EKS-ORN-00028

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00028

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/Trio	346.9	9.2E-104	2740	2995	256

Status

Unreviewed

Ensembl Protein

ENSONIP00000009811

UniProt Accession

I3JLR7;

Protein Name

Protein Synonyms/Alias

Gene Name

TRIO (1 of 2)

Gene Synonyms/Alias

TRIO (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000007788	ENSONIP00000009811	ENSONIT00000009817

Organism

Oreochromis niloticus

Functional Description

Protein Length

3044

Protein Sequence
(FASTA)

TGFRRNEEMR AMEVLPILKE KVAFLSGGRD RRGGPVLTFP SRSNHDRIRT DDLRRLIAYL 60

AGIPSEEVCK HGFTVIVDMR GSKWDSIKPL LKILQESFPS CIHIALIIKP DNFWQKQRTN 120

FGSSKFEFET TMVSLEGLTK VVDPSQLTAD FDGSLDYNHE EWIEVRVAFE DFSGHATQML 180

ARLEEMQETV SRKDFPQDLE GARRMIEEHA TLKKKVIKAP IEELDTEGQR LLQRIQSSES 240

FSNRNGSSGG SSSSGSGVCN ADTQGLVPRI TQLLDKLHST RQHLHQAWHV RKLQLDQCFQ 300

LRLFEQDAEK IFFWIMHNKG LFLAGYTEIG NNHPHAVELQ TQHSHFAMNC MNVYVNINRI 360

MSVGNRLLES GHYASQQIKQ ISSQLEQEWK AFAAALDERS TLLEMSAGFH QKCDQYMSNV 420

DSWCKACGEV DLPSELQDLE DAIHHHQGLY EHITAAYSEV SQDGKALLDK LQRPLTPGSA 480

DSLTATANYS KAVHHVLDII HEVLHHQRQL ENIWQHRKVR LHQRLQLCVF QQDVQQVLDW 540

IENHGEAFLS KHTGVGKSLH RARALQKRHE DFEEVAQNTY TNADKLLEAA EQLAQTGECD 600

PEEIYQAAHQ LEDRIQDFVR RVEQRKVLLD MSVAFHTHVK ELWTWLEELQ KELLDDVYAE 660

SVEAVQDLIK RFGQQQQTTL QVTVNVIKEG EDLIQQLRDS AISSNKTPHN SSINHIESVL 720

QQLDEAQAQM EELFQERKIK LELFLQLRIF ERDAIDIISD LESWNEELTG QMNDFDTEDL 780

TLAEQRLQHH ADKALTMNNL TFDVIHQGQE LLQYVNEVQA SGVELLCDRD VDMATRVQDL 840

LEFLHEKQQE LDLAAEQHRR HLEQCVQLRH LQAEVKQVLG WIRNGESMLN AGLITASSLQ 900

EAEQLQREHE QFQHAIEKTH QSALQVQQKA EALLQANHYD MDMIRDCAES VASHWQQLML 960

KMEDRLKLVN ASVAFYKTSE QVCSVLESLE QEYKREEDWC GGADKLGPNC ETDHVTPMIS 1020

KHLEQKEAFL KACTLARRNA DVFLKYMHRN SVNMPGMLSH VKAPEQQVKN ILNELLQREN 1080

RVLHFWTMKK RRLDQCQQYV VFERSAKQAL EWIHDTGEFY LSTHTSTGSS IHHTQELLKE 1140

HEEFHITAKQ TKERVKLLIQ LADGFCEKGH SHAGEIKKWV TAVDKRYRDF SLRMDKYRCS 1200

LEKALGISSD SNKASKDLQL DIIPATAPGS EVKLRDAAAH ELNEEKRKSA RRKEFIMAEL 1260

IQTEKAYVRD LRECMDTYLW EMTSGVEEIP PGILNKEHII FGNMQDLYEF HHNIFLKELE 1320

KYEQLPEDVG HCFVTWADKF QMYVNYCKNK PDSTQLILEH AGNYFDEIQQ RHRLANSISS 1380

YLIKPVQRIT KYQLLLKELL TCCEEGKGEI KDGLEVMLSV PKKANDAMHL SMLEGFDENI 1440

ESQGELILQD SFQVWDPKTL IRKGRERHLF LFEMSLVFSK EVKDSNGRSK YIYKSKLFTS 1500

ELGVTEHVEG DPCKFALWVG RTPTSDNKIV LKASSIENKQ DWIKHIREVI QERTIHLRGA 1560

LKEPIHIPKT ATTKHHKGRR DGEDLDSQGE GSSQPDTISL ASRTSQNTLD SDKLSGGCEL 1620

TVVIHDFMAS NSNELTVRRG QTVEVLERCH DKPDWCLVRT TDRSPAQEGL VPCSMLCIAH 1680

SRSSMEMEGI FNHKDTLSVC SNDSIMPGSS ATLQPGHGIG SHTSPGPKRP GNTLRKWLTS 1740

PVRRLSSGKA DGHVKKLAHK HKKSREVRKS GEMTIGSQKD SDDSAATPQD ETLEERVRNE 1800

GLSSGTLSKS SSSGMQSCGE EEGEEGADSV PLPPPMAIQQ HSLLQPDSQD DKTSSRLSVR 1860

PSSSETPSAA ELVSAIEELV KSKMALEDRP SSLSVEQGDS SSPSFNPSDN SLLSSSSPME 1920

EMDERRASIL KKRHFILLEL VETERDYVRD LGLVVEKGYM SRMKEEGVPD DMKGKDKIVF 1980

GNIHQIYDWH KDFFLRELEK CLEDPDRLGP LFLKQERRLN MYVVYCQNKP KSEHIVSEYI 2040

DTYFEDLKQR LGHRLQITDL LIKPVQRIMK YQLLLKDFLK HSKKAGLESP DLEKAVEVMC 2100

IVPKRCNDMM NVGRLQGFDG KIVAQGRLLL QDTFMVSDPD GGLLGRMKER RVFLFEQLVI 2160

FSEPLDKKKG FSLPGFLYKN SIKISCLGLE ENVEGDPCKF ILTSRSASGA VESFVLHSSH 2220

PGVREVWTLQ ISQILESQRN FLNALTSPIE YQRNHVGASS APSIGAPGGG NSGSSAAPGG 2280

GGGSSQSSSI PSGPQGGSRR PSRIPQPSRL PQPLRHHPGA DPDGSNKMSG MKRLSPRPVP 2340

PPLLPVGGSP QGKRPIHTTE DQAYTPIPRA TVGPLPSTPT SKPRPGAVSP MASPMATPAF 2400

GKDTLPPPPP SPGQNQKSGS GFWSSMPGSP ASRPGSFTFP GEAGETPVRQ SSNQSQTHRH 2460

STHSKEADRM STCSSASEQS IQSTQSNGSE SSSSSSVSTM LVTQDYTAVK EDEISVIQGE 2520

VVQILASNQQ NMFLVFRAAT EQGPAAEGWI PGFVLGHTST IVPDCPEGSI KKSSSWHTSL 2580

RIRKKSEKKE KEAKKETKLE NGYRKSRDGL ANKVSVKLLN PNYIYDVPPE FLVPLSDVTC 2640

DNGESVTLRC KVCGRPRATV SWKGPNQSNL TNNGHFSIAY SDTGEATLRI IGVASEDDGV 2700

YTCVATNELG SVTSSASLRV LAVSTDGVRV SWKDNFESHY TEVVELGRGR FSVVKRCDHR 2760

GTKRTVAVKH VNKKLMRRDR VTQELNLLQR LQHPHIVTLI DTYETPSSYA LVLEMADQGR 2820

LLDYIVSWGN LTEEKVACYL RNVLEALHYL HNCRIAHLDI KPENLLVSHT ASGQPIVKLT 2880

DFGDAVQLNS AHYVHPLLGS PEFASPELVL GEPVSLTSDL WSLGVVTYVL LSGASPFLDE 2940

SAEETCLNIC RLDFSFPRDY FQGVSQAARD FVCLLLKTDP GRRPPAGLCL QEPWLQAGQG 3000

DGRAEGCLDT SRLISFIDRR KHQTDARPIG GVRSFIHGRL QPRV 3044

Nucleotide Sequence
(FASTA)

ACAGGTTTTA GGAGAAATGA GGAGATGAGA GCGATGGAGG TGCTTCCCAT CCTCAAAGAG 60

AAGGTTGCCT TTCTGTCAGG TGGCAGAGAC AGACGTGGTG GTCCTGTGTT AACGTTCCCA 120

TCACGCAGCA ACCACGACAG AATACGAACA GACGACCTGA GGAGACTGAT CGCTTACCTC 180

GCCGGCATCC CCAGCGAGGA GGTGTGTAAA CATGGCTTCA CGGTCATTGT TGACATGCGT 240

GGCTCCAAGT GGGACAGCAT CAAGCCTCTG CTGAAGATCC TGCAGGAGTC GTTCCCGTCC 300

TGCATCCACA TCGCGCTCAT CATCAAACCG GACAATTTCT GGCAGAAGCA GAGGACCAAC 360

TTCGGCAGCT CCAAGTTTGA ATTCGAGACC ACCATGGTGT CACTCGAAGG CTTGACGAAA 420

GTGGTGGACC CCTCTCAGCT GACGGCAGAC TTTGACGGCA GCCTGGACTA CAACCACGAA 480

GAGTGGATAG AGGTGCGTGT GGCATTTGAG GATTTCTCTG GCCATGCCAC CCAGATGCTG 540

GCTCGACTAG AAGAGATGCA GGAAACCGTG TCAAGGAAAG ACTTTCCCCA AGACCTGGAA 600

GGAGCCAGAC GGATGATAGA AGAGCACGCC ACACTGAAGA AGAAAGTCAT TAAAGCTCCA 660

ATAGAGGAGC TGGACACTGA AGGGCAAAGA TTGCTCCAGC GCATTCAGAG CAGTGAGTCT 720

TTCTCCAACC GCAATGGCAG CAGCGGCGGA AGCAGCAGTA GCGGCAGTGG AGTGTGCAAC 780

GCGGACACCC AAGGCCTGGT GCCGCGCATC ACCCAGCTGC TGGACAAGCT GCACTCCACC 840

CGGCAGCACC TCCACCAGGC GTGGCACGTC CGCAAGCTCC AGCTGGATCA GTGTTTCCAG 900

CTGCGCCTGT TCGAGCAGGA TGCAGAGAAG ATATTTTTCT GGATCATGCA CAACAAGGGT 960

TTGTTCCTGG CAGGCTACAC AGAGATCGGC AACAACCACC CCCATGCTGT GGAGCTGCAA 1020

ACCCAGCACA GCCACTTCGC CATGAACTGC ATGAATGTGT ACGTCAACAT CAACCGGATC 1080

ATGTCCGTGG GGAACCGGCT ACTGGAGTCG GGTCACTACG CTTCCCAGCA GATCAAGCAG 1140

ATCTCAAGTC AGTTGGAGCA GGAGTGGAAG GCATTCGCCG CCGCATTGGA TGAACGTAGC 1200

ACGCTGTTAG AGATGTCGGC TGGTTTCCAT CAGAAATGTG ACCAGTACAT GAGTAATGTG 1260

GACTCCTGGT GTAAGGCATG TGGCGAGGTG GACTTGCCTT CTGAGCTACA AGACCTCGAA 1320

GATGCCATCC ACCATCACCA AGGCCTGTAC GAGCACATCA CAGCTGCTTA CTCGGAGGTG 1380

AGTCAAGATG GCAAAGCTCT GCTGGACAAG CTGCAGCGAC CTTTGACCCC AGGCAGTGCC 1440

GATTCACTGA CGGCAACGGC AAACTACTCT AAGGCGGTTC ACCACGTCCT GGACATCATC 1500

CATGAGGTGC TGCATCACCA GAGACAGCTG GAAAACATCT GGCAGCACCG TAAAGTGCGT 1560

CTGCACCAGC GCCTGCAGCT CTGCGTGTTT CAGCAGGACG TCCAGCAGGT TTTGGACTGG 1620

ATAGAAAACC ATGGCGAGGC CTTCCTCAGC AAACACACAG GGGTGGGAAA GTCTCTCCAC 1680

CGAGCCAGAG CTCTCCAGAA ACGCCATGAA GACTTTGAGG AAGTGGCACA GAATACGTAC 1740

ACCAATGCAG ACAAGCTGCT GGAGGCGGCC GAGCAGCTGG CCCAGACAGG AGAGTGCGAC 1800

CCAGAGGAGA TCTACCAGGC CGCCCACCAG CTCGAAGACA GGATCCAAGA CTTTGTTCGC 1860

CGCGTGGAGC AGCGCAAAGT CCTGCTGGAC ATGTCTGTCG CCTTCCACAC GCACGTCAAA 1920

GAGTTGTGGA CATGGCTGGA GGAGCTCCAG AAGGAGCTGC TGGACGACGT TTATGCCGAA 1980

TCTGTGGAGG CCGTCCAGGA TCTGATCAAG CGCTTCGGCC AGCAGCAGCA GACCACGCTG 2040

CAGGTCACTG TCAACGTCAT CAAGGAGGGA GAGGACCTCA TCCAGCAGCT CAGGGACTCC 2100

GCCATCTCCA GCAACAAGAC GCCCCACAAC AGCTCCATCA ACCACATCGA GAGCGTCCTC 2160

CAGCAGCTGG ATGAAGCCCA GGCACAGATG GAGGAGCTCT TCCAGGAGAG GAAGATCAAA 2220

CTGGAGCTCT TCCTGCAGCT CCGCATCTTT GAGAGGGATG CCATTGATAT CATCTCTGAC 2280

CTGGAGTCGT GGAACGAGGA GTTGACAGGT CAGATGAATG ACTTTGACAC GGAGGACCTG 2340

ACGCTGGCCG AGCAGAGGCT CCAGCACCAC GCTGACAAGG CCTTGACCAT GAACAACCTC 2400

ACCTTCGATG TGATCCACCA GGGCCAGGAG CTGCTGCAGT ATGTCAACGA AGTCCAGGCC 2460

TCCGGTGTGG AGCTGCTGTG CGATCGGGAT GTGGACATGG CCACGCGGGT TCAGGACTTG 2520

CTGGAGTTCC TTCACGAAAA GCAGCAAGAG CTCGATTTAG CAGCTGAGCA GCACCGCAGA 2580

CACCTGGAGC AGTGTGTCCA GCTGAGACAC CTGCAGGCAG AAGTCAAGCA GGTTCTGGGT 2640

TGGATTCGTA ATGGCGAGTC GATGCTGAAT GCTGGTCTGA TAACAGCCAG CTCCCTGCAG 2700

GAAGCTGAGC AACTGCAGAG GGAACACGAA CAATTTCAGC ATGCTATTGA GAAAACACAC 2760

CAGAGTGCCC TGCAGGTTCA GCAGAAGGCG GAGGCTCTGC TTCAGGCCAA CCACTACGAC 2820

ATGGACATGA TCAGAGACTG TGCCGAGAGC GTGGCTTCAC ACTGGCAACA GCTCATGCTG 2880

AAGATGGAGG ACCGACTCAA GCTTGTCAAT GCCTCCGTCG CCTTCTACAA GACCTCTGAA 2940

CAGGTGTGCA GTGTGTTGGA GAGCTTGGAG CAAGAGTACA AGAGAGAGGA GGACTGGTGT 3000

GGAGGAGCTG ACAAACTGGG ACCCAACTGT GAAACAGACC ACGTCACCCC CATGATCAGC 3060

AAGCACCTGG AGCAGAAGGA GGCCTTCCTA AAAGCGTGCA CGCTGGCAAG AAGAAATGCG 3120

GATGTCTTCC TCAAGTACAT GCACAGGAAC AGTGTTAACA TGCCTGGGAT GCTGAGCCAC 3180

GTCAAAGCAC CAGAACAGCA GGTCAAAAAC ATCCTTAATG AGCTACTGCA AAGAGAGAAC 3240

CGCGTTCTCC ACTTCTGGAC GATGAAGAAA CGCAGGCTGG ATCAGTGCCA GCAGTACGTG 3300

GTGTTTGAAC GTAGCGCCAA ACAGGCTCTG GAGTGGATTC ACGACACCGG GGAGTTTTAC 3360

CTGTCCACAC ACACATCCAC AGGCTCGAGT ATCCATCACA CGCAGGAGCT GCTGAAGGAA 3420

CATGAGGAAT TCCACATCAC AGCCAAGCAA ACCAAGGAGC GTGTGAAGCT GCTGATCCAG 3480

CTGGCCGATG GTTTCTGCGA GAAAGGCCAC AGTCATGCAG GGGAGATCAA AAAATGGGTG 3540

ACAGCTGTGG ACAAGCGCTA TCGAGACTTT TCGCTGCGCA TGGACAAGTA CCGCTGCAGT 3600

CTTGAGAAAG CTCTGGGCAT CTCCTCCGAC TCCAACAAGG CGAGCAAGGA TCTGCAGTTG 3660

GACATCATCC CAGCCACGGC TCCAGGGTCA GAGGTCAAGC TGAGGGATGC TGCCGCCCAT 3720

GAGCTGAATG AGGAGAAACG TAAATCTGCA CGCAGAAAGG AGTTCATCAT GGCAGAGCTG 3780

ATTCAGACAG AAAAAGCCTA CGTGCGAGAC CTGCGGGAGT GCATGGATAC CTACCTGTGG 3840

GAGATGACCA GTGGAGTGGA GGAGATTCCT CCAGGGATCC TCAACAAGGA GCACATCATC 3900

TTTGGAAACA TGCAAGACCT TTATGAATTC CACCATAACA TCTTCCTCAA AGAGTTGGAG 3960

AAATATGAGC AGCTACCAGA GGATGTTGGG CATTGCTTCG TCACATGGGC CGATAAGTTC 4020

CAGATGTATG TGAACTACTG TAAGAACAAG CCGGACTCCA CCCAGCTCAT ACTGGAGCAT 4080

GCTGGCAACT ACTTTGATGA AATTCAACAG AGGCACCGAC TGGCCAACTC CATCTCATCC 4140

TATCTGATCA AGCCAGTGCA GAGAATCACC AAGTATCAGC TCCTGCTGAA GGAGCTGTTG 4200

ACGTGCTGTG AAGAAGGTAA AGGAGAGATC AAGGACGGCC TGGAGGTGAT GCTCAGTGTT 4260

CCCAAGAAAG CCAACGATGC CATGCACCTC TCAATGCTGG AAGGTTTCGA TGAAAACATC 4320

GAGTCGCAGG GCGAGCTCAT TCTCCAGGAT TCATTCCAGG TCTGGGATCC AAAGACTCTG 4380

ATCCGAAAGG GACGAGAGCG CCACCTCTTC CTCTTTGAGA TGTCTCTTGT TTTCAGCAAG 4440

GAGGTCAAAG ACTCAAATGG CCGGAGCAAA TACATCTATA AGAGCAAACT CTTTACATCA 4500

GAGTTGGGGG TGACTGAACA CGTTGAAGGA GACCCCTGTA AGTTTGCTCT ATGGGTGGGA 4560

CGCACCCCGA CCTCTGACAA CAAGATTGTA CTCAAGGCAT CCAGCATTGA GAACAAGCAA 4620

GACTGGATCA AACACATCAG AGAGGTGATC CAAGAGCGCA CCATTCACCT GAGAGGAGCA 4680

CTTAAAGAAC CCATTCATAT TCCCAAAACA GCCACCACCA AGCACCACAA GGGACGAAGG 4740

GATGGAGAGG ACCTGGACAG TCAGGGTGAA GGCAGCAGCC AACCAGACAC CATCTCTCTG 4800

GCATCACGCA CCTCTCAGAA CACACTGGAC AGCGACAAGC TCTCCGGCGG CTGTGAGCTG 4860

ACTGTGGTCA TACATGACTT TATGGCCAGC AACAGCAACG AGCTGACGGT GCGGCGGGGT 4920

CAGACGGTGG AGGTTCTGGA GCGCTGTCAC GACAAACCAG ACTGGTGCCT GGTCAGGACC 4980

ACAGACCGCT CTCCTGCCCA GGAGGGCCTG GTGCCCTGCT CTATGCTCTG CATCGCCCAT 5040

TCCAGGTCCT CCATGGAGAT GGAAGGCATC TTCAATCACA AAGACACACT GTCAGTGTGC 5100

AGCAATGACT CCATCATGCC AGGTTCCTCT GCTACGCTGC AGCCCGGTCA CGGCATCGGC 5160

TCCCACACCT CCCCGGGTCC TAAACGACCA GGTAACACGC TACGGAAGTG GCTGACCAGC 5220

CCGGTGCGAC GGCTAAGCAG CGGTAAAGCA GACGGCCACG TGAAGAAGCT GGCCCACAAG 5280

CACAAGAAGA GCCGCGAGGT GAGGAAGAGC GGCGAGATGA CGATAGGCTC TCAGAAAGAC 5340

TCGGACGACA GTGCAGCTAC ACCTCAGGAT GAAACTTTGG AGGAGAGGGT TCGTAACGAG 5400

GGCCTGTCGA GCGGTACGCT GTCCAAGTCC AGTTCTTCGG GAATGCAGAG CTGCGGTGAG 5460

GAGGAGGGCG AGGAGGGCGC AGACTCAGTA CCTCTGCCTC CACCTATGGC CATCCAGCAG 5520

CATAGCTTGC TGCAGCCAGA CTCACAGGAT GACAAGACTT CTTCTCGTCT GTCGGTCCGC 5580

CCGTCCAGTT CAGAAACGCC CAGTGCCGCT GAGCTGGTGA GCGCCATCGA GGAGCTAGTC 5640

AAAAGCAAGA TGGCTCTGGA GGACAGACCC AGCTCTCTGT CTGTAGAACA AGGAGACAGC 5700

AGCTCTCCCT CTTTCAACCC CTCTGACAAC TCCCTCCTCT CCTCTTCCTC CCCCATGGAA 5760

GAAATGGACG AACGCAGGGC CAGTATCCTC AAAAAAAGAC ATTTCATTCT GCTGGAGTTG 5820

GTGGAGACGG AGAGAGATTA CGTCAGAGAC CTCGGCCTGG TGGTGGAGAA GGGCTACATG 5880

AGCAGAATGA AGGAGGAGGG TGTCCCTGAT GATATGAAGG GAAAAGACAA AATTGTGTTT 5940

GGCAACATCC ATCAGATCTA CGACTGGCAC AAAGATTTCT TCCTCAGGGA GTTGGAGAAG 6000

TGTTTGGAGG ACCCTGACAG ACTGGGACCA CTCTTTCTCA AACAGGAACG GAGACTAAAC 6060

ATGTACGTAG TGTACTGTCA GAACAAGCCC AAGTCAGAGC ACATCGTGTC CGAGTATATC 6120

GACACCTACT TTGAGGACCT GAAGCAGCGG CTGGGACACA GACTGCAGAT CACAGACCTG 6180

CTCATCAAGC CAGTCCAGAG GATCATGAAG TACCAGCTGC TGCTCAAGGA TTTCCTGAAA 6240

CACTCTAAAA AGGCCGGGCT CGAGTCTCCA GATTTGGAAA AAGCAGTGGA GGTCATGTGT 6300

ATTGTTCCAA AAAGGTGTAA CGACATGATG AATGTTGGCC GGCTTCAAGG ATTTGATGGG 6360

AAGATTGTGG CTCAGGGCCG CCTTTTGCTG CAGGACACAT TCATGGTGTC CGACCCCGAC 6420

GGTGGTCTGC TCGGTCGGAT GAAGGAGAGG AGGGTCTTCC TGTTTGAGCA GCTTGTCATC 6480

TTCAGTGAGC CCCTGGACAA AAAGAAAGGG TTCTCTCTGC CAGGCTTCCT CTATAAGAAC 6540

AGCATCAAGA TAAGCTGTTT GGGTTTGGAG GAGAATGTAG AAGGTGATCC CTGTAAGTTC 6600

ATTCTCACTT CTCGGTCAGC CAGCGGCGCC GTGGAGTCCT TTGTGCTTCA CTCCTCCCAT 6660

CCAGGGGTGC GTGAGGTCTG GACCCTTCAG ATCAGCCAAA TACTCGAGAG CCAACGCAAC 6720

TTCCTCAATG CTCTGACCTC ACCAATAGAG TATCAGAGGA ACCATGTAGG GGCAAGCAGT 6780

GCACCCAGCA TCGGAGCTCC AGGTGGGGGC AACAGCGGTT CTAGTGCAGC CCCTGGAGGT 6840

GGAGGTGGAA GCTCCCAGAG TAGCTCCATC CCTTCGGGAC CCCAGGGTGG CTCTCGTCGG 6900

CCGTCCAGGA TCCCGCAACC CTCCCGCCTG CCCCAACCCC TACGTCACCA CCCCGGGGCC 6960

GACCCGGATG GCTCCAATAA GATGTCAGGT ATGAAACGTT TGTCCCCTCG TCCTGTCCCT 7020

CCTCCTCTGC TCCCTGTGGG GGGCAGCCCG CAGGGCAAGC GCCCTATCCA CACCACAGAG 7080

GACCAAGCTT ATACCCCCAT CCCACGTGCT ACCGTTGGGC CTCTGCCCTC CACACCCACT 7140

TCTAAACCAC GGCCAGGAGC CGTGTCTCCC ATGGCCTCCC CCATGGCCAC TCCCGCCTTT 7200

GGCAAGGACA CTCTCCCCCC TCCCCCTCCC AGTCCAGGCC AAAACCAAAA GTCTGGATCT 7260

GGATTCTGGA GCTCAATGCC GGGCTCTCCA GCCAGCCGGC CTGGCTCATT CACCTTTCCG 7320

GGAGAGGCAG GAGAGACTCC GGTGCGACAA AGCTCAAATC AGAGCCAAAC CCACAGACAT 7380

TCCACGCACA GCAAGGAGGC CGACCGCATG AGTACGTGCT CATCGGCCAG CGAGCAGTCC 7440

ATCCAGTCCA CCCAGAGTAA CGGGAGTGAA AGTAGCAGCA GCAGTAGCGT ATCCACCATG 7500

TTGGTGACCC AGGACTACAC GGCTGTGAAG GAGGATGAGA TCAGCGTCAT TCAGGGCGAG 7560

GTGGTCCAGA TCTTGGCCAG CAACCAGCAA AACATGTTCC TGGTGTTCAG AGCAGCCACC 7620

GAGCAGGGCC CCGCCGCCGA GGGCTGGATC CCCGGATTTG TGCTGGGACA CACGTCGACC 7680

ATTGTCCCCG ACTGTCCCGA GGGATCCATC AAGAAGTCTT CATCCTGGCA CACGTCCCTG 7740

CGTATTCGCA AGAAGTCTGA GAAAAAGGAG AAGGAGGCAA AGAAGGAGAC CAAGCTGGAA 7800

AACGGTTACA GGAAGTCCAG AGATGGCCTG GCCAATAAAG TTTCTGTAAA GCTTCTAAAC 7860

CCAAACTACA TCTATGATGT TCCCCCTGAG TTCCTTGTAC CTCTGAGTGA TGTGACATGT 7920

GACAACGGAG AGAGCGTCAC CCTAAGGTGT AAGGTTTGTG GGCGACCCCG GGCTACAGTC 7980

AGCTGGAAAG GGCCCAACCA GAGCAACCTC ACTAACAACG GACACTTCAG CATCGCCTAC 8040

AGTGATACGG GTGAAGCGAC TCTGCGGATA ATCGGCGTAG CCTCTGAGGA CGATGGCGTT 8100

TACACGTGTG TTGCCACCAA CGAGCTGGGC AGTGTGACAT CATCAGCTAG CCTCAGAGTG 8160

TTGGCCGTGT CCACTGACGG GGTCCGAGTG AGCTGGAAGG ATAACTTTGA GTCTCACTAC 8220

ACTGAGGTGG TTGAACTGGG AAGGGGTCGT TTCTCTGTCG TCAAGCGCTG CGACCACCGG 8280

GGCACCAAAC GCACGGTGGC TGTGAAACAC GTCAACAAGA AGCTGATGAG GAGAGACAGA 8340

GTGACCCAGG AGCTCAATCT GCTCCAGAGA CTCCAGCACC CACACATAGT CACCCTGATT 8400

GACACCTACG AAACTCCCAG CAGCTACGCG TTAGTCCTGG AGATGGCCGA CCAAGGCCGT 8460

CTGCTGGACT ACATCGTGAG CTGGGGGAAT CTGACTGAGG AGAAGGTGGC CTGCTACTTG 8520

AGGAACGTTT TAGAAGCTTT ACACTACTTA CACAACTGCA GAATAGCACA CTTGGACATA 8580

AAACCTGAGA ACCTGCTGGT GTCCCACACC GCCAGCGGCC AGCCAATAGT CAAGCTCACA 8640

GACTTCGGTG ATGCTGTGCA GCTCAACAGC GCCCACTATG TTCACCCTCT GCTGGGCAGC 8700

CCTGAGTTCG CCTCCCCAGA GCTGGTCCTC GGAGAGCCTG TGTCGCTGAC CTCTGACCTG 8760

TGGAGTCTGG GCGTGGTCAC CTACGTGCTG CTGAGCGGCG CCTCCCCCTT TCTCGACGAG 8820

AGCGCAGAGG AGACCTGCCT GAACATCTGC CGGCTGGACT TCAGCTTCCC CAGGGATTAC 8880

TTCCAGGGCG TCAGCCAGGC GGCCCGGGAC TTCGTCTGCC TGCTTCTGAA GACCGACCCA 8940

GGCAGAAGGC CCCCGGCCGG CCTCTGCCTC CAGGAGCCGT GGCTGCAGGC TGGCCAAGGC 9000

GACGGCCGGG CAGAGGGCTG CTTGGACACC TCCCGCCTCA TTTCTTTCAT TGACAGGAGA 9060

AAACATCAGA CCGATGCCCG GCCCATCGGA GGGGTCAGGA GCTTCATTCA CGGTCGCCTT 9120

CAGCCTCGGG TTTGA 9135

Domain Profile

S: 1     yevleeigRGrFsvvkkvrekatkravaakfvpkkakkkaqvlrEaeiLkrLqHpllvsl  60

         y+++ e+gRGrFsvvk++++++tkr+va+k v+kk +++++v++E+++L+rLqHp++v+l

Q: 2740  YTEVVELGRGRFSVVKRCDHRGTKRTVAVKHVNKKLMRRDRVTQELNLLQRLQHPHIVTL  2799

         89999*******************************************************

S: 61    hdayetprslvlilElcsdeeLLdrlaekeslsEsevkaylrqllealqYLHnsrvlHLD  120

          d+yetp s+ l+lE++++++LLd+++++++l+E++v+ ylr++leal+YLHn+r++HLD

Q: 2800  IDTYETPSSYALVLEMADQGRLLDYIVSWGNLTEEKVACYLRNVLEALHYLHNCRIAHLD  2859

         ************************************************************

S: 121   ikpenllv..laaaeeavkivDlgnAqeltpeepqekllgtpEfvaPEiiegepvseatD  178

         ikpenllv  +a  ++ vk+ D+g+A++l+++++ + llg+pEf++PE++ gepvs ++D

Q: 2860  IKPENLLVshTASGQPIVKLTDFGDAVQLNSAHYVHPLLGSPEFASPELVLGEPVSLTSD  2919

         ********655566889*******************************************

S: 179   iWavGvlayvlLsgvsPfldeskretllnilkgrvsfseelfaglseeAkeFlkkvLqed  238

         +W++Gv++yvlLsg sPfldes++et+lni+++++sf++++f+g+s++A++F++ +L++d

Q: 2920  LWSLGVVTYVLLSGASPFLDESAEETCLNICRLDFSFPRDYFQGVSQAARDFVCLLLKTD  2979

         ************************************************************

S: 239   prkRPsaaecLqhpWl  254

         p +RP a  cLq+pWl

Q: 2980  PGRRPPAGLCLQEPWL  2995

         ***************8

Domain Sequence
(FASTA)

YTEVVELGRG RFSVVKRCDH RGTKRTVAVK HVNKKLMRRD RVTQELNLLQ RLQHPHIVTL 60

IDTYETPSSY ALVLEMADQG RLLDYIVSWG NLTEEKVACY LRNVLEALHY LHNCRIAHLD 120

IKPENLLVSH TASGQPIVKL TDFGDAVQLN SAHYVHPLLG SPEFASPELV LGEPVSLTSD 180

LWSLGVVTYV LLSGASPFLD ESAEETCLNI CRLDFSFPRD YFQGVSQAAR DFVCLLLKTD 240

PGRRPPAGLC LQEPWL 256

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Repeat; SH3 domain; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005089	; F:Rho guanyl-nucleotide exchange factor activity
GO:0035023	; P:regulation of Rho protein signal transduction

KEGG

InterPros

IPR001251	; CRAL-TRIO_dom.
IPR000219	; DH-domain.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001452	; SH3_domain.
IPR018159	; Spectrin/alpha-actinin.
IPR002017	; Spectrin_repeat.

Pfam

PF07679	; I-set; 1.
PF00069	; Pkinase; 1.
PF00621	; RhoGEF; 2.
PF00018	; SH3_1; 1.
PF00435	; Spectrin; 4.

SMARTs

SM00408	; IGc2; 1.
SM00233	; PH; 2.
SM00325	; RhoGEF; 2.
SM00220	; S_TKc; 1.
SM00516	; SEC14; 1.
SM00326	; SH3; 2.
SM00150	; SPEC; 7.

Prosites

PS50191	; CRAL_TRIO; 1.
PS50010	; DH_2; 2.
PS50835	; IG_LIKE; 1.
PS50003	; PH_DOMAIN; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50002	; SH3; 1.

Prints

Created Date

20-Feb-2013