EPS-ORN-00041
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-ORN-00041
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
PPM/PP2C176.98.4E-5210401288249
StatusUnreviewed
Ensembl ProteinENSONIP00000008005
UniProt AccessionI3JGL4;
Protein Name
Protein Synonyms/Alias
Gene NamePHLPP1 (2 of 2)
Gene Synonyms/Alias PHLPP1 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000006349ENSONIP00000008005ENSONIT00000008010
OrganismOreochromis niloticus
Functional Description
Protein Length1569
Protein Sequence
(FASTA)
NSMLSRRRHR HKRNLSLGAP PTTGSTGASS AEAASPAPSS SPLSTLSLDR KTFLRQKQSK 60
QLQASDKTWV RSDLRRGCIH VHDWLTPSYP RPVLCTVDTT SKEVACKLEG SKAGAVLRIN 120
CKPTALSDLS DLGKDTNGHT DDMKSLSDSV DVKNLQSEEN ELTKNVELPS NLLLDDKTAS 180
NSSCSDIESS TCEDFSAGGP RSMEHGDSLS DGLGLGTDSS VLSPNCDSAP EGPDPFESSS 240
DETDLISSPS HSAISLPDIP KTSNQSTRPN FDTEAGADDN TDTHILIKPP SKCSSSSQAR 300
PLTSQASAQP EQEVPGGSRG WLEPINTSPM PTLYIQLHGG AVRRLGDDER PLQILNEYLT 360
NLGFEDPWRV QEEGMNPEIG CLIRFYFGKP RSVGGSERVQ LSGVFNVRKG KLALPVNRWS 420
KRQVTLSGTC LIVSSVKHAH TGKMHILPLI GGKVEEVRRH SHCLAFSSAG PQSQTYYISY 480
DSYTEYLRWQ RTASKIASQR VNSVDLSCCS LEELPAQLFY SQDLTHLNLK NNFMSPHKGV 540
PALTRLGDVR KFCKLRSLSL SNNALSEFPL ALCDITSLTE LNLSGNRLSS VPAELGTMHN 600
LQTLLLDGNL LSSLPVELGS LEGLTYLGLS FNGFSCVPPV LEKLGGMERL CLAGNQLSVL 660
DLAGLQWLSA RYIDLRLNQL QKATVADVEQ LAHIVHLDLR DTGLDELDVS SLCKLELLRC 720
DRNTLALLRV CGHALKSLHA AHNKLKQLEV QPVPENLTVL DLSWNKLGCV PDWVWESSRL 780
EVLDISHNCV TELPVRLLSS GSLRKLLAGW NDVCQLDERL ERSQLEVLDL QHNHLTELPH 840
NLFIKAQSLR YLNVSANKLE NLPAASLSED AFSSLQELYV TNNSLTDKCI PLLTGHGHLR 900
VLHLAYNQLQ TFTASKLARL EQLEELDLSG NRLRAVPTTI LNCQRLHTLS AHSNCISAFP 960
EVLQLPEIKC VDLSCNELTE VTLPEILPSK LQELDLTGNP RLSLDHKSLE HLNNIRCLRV 1020
DPSHSAPCGS ESQGVPAVWS HGYTEASGVK NKLCVAALAL DSFCGINEAL YGVFDGDRNV 1080
EVPYLLQCTM GDVLAEELHR GQRQEDYITN TFLTMQRKLG TAGQRMGGSA ALCHIRHDPV 1140
ASSEHGGCFT LKAANIGRCQ AVLCRDGKAM QLSHIHTVKD EAEYQRVRQH NAIITEDNKV 1200
SGVTDSTRIM GYSFLCPSVT PRPHVSTVTL TPQDEFFLLG SRRLWDMLSP SEAVEAVRNL 1260
PDALAAAKKL VTLAQSYGCS DSLSAVVVKL SITEDCCCFC EPPPPPPSPG PAAQLGAHPY 1320
SGSSDGSVPL PPPPHASSGT VSELSSEFST SEMSSEVGST ASSEEPLTQT EPSSSQLNPP 1380
GRAGTHRPTC RGSSFHRQFS GALSDNGLDS EDEEPIAGVF SNGSRVEVEA DVHCLLRHNC 1440
AQSQQSTDSP APVTLQSESL PLAFPSPSAS PVPPSSPYLG GEARSGTLGR KARGNGSVAC 1500
QGRSQDLIEE AADAPVKKQG GYFNAPAQPD PDDQLIIPPE LEEEVRQIIQ QQQQQLQTHS 1560
QQAHNYQNP 1569
Nucleotide Sequence
(FASTA)
AACTCTATGC TGAGCAGGAG GCGGCACAGG CACAAGAGGA ATCTGTCTCT GGGGGCTCCG 60
CCGACCACCG GCTCGACCGG AGCGTCGTCT GCGGAGGCGG CCAGCCCAGC TCCCTCATCC 120
TCGCCGCTGA GCACCCTCAG TCTTGATCGA AAAACCTTCC TCCGACAGAA GCAGTCGAAG 180
CAGCTTCAGG CCTCTGATAA AACATGGGTG AGATCGGACC TCCGGCGGGG TTGCATCCAC 240
GTCCACGACT GGCTCACGCC CTCCTACCCG CGACCAGTGC TGTGTACAGT GGACACTACT 300
TCTAAAGAGG TAGCCTGTAA GCTCGAAGGA AGTAAAGCCG GGGCTGTGTT GAGAATTAAC 360
TGCAAACCTA CTGCTTTAAG TGACCTCAGT GATCTTGGCA AAGATACTAA TGGCCATACT 420
GATGACATGA AAAGTCTCAG TGACAGTGTG GATGTTAAAA ATCTCCAAAG TGAGGAGAAT 480
GAACTCACAA AAAATGTGGA ACTGCCTTCT AACTTGCTAC TTGATGACAA AACTGCTAGT 540
AATTCTTCAT GCTCTGACAT AGAGAGCAGC ACCTGTGAGG ACTTCAGTGC AGGGGGACCA 600
AGAAGCATGG AGCACGGGGA TTCACTCAGC GATGGGTTGG GTTTGGGCAC TGACTCTTCT 660
GTTCTGAGCC CAAACTGTGA CAGTGCCCCA GAGGGACCTG ACCCATTTGA GAGCTCCTCT 720
GATGAAACAG ACCTCATCTC TTCTCCCTCA CATTCAGCTA TCTCTCTCCC AGACATCCCC 780
AAGACTTCAA ACCAATCCAC AAGACCAAAC TTTGACACTG AAGCTGGGGC TGATGACAAC 840
ACAGATACAC ACATATTAAT CAAACCTCCT TCTAAATGCT CCAGCAGCTC ACAGGCTCGC 900
CCTCTGACCA GCCAAGCATC TGCCCAGCCT GAGCAAGAGG TCCCTGGGGG GAGCAGAGGA 960
TGGCTTGAGC CCATCAATAC AAGCCCAATG CCGACCCTCT ACATCCAGCT GCACGGTGGA 1020
GCTGTGAGGC GGCTTGGGGA TGATGAAAGA CCTCTGCAGA TCTTAAATGA GTACCTAACT 1080
AATCTGGGGT TTGAAGATCC ATGGCGAGTG CAGGAGGAGG GGATGAATCC TGAAATTGGC 1140
TGCCTGATCC GCTTCTACTT TGGTAAGCCT CGTAGTGTGG GAGGTTCTGA GCGCGTGCAG 1200
CTGTCTGGGG TGTTCAACGT GCGGAAAGGG AAGCTGGCAC TGCCCGTGAA CCGCTGGTCA 1260
AAACGTCAGG TCACTCTGAG TGGAACTTGC CTCATTGTCT CGTCTGTGAA GCATGCCCAC 1320
ACTGGCAAGA TGCACATCCT CCCTCTCATC GGAGGAAAGG TGGAGGAAGT GAGAAGACAC 1380
AGCCACTGTC TGGCTTTCAG CTCAGCTGGT CCTCAGAGTC AGACCTACTA CATCAGCTAT 1440
GACTCTTACA CCGAGTACCT CCGCTGGCAG AGGACAGCCT CAAAGATTGC CTCTCAGAGG 1500
GTGAACTCGG TGGACCTGTC ATGCTGCAGC CTGGAGGAGC TGCCTGCTCA GCTGTTTTAC 1560
AGCCAGGACC TTACCCACCT CAACCTCAAA AACAACTTCA TGTCCCCTCA CAAAGGTGTT 1620
CCAGCACTCA CCAGATTAGG TGACGTCAGA AAGTTTTGTA AACTGAGAAG CCTTAGTCTG 1680
TCAAATAACG CTCTGTCTGA GTTTCCTCTG GCCTTGTGTG ACATCACCTC CCTCACGGAG 1740
CTAAACCTGT CTGGAAATCG TCTCTCCTCT GTGCCTGCAG AACTAGGAAC AATGCACAAC 1800
CTGCAGACTC TTCTCCTGGA TGGTAACCTT CTGAGTTCAC TGCCTGTGGA GCTGGGCTCT 1860
CTGGAGGGCT TGACCTACCT CGGCTTATCC TTCAATGGTT TCAGCTGTGT GCCCCCTGTC 1920
CTAGAGAAAC TTGGAGGGAT GGAGAGACTC TGTCTGGCAG GGAACCAGCT CTCTGTCCTG 1980
GATTTGGCTG GCCTGCAGTG GCTGTCTGCT CGCTACATAG ATCTCAGGCT GAACCAGCTT 2040
CAGAAGGCGA CAGTGGCAGA TGTGGAGCAG CTGGCCCACA TTGTTCATCT GGACCTGAGG 2100
GATACAGGTC TAGACGAGCT GGATGTCAGC TCTCTCTGCA AGCTGGAGCT CCTCCGCTGT 2160
GACAGAAACA CTCTCGCCCT CCTCAGAGTC TGTGGCCACG CCCTCAAGAG CCTGCATGCT 2220
GCACACAACA AGCTGAAGCA GCTGGAGGTG CAGCCTGTTC CAGAGAATCT GACTGTGCTG 2280
GATTTATCCT GGAACAAGCT GGGATGTGTC CCCGACTGGG TGTGGGAGAG CAGCAGACTG 2340
GAAGTGCTGG ACATCAGCCA TAACTGTGTC ACTGAGCTGC CTGTACGGCT GCTGTCCAGT 2400
GGGAGCCTGA GAAAGCTGCT GGCAGGCTGG AACGATGTGT GTCAGCTGGA TGAGAGGCTG 2460
GAGCGATCAC AACTGGAAGT CCTGGACCTC CAACACAACC ATCTAACTGA GCTCCCACAC 2520
AACTTGTTCA TCAAAGCGCA GAGCCTGCGA TACCTAAATG TGTCAGCCAA TAAGCTGGAG 2580
AACCTCCCTG CAGCCAGCCT ATCAGAGGAT GCCTTCAGCA GCCTTCAAGA GCTCTATGTG 2640
ACTAATAACA GCTTGACCGA CAAGTGCATC CCTCTTCTGA CTGGACACGG CCACCTCAGA 2700
GTGCTTCACC TCGCCTACAA CCAGCTGCAA ACCTTCACTG CCAGTAAACT AGCTCGACTG 2760
GAGCAGCTGG AGGAGCTGGA CTTGAGTGGC AACAGGCTGA GAGCAGTGCC CACGACCATT 2820
CTCAACTGTC AGCGCCTGCA CACGCTTTCT GCCCACTCCA ATTGTATCAG CGCCTTCCCT 2880
GAGGTCCTCC AGCTGCCTGA GATTAAGTGT GTCGATCTGA GCTGCAACGA GTTGACTGAG 2940
GTGACTCTGC CAGAGATCCT TCCTTCAAAA CTCCAGGAGC TCGACCTCAC AGGAAATCCT 3000
CGACTCAGCC TCGACCACAA GAGCCTGGAA CACCTAAATA ATATCCGATG TCTGAGGGTG 3060
GATCCTTCAC ATTCAGCTCC TTGTGGGAGT GAGAGCCAAG GAGTCCCTGC AGTCTGGAGT 3120
CACGGCTACA CGGAGGCCTC TGGAGTTAAA AACAAGTTGT GTGTGGCTGC TCTGGCTCTG 3180
GACAGCTTCT GTGGCATTAA CGAAGCTCTG TATGGAGTTT TTGATGGAGA CCGGAATGTC 3240
GAGGTGCCTT ATCTGCTGCA ATGCACCATG GGAGATGTGC TCGCAGAGGA ACTTCACAGG 3300
GGCCAGAGGC AAGAGGACTA CATCACCAAC ACTTTCCTCA CCATGCAAAG GAAACTGGGC 3360
ACAGCAGGCC AGAGGATGGG TGGGTCAGCA GCTCTGTGTC ACATCAGACA TGACCCGGTA 3420
GCTTCCAGTG AGCATGGCGG CTGCTTCACT CTGAAAGCCG CCAACATCGG CAGGTGCCAG 3480
GCTGTTTTGT GCCGAGATGG CAAAGCTATG CAACTTTCAC ACATCCACAC TGTCAAAGAC 3540
GAGGCCGAGT ACCAGAGGGT TCGACAGCAT AACGCTATTA TCACTGAGGA TAACAAAGTC 3600
AGCGGTGTAA CAGACTCCAC CAGGATTATG GGTTACTCCT TCCTCTGCCC ATCAGTGACA 3660
CCCCGCCCCC ATGTTTCCAC GGTGACGCTT ACCCCACAGG ACGAGTTTTT TCTCCTGGGC 3720
AGCCGGAGAC TGTGGGACAT GTTGTCTCCC AGCGAGGCGG TGGAGGCGGT AAGGAACTTA 3780
CCAGACGCTC TGGCTGCTGC AAAGAAGCTG GTGACTCTGG CCCAGAGCTA CGGCTGCTCC 3840
GATAGCCTCA GTGCCGTCGT TGTGAAGCTC AGCATCACTG AAGACTGCTG CTGCTTCTGC 3900
GAGCCACCGC CTCCGCCACC CAGCCCTGGC CCAGCAGCTC AGCTCGGCGC ACATCCTTAT 3960
TCGGGAAGCA GTGACGGCAG CGTGCCGCTG CCCCCGCCGC CGCACGCCTC CTCAGGAACA 4020
GTGAGCGAGT TAAGCAGCGA GTTCAGCACA TCTGAGATGA GCAGCGAGGT GGGATCAACG 4080
GCGTCCTCGG AGGAGCCACT GACGCAGACT GAACCCTCAT CCTCTCAACT GAACCCCCCA 4140
GGGCGAGCTG GCACACACAG GCCCACCTGT AGGGGGAGCA GCTTCCACAG GCAGTTCTCT 4200
GGAGCACTGT CTGATAACGG GCTTGACAGC GAGGATGAGG AGCCCATCGC TGGTGTCTTC 4260
TCCAATGGCA GCCGAGTGGA GGTGGAAGCT GACGTCCACT GTCTTTTACG ACACAACTGC 4320
GCTCAGTCTC AGCAAAGCAC AGACAGCCCT GCCCCTGTCA CGCTGCAGAG TGAGTCTCTG 4380
CCTCTGGCCT TCCCTTCTCC ATCTGCCTCC CCCGTCCCGC CCTCCTCTCC CTACCTCGGT 4440
GGGGAGGCTC GGTCAGGCAC TCTGGGCCGG AAGGCTCGAG GTAATGGCTC TGTGGCCTGC 4500
CAAGGCAGGA GCCAGGACCT CATTGAGGAG GCTGCCGATG CTCCCGTCAA GAAGCAGGGG 4560
GGCTACTTCA ACGCCCCCGC CCAGCCAGAC CCTGATGATC AGCTCATCAT TCCCCCAGAG 4620
CTGGAAGAAG AAGTCCGGCA GATCATCCAG CAACAGCAAC AGCAGCTACA GACACACAGC 4680
CAGCAAGCAC ACAACTACCA GAATCCT 4707
Domain Profile
S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61
         ++g+++ +g +n+++ a+ + ++f+  +e     a++gv+DG+++ ev + +++++ ++l
Q: 1040  SHGYTEASGVKNKLCVAALALDSFCGINE-----ALYGVFDGDRNVEVPYLLQCTMGDVL  1094
         6899**************99999999876.....49************************
S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115
         aeel     + ++ +++++++Fl+++++l       ++ +++G +a +++i+++      
Q: 1095  AEELH----RGQRQEDYITNTFLTMQRKL------GTAGQRMGGSAALCHIRHDpvasse  1144
         ***99....8999999*************......999**************999999**
S: 116   .....klyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlG  170
              +l  an+G ++avLcr+gka++ls  H+++ e E++R++++ + +++++  +v G
Q: 1145  hggcfTLKAANIGRCQAVLCRDGKAMQLSHIHTVKDEAEYQRVRQHNAIITEDN--KVSG  1202
         ***999999*************************************99999998..****
S: 171   vLavsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle  230
         v+  +R +G  +l p vtp+P+v+ ++lt++def+ L+s  lwd++s+ eav++vr+  +
Q: 1203  VTDSTRIMGYSFLCPSVTPRPHVSTVTLTPQDEFFLLGSRRLWDMLSPSEAVEAVRNLPD  1262
         ************************************************************
S: 231   kkeaeqeaakkLvklalargskdnvsaivv  260
             + +aakkLv+la+++g++d++sa+vv
Q: 1263  ----ALAAAKKLVTLAQSYGCSDSLSAVVV  1288
         ....************************97
Domain Sequence
(FASTA)
SHGYTEASGV KNKLCVAALA LDSFCGINEA LYGVFDGDRN VEVPYLLQCT MGDVLAEELH 60
RGQRQEDYIT NTFLTMQRKL GTAGQRMGGS AALCHIRHDP VASSEHGGCF TLKAANIGRC 120
QAVLCRDGKA MQLSHIHTVK DEAEYQRVRQ HNAIITEDNK VSGVTDSTRI MGYSFLCPSV 180
TPRPHVSTVT LTPQDEFFLL GSRRLWDMLS PSEAVEAVRN LPDALAAAKK LVTLAQSYGC 240
SDSLSAVVV 249
KeywordComplete proteome; Leucine-rich repeat; Reference proteome; Repeat.
Sequence SourceEnsembl
Orthology
Ortholog group
Caenorhabditis elegans"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EPS-CAE-00017
EPS-GAM-00030
EPS-GAA-00048
EPS-TAR-00050
EPS-TEN-00040
EPS-XIM-00054
Gene Ontology
GO:0003824; F:catalytic activity
GO:0008152; P:metabolic process
KEGG
InterPros
IPR001611; Leu-rich_rpt.
IPR025875; Leu-rich_rpt_4.
IPR003591; Leu-rich_rpt_typical-subtyp.
IPR001932; PP2C-like.
Pfam
PF00560; LRR_1; 3.
PF12799; LRR_4; 1.
PF00481; PP2C; 1.
SMARTs
SM00369; LRR_TYP; 1.
SM00332; PP2Cc; 1.
Prosites
PS51450; LRR; 18.
Prints
Created Date20-Feb-2013