EKS-ORN-00313

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00313

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	360.0	7.5E-108	21	272	252

Status

Unreviewed

Ensembl Protein

ENSONIP00000007738

UniProt Accession

I3JFU6;

Protein Name

Protein Synonyms/Alias

Gene Name

SIK2

Gene Synonyms/Alias

SIK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000006144	ENSONIP00000007738	ENSONIT00000007743
ENSONIG00000006144	ENSONIP00000007737	ENSONIT00000007742

Organism

Oreochromis niloticus

Functional Description

Protein Length

919

Protein Sequence
(FASTA)

MVMADSVQKP LIRGPVRVGF YDIERTLGKG NFAVVKLARH RITKTEVAIK IIDKTQLDAV 60

NLEKIYREVQ IMKMLDHPHI IKLYQVMETK NMLYLVTEYA KSGEIFDYLA KHGRLSELEA 120

RRKFWQILSA VEYCHNRNIV HRDLKAENLL LDGHMNIKIA DFGFGNFFQP GKPLATWCGS 180

PPYAAPEVFE GQQYEGPQLD IWSMGVVLYV LVCGALPFDG PTLPDLRQRV LEGRFRIPYF 240

MTEDCEHLIR RMLVLDPSKR LSVAQIKEHK WMTLDVPIQR PVLYQQPLSS EGEAGVGEYS 300

EQVLRLMHSL GIDQHKTIES LQNKSYNHFA AIYYLLVERL KAHRCSFPVE QRLDARQRRP 360

STIAEQTVVK STSVSAQVGL LQQGSRLLRS PAVPQASSDA FAFPQTASPL EQTFMVEDVN 420

TPKVNGCLLD PLPPPIVLRK SSTSSPSNMM ETSIDEGIET EEPDTEDDPP HLLSAYQTAR 480

FGQRRHTLSE VTNQPGPSNQ GKLFTLGQNP SMGSVDSDIG YDMGSMHSDL GLLEDPPCLS 540

EVVPPNSSPP GVTPTSFLSA RPANPAMAAL TSQHRETHNR SPISFREGRR ASDTSLTQGL 600

VAFRQHLQNL ARTKGILELN KVQLLVEQMG SGDGATMDPL GPQHHLHNLL EKGEACKQQE 660

GLALYQGGPQ PPLLSRRQSL ETHYLTHRLQ KANVLANSPA SCQVFCKETP RSLEQQLQEH 720

RLHQKRMYLQ QQSQGMGLQT YFNQMQIDEG SYPTGSPPLD PAASQSSPQG SPASPPFSHA 780

HNLSPVMEPG EALGYDAYMT HHHYTQHLPP GSHLHHQFHH PQPHEAAASS LGFSYPGGCE 840

QQVLGPSTEA LLPEQYEFAL DPSCLPPPAG GEVNTGAMGG VLAASGQSDG LGLPELQGSL 900

LDSEMMETVD SQHGFVLVN 919

Nucleotide Sequence
(FASTA)

ATGGTCATGG CTGACAGTGT CCAAAAACCG CTGATCCGGG GTCCGGTCCG AGTGGGCTTC 60

TACGACATCG AGCGCACTTT AGGAAAGGGC AATTTCGCTG TGGTGAAGTT GGCCCGACAC 120

CGCATAACCA AGACGGAGGT GGCCATTAAG ATCATCGACA AGACCCAGCT GGATGCCGTC 180

AACCTGGAGA AGATCTACAG AGAAGTTCAG ATCATGAAAA TGCTGGACCA CCCCCACATT 240

ATTAAGCTCT ACCAGGTGAT GGAGACGAAG AACATGCTTT ATTTAGTCAC GGAGTATGCC 300

AAGAGTGGGG AGATCTTTGA CTATCTGGCA AAGCATGGCC GTCTCAGTGA GCTAGAGGCC 360

AGGAGGAAGT TCTGGCAGAT CCTGTCAGCG GTTGAGTACT GTCACAACCG GAACATCGTT 420

CACAGAGACC TGAAGGCTGA GAATCTGCTG CTGGATGGCC ATATGAACAT CAAGATTGCA 480

GATTTTGGAT TTGGCAACTT TTTCCAGCCC GGGAAGCCTC TGGCCACATG GTGTGGCAGC 540

CCGCCCTATG CTGCTCCAGA GGTCTTTGAG GGACAACAGT ATGAAGGCCC ACAGCTGGAT 600

ATCTGGAGTA TGGGGGTGGT GCTTTACGTG CTGGTGTGTG GTGCATTGCC ATTTGATGGG 660

CCCACTCTGC CTGACCTCCG GCAGAGAGTA CTAGAGGGAA GGTTTCGCAT CCCCTACTTC 720

ATGACTGAAG ACTGTGAGCA CCTGATCCGC AGAATGTTGG TCCTGGACCC GTCAAAGCGT 780

CTCTCTGTGG CCCAGATTAA AGAACACAAG TGGATGACTC TGGATGTTCC AATACAGAGG 840

CCAGTACTGT ACCAACAGCC TCTGTCTTCT GAGGGTGAGG CCGGTGTAGG AGAATACAGT 900

GAACAGGTCC TTCGGTTGAT GCACAGCCTT GGTATCGACC AGCACAAGAC TATAGAGTCT 960

CTGCAGAACA AAAGCTACAA CCACTTTGCT GCTATCTATT ACCTGCTGGT GGAGCGGCTA 1020

AAGGCCCATC GCTGCAGCTT CCCCGTCGAA CAGAGGCTCG ACGCCCGCCA GCGACGACCC 1080

AGCACCATCG CCGAACAGAC TGTCGTCAAG TCGACCAGTG TTTCTGCCCA GGTGGGTTTG 1140

CTCCAGCAGG GCAGTCGTTT GTTGCGTTCT CCTGCTGTGC CTCAAGCGTC CTCTGATGCT 1200

TTCGCCTTCC CCCAGACTGC ATCTCCCCTG GAGCAGACTT TCATGGTGGA GGATGTCAAC 1260

ACACCCAAAG TTAACGGCTG CCTGCTGGAC CCCCTACCTC CCCCCATTGT CCTGCGCAAG 1320

TCCTCCACCT CGTCGCCTAG CAACATGATG GAGACATCCA TTGATGAGGG CATTGAAACA 1380

GAGGAGCCCG ACACAGAGGA TGATCCGCCT CACCTGCTCT CAGCCTATCA GACAGCTCGA 1440

TTTGGCCAGC GGCGACACAC CTTGTCTGAG GTCACCAACC AGCCAGGGCC TTCGAACCAG 1500

GGTAAATTAT TCACTTTAGG CCAAAATCCT TCCATGGGTA GCGTGGATTC GGACATTGGC 1560

TACGACATGG GCTCGATGCA CAGCGATCTC GGTCTGCTGG AGGATCCTCC CTGTCTGAGT 1620

GAAGTGGTTC CGCCCAACAG CTCTCCCCCT GGTGTCACCC CTACGTCTTT CTTGAGTGCC 1680

AGGCCTGCCA ACCCAGCTAT GGCTGCACTG ACTTCCCAGC ATAGGGAGAC CCACAACCGT 1740

TCCCCAATCA GCTTCAGGGA AGGGCGCCGT GCCTCCGACA CCTCCCTCAC TCAAGGTCTA 1800

GTCGCATTTC GGCAGCACCT TCAGAACTTG GCGAGGACCA AAGGCATCCT GGAGCTGAAC 1860

AAAGTCCAGC TGCTGGTGGA GCAGATGGGC TCTGGGGATG GGGCCACCAT GGACCCCTTG 1920

GGACCACAGC ACCACTTGCA CAACCTCCTC GAGAAGGGTG AAGCATGCAA GCAGCAGGAA 1980

GGCCTAGCTT TATACCAAGG TGGGCCGCAG CCGCCTCTGC TGTCCCGCAG ACAGAGTTTG 2040

GAGACACATT ACCTCACACA CAGACTACAG AAGGCCAACG TCTTGGCTAA CAGTCCTGCT 2100

AGCTGCCAGG TTTTCTGTAA GGAGACTCCT CGAAGTTTAG AGCAACAGCT GCAGGAACAC 2160

AGACTGCATC AGAAGAGGAT GTACCTGCAG CAGCAATCAC AGGGCATGGG GCTGCAGACC 2220

TACTTCAACC AGATGCAGAT TGATGAAGGA TCCTACCCAA CAGGCAGCCC TCCGCTGGAC 2280

CCAGCGGCAT CTCAAAGTTC CCCTCAGGGC TCCCCAGCCT CACCTCCATT CAGCCACGCT 2340

CATAACCTGA GCCCTGTGAT GGAACCAGGC GAGGCCTTGG GTTATGATGC CTACATGACC 2400

CATCACCACT ACACCCAACA TCTGCCTCCA GGATCTCACC TCCACCACCA GTTCCACCAT 2460

CCTCAGCCTC ATGAAGCTGC TGCCAGCAGC CTGGGCTTCA GCTACCCTGG AGGCTGCGAG 2520

CAGCAGGTCC TGGGGCCTTC CACTGAGGCT CTTCTGCCAG AGCAGTACGA GTTCGCACTG 2580

GATCCCTCCT GCCTGCCCCC ACCTGCTGGA GGAGAGGTTA ATACCGGAGC TATGGGTGGA 2640

GTTTTGGCTG CTTCTGGGCA GTCCGACGGC TTAGGCTTGC CTGAGCTGCA GGGCTCCCTC 2700

TTGGACAGTG AGATGATGGA GACTGTGGAC TCGCAGCATG GCTTTGTACT GGTCAACTAA 2760

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++ +tlG+g+f+ Vkla+h+ tk++va+Kii+k++l++ +leki+rE++i+k+l+hp+i

Q: 21    YDIERTLGKGNFAVVKLARHRITKTEVAIKIIDKTQLDAVNLEKIYREVQIMKMLDHPHI  80

         899*********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ikl++v+etk++lylv+eya+ ge+fdy+ ++grl+e ear+ f q++sav+Y+h+++iv

Q: 81    IKLYQVMETKNMLYLVTEYAKSGEIFDYLAKHGRLSELEARRKFWQILSAVEYCHNRNIV  140

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld ++nikiaDFG++n+f++gk l t+cGsppYaaPe+++g++Yegp++D

Q: 141   HRDLKAENLLLDGHMNIKIADFGFGNFFQPGKPLATWCGSPPYAAPEVFEGQQYEGPQLD  200

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +Ws+GvvLy+lv+g+lPfd+++l +l++++l+g+++ip+ +++++e+L+r++Lv dp+kR

Q: 201   IWSMGVVLYVLVCGALPFDGPTLPDLRQRVLEGRFRIPYFMTEDCEHLIRRMLVLDPSKR  260

         ************************************************************

S: 241   atieeilkhewl  252

         +++ +i++h+w+

Q: 261   LSVAQIKEHKWM  272

         ***********8

Domain Sequence
(FASTA)

YDIERTLGKG NFAVVKLARH RITKTEVAIK IIDKTQLDAV NLEKIYREVQ IMKMLDHPHI 60

IKLYQVMETK NMLYLVTEYA KSGEIFDYLA KHGRLSELEA RRKFWQILSA VEYCHNRNIV 120

HRDLKAENLL LDGHMNIKIA DFGFGNFFQP GKPLATWCGS PPYAAPEVFE GQQYEGPQLD 180

IWSMGVVLYV LVCGALPFDG PTLPDLRQRV LEGRFRIPYF MTEDCEHLIR RMLVLDPSKR 240

LSVAQIKEHK WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013