EKS-ORN-00188

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00188

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	509.3	3.9E-153	628	933	306

Status

Unreviewed

Ensembl Protein

ENSONIP00000006999

UniProt Accession

I3JDQ8;

Protein Name

Protein Synonyms/Alias

Gene Name

LATS1

Gene Synonyms/Alias

LATS1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000005566	ENSONIP00000006997	ENSONIT00000007002
ENSONIG00000005566	ENSONIP00000006999	ENSONIT00000007004
ENSONIG00000005566	ENSONIP00000006998	ENSONIT00000007003

Organism

Oreochromis niloticus

Functional Description

Protein Length

1053

Protein Sequence
(FASTA)

MKRGEKPEGY RQRRPKTFPV TNYSGNSQQM LQEIRNSLRN LSKPSDPPKV DTGAQGKMLP 60

EDSRQLGRSS NPKNPHHKTL QEIREALMPF KNEPNTSGFQ REPRFAGLEE SKEFVSQLAF 120

TTCFELQTTW VRLFPTPALQ ASNPQIQPAV LRRSSWKGSK EGMMYRSDSP GPPPAFPQGH 180

PTNNQRVTPP PNRGGMPSAS SWDSNPSTKR YSGNMDYLVP RISPVPQGQW PDGYSAAPQN 240

QRGISPVPMG HQPIIMPSSG GNKFTFPPSW TQSGSSQPDY MTGGSRHPPP PYPVNQSSRH 300

SPTDQQTGGP ASSPSYHNGG NIPHSMMVPN RKSHNLDLYF SGLPQSWSSQ PQPSSGNGSN 360

QDHSPSWQHN MPVRSNSFTS HHSRCTHPTS SQPSATTVTA IIPAPILLPV KSTRVQKAEL 420

HTAVAPTHPP WKPQAAPPPA APAYLEPAGT VPQVVSEAPD YHGPPPPYPK HLLQQQAAPS 480

PPGYDAGANR LSAGREDPAD EESSGRGDGS KEKPSESPEG GAAKEEDRKQ ITTSPVPVRR 540

NKKDEERRGE SGRVNLYSPQ AFKFFMEQHI ENILKNHQQR IHRRKQLENE MQRVGLSSEA 600

QEQMRMMLCQ KESNYIRLKR AKMDKCMFKR IKTLGIGAFG EVCLARKEDT GALYAMKTLR 660

KKDVLLRNQV AHVKAERDIL AEADNEWVVR LYYSFQDKDN LYFVMEYIPG GDMMSLLIRL 720

GIFKEELAQF YIAELTCAVE SVHKMGFIHR DIKPDNILID RDGHIKLTDF GLCTGFRWTH 780

DSKYYQSGDH VRQDSMDFSK EWEDPANCRC TDRLKPLERR KARQHQRCLA HSLVGTPNYI 840

APEVLLRTGY TQLCDWWSVG VILYEMVVGQ PPFLATTPLE TQLKVINWKS TLHIPPQAKL 900

SAEASDLIVK LCRGPEDRLG KNGADEIKAH PFFKSIDFSS DLRQQEAPYI PTIAHSTDTS 960

NFDAVDPDKM WSSDGDDEDS HNDTLNCWFR NGKHPEHAFY EFTFRRFFDD NGHPYSCPKP 1020

IEYEGYEDEA DSEGAAQEAA SSSALQGRDL VYV 1053

Nucleotide Sequence
(FASTA)

ATGAAAAGAG GGGAGAAACC CGAAGGATAC CGGCAGAGGA GACCCAAAAC GTTTCCCGTC 60

ACGAACTACA GTGGCAACAG CCAACAGATG CTGCAGGAAA TACGGAACAG CCTGCGCAAC 120

CTGTCGAAAC CGTCAGACCC ACCTAAAGTG GACACTGGTG CACAAGGGAA GATGCTCCCA 180

GAGGATTCAA GGCAACTGGG TCGCAGCAGC AACCCGAAAA ACCCTCACCA CAAAACCTTA 240

CAGGAGATCC GTGAGGCCCT CATGCCTTTT AAAAATGAGC CCAACACTTC AGGCTTCCAG 300

CGGGAACCCC GTTTTGCAGG GCTCGAGGAG AGTAAAGAAT TTGTTTCTCA GTTGGCATTT 360

ACAACTTGTT TTGAGCTACA GACTACATGG GTAAGGTTGT TTCCAACCCC AGCTCTGCAG 420

GCCTCAAACC CCCAGATCCA GCCGGCTGTC CTGAGGAGGT CAAGCTGGAA GGGCTCCAAG 480

GAAGGAATGA TGTACCGATC CGACAGCCCT GGACCGCCTC CTGCCTTCCC ACAGGGCCAC 540

CCTACAAACA ACCAGAGGGT CACACCTCCA CCAAACCGTG GTGGCATGCC TTCTGCGTCA 600

TCCTGGGACA GCAACCCATC AACAAAGCGG TACTCTGGAA ACATGGATTA CCTTGTGCCA 660

CGCATCTCTC CAGTACCCCA GGGGCAGTGG CCTGATGGGT ACAGCGCAGC ACCTCAGAAT 720

CAACGTGGGA TCAGCCCAGT GCCCATGGGC CACCAGCCCA TCATAATGCC AAGCTCTGGG 780

GGCAATAAGT TCACCTTTCC CCCTAGCTGG ACTCAGAGTG GCTCCTCTCA GCCAGACTAC 840

ATGACAGGGG GCAGCAGACA TCCCCCTCCT CCGTACCCGG TCAACCAGAG TAGCCGGCAC 900

AGTCCCACTG ACCAGCAGAC AGGAGGACCT GCATCCTCGC CTTCTTACCA CAATGGAGGG 960

AATATCCCTC ATTCCATGAT GGTTCCCAAC CGGAAAAGTC ACAACCTTGA TTTGTACTTT 1020

TCCGGTCTTC CTCAGTCCTG GTCCAGCCAG CCCCAACCTT CCTCCGGCAA CGGCAGCAAC 1080

CAGGACCACT CTCCGTCATG GCAACATAAC ATGCCAGTCC GCTCCAATTC TTTCACCAGC 1140

CACCATAGCA GATGTACTCA CCCGACCAGC TCACAGCCCT CTGCCACCAC AGTCACCGCC 1200

ATCATACCGG CTCCCATTCT TCTGCCGGTG AAAAGCACCC GCGTCCAGAA AGCCGAACTA 1260

CACACTGCTG TCGCTCCCAC ACATCCTCCA TGGAAACCGC AGGCTGCACC ACCTCCTGCT 1320

GCGCCTGCCT ACCTAGAACC CGCAGGTACA GTCCCGCAGG TTGTATCTGA AGCACCTGAC 1380

TACCACGGAC CTCCTCCCCC TTACCCTAAG CACCTCCTCC AACAGCAGGC TGCACCCAGC 1440

CCACCAGGGT ATGACGCAGG GGCCAACAGG CTCAGTGCAG GCAGGGAGGA TCCCGCTGAT 1500

GAGGAGAGCA GCGGTCGTGG GGACGGCTCG AAGGAAAAAC CATCAGAAAG CCCAGAGGGT 1560

GGAGCAGCAA AAGAGGAGGA CAGGAAGCAA ATCACAACAT CACCTGTTCC GGTCCGACGC 1620

AACAAGAAAG ACGAAGAGCG GAGAGGAGAG TCGGGAAGAG TCAATTTGTA TTCCCCGCAG 1680

GCCTTCAAGT TCTTCATGGA GCAACACATA GAGAACATCC TGAAGAACCA CCAGCAGCGG 1740

ATTCACAGAA GGAAGCAACT GGAAAATGAG ATGCAAAGGG TGGGTTTGTC TTCAGAAGCC 1800

CAGGAGCAGA TGCGTATGAT GCTCTGTCAA AAGGAATCTA ACTACATTCG GTTAAAACGA 1860

GCTAAGATGG ACAAGTGCAT GTTCAAACGG ATCAAGACCC TCGGCATCGG CGCCTTCGGC 1920

GAGGTCTGCT TGGCCAGAAA AGAGGACACG GGAGCGCTGT ACGCCATGAA GACTCTCCGC 1980

AAGAAGGACG TGCTCCTGAG AAACCAGGTG GCTCACGTCA AGGCTGAGAG GGACATTCTG 2040

GCGGAGGCCG ACAATGAGTG GGTAGTGCGT CTCTACTACT CTTTCCAAGA TAAGGACAAC 2100

CTGTACTTCG TTATGGAGTA CATCCCCGGA GGGGACATGA TGAGCCTTCT CATCAGACTC 2160

GGCATCTTTA AAGAAGAGCT GGCCCAGTTT TACATCGCAG AGCTCACCTG CGCTGTGGAG 2220

AGCGTCCACA AGATGGGCTT CATCCACCGA GACATCAAGC CTGACAACAT CCTCATAGAC 2280

AGAGACGGTC ACATAAAGCT GACAGACTTC GGTCTTTGCA CTGGTTTCCG CTGGACCCAC 2340

GACTCGAAGT ATTACCAGAG TGGGGACCAT GTGAGGCAGG ACAGCATGGA CTTCAGTAAG 2400

GAATGGGAGG ATCCAGCCAA CTGCCGCTGT ACAGACCGCC TGAAGCCTCT GGAAAGGAGA 2460

AAGGCCCGGC AGCACCAGCG TTGTCTGGCC CATTCACTCG TGGGGACACC CAACTATATC 2520

GCACCAGAAG TGCTGCTTCG AACAGGATAC ACCCAGCTCT GTGATTGGTG GAGTGTAGGA 2580

GTGATCTTGT ATGAAATGGT CGTTGGACAG CCTCCCTTCT TAGCAACCAC ACCCCTGGAG 2640

ACGCAGCTAA AGGTGATAAA CTGGAAGAGC ACGCTGCACA TTCCCCCGCA GGCCAAGCTC 2700

AGCGCAGAGG CATCGGATCT CATCGTTAAA CTGTGCCGCG GCCCTGAGGA CCGCCTCGGT 2760

AAGAACGGTG CGGATGAAAT CAAAGCCCAT CCTTTCTTCA AAAGCATCGA CTTCTCCAGC 2820

GACCTCAGAC AGCAGGAGGC ACCATACATC CCCACCATCG CCCACTCCAC GGACACCTCC 2880

AACTTTGATG CCGTGGACCC GGATAAAATG TGGAGCAGTG ACGGCGATGA TGAGGACAGC 2940

CATAACGACA CTCTAAACTG CTGGTTCCGC AACGGAAAAC ACCCCGAGCA CGCCTTCTAC 3000

GAGTTTACCT TCCGGCGCTT CTTTGACGAC AACGGCCATC CGTACAGCTG CCCCAAGCCC 3060

ATTGAGTACG AGGGCTACGA GGACGAGGCC GACTCGGAGG GCGCCGCGCA GGAGGCCGCC 3120

AGCTCCTCGG CGTTACAGGG ACGAGACCTG GTCTACGTGT AG 3162

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         f+ +k++g+GafGev+l+rk+dt+++ya+k+lrkkd+l +nqvahvkaerdilaead+ew

Q: 628   FKRIKTLGIGAFGEVCLARKEDTGALYAMKTLRKKDVLLRNQVAHVKAERDILAEADNEW  687

         889*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vv+lyysfqdk+nly+vmey+PGGd+m+lli+ +i+keela+fyiael++avesvhk+Gf

Q: 688   VVRLYYSFQDKDNLYFVMEYIPGGDMMSLLIRLGIFKEELAQFYIAELTCAVESVHKMGF  747

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddlease.......  173

         ihrd+kPdn+lid++GhikltdfGlctG+++th+s+yy++ +++++d++++s+

Q: 748   IHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHVRQDSMDFSKewedpan  807

         **************************************************9999******

S: 174   .....elkvlerrkkkknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyeml  228

              +lk+lerrk+++++r+la+slvGtp+yiapevl+++gy++lcdwWs+Gvilyem+

Q: 808   crctdRLKPLERRKARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILYEMV  867

         ****99******************************************************

S: 229   vGypPflaetpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdei  288

         vG+pPfla tp et+ kvinwk+tl++p++++ls+ea+dli +l+  +e+rlgk+G+dei

Q: 868   VGQPPFLATTPLETQLKVINWKSTLHIPPQAKLSAEASDLIVKLCRGPEDRLGKNGADEI  927

         ************************************************************

S: 289   kkhpff  294

         k+hpff

Q: 928   KAHPFF  933

         *****9

Domain Sequence
(FASTA)

FKRIKTLGIG AFGEVCLARK EDTGALYAMK TLRKKDVLLR NQVAHVKAER DILAEADNEW 60

VVRLYYSFQD KDNLYFVMEY IPGGDMMSLL IRLGIFKEEL AQFYIAELTC AVESVHKMGF 120

IHRDIKPDNI LIDRDGHIKL TDFGLCTGFR WTHDSKYYQS GDHVRQDSMD FSKEWEDPAN 180

CRCTDRLKPL ERRKARQHQR CLAHSLVGTP NYIAPEVLLR TGYTQLCDWW SVGVILYEMV 240

VGQPPFLATT PLETQLKVIN WKSTLHIPPQ AKLSAEASDL IVKLCRGPED RLGKNGADEI 300

KAHPFF 306

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013