EKS-ORN-00399

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00399

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	363.8	6.4E-109	25	289	265

Status

Unreviewed

Ensembl Protein

ENSONIP00000005296

UniProt Accession

I3J8V6;

Protein Name

Protein Synonyms/Alias

Gene Name

MINK1

Gene Synonyms/Alias

MINK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000004209	ENSONIP00000005296	ENSONIT00000005300

Organism

Oreochromis niloticus

Functional Description

Protein Length

1314

Protein Sequence
(FASTA)

MSENAPTRSL DDIDLAALRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL AAIKVMDVTE 60

EEEEEIKAEI NMLKKYSHHR NIATYYGAFV KKSPPGHDDQ LWLVMEFCGA GSVTDLVKNT 120

KGSSLKEDWI AYICREILRG LSHLHAHKVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 180

TVGRRNTFIG TPYWMAPEVI ACDENPDSTY DYRSDIWSLG ITAIEMAEGA PPLCDMHPMR 240

ALFLIPRNPP PKLKSKKWSK KFIDFIESCL VKTYPSRPST EQLLKHSFIR DQPTERQVRI 300

QLKDHIDRTR KKRGEKEETE YEYSGSDEEE DNRGDDRESS SILNVPGEST LRRDFQRLQQ 360

ENKERSEAHK RQQAQLAAQR RDPEEHKRQL LHDRQKRIEE QKEQRRRLEE QQRKQGEMVR 420

QQEKGPHRRL DDMRREEDRR LAEREQEFIR HKLEEEQRQL EILQQQLLQE QALLMEYKRK 480

QLEEQRQSER LQRQLQQEHA YLVSLQQQQQ EKKPQLYHYN KNLEPNNKPT WAREVEERSK 540

LNRQGSPKIC TTVSDTAIQS RSDSISQSGA VQSAQTPPMQ RPVEPQFQMA HLVPLKPYAA 600

PVPRSQSLCD QPTKTMSAFP TQDPSLTPTP RPIHSRELVR QNSDPTSETQ APQAHQIRED 660

RGPWIRLPDV ELPPKIPQRT ASIATALNTN LTSGIRHPVR ASNPDLSRND RWERGDSMSI 720

ISNLPQTGSL ERHRILSSSK MDSPILSHDP RHKPGESRTS SRPGRPADHG LFAKERAEEP 780

PRPPVKANDY SSSSESSESS EESESGEGAE EEESPTDFIN ALKAKKIPHF APVLNKHSQT 840

AMTAYVFQLA HNEFLEGSVS IVSISVKKKK KEKEKKKTPE KRSHNGYTNL PDVVQPSHSP 900

TDSATHSSPG KDSVYDYQSR GLVKASGKSS FTTFVDLGMY QSPGGTGDNI SVSGLCFPSS 960

SSRFDQLKME VRKGSMVNVN PTNTRPPNDT PEIRKYKKRF NSEILCAALW GVNLLVGTEN 1020

GLKLLDRSGQ GKVYPLINSR RFQQMDVLEG LNLLITISGK KNKVRVYYLA WLRNKILHND 1080

PEVEKKQGWT TVGEMEGCVH YKVVKYERIK FLVIALKNAV EVYAWAPKPY HKFMAFKSFS 1140

DLPHRPVLVD LTVEEGQRLK VIYGSCAGFH AIDVDSGNNY DIYIPVHIQS QVTPHAIVFL 1200

PSSDGMEMLL CYEDEGVYVN TYGRIIKDVV LQWGEMPTSV AHICSNQIMG WGEKAIEIRS 1260

VETGHLDGVF MHKRAQRLKF LCERNDKVFF ASVRSGGSSQ VYFMTLNRNC IMNW 1314

Nucleotide Sequence
(FASTA)

ATGTCTGAAA ACGCCCCCAC AAGAAGCCTG GATGACATAG ACCTCGCAGC TCTGAGGGAT 60

CCAGCAGGAA TCTTCGAGCT GGTCGAGGTC GTTGGCAATG GCACATATGG ACAGGTGTAC 120

AAGGGACGTC ACGTGAAGAC GGGCCAGCTG GCTGCCATCA AGGTGATGGA TGTTACAGAG 180

GAGGAAGAAG AGGAGATCAA GGCTGAAATA AACATGCTGA AAAAATACAG CCACCACCGC 240

AACATAGCCA CATACTACGG TGCCTTTGTC AAGAAGAGTC CGCCGGGACA CGACGACCAG 300

CTTTGGCTGG TGATGGAGTT TTGTGGGGCG GGGTCAGTGA CCGACCTGGT GAAAAACACT 360

AAGGGCAGCT CTCTAAAGGA GGACTGGATT GCTTACATCT GCAGAGAGAT CCTAAGGGGT 420

CTCTCTCACC TCCATGCCCA TAAAGTTATC CACAGAGACA TCAAGGGCCA GAACGTTCTG 480

CTAACAGAGA ATGCAGAGGT CAAACTGGTC GATTTTGGGG TCAGCGCCCA GTTGGACAGG 540

ACAGTTGGGC GAAGAAACAC CTTTATTGGC ACACCGTACT GGATGGCACC TGAGGTCATT 600

GCCTGCGATG AGAATCCTGA CTCCACCTAT GACTACAGGA GTGATATTTG GTCCTTGGGA 660

ATCACAGCTA TTGAGATGGC CGAAGGAGCT CCTCCCTTGT GTGACATGCA CCCAATGAGA 720

GCCCTCTTCC TGATCCCCAG GAACCCCCCT CCAAAACTTA AATCGAAGAA GTGGTCCAAG 780

AAATTTATTG ACTTTATAGA GAGCTGCCTT GTGAAGACAT ATCCCAGCCG GCCATCCACG 840

GAGCAGCTGC TCAAGCATTC CTTCATCAGG GATCAGCCCA CTGAACGCCA GGTCCGAATT 900

CAACTCAAAG ACCATATTGA CCGTACACGC AAAAAAAGGG GAGAGAAGGA AGAAACAGAG 960

TACGAGTACA GTGGTAGTGA TGAAGAGGAG GACAATCGTG GAGATGACAG AGAGTCAAGT 1020

TCAATCCTCA ATGTGCCGGG TGAGTCCACC TTGCGGCGGG ACTTCCAGCG TCTGCAGCAG 1080

GAGAACAAAG AGCGCTCGGA GGCTCACAAG AGGCAGCAGG CCCAACTGGC AGCTCAGCGC 1140

CGGGACCCCG AGGAGCACAA GAGGCAACTG TTGCATGACC GACAGAAACG CATCGAAGAA 1200

CAGAAGGAAC AGCGTCGCAG ACTTGAAGAG CAACAGAGAA AACAGGGAGA GATGGTGAGG 1260

CAGCAAGAAA AGGGTCCCCA TCGGAGACTT GACGATATGA GACGGGAGGA AGATAGGAGG 1320

CTGGCAGAGA GGGAGCAGGA GTTTATCAGG CATAAGTTAG AAGAGGAGCA GCGGCAGTTA 1380

GAAATCCTCC AACAGCAGTT GCTTCAGGAG CAAGCGCTGT TAATGGAATA TAAACGCAAG 1440

CAGCTCGAGG AACAGCGTCA GTCCGAGCGG CTGCAGAGAC AGCTGCAACA GGAACATGCC 1500

TACCTGGTGT CCCTGCAACA ACAGCAGCAA GAAAAGAAAC CTCAGCTTTA CCACTACAAC 1560

AAAAACCTGG AGCCCAACAA CAAACCGACT TGGGCCCGCG AGGTGGAGGA GAGGAGTAAG 1620

CTCAACAGAC AGGGCTCACC CAAAATCTGC ACTACTGTCT CCGACACTGC CATCCAGTCA 1680

CGCTCTGACT CAATCAGCCA GTCAGGAGCG GTCCAGTCTG CGCAGACCCC ACCGATGCAA 1740

AGGCCTGTTG AACCCCAATT CCAGATGGCT CACTTGGTTC CTCTGAAGCC TTATGCTGCC 1800

CCTGTCCCTC GCTCTCAGTC ACTCTGTGAC CAGCCCACTA AGACCATGTC CGCCTTCCCT 1860

ACCCAGGATC CTTCCCTGAC CCCCACACCC CGCCCTATCC ACTCCAGAGA GCTGGTGCGT 1920

CAGAATTCAG ACCCCACTTC TGAAACCCAG GCACCACAGG CACACCAAAT CAGAGAGGAT 1980

CGTGGCCCGT GGATCCGCCT GCCGGATGTA GAACTTCCAC CCAAGATTCC ACAGAGGACG 2040

GCGTCTATCG CCACAGCTCT CAACACCAAC CTAACCTCTG GTATAAGGCA CCCAGTAAGA 2100

GCCAGCAATC CAGATCTCAG TCGCAATGAT CGCTGGGAGA GAGGAGACAG CATGAGCATC 2160

ATATCCAATC TTCCCCAGAC GGGCAGTTTA GAGAGGCATC GCATCCTCAG TTCCTCCAAA 2220

ATGGATTCGC CCATTCTCTC CCACGATCCT CGTCACAAGC CAGGAGAATC TCGAACCTCC 2280

TCCCGGCCTG GGCGTCCTGC TGATCATGGC CTCTTTGCCA AGGAGCGTGC CGAGGAGCCG 2340

CCAAGACCTC CGGTCAAAGC CAACGATTAC TCGTCCTCTT CGGAAAGCAG CGAGAGTAGT 2400

GAAGAAAGTG AAAGCGGCGA GGGAGCAGAG GAGGAAGAAA GCCCCACAGA TTTCATCAAT 2460

GCACTGAAAG CAAAGAAGAT TCCACATTTT GCACCAGTGC TTAACAAGCA CTCGCAAACA 2520

GCCATGACAG CATATGTCTT CCAGCTGGCT CATAATGAAT TCCTCGAGGG TAGCGTTTCT 2580

ATAGTCTCCA TTTCGGTTAA AAAAAAAAAA AAAGAAAAGG AAAAAAAAAA GACCCCAGAG 2640

AAGCGCAGCC ATAACGGATA CACTAACTTG CCAGATGTGG TGCAGCCCTC TCACTCCCCC 2700

ACTGACTCAG CCACTCACTC CTCTCCTGGG AAGGACTCTG TTTACGATTA TCAGTCCAGA 2760

GGTTTGGTTA AGGCATCTGG CAAATCCTCT TTCACTACCT TTGTGGATCT GGGAATGTAC 2820

CAGTCACCAG GAGGTACAGG CGATAACATA TCTGTCAGTG GTTTGTGTTT TCCCTCTTCA 2880

AGCTCCAGGT TTGATCAGCT GAAGATGGAA GTGAGGAAAG GATCCATGGT GAATGTCAAT 2940

CCCACCAACA CACGCCCTCC TAATGACACA CCAGAGATTC GCAAGTATAA GAAGAGGTTC 3000

AACTCTGAGA TCCTGTGTGC TGCACTTTGG GGTGTGAACC TTTTGGTAGG CACGGAGAAT 3060

GGTTTGAAGC TACTGGATCG TAGTGGTCAG GGCAAGGTGT ACCCCCTCAT CAACTCACGC 3120

AGGTTCCAGC AGATGGACGT CCTGGAGGGC CTCAACCTGC TCATCACCAT ATCAGGCAAG 3180

AAAAACAAAG TGCGTGTCTA CTACCTGGCA TGGCTGAGGA ATAAGATCCT CCACAATGAT 3240

CCTGAGGTAG AAAAGAAGCA GGGTTGGACC ACAGTGGGAG AGATGGAGGG CTGTGTACAC 3300

TACAAAGTGG TGAAATACGA GAGGATAAAG TTCCTGGTGA TTGCTTTGAA GAATGCGGTG 3360

GAAGTTTATG CTTGGGCGCC CAAACCTTAT CACAAATTCA TGGCCTTCAA GTCTTTTTCA 3420

GATTTGCCAC ACAGGCCTGT CTTGGTCGAC TTGACAGTGG AGGAAGGCCA GAGGTTGAAG 3480

GTCATCTATG GATCTTGCGC TGGCTTCCAC GCCATCGATG TGGACTCTGG AAACAACTAT 3540

GATATTTATA TTCCCGTTCA CATCCAGAGC CAAGTGACAC CACACGCAAT CGTGTTCCTG 3600

CCCAGCTCAG ACGGCATGGA GATGCTGCTG TGCTACGAGG ACGAGGGCGT CTACGTCAAC 3660

ACATATGGGC GCATAATAAA GGACGTTGTC CTGCAGTGGG GCGAGATGCC TACATCTGTT 3720

GCTCATATCT GCTCAAACCA GATCATGGGT TGGGGAGAAA AGGCCATTGA GATCCGCTCT 3780

GTGGAGACTG GCCACTTGGA CGGTGTTTTT ATGCACAAAA GAGCTCAGCG GCTGAAGTTC 3840

CTTTGCGAGA GAAATGACAA GGTGTTTTTC GCATCAGTGC GGTCTGGAGG CAGCAGCCAG 3900

GTGTACTTCA TGACGTTGAA CAGAAACTGC ATCATGAACT GGTGA 3945

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59

         +el+e++g+G++g+vy++r++ktg+l+aik++++++ e++ee++ ei++lkk++h +ni

Q: 25    FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-EEEEEIKAEINMLKKYSHhRNIA  83

         899********************************9.9999************998****

S: 60    eylesflk......eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLey  113

         +y+++f+k      +++lwlvme++ +Gs++dlvk+++ s+lkE++iayi+re+l++L++

Q: 84    TYYGAFVKksppghDDQLWLVMEFCGAGSVTDLVKNTKGSSLKEDWIAYICREILRGLSH  143

         *************9**********************************************

S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe  173

         lH++kviHrdik++n+Llte++eVkL+dfgv+aql++t+ +r+t++gtpywmAPEvia++

Q: 144   LHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD  203

         ************************************************************

S: 174   ...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskef  230

            +++Yd+++DiwslGItaie+aeg+pP++d++p++al++i++n+ppklksk k+sk+f

Q: 204   enpDSTYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPKLKSK-KWSKKF  262

         99999*********************************************888.******

S: 231   kefvekclqknpekRpsasellkhkFl  257

          +f+e+cl k + +Rps+++llkh+F+

Q: 263   IDFIESCLVKTYPSRPSTEQLLKHSFI  289

         **************************7

Domain Sequence
(FASTA)

FELVEVVGNG TYGQVYKGRH VKTGQLAAIK VMDVTEEEEE EIKAEINMLK KYSHHRNIAT 60

YYGAFVKKSP PGHDDQLWLV MEFCGAGSVT DLVKNTKGSS LKEDWIAYIC REILRGLSHL 120

HAHKVIHRDI KGQNVLLTEN AEVKLVDFGV SAQLDRTVGR RNTFIGTPYW MAPEVIACDE 180

NPDSTYDYRS DIWSLGITAI EMAEGAPPLC DMHPMRALFL IPRNPPPKLK SKKWSKKFID 240

FIESCLVKTY PSRPSTEQLL KHSFI 265

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013