EKS-ORN-00015
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00015
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph491.74.4E-148608866259
StatusUnreviewed
Ensembl ProteinENSONIP00000005775
UniProt AccessionI3JA84;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB4 (2 of 2)
Gene Synonyms/Alias EPHB4 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000004584ENSONIP00000005774ENSONIT00000005778
ENSONIG00000004584ENSONIP00000005775ENSONIT00000005779
OrganismOreochromis niloticus
Functional Description
Protein Length970
Protein Sequence
(FASTA)
LSLTVAVCVS DVLMNTKLAT SDLRWTSYPA DDPQWEEASS RDDDHNTVRT YEICTIASSS 60
SYWLRTRWIP LKAATTVYVE IWFSMMECSS LSRQPCKETF NLYYYPSDAD NATLTSPAWM 120
ENPYIKVATV AADHLMLRGT RGRPNVKELR LEGLRKAGLY LAFQSQSNCM ALLSVRVFYK 180
KCPPLRRAFA SFPETVPHSL VEQAQGVCVE NAVTPPGEQS QPPSMLCSEV GEWVGQPTSS 240
CACRPGYEAG ETDMRCRACP SGHFKAESGS VGCSSCPANS NTRIPGSAYC PCHSGFYRAD 300
SDPPHTACTQ PPSAPRSPVS QLNDTTVTLE WSEPLDRGGR QDLTYRVLCS TCGPATATKD 360
TSCSPCGDSI LYRPAQNGLT QRRVVIWGLH PQTKYIFTIQ SLNGVSALSH SEPASSKLNI 420
TTSRDVPPPV SGLRRVEASE SSMSLEWSVP VVQNQYQILD YELRYRPEDS EEAVEWQYVF 480
SRSSSLVLNG LQRATRYQVQ VRARSQAGYG SFGAETGFNT LPDESERVGV SQLMVTGVAA 540
SLGILLLVVA AIVGVFCYRR RKRSAHIHDK SGHYHMGQTM KVYIDPFTYE DPNEAVREFA 600
KEIDASFVKI EEVIGAGEFG EVCRGRLRIP GRKENYVAIK TLKGGYTEKQ RRDFLSEASI 660
MGQFQHPNII HLEGVITTSC PVMILTEFME NGALDSFLRM NDGQFTTIQL VGMLRGIAAG 720
MKYLSEMSYV HRDLAARNIL VNSNLVCKVS DFGLSRFLTE NSSDPTYTSS LGGKIPIRWT 780
APEAIAYRKF TSASDTWSYG IVMWEVMSYG ERPYWDMSNQ DVINAIEQDY RLPPPPECPA 840
SLHALMLDCW QKERANRPRF CDVVAALDRL IRNPTSLKVT HPEAQSLSHP LLDQRVPPPL 900
SACGSVSEWL RAIKMERYEQ SFLQAGFTNL DIVSQLNTED LLRVGVTLAG HQKKILSSIQ 960
TLRIHKAPPT 970
Nucleotide Sequence
(FASTA)
CTTTCGCTGA CTGTTGCTGT CTGTGTTTCA GATGTGCTGA TGAACACCAA GCTGGCCACA 60
TCTGACCTAA GATGGACGAG CTACCCTGCT GATGACCCGC AGTGGGAGGA AGCGAGCTCG 120
AGGGACGATG ACCATAACAC CGTGCGGACC TATGAGATCT GTACGATCGC TAGTAGTTCT 180
TCCTATTGGC TGAGGACGCG CTGGATACCC CTGAAGGCGG CGACCACAGT CTACGTGGAG 240
ATCTGGTTTT CCATGATGGA GTGTTCCAGT CTGAGCAGGC AGCCCTGCAA AGAGACCTTC 300
AACCTGTATT ACTACCCGTC AGACGCTGAC AACGCCACGC TCACTAGCCC GGCCTGGATG 360
GAAAACCCTT ACATCAAAGT AGCCACGGTC GCCGCTGACC ACCTGATGCT GCGCGGCACC 420
AGGGGGCGCC CTAACGTCAA GGAGCTGCGC CTAGAGGGAC TGCGTAAGGC GGGGCTTTAC 480
CTGGCCTTCC AAAGCCAGAG CAACTGCATG GCATTGCTCT CTGTGCGCGT GTTCTACAAG 540
AAGTGCCCGC CCCTGCGCCG CGCCTTTGCC TCTTTCCCTG AAACCGTCCC CCACTCGCTG 600
GTGGAGCAGG CTCAGGGTGT GTGCGTGGAG AATGCTGTGA CGCCGCCTGG CGAGCAGTCA 660
CAACCTCCCA GCATGCTTTG TAGCGAGGTT GGGGAGTGGG TAGGGCAGCC AACGTCCAGC 720
TGCGCCTGTC GTCCTGGATA CGAAGCTGGA GAGACCGACA TGCGCTGTCG AGCGTGTCCG 780
TCTGGTCATT TTAAAGCCGA GTCAGGATCT GTTGGCTGCA GCTCCTGTCC AGCCAATAGC 840
AACACACGAA TTCCAGGCTC CGCCTACTGC CCGTGTCACT CCGGTTTCTA TCGAGCCGAC 900
TCGGACCCGC CGCACACTGC CTGCACACAG CCCCCCTCGG CCCCTCGCTC CCCGGTGAGT 960
CAGCTCAACG ACACCACGGT GACTCTGGAG TGGAGCGAAC CGCTGGACCG CGGAGGACGA 1020
CAAGACCTGA CCTATAGAGT TCTGTGCTCT ACCTGTGGCC CAGCCACCGC CACAAAGGAC 1080
ACTTCCTGTT CCCCGTGTGG TGACAGCATT CTTTACCGAC CGGCACAGAA CGGCCTGACC 1140
CAGCGGCGCG TTGTCATATG GGGGCTCCAC CCACAAACAA AGTACATCTT CACCATCCAG 1200
TCGTTAAACG GCGTCTCTGC ACTCAGCCAC TCAGAGCCCG CCTCCAGCAA GCTCAACATC 1260
ACCACCAGCA GAGATGTTCC TCCTCCAGTA TCTGGTCTGA GGAGGGTGGA GGCCTCAGAG 1320
AGCAGTATGT CTTTAGAGTG GAGCGTCCCA GTTGTGCAGA ACCAGTACCA GATCCTGGAC 1380
TACGAGCTCC GCTACAGGCC TGAGGATAGC GAGGAGGCGG TAGAGTGGCA GTACGTGTTC 1440
AGCAGGTCTT CTTCTCTGGT GCTGAACGGG CTGCAACGGG CGACACGGTA CCAGGTGCAG 1500
GTCCGCGCTC GCTCTCAGGC CGGTTATGGC TCATTCGGCG CTGAGACCGG CTTCAACACG 1560
CTGCCTGACG AGTCTGAGAG GGTAGGCGTG TCCCAGCTGA TGGTGACCGG AGTTGCAGCC 1620
TCTTTGGGGA TACTGCTGCT CGTTGTGGCG GCCATAGTCG GCGTGTTCTG CTACCGCAGG 1680
AGGAAGAGGA GCGCGCACAT CCACGACAAG AGCGGGCACT ACCATATGGG ACAGACGATG 1740
AAGGTCTACA TCGACCCGTT CACCTATGAG GACCCAAACG AGGCGGTGAG GGAGTTTGCC 1800
AAAGAGATCG ACGCCTCCTT CGTTAAGATC GAGGAAGTCA TTGGCGCAGG TGAGTTTGGA 1860
GAGGTGTGTC GTGGTCGGCT GAGGATCCCG GGCAGGAAGG AGAACTACGT GGCCATTAAG 1920
ACCCTGAAGG GTGGCTACAC GGAAAAGCAG AGGCGGGACT TCCTGTCGGA GGCGTCCATC 1980
ATGGGACAGT TCCAGCACCC CAACATCATC CACCTGGAGG GAGTCATCAC CACTTCCTGT 2040
CCTGTCATGA TCCTCACTGA GTTCATGGAA AACGGAGCGC TCGACAGCTT CCTGAGGATG 2100
AATGATGGCC AGTTCACCAC CATCCAGCTG GTTGGGATGC TGCGCGGCAT CGCAGCAGGG 2160
ATGAAGTATC TGTCTGAAAT GAGCTACGTC CATAGAGACC TGGCGGCTCG TAACATCCTG 2220
GTGAACTCCA ACCTGGTCTG TAAGGTGTCA GATTTCGGCC TGAGCAGGTT TCTGACTGAA 2280
AACTCGTCAG ACCCGACGTA CACCAGCTCT CTGGGTGGCA AGATTCCCAT TCGGTGGACG 2340
GCTCCTGAAG CCATCGCGTA CAGGAAGTTC ACTTCAGCCA GTGACACCTG GAGTTACGGC 2400
ATTGTCATGT GGGAAGTGAT GTCATACGGG GAGCGACCAT ACTGGGACAT GAGCAACCAG 2460
GACGTGATAA ACGCCATCGA GCAGGACTAC CGGCTGCCCC CGCCGCCGGA GTGCCCCGCC 2520
TCCCTGCACG CGCTTATGCT GGACTGCTGG CAGAAGGAGC GAGCCAACCG GCCGAGGTTC 2580
TGCGACGTGG TGGCGGCGCT CGACAGGCTG ATCCGAAACC CCACCTCTCT GAAAGTAACG 2640
CACCCAGAGG CACAGAGCCT GTCCCATCCT CTGTTGGACC AGCGAGTCCC CCCTCCTCTC 2700
TCAGCCTGCG GTTCGGTCTC CGAGTGGCTC CGAGCCATAA AGATGGAGCG ATACGAGCAG 2760
AGCTTCCTGC AGGCCGGATT CACCAACCTG GACATCGTCT CACAGCTCAA CACTGAAGAC 2820
CTCCTCAGAG TGGGCGTGAC CCTTGCCGGG CACCAGAAGA AGATACTCTC TTCCATCCAG 2880
ACGCTCAGGA TACACAAAGC TCCACCCACC 2910
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGevc+Grl++pg++e +vaiktlk+g+tekqrrdflseasi+Gqf+hp
Q: 608   VKIEEVIGAGEFGEVCRGRLRIPGRKENYVAIKTLKGGYTEKQRRDFLSEASIMGQFQHP  667
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         nii+leGv+t s pvmi+te+mengaldsflr +dgqft+iqlvgmlrGia+gmkyls+m
Q: 668   NIIHLEGVITTSCPVMILTEFMENGALDSFLRMNDGQFTTIQLVGMLRGIAAGMKYLSEM  727
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr+l ++s +++yt+s ggkipirwtapeaiay
Q: 728   SYVHRDLAARNILVNSNLVCKVSDFGLSRFLTENSsDPTYTSSlGGKIPIRWTAPEAIAY  787
         *******************************76666*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasd wsyGiv+wev+syGerpywdmsnqdvi+aie++yrlppp +cpa+l+ lml
Q: 788   RKFTSASDTWSYGIVMWEVMSYGERPYWDMSNQDVINAIEQDYRLPPPPECPASLHALML  847
         ************************************************************
S: 239   dcwqkdraerpkfeqivsi  257
         dcwqk+ra+rp+f ++v++
Q: 848   DCWQKERANRPRFCDVVAA  866
         ****************987
Domain Sequence
(FASTA)
VKIEEVIGAG EFGEVCRGRL RIPGRKENYV AIKTLKGGYT EKQRRDFLSE ASIMGQFQHP 60
NIIHLEGVIT TSCPVMILTE FMENGALDSF LRMNDGQFTT IQLVGMLRGI AAGMKYLSEM 120
SYVHRDLAAR NILVNSNLVC KVSDFGLSRF LTENSSDPTY TSSLGGKIPI RWTAPEAIAY 180
RKFTSASDTW SYGIVMWEVM SYGERPYWDM SNQDVINAIE QDYRLPPPPE CPASLHALML 240
DCWQKERANR PRFCDVVAA 259
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gasterosteus aculeatus"; ?>
EKS-GAA-00012
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013