EKS-ORN-00475

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00475

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	442.0	7.7E-133	278	526	249

Status

Unreviewed

Ensembl Protein

ENSONIP00000008685

UniProt Accession

I3JIJ0;

Protein Name

Protein Synonyms/Alias

Gene Name

SRC (2 of 2)

Gene Synonyms/Alias

SRC (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000006882	ENSONIP00000008684	ENSONIT00000008689
ENSONIG00000006882	ENSONIP00000008685	ENSONIT00000008690

Organism

Oreochromis niloticus

Functional Description

Protein Length

544

Protein Sequence
(FASTA)

MGAGKSKPKE PGQRSMSLDG TIGTGSDSGH FHHLGPAQQT QTPNRSPAVG TGRRGHQGQH 60

QHAPTNTPEL ALFGGVDHTG TVTSPHRGPL SGGVTTFVAL YDYESRTASD LTFRKGDRLQ 120

IVNNTEGDWW LARSLTTGES GYIPSNYVAP SDSIQAEEWY FGKITRRDSE RLLLNPQNRR 180

GTFLVRESET TKGAYCLSVL DYDNTKGANV KHYKIRKLDS GGFYITSRTQ FTSLQQLVFH 240

YRKHSDGLCH ALTDVCPVTK PQTQGLARDA WEIPRESLRL DVKLGQGCFG EVWMGTWNGT 300

TRVAIKTLKP GTMSPEAFLQ EAQVMKKLRH EKLVQLYAVV SEEPIYIVTE YMSQGSLLDF 360

LKGEAGKLLR LPQLVDMAAQ IAAGMAYVER MNYVHRDLRA ANILVGDSLV CKVADFGLAR 420

LIEDNEYTAR QGAKFPIKWT APEAALYGRF TIKSDVWSFG VLLTELATKG RVPYPGMVNR 480

EVLDQVERGY RMPCPAECPS SLHELMLTCW RKDPEERPTF EYLQGFLEDY FTSTEPQYQP 540

GENL 544

Nucleotide Sequence
(FASTA)

ATGGGGGCGG GCAAGAGCAA GCCCAAGGAG CCGGGCCAGC GCTCCATGAG CCTGGATGGT 60

ACCATAGGCA CAGGCTCCGA CAGCGGGCAC TTCCACCACC TGGGACCCGC CCAGCAGACC 120

CAAACACCCA ACAGGAGCCC TGCCGTCGGA ACAGGCAGGC GGGGGCATCA AGGGCAGCAC 180

CAGCACGCCC CAACAAATAC TCCCGAGCTG GCTCTCTTCG GAGGAGTGGA CCACACGGGA 240

ACTGTCACAT CACCTCATAG AGGACCTCTT TCAGGAGGTG TCACTACATT TGTGGCTTTG 300

TATGATTATG AGTCACGAAC AGCATCTGAT CTGACCTTTA GGAAAGGGGA CCGGCTGCAG 360

ATTGTCAACA ACACAGAAGG GGATTGGTGG CTCGCTCGCT CCCTGACAAC TGGAGAGAGC 420

GGTTATATCC CCAGCAACTA TGTGGCTCCA TCCGACTCCA TCCAAGCAGA AGAGTGGTAT 480

TTTGGGAAGA TCACTCGACG TGACTCGGAG AGGCTCCTTC TCAACCCTCA GAACAGACGA 540

GGAACTTTCT TGGTGAGGGA GAGCGAGACT ACTAAAGGGG CGTATTGCCT GTCAGTGCTG 600

GATTATGATA ACACCAAAGG CGCTAATGTT AAACATTACA AAATCAGGAA ACTGGATAGC 660

GGAGGTTTCT ACATCACTTC ACGCACCCAG TTCACCAGCC TACAGCAGCT AGTCTTCCAC 720

TATCGCAAGC ACTCTGATGG ACTTTGCCAC GCTCTAACAG ATGTTTGTCC AGTGACCAAA 780

CCTCAGACGC AGGGACTGGC TAGGGATGCC TGGGAGATCC CCAGAGAGTC TCTCCGCCTC 840

GACGTCAAAC TGGGACAGGG CTGCTTTGGA GAAGTCTGGA TGGGTACGTG GAACGGTACA 900

ACACGAGTAG CCATTAAGAC TCTAAAGCCC GGCACCATGT CTCCAGAGGC CTTCCTTCAA 960

GAAGCACAGG TCATGAAGAA GCTGCGGCAC GAAAAGCTGG TCCAGCTGTA CGCCGTTGTG 1020

TCTGAGGAGC CCATTTATAT CGTAACGGAG TATATGAGCC AAGGCAGCTT ACTGGACTTT 1080

CTTAAAGGGG AAGCAGGAAA GCTGCTTCGT CTGCCTCAGC TGGTAGATAT GGCTGCTCAG 1140

ATTGCAGCAG GCATGGCCTA CGTGGAGAGG ATGAACTATG TCCACAGAGA CCTGCGTGCT 1200

GCAAACATCC TGGTAGGAGA CAGCCTCGTG TGCAAGGTGG CTGACTTTGG TCTGGCAAGA 1260

CTCATTGAGG ACAATGAGTA CACTGCAAGA CAGGGAGCCA AGTTCCCAAT CAAATGGACA 1320

GCACCGGAGG CAGCTCTGTA TGGTCGTTTC ACCATTAAGT CAGACGTCTG GTCCTTTGGT 1380

GTGCTGCTCA CAGAGCTGGC AACTAAAGGC AGAGTTCCCT ATCCAGGTAT GGTTAACCGA 1440

GAAGTGCTTG ACCAAGTGGA GCGTGGCTAC AGGATGCCTT GTCCAGCAGA GTGCCCAAGC 1500

TCCTTGCATG AGCTCATGCT TACCTGCTGG AGGAAGGATC CAGAAGAGAG GCCTACATTT 1560

GAGTACCTGC AGGGCTTCCT AGAGGACTAC TTCACCTCCA CAGAACCCCA GTATCAGCCT 1620

GGGGAGAACC TATAG 1635

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l  klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly

Q: 278   LRLDVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  337

         57889*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m++Gslldflk e gk l+lp+lvd+aaq+a+Gmay+e++n++hr

Q: 338   AVVSE-EPIYIVTEYMSQGSLLDFLKGEAGKLLRLPQLVDMAAQIAAGMAYVERMNYVHR  396

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvg+slv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 397   DLRAANILVGDSLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  456

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfG+llte+ tkG+vPypGm n+evl+qvergyr+p+p+ecp++l+el+l+cw+kdpee

Q: 457   WSFGVLLTELATKGRVPYPGMVNREVLDQVERGYRMPCPAECPSSLHELMLTCWRKDPEE  516

         ************************************************************

S: 241   rPtfetlqev  250

         rPtfe+lq +

Q: 517   RPTFEYLQGF  526

         *******976

Domain Sequence
(FASTA)

LRLDVKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60

AVVSEEPIYI VTEYMSQGSL LDFLKGEAGK LLRLPQLVDM AAQIAAGMAY VERMNYVHRD 120

LRAANILVGD SLVCKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGVLLTELA TKGRVPYPGM VNREVLDQVE RGYRMPCPAE CPSSLHELML TCWRKDPEER 240

PTFEYLQGF 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013