EKS-ORN-00010
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00010
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph508.14.4E-153615871257
StatusUnreviewed
Ensembl ProteinENSONIP00000005166
UniProt AccessionI3J8H6;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA5
Gene Synonyms/Alias EPHA5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000004099ENSONIP00000005166ENSONIT00000005170
OrganismOreochromis niloticus
Functional Description
Protein Length982
Protein Sequence
(FASTA)
ISLLLIFTYH LLYFQPSTVN LLDSRSVMGD LGWVAYPKNG WEEIGEVDEN YAPIHTYQVC 60
RVMEQNQNNW LHTNWILTEG AQRVFIELKF TLRDCNSLPG GVGTCKETFN MYYYETDEED 120
RAMKESRYIK IDTIAADESF TELDLGDRVM KLNTEVRDLG PLTRKGFYLA FQDLGACIAL 180
VSVRVFYKRC PFLVKSLAEF PDTIPGSEAS QLVEVVGRCV NNSLPLYEPP RMHCSTEGEW 240
LVPIGKCVCQ PGFEEINGSC QVCKVGFYRS LLESLACSKC PPHSVARQMG ATACSCEDGY 300
YKLDSDPSNM ACTRPPSAPR NAISNVNETS VFLEWSIPMD TGGRKDVRYN VICRQVLPDG 360
RGLEECGPNA RFLPRRTGLS NTSVMVADLQ SHTNYSFLLE AVNGVSDLAK GHAKQYVSLN 420
VTTNQAAPSP VSVVRKGHTG KSSIALSWAE PDRPNGIILE YEIKYFEKLK EQDSSYTIIK 480
SKDTEMVVEG LKPSSAYIFQ VRARTSAGYG AFSRRFEFQT SPYSVTATSE RAQASIVAVA 540
ITLALVLLAV VAGFLLSGRR CGYSKAKQDP EEEKMHFHNG HIKFPGVRTY IDPLTYEDPN 600
QAVHEFAQEI DVSYISIERI IGAGEFGEVC SGPLRLPGKR EIQVAIKTLK AGYTEQQRRD 660
FLWEASIMGQ FNHPNIIRLE GVVTKSKPVM IITEYMENGS LDTFLKKNDG QFTVIQLVGM 720
LRGIASGMRY LSDMGYVHRD LAARNILVNS NLVCKVSDFG LSRVLEDDPE AAYTTRGGKI 780
PIRWTAPEAI AYRKFTSASD VWSYGIVMWE VMSYGERPYW EMSNQDVIKA VEESYRLPGP 840
MDCPEALYHL MMDCWQRERS NRPKFDEIVC LLDKFIRNPS SLKKLVNSSH RVSNLLVEHA 900
SVEGNCSTRS QTVGEWLDSI KMGRYTELFM EGGYSSLETV AQMTSEDLRR VGVNLAGHQK 960
KIITSIQEMR VHMNSTNSTV NI 982
Nucleotide Sequence
(FASTA)
ATCAGCTTGT TGCTCATCTT TACTTACCAT CTCTTGTATT TTCAACCTTC AACAGTAAAC 60
CTGTTGGATT CCCGCTCTGT GATGGGAGAC CTGGGATGGG TGGCCTACCC TAAGAATGGG 120
TGGGAGGAGA TTGGGGAAGT AGACGAGAAC TATGCTCCCA TCCACACCTA CCAAGTATGC 180
CGTGTGATGG AGCAAAACCA GAACAACTGG CTCCACACCA ACTGGATCCT GACTGAGGGT 240
GCCCAGCGGG TATTTATTGA GCTCAAGTTC ACCCTGAGAG ACTGCAACAG CCTGCCAGGG 300
GGTGTCGGGA CCTGCAAGGA GACCTTTAAT ATGTATTACT ATGAAACAGA TGAGGAAGAC 360
AGGGCAATGA AGGAGAGCAG GTACATCAAA ATTGATACCA TAGCAGCTGA TGAGAGCTTC 420
ACTGAGCTGG ACCTTGGGGA TCGTGTGATG AAGCTTAACA CTGAAGTCCG CGATTTAGGT 480
CCTCTGACCC GGAAAGGCTT CTACTTGGCA TTTCAGGATT TAGGGGCCTG CATTGCTTTA 540
GTCTCAGTGA GGGTTTTCTA CAAACGCTGC CCATTCTTGG TGAAGAGCTT GGCTGAGTTC 600
CCTGACACAA TCCCAGGCTC AGAAGCCTCA CAGCTGGTAG AGGTAGTGGG CCGCTGTGTC 660
AATAACTCCC TGCCTTTATA CGAGCCTCCC AGGATGCATT GCAGCACAGA GGGAGAGTGG 720
CTGGTGCCCA TTGGGAAGTG TGTTTGCCAG CCGGGATTTG AGGAAATCAA CGGATCTTGT 780
CAAGTCTGCA AAGTGGGGTT TTACCGCTCG CTGCTGGAGT CTTTGGCCTG TAGTAAATGT 840
CCACCTCACA GTGTGGCCAG ACAGATGGGA GCCACTGCTT GCAGCTGTGA AGACGGATAC 900
TATAAGCTAG ACTCTGACCC TTCTAATATG GCTTGCACAC GCCCTCCGTC TGCTCCTCGT 960
AATGCTATTT CCAATGTCAA TGAGACCAGC GTCTTCTTGG AGTGGTCCAT TCCTATGGAT 1020
ACAGGTGGCA GGAAGGATGT GCGCTATAAC GTCATCTGTA GACAGGTCCT GCCAGACGGA 1080
AGGGGCTTGG AAGAGTGCGG TCCCAATGCA CGTTTTCTGC CACGCCGCAC TGGCCTGTCG 1140
AACACCTCAG TGATGGTGGC TGACCTGCAG TCACACACCA ACTACAGCTT CTTGTTGGAA 1200
GCCGTCAACG GAGTGTCAGA CCTAGCCAAA GGCCATGCAA AGCAGTATGT GTCACTTAAT 1260
GTGACAACCA ATCAGGCAGC ACCGTCCCCA GTGAGTGTGG TGAGGAAAGG TCATACAGGG 1320
AAGAGCAGCA TTGCCCTTTC TTGGGCAGAG CCTGATCGTC CCAACGGCAT CATCCTAGAG 1380
TATGAGATCA AGTATTTTGA AAAGCTAAAG GAACAGGACT CCAGTTACAC AATAATAAAA 1440
TCCAAGGACA CTGAAATGGT GGTGGAAGGC CTGAAGCCCT CTTCAGCTTA CATCTTCCAG 1500
GTACGAGCCA GGACCTCAGC AGGCTATGGT GCATTTAGCC GGCGCTTTGA ATTCCAGACC 1560
AGCCCTTACT CAGTAACTGC TACTAGTGAG CGTGCTCAAG CTTCGATAGT AGCGGTGGCC 1620
ATCACACTGG CTCTGGTCCT GCTGGCAGTG GTTGCTGGAT TCCTGCTCAG TGGGCGGCGC 1680
TGTGGCTACA GCAAAGCAAA GCAAGATCCC GAAGAGGAAA AGATGCACTT CCACAATGGC 1740
CACATAAAAT TTCCAGGGGT GCGTACTTAT ATCGATCCCC TCACCTATGA AGATCCCAAC 1800
CAGGCAGTGC ATGAATTTGC CCAGGAGATT GACGTTTCAT ACATCTCCAT TGAAAGGATC 1860
ATTGGTGCTG GGGAATTTGG TGAAGTGTGC AGTGGACCGC TGAGGCTGCC CGGGAAACGA 1920
GAGATCCAGG TTGCCATTAA GACCTTGAAA GCAGGCTACA CAGAGCAGCA GAGACGTGAC 1980
TTTCTATGGG AGGCGTCAAT CATGGGCCAG TTTAACCACC CAAACATCAT CCGTCTGGAG 2040
GGTGTGGTTA CTAAGAGCAA GCCGGTGATG ATCATCACAG AATACATGGA GAATGGCTCA 2100
TTGGACACTT TTCTCAAGAA AAATGATGGC CAGTTTACTG TAATCCAGCT GGTTGGTATG 2160
CTGCGTGGGA TTGCATCTGG CATGAGATAC CTGTCTGACA TGGGCTATGT CCACCGTGAT 2220
CTAGCGGCTC GTAACATCCT GGTCAACAGT AACCTTGTGT GTAAAGTGTC TGATTTTGGT 2280
CTATCCCGAG TCCTGGAAGA TGATCCGGAG GCTGCATATA CCACACGGGG CGGAAAGATT 2340
CCCATTCGCT GGACGGCTCC AGAAGCAATT GCATACAGGA AGTTCACCTC GGCTAGTGAT 2400
GTGTGGAGTT ATGGGATTGT CATGTGGGAA GTGATGTCAT ACGGAGAGAG GCCCTACTGG 2460
GAGATGTCCA ATCAAGATGT AATAAAAGCA GTGGAGGAAA GCTATAGGTT GCCAGGTCCT 2520
ATGGACTGTC CTGAGGCCCT GTACCATCTC ATGATGGACT GCTGGCAGCG AGAACGCAGC 2580
AACCGTCCCA AGTTTGATGA GATCGTTTGC CTGCTAGACA AATTCATTCG GAACCCCAGC 2640
TCGTTAAAAA AGCTTGTCAA CTCCTCACAC AGAGTTTCCA ACCTGTTAGT GGAGCATGCC 2700
AGCGTAGAAG GGAACTGTAG CACTCGAAGC CAGACTGTAG GAGAGTGGCT CGACTCCATC 2760
AAGATGGGAC GTTACACTGA ACTGTTTATG GAAGGAGGTT ACTCTTCACT GGAAACAGTG 2820
GCTCAGATGA CATCAGAGGA TTTGCGAAGA GTAGGAGTGA ACTTGGCTGG ACACCAGAAA 2880
AAAATTATTA CTAGCATTCA GGAGATGAGG GTCCATATGA ACAGCACCAA CTCTACTGTA 2940
AACATATGA 2949
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++ie++iGaGefGevcsG l+lpgkrei+vaiktlkag+te+qrrdfl easi+Gqf+hp
Q: 615   ISIERIIGAGEFGEVCSGPLRLPGKREIQVAIKTLKAGYTEQQRRDFLWEASIMGQFNHP  674
         689*********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvtkskpvmi+teymeng+ld+fl+k+dgqftviqlvgmlrGiasgm+ylsdm
Q: 675   NIIRLEGVVTKSKPVMIITEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIASGMRYLSDM  734
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarnilvnsnlvckvsdfGlsrvledd+eaaytt+ggkipirwtapeaiayrk
Q: 735   GYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRK  794
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasdvwsyGiv+wev+syGerpyw+msnqdvika+ee yrlp pmdcp+aly+lm+dc
Q: 795   FTSASDVWSYGIVMWEVMSYGERPYWEMSNQDVIKAVEESYRLPGPMDCPEALYHLMMDC  854
         ************************************************************
S: 241   wqkdraerpkfeqivsi  257
         wq++r++rpkf++iv +
Q: 855   WQRERSNRPKFDEIVCL  871
         **************976
Domain Sequence
(FASTA)
ISIERIIGAG EFGEVCSGPL RLPGKREIQV AIKTLKAGYT EQQRRDFLWE ASIMGQFNHP 60
NIIRLEGVVT KSKPVMIITE YMENGSLDTF LKKNDGQFTV IQLVGMLRGI ASGMRYLSDM 120
GYVHRDLAAR NILVNSNLVC KVSDFGLSRV LEDDPEAAYT TRGGKIPIRW TAPEAIAYRK 180
FTSASDVWSY GIVMWEVMSY GERPYWEMSN QDVIKAVEES YRLPGPMDCP EALYHLMMDC 240
WQRERSNRPK FDEIVCL 257
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00005
EKS-BOT-00003
EKS-CAJ-00003
EKS-CAP-00002
EKS-DAR-00003
EKS-EQC-00002
EKS-GAG-00002
EKS-GAA-00010
EKS-GOG-00011
EKS-ICT-00003
EKS-LOA-00003
EKS-MAM-00003
EKS-MOD-00003
EKS-MUP-00005
EKS-MYL-00007
EKS-NOL-00003
EKS-ORA-00002
EKS-ORL-00011
EKS-OTG-00008
EKS-PAT-00004
EKS-PES-00002
EKS-POA-00003
EKS-PTV-00002
EKS-SAH-00003
EKS-SOA-00001
EKS-TAG-00002
EKS-TEN-00010
EKS-XIM-00009
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013