EKS-ORN-00012
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00012
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph493.61.1E-148621880260
StatusUnreviewed
Ensembl ProteinENSONIP00000006537
UniProt AccessionI3JCE7;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB4 (1 of 2)
Gene Synonyms/Alias EPHB4 (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000005204ENSONIP00000006537ENSONIT00000006542
OrganismOreochromis niloticus
Functional Description
Protein Length984
Protein Sequence
(FASTA)
VRPQAWRVAG NWGEMGGIKT NMRVSSAEVL MNTKTETSDL KWTVFSHARP QWEEVSGLDE 60
ENNSVRINQI CQTDSSSSHW LRSGYIQRRG ASQVYVELRF TMMECSSRST HHRSCKETFN 120
LYYYEADSNE ATATNPPWME NPYIKVDTVA ADFLLRKDGE KKLNVKTLRL GPLNKRGFYL 180
AFQAQGACMA LLSVRVFFKK CPPLVSALSS FPETIPRTLV QEAQGVCVEH AAQQGPRPRP 240
PKLFCGEDGQ WVGQPTTSCA CVPGFEPAEG YTRCTACPVG QFKSGVEGQC RGCPGFSQAT 300
NRGASVCECR PGYLRAESDT PDTPCTRTPS APRSIIPKVN FTTVTLDWNE PLDSGSRNDL 360
SYAVRCSLCR SPKETCLPCG DGVSYRPAKD GLLGHRVEVW GLLPHTTYTF TIQALNGVSQ 420
LSEKEPASES VNITTSHDVP PLVSVIRKSD STESSLTLHW SVPTQPHYTI LQYELRYCEK 480
KEQRSEDQCH SIQSNRNQAV LTDLRRASQY EVQVRARTQA GYGSFSPPII FRTLPDGRDS 540
GSEFLVPGIF IAVGMLLLVT FVFVAAYCIR RHSRIKDPEL SDKNSQYLIG QGVKVYIDPF 600
TYEDPNEAVR EFAKEIDVSF VKIEEVIGAG EFGEVCRGRL KIPGKKENYV AIKTLKGGYT 660
DKQRRDFLSE ASIMGQFQHP NIIHLEGIIT ASCPVMILTE YMENGALDSF LRLNDSQFTP 720
IQLVGMLRGI ASGMKYLAEM SYVHRDLAAR NILINSNLVC KVSDFGLSRF LQENSSDPTY 780
TSSLGGKIPI RWTAPEAIAF RKFTSASDVW SYGIVMWEVM SFGERPYWDM SNQDVINAIE 840
QDYRLPPPPD CPTHLHQLML DCWQKDRSAR PRFAELVSAL DKLIRNPASL KIVAQEGAGP 900
SYPLLDQRAP LALPPCASVG DWLRAIKMER YEDSFLQAGF NSVDQLAQIT TQDLLHMGVT 960
LAGHQRKILS SIQTMTFQNK STAT 984
Nucleotide Sequence
(FASTA)
GTTCGACCGC AGGCGTGGCG TGTCGCTGGG AACTGGGGGG AGATGGGGGG AATAAAAACA 60
AACATGAGAG TCTCTTCTGC AGAGGTCCTG ATGAACACTA AGACAGAGAC TTCGGATCTC 120
AAATGGACCG TCTTCTCCCA TGCCAGGCCA CAGTGGGAGG AAGTAAGTGG TTTAGATGAG 180
GAGAACAACA GCGTGAGGAT CAATCAGATT TGCCAAACGG ACAGTTCATC CAGCCACTGG 240
CTGCGCAGTG GCTACATCCA GCGACGGGGA GCGTCTCAGG TGTACGTGGA ACTGCGATTC 300
ACCATGATGG AGTGCTCTTC CAGGAGCACA CACCACCGTA GCTGCAAGGA GACCTTCAAC 360
CTCTACTACT ACGAGGCAGA CTCCAACGAA GCCACTGCTA CGAACCCACC CTGGATGGAG 420
AACCCCTACA TCAAGGTGGA CACAGTGGCT GCAGACTTTC TACTAAGGAA GGACGGGGAG 480
AAGAAATTGA ACGTGAAGAC CTTGAGACTC GGCCCTCTTA ATAAGAGAGG CTTTTACTTG 540
GCCTTTCAGG CTCAGGGTGC CTGCATGGCT CTGCTGTCTG TCAGGGTGTT CTTCAAGAAG 600
TGTCCTCCCC TGGTCAGTGC TCTTTCCTCT TTCCCTGAGA CTATACCGCG TACTCTAGTG 660
CAAGAGGCAC AGGGTGTGTG TGTGGAGCAC GCAGCTCAGC AAGGTCCCCG TCCTCGGCCG 720
CCTAAGCTCT TCTGCGGGGA GGATGGCCAG TGGGTGGGCC AGCCAACAAC CTCCTGTGCA 780
TGCGTACCGG GATTTGAACC AGCTGAGGGG TACACGAGAT GCACAGCCTG TCCTGTGGGC 840
CAGTTTAAGT CAGGCGTAGA GGGACAGTGC AGAGGCTGCC CAGGATTCAG CCAGGCCACC 900
AACAGGGGAG CGTCAGTGTG TGAATGTCGC CCTGGGTACC TACGTGCCGA ATCAGACACT 960
CCTGACACCC CGTGCACTAG AACTCCCTCG GCCCCTCGCA GCATAATCCC TAAGGTCAAC 1020
TTCACCACCG TCACTCTGGA TTGGAATGAG CCGCTGGACA GCGGCAGCAG AAACGACCTG 1080
AGCTACGCCG TCAGGTGCTC TCTGTGCAGG TCACCAAAGG AAACGTGCCT CCCCTGCGGA 1140
GACGGCGTCA GTTACCGGCC TGCGAAAGAC GGCCTGCTGG GTCACAGGGT AGAGGTGTGG 1200
GGCCTGCTGC CACACACAAC GTATACGTTC ACTATTCAGG CACTCAACGG AGTGTCTCAG 1260
CTCAGCGAGA AGGAGCCTGC CAGCGAAAGT GTCAACATCA CTACAAGCCA TGACGTGCCG 1320
CCACTGGTGT CTGTGATTCG GAAGAGCGAC TCCACAGAGA GCAGTCTGAC TCTGCACTGG 1380
TCGGTCCCGA CTCAGCCACA CTACACCATC CTGCAGTATG AGCTGCGCTA CTGTGAGAAG 1440
AAGGAGCAGC GTAGCGAGGA TCAGTGCCAC TCCATACAGA GTAACAGAAA CCAGGCTGTA 1500
CTGACAGACC TCCGCCGGGC TAGCCAGTAT GAAGTGCAGG TCCGGGCGCG TACCCAGGCC 1560
GGCTACGGCA GCTTTAGTCC ACCAATCATT TTCCGCACGC TGCCCGATGG ACGTGACTCT 1620
GGCTCCGAGT TCTTGGTACC TGGCATCTTT ATCGCTGTCG GGATGCTGCT GCTTGTCACT 1680
TTCGTCTTTG TGGCCGCCTA CTGCATACGC CGGCACAGCC GAATAAAGGA TCCGGAGCTG 1740
AGTGACAAAA ACAGCCAGTA CCTCATTGGC CAAGGGGTCA AGGTTTATAT CGACCCTTTC 1800
ACCTACGAAG ACCCTAATGA GGCAGTGAGA GAATTTGCCA AGGAAATCGA TGTTTCCTTT 1860
GTCAAGATTG AGGAGGTCAT TGGTGCTGGC GAGTTTGGGG AGGTGTGTCG AGGACGGCTG 1920
AAGATACCAG GAAAAAAGGA AAACTACGTT GCAATTAAAA CTCTAAAGGG TGGCTACACC 1980
GACAAGCAGA GACGGGACTT CCTGTCTGAG GCGTCCATCA TGGGACAGTT CCAACACCCC 2040
AACATTATCC ATCTGGAGGG AATCATTACA GCCAGCTGTC CAGTCATGAT CCTGACAGAG 2100
TATATGGAGA ACGGCGCTCT GGACTCATTT CTACGGCTGA ACGACAGCCA GTTCACACCC 2160
ATCCAGCTGG TTGGTATGCT GCGTGGCATT GCCTCTGGCA TGAAGTACCT GGCAGAGATG 2220
AGCTACGTCC ACCGAGACCT GGCTGCCCGC AACATCCTGA TCAACAGCAA CCTGGTGTGC 2280
AAGGTGTCTG ACTTTGGCTT GTCACGCTTC CTTCAGGAGA ACTCCTCTGA CCCAACCTAC 2340
ACCAGCTCTC TGGGAGGTAA GATCCCAATC CGCTGGACAG CACCGGAGGC AATAGCCTTC 2400
AGAAAGTTTA CCTCAGCCTC AGATGTGTGG AGCTACGGCA TCGTCATGTG GGAGGTCATG 2460
TCTTTTGGAG AAAGACCGTA CTGGGACATG AGCAACCAGG ATGTGATCAA TGCCATAGAG 2520
CAGGACTACC GCCTGCCCCC GCCGCCTGAC TGCCCCACCC ACCTGCACCA ACTGATGTTG 2580
GACTGCTGGC AGAAGGACCG GTCGGCGCGA CCTCGCTTTG CGGAGCTCGT TAGCGCTTTG 2640
GACAAACTCA TCCGCAACCC CGCGTCGCTG AAAATAGTGG CTCAAGAAGG AGCAGGGCCG 2700
TCCTACCCCC TGCTGGACCA GCGTGCACCT TTAGCTCTCC CGCCGTGTGC TTCGGTGGGG 2760
GATTGGCTTA GGGCCATCAA GATGGAGCGT TACGAAGACA GTTTCCTTCA GGCTGGCTTC 2820
AACTCAGTGG ACCAGCTGGC CCAGATCACC ACACAGGATC TGCTGCACAT GGGTGTGACT 2880
TTGGCTGGGC ATCAGAGGAA AATCCTTTCC AGCATCCAAA CAATGACCTT TCAAAACAAG 2940
AGCACTGCAA CT 2952
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGevc+Grlk+pgk+e +vaiktlk+g+t+kqrrdflseasi+Gqf+hp
Q: 621   VKIEEVIGAGEFGEVCRGRLKIPGKKENYVAIKTLKGGYTDKQRRDFLSEASIMGQFQHP  680
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         nii+leG++t s pvmi+teymengaldsflr +d+qft iqlvgmlrGiasgmkyl++m
Q: 681   NIIHLEGIITASCPVMILTEYMENGALDSFLRLNDSQFTPIQLVGMLRGIASGMKYLAEM  740
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnil+nsnlvckvsdfGlsr+l+++s +++yt+s ggkipirwtapeaia+
Q: 741   SYVHRDLAARNILINSNLVCKVSDFGLSRFLQENSsDPTYTSSlGGKIPIRWTAPEAIAF  800
         *******************************88877*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasdvwsyGiv+wev+s+Gerpywdmsnqdvi+aie++yrlppp dcp+ l+qlml
Q: 801   RKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTHLHQLML  860
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqkdr++rp+f+++vs+l
Q: 861   DCWQKDRSARPRFAELVSAL  880
         ****************9975
Domain Sequence
(FASTA)
VKIEEVIGAG EFGEVCRGRL KIPGKKENYV AIKTLKGGYT DKQRRDFLSE ASIMGQFQHP 60
NIIHLEGIIT ASCPVMILTE YMENGALDSF LRLNDSQFTP IQLVGMLRGI ASGMKYLAEM 120
SYVHRDLAAR NILINSNLVC KVSDFGLSRF LQENSSDPTY TSSLGGKIPI RWTAPEAIAF 180
RKFTSASDVW SYGIVMWEVM SFGERPYWDM SNQDVINAIE QDYRLPPPPD CPTHLHQLML 240
DCWQKDRSAR PRFAELVSAL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00008
EKS-BOT-00007
EKS-CAJ-00008
EKS-CAF-00009
EKS-CAP-00006
EKS-DAR-00013
EKS-EQC-00009
EKS-FEC-00006
EKS-GAA-00011
EKS-GOG-00008
EKS-HOS-00009
EKS-ICT-00008
EKS-LOA-00009
EKS-MAM-00007
EKS-MOD-00008
EKS-MUM-00009
EKS-MUP-00009
EKS-MYL-00010
EKS-ORA-00007
EKS-ORC-00008
EKS-ORL-00012
EKS-OTG-00009
EKS-PAT-00009
EKS-PRC-00003
EKS-RAN-00008
EKS-SAH-00007
EKS-SUS-00006
EKS-TEN-00011
EKS-TUT-00005
EKS-XIM-00010
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013