EPS-ORN-00167

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORN-00167

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP7	463.7	3.3E-139	128	467	340

Status

Unreviewed

Ensembl Protein

ENSONIP00000009614

UniProt Accession

I3JL70;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPEF2 (2 of 2)

Gene Synonyms/Alias

PPEF2 (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000007629	ENSONIP00000009614	ENSONIT00000009620

Organism

Oreochromis niloticus

Functional Description

Protein Length

658

Protein Sequence
(FASTA)

MGCGLRKSEV QQKKCDRAIR AALLIQRWYR QYVARLEIRR RCTWNIFQSI EYAGQQDQIK 60

LYNFFGFLMD HFTPASSERN LISHIFRENE ICRDAEWERY FCYKSIDVPD SYTGPHLTFP 120

MTFCGVSKLV EAFKHKQQLH ARYVLQILGE TWRLLRILPN ISHLSSCHTK EITICGDLHG 180

QLEDLLLIFY KNGLPSPEKP YVFNGDFVDR GKNSLEILLI LFGFLLLYPN DVHLNRGNHE 240

DHIVNLRYGF TKEVLGKYRV HGKKILKLLQ KIFSWLPLAT VIDHKVLIVH GGISDTTDLN 300

VIARVDRHKV NNLHISHQQM NWSVDDELKK RRRLAGFDQS YGERKKPDSD SDPECEEGIE 360

TYEHEWEQMV DLLWSDPMPQ NGCIPNEVRG GGCYWGPDVT EEVLGRHNLQ LLIRSHECKQ 420

DGYEFCHNRR VLTIFSASNY YEVGSNRGAY IRMGADLVPH FVQYQASRTC RELTLRQSVG 480

WTERSALQAL RRQLFVHKSD LISAFREFDP NNTGIISPSH WASATESVLK LGLPWRVLRP 540

QLVSSTKNGM VDYQEWIREL SITEPKLEIS DTSLLETMYK NHSNLETIFR IIDTDHSGLI 600

SYEEFRQTWK LLSSHLKTEI SDDVIANLAQ SIDFNKDGSI DINEFMEAFR LVDLSAHS 658

Nucleotide Sequence
(FASTA)

ATGGGCTGTG GCCTGAGAAA ATCAGAAGTA CAGCAGAAGA AATGTGACAG AGCAATCAGA 60

GCGGCTTTAT TGATTCAGCG CTGGTATCGG CAGTATGTTG CCCGGCTGGA GATCAGACGC 120

AGGTGCACGT GGAACATCTT CCAGTCTATT GAATATGCAG GACAACAAGA TCAGATCAAG 180

CTGTACAATT TTTTTGGCTT CTTGATGGAC CACTTCACCC CAGCCAGCAG TGAAAGAAAT 240

CTAATTTCTC ACATCTTTCG TGAGAACGAA ATCTGCCGTG ATGCAGAATG GGAAAGATAT 300

TTTTGCTACA AGAGTATAGA TGTACCTGAC AGCTACACGG GGCCCCACCT GACCTTCCCC 360

ATGACGTTCT GCGGAGTGTC AAAGCTTGTG GAGGCTTTTA AGCACAAGCA ACAGCTCCAT 420

GCACGATATG TTCTGCAGAT TCTTGGGGAG ACTTGGAGAC TTCTAAGAAT TCTTCCAAAC 480

ATCAGTCATC TCTCCTCCTG TCACACCAAG GAGATTACTA TATGTGGAGA CCTCCATGGG 540

CAGCTAGAAG ATCTGCTATT GATATTCTAT AAAAATGGTT TGCCATCTCC TGAGAAACCG 600

TATGTGTTCA ATGGGGACTT TGTGGATCGT GGCAAAAACT CCTTGGAGAT TCTGCTCATC 660

CTGTTTGGGT TCCTGCTACT CTACCCCAAT GATGTTCATT TAAACAGAGG GAACCATGAG 720

GACCACATTG TTAACCTAAG ATATGGCTTT ACTAAAGAGG TTTTGGGAAA ATATAGGGTG 780

CACGGCAAGA AGATCCTGAA GCTTCTCCAA AAGATCTTCA GCTGGCTACC TCTGGCTACT 840

GTGATTGATC ACAAGGTGCT GATTGTGCAT GGAGGGATCT CTGACACAAC AGACCTGAAC 900

GTAATAGCCA GAGTGGACAG ACACAAAGTA AATAACCTGC ACATCAGCCA TCAGCAAATG 960

AACTGGTCCG TGGATGACGA GCTGAAGAAA AGACGTAGGT TGGCTGGGTT TGACCAGTCA 1020

TATGGAGAAA GGAAGAAGCC AGACTCTGAC TCAGACCCAG AGTGTGAAGA AGGAATAGAG 1080

ACCTACGAGC ATGAGTGGGA ACAAATGGTA GACCTGTTGT GGAGTGATCC TATGCCCCAA 1140

AATGGCTGCA TTCCCAATGA AGTGAGAGGT GGAGGCTGCT ACTGGGGCCC AGATGTCACA 1200

GAGGAGGTTC TCGGAAGACA CAACCTGCAG CTCCTCATCC GCTCCCATGA ATGCAAACAG 1260

GATGGCTATG AGTTCTGCCA CAACCGCAGG GTACTAACAA TTTTTTCGGC TTCAAATTAC 1320

TATGAGGTGG GCAGCAATAG AGGAGCCTAT ATAAGAATGG GAGCTGATCT GGTCCCTCAC 1380

TTCGTTCAGT ATCAGGCCAG CAGGACTTGC AGAGAGCTCA CACTGAGACA AAGTGTTGGC 1440

TGGACAGAGA GATCAGCTCT ACAAGCTCTG AGGCGACAGC TGTTCGTACA CAAGTCAGAT 1500

CTCATCAGTG CCTTCCGAGA GTTTGATCCC AACAACACAG GGATAATCTC TCCAAGTCAC 1560

TGGGCAAGTG CCACAGAGAG CGTGCTGAAG CTGGGTTTGC CTTGGAGAGT GCTGCGCCCA 1620

CAGCTTGTAA GCAGCACCAA GAATGGCATG GTGGACTATC AGGAGTGGAT AAGGGAGCTC 1680

TCCATCACTG AGCCCAAACT AGAGATATCA GATACCAGCC TACTGGAGAC GATGTACAAA 1740

AACCACTCCA ACTTGGAAAC TATCTTTCGA ATCATAGACA CAGATCACTC AGGTTTGATC 1800

TCTTACGAGG AATTTCGTCA AACCTGGAAA CTCCTGAGCT CTCATCTCAA GACAGAGATC 1860

AGTGATGATG TCATTGCAAA CCTGGCCCAG AGCATCGATT TTAACAAGGA CGGAAGCATC 1920

GATATTAATG AGTTCATGGA GGCTTTCCGT CTGGTGGACC TCTCTGCACA TTCCTGA 1977

Domain Profile

S: 3     lllevfkkkrilhakyvlevlfeakkvlkqlpnishvstavskevtvvGdlhGklddlll  62

          l+e+fk+k++lha+yvl++l e+ + l+ lpnish+s++ +ke+t++GdlhG+l+dlll

Q: 128   KLVEAFKHKQQLHARYVLQILGETWRLLRILPNISHLSSCHTKEITICGDLHGQLEDLLL  187

         589*********************************************************

S: 63    vlkknGlPsernpyvfnGdfvdrGkrglevllvllslflvfPnavylnrGnhedkvmnar  122

         +++knGlPs ++pyvfnGdfvdrGk++le+ll+l  + l++Pn+v+lnrGnhed+++n+r

Q: 188   IFYKNGLPSPEKPYVFNGDFVDRGKNSLEILLILFGFLLLYPNDVHLNRGNHEDHIVNLR  247

         ************************************************************

S: 123   yGfekevlskykrkgkrilrileevyewlPlgsivdsrvlvvhGGlsestsldllksver  182

         yGf+kevl ky+ +gk+il++l++++ wlPl++++d +vl+vhGG+s++t+l+ + +v+r

Q: 248   YGFTKEVLGKYRVHGKKILKLLQKIFSWLPLATVIDHKVLIVHGGISDTTDLNVIARVDR  307

         ************************************************************

S: 183   kkrksvllpPeessrd........................lgrldtdgepresltetewe  218

         +k++ + +  ++ +                              d + e   +  e+ewe

Q: 308   HKVNNLHISHQQMNWSvddelkkrrrlagfdqsygerkkpDSDSDPECEEGIETYEHEWE  367

         *****99999987776889**************98876333333333333345679****

S: 219   qiidilwsdPratnGlvPntlrGaGvyfGPdvtedflkkyelklvirsheckpegyeilh  278

         q++d+lwsdP  +nG++Pn++rG+G+y+GPdvte++l +++l+l+irsheck +gye++h

Q: 368   QMVDLLWSDPMPQNGCIPNEVRGGGCYWGPDVTEEVLGRHNLQLLIRSHECKQDGYEFCH  427

         ************************************************************

S: 279   dgkvvtifsasnyyeegsnkgayiklnsqltprfvqyiva  318

         + +v+tifsasnyye+gsn+gayi++ ++l+p+fvqy+++

Q: 428   NRRVLTIFSASNYYEVGSNRGAYIRMGADLVPHFVQYQAS  467

         *************************************975

Domain Sequence
(FASTA)

KLVEAFKHKQ QLHARYVLQI LGETWRLLRI LPNISHLSSC HTKEITICGD LHGQLEDLLL 60

IFYKNGLPSP EKPYVFNGDF VDRGKNSLEI LLILFGFLLL YPNDVHLNRG NHEDHIVNLR 120

YGFTKEVLGK YRVHGKKILK LLQKIFSWLP LATVIDHKVL IVHGGISDTT DLNVIARVDR 180

HKVNNLHISH QQMNWSVDDE LKKRRRLAGF DQSYGERKKP DSDSDPECEE GIETYEHEWE 240

QMVDLLWSDP MPQNGCIPNE VRGGGCYWGP DVTEEVLGRH NLQLLIRSHE CKQDGYEFCH 300

NRRVLTIFSA SNYYEVGSNR GAYIRMGADL VPHFVQYQAS 340

Keyword

Calcium; Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005509	; F:calcium ion binding
GO:0004721	; F:phosphoprotein phosphatase activity

KEGG

InterPros

IPR011992	; EF-hand-like_dom.
IPR018247	; EF_Hand_1_Ca_BS.
IPR018249	; EF_HAND_2.
IPR002048	; EF_hand_Ca-bd.
IPR000048	; IQ_motif_EF-hand-BS.
IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.

SMARTs

SM00054	; EFh; 3.
SM00015	; IQ; 1.
SM00156	; PP2Ac; 1.

Prosites

PS00018	; EF_HAND_1; 2.
PS50222	; EF_HAND_2; 3.
PS50096	; IQ; 1.
PS00125	; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013