EKS-ORN-00450

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00450

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ack	415.7	8.5E-125	120	377	258

Status

Unreviewed

Ensembl Protein

ENSONIP00000008166

UniProt Accession

I3JH23;

Protein Name

Protein Synonyms/Alias

Gene Name

TNK2 (2 of 2)

Gene Synonyms/Alias

TNK2 (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000006477	ENSONIP00000008166	ENSONIT00000008171

Organism

Oreochromis niloticus

Functional Description

Protein Length

1045

Protein Sequence
(FASTA)

MQCEEGTEWL LELLTDVQLQ QYFLRIRDDL NVTRLSHFDY VKNEDLEKIG MGRPGQRRLW 60

EAVKRRRALY KRKSWMSKVF PVKRPDADPQ QPHGASSAAV PASSESGAAL TCLIRESELQ 120

LFERLGDGTF GVVRRGEWTA PNGRVLSVAV KCLKSNVLDS DGLDDFIREV NAMHSLSHQN 180

LIRLYGIVLT QPMKMVTELA PLGSLLDRLR KRQGHILISS LCNYAVQVAC GMAYLEQKRF 240

LHRDLAARNV LLSTNETVKI GDFGLMRALP KHTDQYVMEE GHKIPFPWCA PESLKSRTFS 300

HASDTWMFGV TLWEMFTHGQ EPWLGLNGSQ ILHKVDVEAE RLCKPDDCPQ DIYNVMLQCW 360

SPKPEDRPTF IALRDFLLET MPTDMRALQD FEEEDKLQIT MNDVITIIEG RAEHYWWRGQ 420

NRRTLRVGQF PRHVVTSVAG LSAQDISRPL KHSFIHTGHG DTDPQRSWGH ADRIDSLYLG 480

NPMDPPDVLG MDSGIARLTK LPNRAKKPFY DSVMDDYDDE EDASASSGLK KLGASLGLKL 540

RPWEGTGVRS AKSEVSLIDF TDDSFSSTTP SPLTESRQLD EDTLKDRKLL QSASQGNIKA 600

YDTPSILDWP LPQPAYDEVT AEPEDQSEDQ EVRSIYKGLT EEASSSAGLT GRSESQSADL 660

FQELQREVEK AVVMVKLQVP MATGRSLPSS PLPMPLAPLG PHRQIHLPPP SPSSSSSFAS 720

CFEDRPVLPP RSPVPPLRPS KHNLSARAIN PEARTSSISL GNEDDTPPQI PPRDHAFSQP 780

GSRSSSPVAL PPPPLAVSPR RASGLLGPLL SSNSPSSSSS LPQASSHSSR LGVPGSSYSS 840

TSLLDPLAFR EGRGLSSLID SSQSSAPVPL PERPAFLERY QRGRQDCVRS PTTIIHIPYF 900

MFLNRYGTAN MAAVKPMMQQ QQQHPGGAKP NTSYNNNNGR TAAPSMQREQ SITQRECNAQ 960

KAGDLKHIHK VQGAVHGVTI EECQAALQSH EWSIPQAINH LKVEQLFRLG LRSRAECEEL 1020

LQHHQWDLER ASTVMLDTYG PHRNR 1045

Nucleotide Sequence
(FASTA)

ATGCAGTGTG AGGAGGGCAC AGAGTGGCTG CTGGAGCTAC TGACAGATGT GCAGCTGCAG 60

CAGTACTTCC TGCGGATCCG TGATGATCTC AACGTCACAC GACTCTCACA CTTTGACTAC 120

GTCAAGAATG AAGACCTGGA GAAGATCGGC ATGGGACGCC CGGGTCAGAG GAGGCTCTGG 180

GAGGCAGTCA AGAGGAGACG AGCGCTTTAT AAAAGAAAAT CCTGGATGAG CAAGGTGTTT 240

CCAGTGAAAC GGCCGGACGC TGACCCACAG CAGCCCCACG GGGCATCGTC TGCTGCGGTC 300

CCGGCCAGTA GTGAGTCAGG GGCTGCGCTC ACCTGCCTGA TCAGAGAGTC GGAGCTTCAG 360

CTGTTCGAGC GGCTTGGAGA CGGGACATTC GGGGTGGTGC GGCGAGGAGA GTGGACTGCA 420

CCAAACGGCA GAGTGTTGTC AGTGGCAGTA AAATGCCTGA AATCAAATGT ACTGGACTCA 480

GACGGTCTGG ATGATTTCAT CAGAGAGGTG AATGCCATGC ATTCACTGAG CCACCAAAAC 540

CTCATCCGCC TGTATGGCAT CGTCCTCACA CAGCCTATGA AGATGGTGAC TGAGCTGGCT 600

CCTCTGGGCT CCCTGTTGGA TCGGCTCAGA AAGCGGCAGG GTCACATCCT CATCTCCTCG 660

CTGTGTAACT ATGCCGTGCA GGTGGCATGT GGGATGGCCT ACCTGGAGCA GAAGCGTTTC 720

CTCCACAGGG ATCTCGCAGC CCGTAATGTG CTGCTGTCCA CCAATGAAAC TGTGAAGATC 780

GGAGACTTTG GCCTAATGAG GGCGCTGCCT AAACATACCG ACCAATACGT CATGGAGGAA 840

GGCCACAAAA TCCCTTTCCC CTGGTGTGCT CCAGAGTCTC TGAAGTCTCG TACTTTCTCT 900

CACGCATCTG ACACCTGGAT GTTTGGGGTC ACCCTTTGGG AGATGTTCAC CCACGGACAG 960

GAGCCGTGGT TGGGTCTGAA TGGGAGCCAG ATCCTTCACA AGGTGGACGT GGAGGCTGAG 1020

AGGCTGTGTA AACCAGACGA TTGTCCTCAG GATATCTACA ATGTCATGCT GCAGTGCTGG 1080

AGCCCCAAAC CTGAAGACAG ACCAACTTTC ATTGCCCTCA GAGACTTCCT GCTCGAGACC 1140

ATGCCCACAG ATATGAGAGC CCTGCAGGAC TTTGAGGAGG AAGACAAGCT CCAGATTACA 1200

ATGAATGATG TTATCACCAT CATTGAAGGA AGGGCAGAGC ACTACTGGTG GCGAGGTCAG 1260

AACAGGCGCA CGCTGCGTGT CGGTCAGTTT CCCCGTCATG TAGTGACGTC AGTCGCCGGT 1320

CTTTCCGCCC AGGACATCAG CCGGCCACTT AAACACTCGT TTATACACAC TGGACATGGA 1380

GACACAGACC CCCAGAGGAG CTGGGGACAC GCAGACCGCA TAGACAGCCT GTACTTGGGG 1440

AACCCCATGG ACCCTCCTGA TGTCCTGGGA ATGGATTCAG GCATCGCGAG ACTGACCAAA 1500

CTTCCCAACC GTGCCAAGAA GCCGTTCTAC GACTCTGTGA TGGATGATTA CGATGACGAG 1560

GAAGACGCCA GCGCGTCGTC TGGGTTGAAG AAGCTGGGAG CATCACTGGG TCTGAAGCTT 1620

CGGCCGTGGG AGGGGACAGG CGTGCGTTCA GCCAAGAGCG AGGTGTCGCT TATTGACTTC 1680

ACTGATGACA GTTTCAGCTC TACCACACCT TCTCCGCTCA CTGAGTCTCG GCAGCTGGAT 1740

GAAGACACCC TAAAGGACAG GAAGCTATTA CAAAGTGCTT CACAGGGGAA TATAAAAGCA 1800

TATGACACTC CCTCCATTCT GGACTGGCCT CTCCCCCAGC CAGCGTACGA TGAAGTTACT 1860

GCAGAGCCTG AGGATCAATC AGAGGACCAG GAAGTGCGGT CCATATACAA AGGATTGACT 1920

GAAGAAGCTT CTTCATCTGC TGGCTTGACA GGAAGGAGCG AATCCCAGTC AGCCGACCTC 1980

TTCCAGGAGC TACAGAGGGA GGTAGAGAAA GCTGTAGTGA TGGTGAAGCT GCAGGTTCCA 2040

ATGGCAACAG GCCGCTCCCT CCCCTCCTCC CCACTCCCCA TGCCTCTGGC TCCTTTGGGC 2100

CCGCACCGGC AGATCCACCT TCCCCCTCCA TCTCCCTCGT CTTCCTCCTC CTTTGCCTCC 2160

TGCTTTGAGG ACAGGCCTGT GCTGCCTCCT CGCAGCCCCG TCCCTCCTCT GCGTCCCTCC 2220

AAACACAACC TCTCTGCCCG TGCCATAAAC CCAGAAGCAC GCACCAGCTC CATTTCACTG 2280

GGCAACGAAG ATGACACACC TCCTCAGATC CCACCCAGAG ACCACGCCTT TTCTCAGCCA 2340

GGCTCTCGCT CCTCGTCACC TGTAGCATTG CCACCTCCTC CTCTCGCCGT CTCGCCCCGT 2400

CGGGCATCGG GACTGCTGGG TCCACTCCTG TCCTCCAACT CTCCATCTTC TTCTTCCTCT 2460

TTGCCTCAAG CTTCATCCCA TTCCTCACGC TTAGGAGTTC CTGGCTCGTC GTACTCCTCC 2520

ACATCCTTAC TGGATCCACT CGCCTTTCGT GAGGGGCGTG GCCTTTCCTC ACTGATTGAC 2580

AGTTCGCAGA GCTCTGCCCC CGTCCCACTG CCGGAGAGAC CAGCTTTCCT GGAGAGATAC 2640

CAAAGAGGAA GACAGGACTG TGTGCGCTCA CCAACCACAA TAATTCATAT ACCATATTTC 2700

ATGTTTCTTA ACAGATACGG GACAGCCAAC ATGGCGGCAG TCAAACCCAT GATGCAGCAG 2760

CAGCAGCAGC ACCCTGGTGG AGCCAAACCG AACACCTCCT ACAACAACAA TAATGGCCGA 2820

ACTGCAGCTC CCAGCATGCA GCGGGAACAG AGCATCACAC AGCGAGAATG TAATGCTCAA 2880

AAAGCTGGAG ATTTGAAACA CATTCATAAG GTCCAAGGAG CTGTGCACGG TGTCACGATA 2940

GAGGAGTGTC AGGCTGCTCT GCAGAGCCAC GAGTGGAGCA TCCCTCAGGC CATAAACCAT 3000

TTAAAGGTGG AGCAGCTGTT TCGGCTGGGG CTGCGTTCAA GAGCCGAGTG CGAGGAGCTG 3060

CTGCAGCATC ACCAGTGGGA CCTGGAACGT GCCAGCACGG TCATGCTGGA CACATACGGA 3120

CCACATCGCA ACAGGTAA 3138

Domain Profile

S: 2     klleklGeGsfgvvkrgeWsapsgksvqvavkvlksdkllstelddflrevsvllklehe  61

         +l e+lG+G+fgvv+rgeW+ap+g++++vavk+lks++l s  lddf+rev+++++l+h+

Q: 120   QLFERLGDGTFGVVRRGEWTAPNGRVLSVAVKCLKSNVLDSDGLDDFIREVNAMHSLSHQ  179

         6789********************************************************

S: 62    nlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglayles  121

         nl+rlyG+vltqp+k+vtela+lgslldrlrk++   ++l++ l++yavq+a g+ayle+

Q: 180   NLIRLYGIVLTQPMKMVTELAPLGSLLDRLRKRQG--HILISSLCNYAVQVACGMAYLEQ  237

         ********************************999..9**********************

S: 122   krlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPeslrtr  181

         kr++hrdlaarn+ll ++++vki+dfGl+ral+++ d+yv++e +k+Pf+WcaPesl+ r

Q: 238   KRFLHRDLAARNVLLSTNETVKIGDFGLMRALPKHTDQYVMEEGHKIPFPWCAPESLKSR  297

         ************************************************************

S: 182   kfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediyslll  241

         +fs+asd+W+fGvtlWemf++G+ePW gl+g+qil+k+d e erl kP++cp+diy+++l

Q: 298   TFSHASDTWMFGVTLWEMFTHGQEPWLGLNGSQILHKVDVEAERLCKPDDCPQDIYNVML  357

         ************************************************************

S: 242   kcWakkpadrpkfsalkekl  261

         +cW+ kp+drp+f al+++l

Q: 358   QCWSPKPEDRPTFIALRDFL  377

         ****************9986

Domain Sequence
(FASTA)

QLFERLGDGT FGVVRRGEWT APNGRVLSVA VKCLKSNVLD SDGLDDFIRE VNAMHSLSHQ 60

NLIRLYGIVL TQPMKMVTEL APLGSLLDRL RKRQGHILIS SLCNYAVQVA CGMAYLEQKR 120

FLHRDLAARN VLLSTNETVK IGDFGLMRAL PKHTDQYVME EGHKIPFPWC APESLKSRTF 180

SHASDTWMFG VTLWEMFTHG QEPWLGLNGS QILHKVDVEA ERLCKPDDCP QDIYNVMLQC 240

WSPKPEDRPT FIALRDFL 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Ciona intestinalis"; ?>Drosophila melanogaster"; ?>Gasterosteus aculeatus"; ?>Oryzias latipes"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR015116	; GTPase_binding.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF09027	; GTPase_binding; 1.
PF07714	; Pkinase_Tyr; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50002	; SH3; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013