EPS-ORN-00162

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORN-00162

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP5	596.5	1.2E-179	177	488	312

Status

Unreviewed

Ensembl Protein

ENSONIP00000007403

UniProt Accession

I3JEW2;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP5C

Gene Synonyms/Alias

PPP5C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000005880	ENSONIP00000007403	ENSONIT00000007408

Organism

Oreochromis niloticus

Functional Description

Protein Length

491

Protein Sequence
(FASTA)

MAYISENGSE KKMAEGGNDA ELLKEKANKY FKEKDYENAI KYYTEALELN PSNAIYYSNR 60

SLAYLRTECY GYALADATKA LEVDKNYIKG YYRRATSNMA LGKFKAALKD YETVVRVRPN 120

DKDARMKYQE CNKIVKQKAF ERAIASDETK KSVVDSLDIE NMTIEDDYTG PKLEDGKVTL 180

KFMKEMMDWF KDQKKLHRKC AYQILVQVKD VLSKLPSLVE ITLKETEKIT ICGDTHGQYY 240

DLLNIFKLNG LPSDTNPYLF NGDFVDRGSF SVEVILTLFG FKLLYPNNFH LLRGNHETDN 300

MNQMYGFEGE VKAKYTAQMF QLFSEVFQWL PLAQCINNKV LVMHGGLFSE DGVTLEDLRK 360

IDRNRQPPDS GPMCDLLWSD PQPQNGRSIS KRGVSCQFGP DVTERFLEQN KLDFIVRSHE 420

VKAEGYEVTH SGKCITVFSA PNYCDQMGNK GAYIHLRGSD LKPEFHQFTA VPHPNVKPMA 480

YANTLMQLGM M 491

Nucleotide Sequence
(FASTA)

ATGGCGTACA TATCGGAAAA CGGCAGTGAG AAGAAGATGG CGGAGGGAGG TAATGATGCC 60

GAGCTACTCA AGGAGAAGGC GAATAAGTAC TTTAAAGAAA AAGACTATGA AAATGCGATC 120

AAGTACTACA CAGAAGCCTT GGAACTCAAT CCATCCAATG CCATATACTA CAGCAACCGA 180

AGCCTGGCAT ACCTACGCAC AGAGTGCTAT GGTTATGCCC TGGCGGATGC CACAAAGGCC 240

CTGGAGGTAG ACAAAAACTA CATTAAGGGA TATTACCGCC GTGCCACCTC CAACATGGCA 300

CTGGGCAAAT TTAAAGCTGC ACTAAAAGAC TACGAAACGG TAGTGAGGGT TCGACCGAAT 360

GACAAGGATG CAAGGATGAA GTATCAAGAA TGTAACAAGA TTGTGAAACA GAAGGCTTTT 420

GAGAGAGCCA TTGCCAGCGA CGAGACAAAG AAATCTGTTG TTGACTCTTT GGACATTGAA 480

AACATGACGA TTGAGGATGA CTATACAGGC CCAAAACTTG AAGACGGGAA GGTCACATTG 540

AAGTTCATGA AAGAGATGAT GGATTGGTTC AAAGATCAGA AGAAACTGCA CAGAAAGTGT 600

GCTTATCAGA TTTTGGTGCA AGTTAAAGAT GTTCTGTCAA AACTGCCAAG TCTTGTTGAA 660

ATCACGTTAA AAGAGACAGA AAAAATAACT ATTTGTGGGG ACACCCATGG CCAATACTAC 720

GATCTCCTCA ACATCTTCAA GTTGAACGGC TTACCTTCTG ACACCAACCC TTATCTGTTC 780

AATGGTGACT TTGTGGATCG TGGCTCTTTC TCTGTTGAGG TCATTCTTAC CCTTTTTGGC 840

TTCAAGCTGC TCTACCCCAA CAACTTCCAC TTGCTTAGAG GTAACCATGA GACGGACAAC 900

ATGAACCAGA TGTATGGATT TGAAGGGGAG GTCAAAGCCA AGTACACAGC CCAGATGTTT 960

CAGCTTTTCA GCGAGGTGTT CCAGTGGCTT CCTCTTGCAC AGTGTATCAA CAATAAAGTA 1020

CTGGTTATGC ATGGTGGGCT GTTCAGTGAA GATGGTGTCA CATTGGAAGA CTTGAGGAAG 1080

ATTGACAGGA ATAGACAGCC TCCAGACTCA GGTCCTATGT GTGACCTCCT CTGGTCAGAT 1140

CCACAGCCAC AGAATGGCCG GTCGATCAGT AAGCGAGGGG TGAGTTGCCA GTTTGGGCCC 1200

GATGTGACGG AGCGCTTCCT GGAGCAGAAC AAGCTGGATT TCATTGTGCG TAGTCATGAG 1260

GTCAAAGCTG AGGGGTACGA GGTCACTCAC TCAGGGAAGT GCATCACCGT GTTTTCAGCA 1320

CCCAACTACT GTGATCAGAT GGGAAACAAA GGAGCATATA TCCACCTCAG GGGATCAGAC 1380

CTCAAACCAG AATTTCACCA GTTCACAGCT GTGCCTCATC CGAATGTCAA GCCCATGGCA 1440

TATGCCAACA CGCTAATGCA GTTGGGGATG ATGTAG 1476

Domain Profile

S: 2     kvsiefikklvndlklkkkllrkkavailvsvadvlfklevelennskedvkitvcGdth  61

         kv+ +f+k++++++k++kkl+rk+a++ilv+v+dvl+kl  ++e ++ke++kit+cGdth

Q: 177   KVTLKFMKEMMDWFKDQKKLHRKCAYQILVQVKDVLSKLPSLVEITLKETEKITICGDTH  236

         7999********************************************************

S: 62    GqfydllnifelnGlpseknpylfnGdfvdrGsfsveviltlfglkllyPdhffllrGnh  121

         Gq+ydllnif+lnGlps++npylfnGdfvdrGsfsveviltlfg+kllyP++f+llrGnh

Q: 237   GQYYDLLNIFKLNGLPSDTNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPNNFHLLRGNH  296

         ************************************************************

S: 122   esdnmnkiyGfegevkakytaklyelfaevfewlPlaqlingkvlvmhGGlfsedgvtld  181

         e+dnmn++yGfegevkakyta++++lf+evf+wlPlaq+in+kvlvmhGGlfsedgvtl+

Q: 297   ETDNMNQMYGFEGEVKAKYTAQMFQLFSEVFQWLPLAQCINNKVLVMHGGLFSEDGVTLE  356

         ************************************************************

S: 182   dirkiernaqPPeeGalcellWsdPqeanGrgvskrGvglqfGpdvtkrfleenkldyii  241

         d+rki+rn+qPP++G++c+llWsdPq++nGr++skrGv++qfGpdvt+rfle+nkld+i+

Q: 357   DLRKIDRNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTERFLEQNKLDFIV  416

         ************************************************************

S: 242   rshevkaegveveqkgklvtvfsapnycdsqgnlasvihvrnddlrliietfeavehpdv  301

         rshevkaeg+ev+++gk++tvfsapnycd++gn++++ih+r++dl++ +++f+av+hp+v

Q: 417   RSHEVKAEGYEVTHSGKCITVFSAPNYCDQMGNKGAYIHLRGSDLKPEFHQFTAVPHPNV  476

         ************************************************************

S: 302   kpmaysngllgl  313

         kpmay+n+l++l

Q: 477   KPMAYANTLMQL  488

         *********987

Domain Sequence
(FASTA)

KVTLKFMKEM MDWFKDQKKL HRKCAYQILV QVKDVLSKLP SLVEITLKET EKITICGDTH 60

GQYYDLLNIF KLNGLPSDTN PYLFNGDFVD RGSFSVEVIL TLFGFKLLYP NNFHLLRGNH 120

ETDNMNQMYG FEGEVKAKYT AQMFQLFSEV FQWLPLAQCI NNKVLVMHGG LFSEDGVTLE 180

DLRKIDRNRQ PPDSGPMCDL LWSDPQPQNG RSISKRGVSC QFGPDVTERF LEQNKLDFIV 240

RSHEVKAEGY EVTHSGKCIT VFSAPNYCDQ MGNKGAYIHL RGSDLKPEFH QFTAVPHPNV 300

KPMAYANTLM QL 312

Keyword

Complete proteome; Hydrolase; Iron; Metal-binding; Reference proteome; Repeat; TPR repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.
IPR011236	; Ser/Thr_PPase_5.
IPR001440	; TPR-1.
IPR013026	; TPR-contain_dom.
IPR011990	; TPR-like_helical.
IPR019734	; TPR_repeat.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.
PF00515	; TPR_1; 1.

SMARTs

SM00156	; PP2Ac; 1.
SM00028	; TPR; 3.

Prosites

PS00125	; SER_THR_PHOSPHATASE; 1.
PS50005	; TPR; 3.
PS50293	; TPR_REGION; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013