EKS-ORN-00489

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00489

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	319.1	2.8E-95	179	414	236

Status

Unreviewed

Ensembl Protein

ENSONIP00000006462

UniProt Accession

I3JC72;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K12 (1 of 2)

Gene Synonyms/Alias

MAP3K12 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000005141	ENSONIP00000006462	ENSONIT00000006467

Organism

Oreochromis niloticus

Functional Description

Protein Length

906

Protein Sequence
(FASTA)

MALMHEPRAP SPSLSGFNTP LSDPPSFRRL DAETPCTPEM DLTPTQCVLR NVLSIDTGGA 60

VEPGGGGREG HTTRHNQTPC EEQQEHFANS VLKLHEHDGG PGRTEGEGQD TDSSAVRSQA 120

NDARLQCQST GGGGGFLEGL FGCLRPVWTM IGKAYSTEHK HDLDASEEWE VPFEEISDLQ 180

WVGSGAQGAV FLGKLHGQEV AVKKVRNIKE TDIKHLRKLK HPNIITFKGI CTQAPCYCII 240

MEYCAQGQLY EVLRAGRKIT PSLLMDWAMG IAGGMNYLHL HKIIHRDLKS PNMLITYDDA 300

VKISDFGTSK ELNDKSTKMS FAGTVAWMAP EVIRNEPVSE KVDIWSFGVV LWEMLTGEVP 360

YKDVDSSAII WGVGNNSLQL PVPDSCPESF KLLLRQCWNC KPRNRPSFRQ ILLHLDIASA 420

DILSTAQETY FKSQAEWRDE VRHHFEKIKS EGTCLHRLDE ELIKRRREEL RHALDIREHY 480

ERKLERANNL YMELNAIMLQ LEIKEKELLK REQSLDKKYP GCFKHHSTRQ SASSNSMEKL 540

MKKRNVPQKL PSHSKRPDLL KSEVILPKLD SSMTQVTIPN KGSTSPGRSR RGKPRYRKAG 600

KGSSGDLAQL KATLSSSLAM INATSSVPSK HRLDPSAALR GLQHDLLLKK MSSSSPDLIS 660

TTLEVEGRSD VGVGGDDLAE TPPRSDTPSE DAASIPFSSS PDSPCGRGAA AGRASTLGNA 720

RVTHEGEEKE EGPVITRSPR SQRLTPSALL YRAAVTRSQR RGVSSEEEEG EVDSEVELPR 780

RRRPVSITKC QSLSTFSSEN LSVSDGEEGN TTDHSHSGTP DVVSTNTDER LDDKSDDLLS 840

QGSEIPADPS DPTQLGSDGL SEKEAILQQV KTQLASNDPN YEDDSDCDSA ELDHSCTADP 900

SQPPTN 906

Nucleotide Sequence
(FASTA)

ATGGCCCTCA TGCATGAACC TCGCGCCCCA TCGCCCTCTC TTTCCGGCTT CAACACACCC 60

CTCTCCGATC CTCCGTCCTT TCGCCGCCTC GATGCCGAAA CACCCTGCAC CCCAGAAATG 120

GACTTGACCC CAACCCAATG CGTCCTTCGC AACGTCCTCT CCATAGACAC CGGAGGTGCT 180

GTGGAACCCG GGGGTGGAGG AAGAGAGGGG CACACTACCA GACACAACCA GACACCCTGC 240

GAGGAACAAC AGGAGCACTT TGCCAACAGT GTCCTGAAAC TCCATGAGCA CGATGGCGGT 300

CCTGGAAGGA CGGAGGGAGA GGGACAGGAT ACGGACAGCA GTGCAGTCAG GAGCCAGGCG 360

AATGACGCCA GGTTACAGTG CCAGTCTACA GGAGGGGGAG GAGGGTTTTT GGAGGGGTTG 420

TTTGGGTGTC TGCGGCCTGT CTGGACAATG ATCGGCAAAG CCTACTCCAC AGAGCACAAG 480

CATGACCTGG ACGCTTCAGA GGAGTGGGAA GTCCCATTCG AGGAGATATC GGACCTGCAG 540

TGGGTGGGCA GCGGAGCCCA GGGCGCCGTC TTCCTCGGTA AACTGCACGG GCAGGAAGTG 600

GCTGTGAAGA AAGTGCGGAA CATTAAAGAG ACGGACATCA AGCACCTGCG GAAGCTCAAA 660

CATCCCAACA TCATCACCTT CAAAGGTATC TGTACCCAGG CTCCTTGTTA TTGTATCATC 720

ATGGAGTACT GCGCCCAGGG ACAGCTATAC GAGGTGCTGA GAGCAGGCAG GAAGATCACG 780

CCATCCCTGC TCATGGACTG GGCCATGGGC ATCGCTGGAG GCATGAACTA TCTTCACCTC 840

CACAAAATCA TCCACAGAGA CCTCAAATCA CCCAACATGC TGATCACCTA TGACGACGCA 900

GTGAAGATCT CTGACTTTGG CACATCTAAG GAGCTCAATG ACAAGAGCAC TAAGATGTCC 960

TTTGCTGGCA CTGTAGCCTG GATGGCCCCC GAGGTCATAC GTAATGAACC GGTCTCGGAG 1020

AAGGTGGATA TTTGGTCATT TGGTGTTGTG CTGTGGGAGA TGTTGACAGG AGAGGTGCCG 1080

TACAAGGATG TGGACTCCTC CGCTATCATC TGGGGAGTGG GCAACAACAG TCTGCAGCTG 1140

CCCGTGCCCG ACAGCTGTCC AGAGAGCTTC AAACTGCTGC TGAGGCAATG CTGGAACTGC 1200

AAGCCCAGAA ATAGACCTTC ATTTCGACAG ATTCTCCTGC ATCTGGACAT TGCCTCAGCG 1260

GATATATTAT CAACCGCACA AGAAACTTAC TTTAAGTCTC AGGCGGAGTG GAGAGACGAG 1320

GTGAGACATC ATTTTGAGAA GATTAAGTCT GAGGGCACGT GTCTTCACCG ACTGGACGAG 1380

GAGCTGATCA AAAGACGCAG GGAAGAACTG AGACATGCAC TGGACATCCG AGAACACTAC 1440

GAGAGGAAGC TGGAGAGAGC CAATAACCTC TACATGGAAC TGAATGCTAT CATGCTGCAG 1500

CTGGAGATCA AAGAGAAGGA GCTGCTTAAG AGGGAGCAGT CACTGGACAA GAAGTACCCA 1560

GGCTGCTTCA AGCATCACAG TACCAGACAG TCAGCCTCCT CCAATTCCAT GGAGAAACTC 1620

ATGAAGAAAC GCAATGTACC TCAGAAACTG CCCTCACACA GCAAGAGGCC AGACTTACTA 1680

AAGTCAGAGG TCATCCTCCC TAAGCTGGAC TCGTCCATGA CCCAGGTCAC AATCCCCAAC 1740

AAGGGCTCTA CCTCCCCCGG CCGCTCACGC CGAGGAAAAC CCCGCTACAG AAAGGCTGGA 1800

AAAGGCAGCA GTGGCGACCT GGCTCAGCTG AAAGCCACTT TGTCCTCGTC TTTAGCAATG 1860

ATCAATGCAA CCTCGTCTGT TCCCAGCAAG CACCGTCTAG ACCCCAGCGC AGCCCTCAGG 1920

GGCTTACAGC ATGACCTTCT CCTCAAGAAG ATGTCCTCCT CCAGTCCCGA TCTTATTTCT 1980

ACCACTCTGG AGGTCGAGGG CCGGAGTGAC GTGGGTGTAG GGGGGGATGA CTTGGCAGAA 2040

ACGCCTCCAC GCAGTGACAC ACCGAGCGAA GACGCGGCAT CTATTCCTTT TTCCAGTAGC 2100

CCTGACTCCC CTTGTGGCAG AGGAGCAGCG GCGGGCAGGG CGTCCACACT CGGGAACGCT 2160

CGTGTCACCC ACGAAGGTGA GGAGAAGGAG GAAGGGCCGG TGATCACACG CTCGCCCAGA 2220

AGTCAACGGC TTACGCCTTC AGCACTGCTC TACAGGGCAG CAGTCACACG CAGTCAGAGA 2280

CGTGGAGTGT CATCAGAGGA AGAGGAAGGA GAAGTGGACA GTGAAGTGGA GCTGCCGAGG 2340

AGACGGCGGC CTGTGAGCAT CACCAAATGC CAGTCCCTGT CGACCTTTAG CTCAGAGAAC 2400

CTATCGGTTT CGGACGGTGA GGAGGGCAAC ACTACTGACC ACTCCCACAG CGGTACGCCC 2460

GACGTGGTCA GCACCAACAC AGACGAGCGA CTGGACGACA AGAGCGACGA CCTGCTGTCT 2520

CAGGGCTCGG AGATTCCTGC TGACCCGTCT GACCCCACTC AGCTGGGCTC CGATGGTCTG 2580

TCCGAAAAAG AAGCCATTCT GCAACAAGTC AAGACGCAGC TCGCCTCAAA TGACCCCAAT 2640

TATGAGGATG ACTCAGACTG TGACAGTGCA GAACTGGACC ATTCGTGCAC TGCAGACCCC 2700

AGTCAACCTC CAACCAAC 2718

Domain Profile

S: 4     eeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiellG  63

          +++gsga+g+v+ +k++++evavKk+r+ +e+         ++k+l+kl+hpnii+++G

Q: 179   LQWVGSGAQGAVFLGKLHGQEVAVKKVRNIKET---------DIKHLRKLKHPNIITFKG  229

         689**************************9999.........******************

S: 64    vcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkkii  123

         +c++ p+++++mey+++g+L++vl++   r+i+++ l++wa+ iA Gm+YLh +   kii

Q: 230   ICTQAPCYCIIMEYCAQGQLYEVLRA--GRKITPSLLMDWAMGIAGGMNYLHLH---KII  284

         **************************..99************************...9**

S: 124   hrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseksD  182

         hrdLks+n+L+ + ++ +ki+dFGt++el++ stkms+agt+awmaPEv+++e+vsek+D

Q: 285   HRDLKSPNMLI-TYDDAVKISDFGTSKELNDkSTKMSFAGTVAWMAPEVIRNEPVSEKVD  343

         ***********.999***************99****************************

S: 183   vwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedpe  242

         +wS+gvvLWe+lt+evPykd+++ ai+++v++++l+lp+p+scpe++k L+++cwn +p+

Q: 344   IWSFGVVLWEMLTGEVPYKDVDSSAIIWGVGNNSLQLPVPDSCPESFKLLLRQCWNCKPR  403

         ************************************************************

S: 243   kRpsfseivks  253

         +Rpsf++i+ +

Q: 404   NRPSFRQILLH  414

         ********876

Domain Sequence
(FASTA)

LQWVGSGAQG AVFLGKLHGQ EVAVKKVRNI KETDIKHLRK LKHPNIITFK GICTQAPCYC 60

IIMEYCAQGQ LYEVLRAGRK ITPSLLMDWA MGIAGGMNYL HLHKIIHRDL KSPNMLITYD 120

DAVKISDFGT SKELNDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWEMLTGE 180

VPYKDVDSSA IIWGVGNNSL QLPVPDSCPE SFKLLLRQCW NCKPRNRPSF RQILLH 236

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017419	; MAP3K12_MAP3K13.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013