EKS-ORN-00387

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00387

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	495.9	2.9E-149	688	944	257

Status

Unreviewed

Ensembl Protein

ENSONIP00000005300

UniProt Accession

I3J8W0;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB4 (2 of 2)

Gene Synonyms/Alias

ERBB4 (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000004212	ENSONIP00000005301	ENSONIT00000005305
ENSONIG00000004212	ENSONIP00000005300	ENSONIT00000005304

Organism

Oreochromis niloticus

Functional Description

Protein Length

1295

Protein Sequence
(FASTA)

VCAGTENKLS TLSDLEQQYR TLRKYYESCE VVMGNLEITS IDRSRDLTFL RSIREVTGYV 60

LVALNQFDYL PLENLRIIRG TKLYEDRYSL AIFLNYRRDG NFGLRQLGLK NLTEILNGGV 120

YVDQNKFLCH ADTIHWQDIV KYPRIQPVVV PTNSSVTCQK CHRSCNGRCW GPKEDQCQSL 180

TKTVCAEQCD GRCFGPFVSD CCHRECAGGC YGPKDTDCFA SVSINDSGAC VTQCPQPFVY 240

NPTTFQLEHN PRAKYTYGAF CVKKCPHNFV VDHSSCVRAC PSNKMEVEEN RIKMCIPCTD 300

ICPKACDGIG TASLQTAQTV DSNNIDKFVN CTKINGNLVF LITGIKGDVY HNIEALDPEK 360

LNVFRTVREI TGFLNIQSWP DNMTDLSVFS NLATIGGRAL YSGISLLVLK QPGITSLQLQ 420

SLREISAGNV HIAENSQLCY YNTVNWTRLF RTTNQKVLIR NNRSPQECSK EHMVCDPLCS 480

DAGCWGPGPD QCLSCRYFSR GRTCVESCNL YEGDIREYAN GSVCVECDAQ CERADGDSLT 540

CLGPGPEHCV KCLHFKDGPN CVEKCPDGLQ GANSFIFKYA EANNECHPCH ANCTQGCIGP 600

RLQDCIGWMD RQNLPIHHIT PLIAAGVIGG LFMVVIMVLS VAVSVRRKNI KKKRALRRFL 660

ETELVEPLTP SGTAPNQAQL RILKETELKR VKILGSGAFG TVYKGIWVPE GETVKIPVAI 720

KILNEATGPK ANVEFMDEAL IMASMEHPHL VRLLGVCLSP TIQLVTQLMP HGCLLDYVHE 780

HKDNIGSQLL LNWCVQIAKG MMYLEERRLV HRDLAARNVL VKSPNHIKIT DFGLARLLDV 840

NEKEYNADGG KMPIKWMALE CIHYRKFTHQ SDVWSYGVTI WELMTFGGKP YDGISTRDIP 900

DLLEKGERLP QPPICTIDVY MVMVKCWMID ADSRPKFKEL AAEFTRMARD PQRYLVIQGD 960

DRMKLPSPSD SKFFQSLLDE EELDDLMDAE EYLVPHSFNI PPLAYTPRTR MDSNKRGSCK 1020

HRPALTFLTS AQNQFGCQDP SFSMEDMLAA MPRVISGPPV SGSCLAPQEL ASGGKIVGGF 1080

GRGSQDDPRC NGTLRKQASP RCGGEDSNGQ RYSADPTGLL AERGAKGDPM RDKSNSDYLI 1140

PVEENPFVTR RRNGDAHTVI DGASCHTLHL AGATAAPKSQ STHGDDEYVN EPLYLNTLLN 1200

AGAKNGCITS STIMFDKKGK KATFDNPEYW QHSLPPKSSL HNPEYLQDCS TRFFYRQNGR 1260

IRPAVAENQE YLSEAAMKTG NVLPPPPYRQ RNTVV 1295

Nucleotide Sequence
(FASTA)

GTATGTGCTG GAACAGAGAA CAAGCTGAGC ACGCTGTCGG ACCTGGAGCA GCAGTATCGC 60

ACTCTGAGGA AATACTATGA GAGCTGTGAA GTTGTAATGG GCAACCTCGA GATCACAAGC 120

ATTGACCGCA GTCGTGACCT CACCTTCCTC AGATCTATCA GGGAAGTGAC AGGCTATGTG 180

TTGGTGGCTC TGAACCAGTT TGACTACCTG CCATTAGAGA ACTTGAGAAT CATCCGAGGA 240

ACCAAGCTAT ACGAGGACCG CTACTCCCTT GCAATCTTCC TCAATTACAG ACGTGATGGA 300

AACTTTGGCC TGCGCCAGTT GGGTCTAAAA AATCTCACAG AGATCCTAAA TGGAGGTGTT 360

TATGTTGACC AAAACAAGTT CTTGTGCCAT GCGGACACAA TCCATTGGCA AGATATCGTC 420

AAGTACCCAC GGATCCAACC TGTGGTGGTG CCCACCAACA GCAGTGTCAC ATGTCAAAAA 480

TGCCACCGTT CCTGCAATGG TCGTTGCTGG GGACCCAAAG AGGACCAGTG CCAAAGCTTA 540

ACTAAGACAG TGTGTGCGGA GCAGTGTGAC GGCCGTTGCT TTGGTCCCTT TGTTAGTGAC 600

TGCTGCCACC GTGAGTGTGC AGGTGGCTGT TATGGCCCAA AGGACACAGA CTGCTTTGCC 660

TCAGTTAGCA TTAATGACAG TGGGGCATGT GTGACCCAGT GCCCTCAGCC ATTTGTCTAC 720

AACCCTACCA CCTTCCAGCT GGAGCATAAC CCTAGGGCAA AGTACACCTA TGGAGCTTTC 780

TGCGTCAAGA AGTGTCCACA TAACTTTGTG GTAGACCACA GCTCCTGTGT GAGAGCATGC 840

CCCAGTAACA AGATGGAGGT GGAGGAGAAT CGCATTAAGA TGTGCATCCC TTGTACTGAC 900

ATCTGTCCAA AAGCATGTGA CGGGATAGGC ACAGCAAGCC TACAGACTGC TCAGACAGTG 960

GACTCCAACA ACATTGACAA GTTTGTCAAC TGCACCAAAA TCAATGGCAA CCTGGTGTTC 1020

CTCATTACTG GAATCAAAGG GGATGTCTAT CACAACATTG AAGCTTTGGA CCCGGAAAAA 1080

CTCAATGTAT TCCGCACCGT TCGGGAAATT ACAGGTTTTC TAAACATTCA GTCATGGCCT 1140

GACAACATGA CAGACTTGAG TGTTTTCTCC AACCTGGCTA CTATTGGGGG AAGAGCATTG 1200

TACAGTGGGA TCTCTCTGCT GGTGTTGAAA CAGCCGGGGA TCACATCACT TCAGCTTCAG 1260

TCTCTGAGAG AGATCAGTGC TGGGAATGTC CACATTGCAG AGAACAGCCA GCTTTGCTAC 1320

TACAACACCG TCAATTGGAC AAGACTGTTC CGTACTACAA ACCAAAAGGT TCTTATTCGC 1380

AACAACCGAA GTCCACAGGA ATGCTCCAAG GAGCACATGG TGTGTGACCC ACTGTGTTCA 1440

GATGCTGGAT GTTGGGGTCC TGGCCCAGAC CAATGCCTGT CCTGCCGATA TTTCAGTCGT 1500

GGACGAACGT GTGTAGAATC CTGCAATCTC TATGAGGGGG ATATTCGAGA ATATGCCAAT 1560

GGGTCAGTGT GCGTAGAGTG TGATGCCCAG TGTGAAAGAG CTGACGGTGA CTCTTTGACC 1620

TGTCTTGGGC CGGGCCCAGA GCATTGTGTG AAATGCCTTC ATTTCAAAGA CGGTCCAAAC 1680

TGTGTGGAAA AGTGTCCCGA TGGCCTGCAA GGTGCCAACA GCTTCATCTT CAAGTACGCT 1740

GAAGCCAACA ACGAATGCCA TCCCTGCCAT GCTAACTGCA CCCAAGGGTG CATTGGACCG 1800

AGACTTCAAG ACTGCATTGG CTGGATGGAC AGACAAAATC TTCCCATCCA TCACATAACC 1860

CCTCTGATTG CAGCAGGGGT AATCGGAGGC CTCTTCATGG TGGTGATCAT GGTACTCAGT 1920

GTAGCAGTGT CTGTGCGACG GAAGAACATT AAGAAAAAGA GGGCCCTTCG CCGCTTCCTG 1980

GAGACAGAGT TGGTTGAACC TTTAACACCC AGTGGAACGG CACCCAATCA AGCCCAGCTT 2040

CGCATCCTGA AAGAAACAGA ACTTAAAAGA GTCAAGATCC TCGGCTCCGG AGCTTTTGGA 2100

ACTGTTTACA AGGGTATCTG GGTCCCAGAA GGGGAAACTG TGAAAATCCC TGTTGCCATT 2160

AAAATCCTAA ATGAGGCCAC AGGACCCAAG GCTAATGTGG AATTCATGGA TGAGGCTCTG 2220

ATCATGGCTA GCATGGAGCA CCCGCACCTG GTCCGACTGC TGGGTGTCTG CTTGAGTCCG 2280

ACAATCCAGC TGGTCACACA GCTGATGCCT CACGGATGCC TGCTCGACTA CGTCCATGAG 2340

CACAAAGACA ACATTGGATC ACAGCTATTG CTCAATTGGT GTGTCCAGAT AGCCAAGGGA 2400

ATGATGTATC TAGAGGAGCG GAGGCTTGTC CACAGGGATT TGGCAGCCCG AAATGTTCTG 2460

GTCAAATCTC CCAACCACAT CAAGATCACT GACTTTGGCC TGGCTCGTCT GTTGGATGTC 2520

AATGAAAAAG AATATAATGC TGATGGAGGA AAGATGCCCA TCAAATGGAT GGCCCTTGAG 2580

TGTATTCATT ACAGGAAGTT TACCCATCAG AGTGACGTTT GGAGTTACGG TGTAACCATT 2640

TGGGAGCTGA TGACCTTTGG AGGGAAGCCA TATGATGGGA TTTCTACCAG AGATATCCCA 2700

GATCTGTTAG AGAAGGGAGA GCGTCTGCCT CAGCCACCCA TCTGCACCAT TGACGTTTAC 2760

ATGGTCATGG TCAAATGCTG GATGATTGAT GCAGACAGTC GACCCAAGTT CAAGGAGCTG 2820

GCTGCTGAGT TCACTCGAAT GGCTCGAGAT CCCCAAAGAT ATCTGGTCAT CCAGGGTGAT 2880

GATCGCATGA AGCTGCCCAG CCCCAGTGAC AGCAAGTTCT TCCAGAGCCT CTTAGATGAG 2940

GAGGAACTAG ATGACCTGAT GGATGCTGAG GAGTACTTGG TGCCCCACTC CTTCAACATT 3000

CCCCCACTGG CATACACTCC ACGCACAAGG ATGGACTCCA ACAAGAGAGG ATCCTGTAAA 3060

CATCGCCCTG CACTTACTTT TCTTACTTCT GCTCAGAACC AATTTGGCTG TCAGGATCCC 3120

AGTTTCAGCA TGGAGGATAT GCTGGCCGCC ATGCCGAGAG TGATCTCTGG TCCCCCTGTT 3180

TCTGGAAGCT GCCTCGCTCC ACAGGAACTT GCCTCAGGAG GAAAAATTGT TGGTGGATTT 3240

GGCCGTGGTA GCCAGGATGA CCCCCGCTGC AATGGCACTC TGAGAAAACA AGCATCCCCA 3300

AGATGCGGAG GTGAGGACAG TAATGGACAG CGTTACAGCG CCGATCCCAC CGGTCTTTTA 3360

GCAGAGCGAG GAGCAAAAGG CGATCCCATG AGAGACAAGA GCAATTCAGA TTATCTCATC 3420

CCTGTAGAGG AAAACCCCTT TGTCACACGG CGTAGGAATG GAGATGCCCA CACAGTGATT 3480

GATGGAGCTA GCTGCCACAC TCTGCATTTG GCTGGAGCCA CTGCTGCCCC CAAAAGTCAA 3540

TCCACTCATG GTGATGATGA GTATGTCAAC GAGCCACTGT ACCTGAATAC CCTCCTCAAC 3600

GCTGGGGCCA AGAATGGATG CATTACCAGC AGCACCATCA TGTTTGATAA GAAAGGCAAG 3660

AAAGCCACTT TTGACAATCC TGAATACTGG CAGCACAGTC TCCCTCCCAA GTCCTCACTG 3720

CACAACCCTG AGTACCTGCA GGACTGCAGC ACACGCTTCT TCTACCGCCA GAATGGACGC 3780

ATTCGCCCTG CTGTGGCTGA AAACCAGGAA TACTTGTCAG AGGCTGCTAT GAAAACAGGC 3840

AATGTATTGC CACCCCCTCC ATACAGACAG AGGAACACTG TGGTGTAG 3888

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         lk++k+lGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as++h

Q: 688   LKRVKILGSGAFGTVYKGIWVPEGETVKIPVAIKILNEATGPKANVEFMDEALIMASMEH  747

         699*********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++lvrllg+cls t+qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiakGm+ylee+

Q: 748   PHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  807

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvkspnh+kitdfGla+ll+ +eke++a+ggk+pikw+ale+i++rk+

Q: 808   RLVHRDLAARNVLVKSPNHIKITDFGLARLLDVNEKEYNADGGKMPIKWMALECIHYRKF  867

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvt+wel+tfG kpydgi++++ipdllekGerl+qppictidvymv+vkcw

Q: 868   THQSDVWSYGVTIWELMTFGGKPYDGISTRDIPDLLEKGERLPQPPICTIDVYMVMVKCW  927

         ************************************************************

S: 241   midaesrpkfkelaeef  257

         mida+srpkfkela+ef

Q: 928   MIDADSRPKFKELAAEF  944

         ***************99

Domain Sequence
(FASTA)

LKRVKILGSG AFGTVYKGIW VPEGETVKIP VAIKILNEAT GPKANVEFMD EALIMASMEH 60

PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120

RLVHRDLAAR NVLVKSPNHI KITDFGLARL LDVNEKEYNA DGGKMPIKWM ALECIHYRKF 180

THQSDVWSYG VTIWELMTFG GKPYDGISTR DIPDLLEKGE RLPQPPICTI DVYMVMVKCW 240

MIDADSRPKF KELAAEF 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 5.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013