EKS-ORN-00295

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00295

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	378.9	1.7E-113	72	368	297

Status

Unreviewed

Ensembl Protein

ENSONIP00000006057

UniProt Accession

I3JB17;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K2 (1 of 2)

Gene Synonyms/Alias

MAP2K2 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000004812	ENSONIP00000006057	ENSONIT00000006061

Organism

Oreochromis niloticus

Functional Description

Protein Length

399

Protein Sequence
(FASTA)

MGPKRKPGPL NITPIGEGQA TSNTIDAASE ANLEALQKKL GELDLDEQQR KRLEAFLTQK 60

AQVGELKDED FEPICELGAG NGGVVNKVRH KPSGLVMARK LIHLEIKPAI RNQIIRELQV 120

LHECNSPYIV GFYGAFYSDG EISICMEHMD GGSLDQVLKE ARRIPEEILG KVSIAVLRGL 180

AYLREKHQIM HRDVKPSNIL VNSRGEIKLC DFGVSGQLID SMANSFVGTR SYMSPERLQG 240

THYSVQSDVW SMGLSLVELA IGRYPIPPPD ARELEAIFGR AVMDGAEGEP HVNMQRPRPP 300

GRPISGSAMD SRPAMAIFEL LDYIVNEPPP KLPLGVFTSD FQDFVTKCLI KNPAERADLK 360

MLMSHTFIKR SEVEEVDFAG WLCKTMGLNQ PSTPTRGAE 399

Nucleotide Sequence
(FASTA)

ATGGGCCCCA AAAGAAAACC CGGTCCCCTT AACATTACGC CCATTGGAGA GGGACAGGCC 60

ACCTCCAACA CCATTGATGC TGCATCTGAA GCCAACCTCG AGGCCTTACA GAAGAAGCTG 120

GGGGAGCTGG ACCTGGATGA ACAGCAGAGG AAACGGCTGG AAGCCTTTCT CACCCAGAAA 180

GCCCAGGTCG GGGAGCTGAA GGATGAAGAT TTCGAACCCA TATGTGAGCT AGGCGCAGGA 240

AACGGAGGGG TGGTCAACAA GGTCCGCCAC AAACCCTCGG GCTTGGTCAT GGCTCGGAAG 300

TTGATCCACC TGGAAATCAA ACCTGCCATC AGAAACCAGA TTATCAGAGA GCTGCAGGTC 360

CTGCATGAAT GCAACTCGCC CTATATTGTG GGCTTTTATG GGGCCTTCTA CAGCGATGGA 420

GAGATCAGCA TCTGTATGGA GCACATGGAT GGTGGATCCT TGGACCAGGT TCTTAAGGAA 480

GCCAGAAGAA TCCCAGAAGA AATCCTTGGA AAAGTTAGCA TAGCTGTGTT GAGGGGATTG 540

GCATATCTGC GAGAGAAGCA CCAGATCATG CACAGAGACG TCAAGCCCTC CAACATACTG 600

GTCAACTCTC GTGGGGAGAT CAAGCTGTGC GACTTCGGTG TTAGCGGCCA GCTCATAGAT 660

TCCATGGCCA ACTCCTTTGT TGGAACGCGC TCCTACATGT CGCCGGAGAG ACTGCAGGGC 720

ACTCATTACT CGGTTCAGTC TGACGTGTGG AGCATGGGTC TGTCTCTGGT AGAGCTGGCG 780

ATTGGCCGCT ACCCCATCCC CCCACCAGAC GCCAGAGAAC TGGAGGCCAT CTTCGGACGG 840

GCCGTTATGG ATGGGGCTGA GGGAGAGCCT CACGTCAACA TGCAGAGGCC TAGACCACCC 900

GGAAGGCCTA TAAGTGGATC TGCGATGGAC AGTAGACCTG CCATGGCCAT CTTTGAACTT 960

TTGGACTACA TTGTCAATGA GCCACCCCCC AAACTGCCGC TTGGTGTGTT CACCAGTGAC 1020

TTCCAGGACT TTGTGACAAA ATGTTTGATT AAAAACCCAG CTGAGAGAGC AGATCTGAAG 1080

ATGCTCATGA GTCACACATT CATCAAGCGA TCAGAAGTGG AGGAAGTGGA CTTTGCTGGC 1140

TGGTTGTGCA AAACCATGGG CCTCAACCAG CCCAGCACTC CCACCCGCGG CGCCGAGTGA 1200

Domain Profile

S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv  61

         e + elGaGnggvV+kv+hk+sg ++a+K i+leik+++++qi+rel+vl+++ nspyiv

Q: 72    EPICELGAGNGGVVNKVRHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIV  130

         56789************************************************.******

S: 62    kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek  121

         +fyGaf+s+g++sicme+mdg+sld+vlk+    ++ripe++lgk+++av+++l+yl+ek

Q: 131   GFYGAFYSDGEISICMEHMDGGSLDQVLKE----ARRIPEEILGKVSIAVLRGLAYLREK  186

         *****************************9....79************************

S: 122   lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv  181

         ++i+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++Ysv

Q: 187   HQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYSV  245

         ******************************************************.*****

S: 182   ksdvWslGltlvelatgrypyeklke..................................  207

         +sdvWs+Gl+lvela+gryp++++++

Q: 246   QSDVWSMGLSLVELAIGRYPIPPPDAreleaifgravmdgaegephvnmqrprppgrpis  305

         ************************999*********************************

S: 208   ...........ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellkh  256

                    i+ell++ivne+ppklp   f+++fq+fv+kCl+k+++eR++lk+l++h

Q: 306   gsamdsrpamaIFELLDYIVNEPPPKLPLGVFTSDFQDFVTKCLIKNPAERADLKMLMSH  365

         ************************************************************

S: 257   afi  259

+fi

Q: 366   TFI  368

*97

Domain Sequence
(FASTA)

EPICELGAGN GGVVNKVRHK PSGLVMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG 60

FYGAFYSDGE ISICMEHMDG GSLDQVLKEA RRIPEEILGK VSIAVLRGLA YLREKHQIMH 120

RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDVWS 180

MGLSLVELAI GRYPIPPPDA RELEAIFGRA VMDGAEGEPH VNMQRPRPPG RPISGSAMDS 240

RPAMAIFELL DYIVNEPPPK LPLGVFTSDF QDFVTKCLIK NPAERADLKM LMSHTFI 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013