EKS-ORN-00586

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00586

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	413.4	5.8E-124	26	321	296

Status

Unreviewed

Ensembl Protein

ENSONIP00000009655

UniProt Accession

I3JLB2;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK10

Gene Synonyms/Alias

MAPK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000007660	ENSONIP00000009655	ENSONIT00000009661
ENSONIG00000007660	ENSONIP00000009656	ENSONIT00000009662

Organism

Oreochromis niloticus

Functional Description

Protein Length

435

Protein Sequence
(FASTA)

MSKSKVDNQF YSVEVGDSTF TVLKRYQNLK PIGSGAQGIV CAGYDAVLDR NVAIKKLSRP 60

FQNQTHAKRA YRELVLMKCV NHKNIISLLN VFTPQKSLEE FQDVYLVMEL MDANLCQVIQ 120

MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 180

MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGEMVR HKILFPGRDY IDQWNKVIEQ 240

LGTPSPEFMK KLQPTVRNYV ENRPKYAGLT FPKLFPDCLF PADSEHNKLK ASQARDLLSK 300

MLIIDPAKRM SVDEALQHPY INVWYDPAEV EAARDNIQIS MPPPQIYDKQ LDEREHSIDE 360

WKELIYKEVM NFEERTKNGV VKGQPSPSGA AVNSSESLPP SSSINDISSM STDQTLASDT 420

DSSLETSAGP LGCCR 435

Nucleotide Sequence
(FASTA)

ATGAGCAAAA GCAAAGTGGA CAACCAGTTC TACAGTGTGG AAGTGGGAGA CTCTACCTTC 60

ACAGTTTTAA AACGCTACCA GAATTTAAAG CCCATTGGTT CTGGAGCTCA GGGAATTGTC 120

TGTGCGGGCT ATGATGCTGT CCTGGACAGA AATGTAGCCA TCAAGAAGCT GAGCAGACCC 180

TTCCAGAACC AGACCCATGC CAAGAGGGCA TACCGGGAGT TGGTGCTCAT GAAATGCGTC 240

AATCACAAAA ATATTATCAG TTTATTAAAT GTCTTCACAC CACAGAAATC ATTAGAGGAA 300

TTCCAGGATG TGTATCTAGT GATGGAACTA ATGGATGCCA ACTTGTGCCA GGTGATTCAG 360

ATGGAGCTTG ACCACGAGAG AATGTCCTAC CTGCTCTACC AGATGCTGTG TGGTATCAAA 420

CATCTGCACT CAGCCGGCAT TATTCACAGG GATCTCAAAC CAAGCAATAT AGTGGTGAAA 480

TCAGACTGTA CCCTGAAAAT CCTGGATTTC GGTCTGGCTA GGACTGCAGG CACCAGTTTC 540

ATGATGACCC CGTATGTGGT GACTCGATAC TACAGAGCCC CAGAGGTCAT ACTAGGAATG 600

GGATACAAGG AGAATGTGGA TATTTGGTCG GTGGGGTGCA TTATGGGAGA AATGGTGCGC 660

CACAAAATCC TTTTCCCTGG CCGGGACTAT ATTGATCAGT GGAACAAGGT GATCGAGCAG 720

CTGGGCACGC CCTCGCCAGA ATTCATGAAG AAACTTCAAC CCACAGTGAG GAACTATGTC 780

GAGAACCGGC CAAAGTACGC AGGCCTCACC TTCCCCAAAC TCTTCCCCGA CTGCCTTTTC 840

CCTGCTGACT CTGAGCACAA CAAACTCAAA GCAAGCCAGG CTAGAGACTT GCTGTCTAAG 900

ATGCTGATTA TCGACCCTGC TAAGCGGATG TCAGTGGATG AGGCCTTACA GCACCCCTAC 960

ATCAACGTGT GGTATGATCC GGCTGAGGTG GAGGCGGCCA GAGATAACAT CCAAATATCC 1020

ATGCCTCCAC CTCAGATCTA CGACAAGCAG CTGGATGAAA GAGAACACTC CATTGATGAA 1080

TGGAAAGAAC TAATCTACAA AGAGGTGATG AACTTTGAGG AGAGAACGAA GAATGGCGTT 1140

GTGAAGGGAC AACCTTCACC TTCAGGTGCA GCCGTGAACA GCAGCGAGAG CCTCCCTCCC 1200

TCCTCCTCAA TCAACGACAT CTCCTCCATG TCCACCGACC AGACCCTGGC CTCAGACACT 1260

GACAGCAGCC TGGAGACCTC TGCAGGACCC TTGGGGTGTT GCAGGTGA 1308

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++ +d+  +++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 26    YQNLKPIGSGAQGIVCAGYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  85

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 86    ISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  144

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 145   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  201

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++E++++k+lfpg+d+idq++k++e+lgtps ef+kk++  ++rny+

Q: 202   YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPSPEFMKKLQP-TVRNYV  260

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +f +lfp+            + ++a+dLl+k+L++dp kR+sv+eaL+hpY

Q: 261   ENRPKYAGLTFPKLFPDclfpadsehnklKASQARDLLSKMLIIDPAKRMSVDEALQHPY  320

         *****************************99*****************************

S: 289   l  289

Q: 321   I  321

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAGYD AVLDRNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

ISLLNVFTPQ KSLEEFQDVY LVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GEMVRHKILF PGRDYIDQWN KVIEQLGTPS PEFMKKLQPT VRNYVENRPK 240

YAGLTFPKLF PDCLFPADSE HNKLKASQAR DLLSKMLIID PAKRMSVDEA LQHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013