTACCTGG GTTTTCAGGA CGTGGGCGCT 540
TGTGTGGCGC TGCTCTCTGT CCGAGTCTAC TACAAGACAT GCCCATCCAC CGTGCAGAGC 600
TTGGCAGTTT TCCCGGAGAC GGTGGCAGAT GCTCTCAGGG AGGTTGAGGG AGCCTGCATA 660
GAGAATGCCG TCAGCCAGGC CACCCCGCGC ATCTACTGCA CAGCTGAGGG TAAATGGGTG 720
GTTCCCATGG TTCAATGCCA ATGTCTCGCA GGCTACGAAG CCACAGGAGA CTCCTGCCAA 780
GCATGCAAAC CAGGGTACTT CAAGCCATCT GTATCGAACG ACTTATGTCA GGTTTGTCCT 840
GATAACACCA AGCCCTCTGC TTCCGGAGCT AGTGAATGTC TGTGTGAAGA AGGTTTCTTC 900
CGGGCTCCTT CAGACCCTCC TACATCGGCC TGCTCTGCTC CACCTAGTGC CCCTCGGGAC 960
CTTACCTCCA TGACTCTGCC AGGGGAGGGC AAGTTGCAGC TGTTCTGGAG CCCACCACTG 1020
GTTACTGGGG GTCGCAGTGA CCTTATGTAC AGTGTGGTGT GCAAACTCTG TGACGAGGCC 1080
TCTTGCATCC CCTGCGGCGA GAAGATCCGC TTTGAGCCAG GACCTACGAA CCTGCAGGAC 1140
CCAACGGTTG TTGTTAGTGA CCTGGACTCT CATCTGAACT ACACGTTCAC TGTAGAGGCT 1200
CAAAGTGGCG TGTCGCAGTT CAGTGCCGAG AGGCCCACTG CAACCATCAC CACTGCTCTG 1260
GACTACACAG ATCCCCCCAA GGTGACGGAG ATCCATCTGG CTGATCGCAG CCCCACCAGT 1320
CTGTCTCTGT CCTGGACTCC TACTCGCCGA CCTCCAGCCC ACATCAATCA TCGCTATGAG 1380
CTTATGTACC GCAGAAAAGA CGACAGTACC GAGGGTGATG TGACCACCTA CAAAGTCCTA 1440
ATTTTGGACA AAAGCTTTGT GCAGATTGAT GGTCTCCTCC CAGCCACTAC TTACACATTC 1500
AGGGTCCATG CTCTGGGCCC TGAAGGCAAC CCTGGCAGCT ATAGTGCCGA CCATGAGTTT 1560
ATTACTTCTC CATTAGCTGC ACCTCAGTTT GGGAACAAGC CCACCATGGT GATGGTAGCT 1620
GTATTCGGAG TAGCGGTTAT TCTGCTTGTT GTGGTGGCTG GCCTGCTGCT GCGTAAACGG 1680
AGACTGAACG CTCGTAGACG AGGAGGACCC GAGGATCCCT ACTTTTCATC AGATCAACAT 1740
AAACCTCTCA AGATGTACAT TGATCCACAT ACCTATGAGG ACCCTAATAT TGCCATCCAC 1800
AAGTTTGTCA CAGAAATTGA CCCCAGTGTG ATCGGCAAAC AAAAAGTCAT CGGTGTAGGA 1860
GAGTTTGGGG AAGTGTTTCG GGGTGTAATG AAGATTCCCG GGAGAGGCGA GGTGCCTGTA 1920
GCAATCAAGA CCCTCAAGCC AGGCTACTCG GAGAAACAGA GGCAGGACTT CTTGAGTGAG 1980
GCCACCATCA TGGGTCAATT CTCACACCCA AATATCATCC ACCTGGAGGG AGTTATCACC 2040
AAATTTAAAC ATGCCATGAT AGTGACTGAA TACATGGAGA ACGGAGCTCT CGACACACAT 2100
CTGAAGGGCC GTGATGGAGA GATTCCCCCG TACCAACTTG TGGGAATGCT GCGTGGAATA 2160
GCCGCTGGCA TGAAATACCT CTCTGACATG AACTATGTCC ACCGTGACCT GGCAGCAAGA 2220
AACGTTCTGG TCAACGGCAA CCTGGAGTGT AAAGTGTCTG ACTTTGGATT GTCACGTGTG 2280
CTGGAAGATG ATGCTGAGGG CACCTACACA ACCAGAGGAG GTAAAATCCC CATCCGCTGG 2340
ACTGCGCCAG AGGCCATCGC ATACAGGAAG TTCACCTCGG CCAGCGACGT GTGGAGCTTT 2400
GGTATTGTCA TGTGGGAAGT CATGGCATTT GGAGAACGAC CCTACTGGGA CATGAGCAAC 2460
CACGAGGTCA TGAAGGCTAT CAACGAGAAC TTCAGGCTTC CTGCTCCAAT GGATTGCCCA 2520
TCCACTATCT ACCAGCTCAT GCTCCAGTGT TGGCTGCACG AACGCTTAAA GCGACCTCGC 2580
TTCTTAGACA TCGTCAACTT TCTGGACAAA CTTCTCAAAA GCCCAGAATC CTTAAAGACC 2640
ATCGCAGACT TTGACCCACG CGTCTCCATC CGGCTGCCCA GCACCAGCGG TGGCGACGGC 2700
ACCATGTTCA GGTCGGTGGC CGAGTGGCTG GAATCCATCA AAATGAGCCA GTACAAGGAA 2760
AGCTTCGCTC GCGCTGGGAT AACGACCATG GAGCAGGTGC TCGCTTTGAG ACATGAAGAC 2820
ATCAGGAACA TCGGAGTGAG GCTGCCCGGT CACATGAAGC GAATAGCATA CAGCATCCTG 2880
GGCCTGAAAG ACGAGACGAG CTCCCTCAGC GTGTTCGCCG TGTGA 2925
Domain Profile
S: 4     ekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhpnii  63
         +kviG GefGev++G +k+pg+ e++vaiktlk g++ekqr+dflsea+i+Gqf+hpnii
Q: 614   QKVIGVGEFGEVFRGVMKIPGRGEVPVAIKTLKPGYSEKQRQDFLSEATIMGQFSHPNII  673
         79**********************************************************
S: 64    rleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdmgyv  123
         +leGv+tk k  mivteymengald+ l+ +dg++   qlvgmlrGia+gmkylsdm+yv
Q: 674   HLEGVITKFKHAMIVTEYMENGALDTHLKGRDGEIPPYQLVGMLRGIAAGMKYLSDMNYV  733
         ************************************************************
S: 124   hrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrkfts  183
         hrdlaarn+lvn nl ckvsdfGlsrvledd+e +ytt+ggkipirwtapeaiayrkfts
Q: 734   HRDLAARNVLVNGNLECKVSDFGLSRVLEDDAEGTYTTRGGKIPIRWTAPEAIAYRKFTS  793
         ************************************************************
S: 184   asdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldcwqk  243
         asdvws+Giv+wev+++Gerpywdmsn++v+kai+e++rlp+pmdcp+++yqlml+cw +
Q: 794   ASDVWSFGIVMWEVMAFGERPYWDMSNHEVMKAINENFRLPAPMDCPSTIYQLMLQCWLH  853
         ************************************************************
S: 244   draerpkfeqivsi  257
         +r +rp+f +iv++
Q: 854   ERLKRPRFLDIVNF  867
         ***********997
Domain Sequence
(FASTA)
QKVIGVGEFG EVFRGVMKIP GRGEVPVAIK TLKPGYSEKQ RQDFLSEATI MGQFSHPNII 60
HLEGVITKFK HAMIVTEYME NGALDTHLKG RDGEIPPYQL VGMLRGIAAG MKYLSDMNYV 120
HRDLAARNVL VNGNLECKVS DFGLSRVLED DAEGTYTTRG GKIPIRWTAP EAIAYRKFTS 180
ASDVWSFGIV MWEVMAFGER PYWDMSNHEV MKAINENFRL PAPMDCPSTI YQLMLQCWLH 240
ERLKRPRFLD IVNF 254
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Oryzias latipes"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-GAM-00004
EKS-GAA-00016
EKS-ORL-00018
EKS-TAR-00016
EKS-TEN-00016
EKS-XIM-00017
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013