EKS-ORN-00350

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00350

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	428.0	3.1E-128	113	435	323

Status

Unreviewed

Ensembl Protein

ENSONIP00000010120

UniProt Accession

I3JMM6;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK1B

Gene Synonyms/Alias

DYRK1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000008036	ENSONIP00000010120	ENSONIT00000010129

Organism

Oreochromis niloticus

Functional Description

Protein Length

665

Protein Sequence
(FASTA)

MTSQHSHTHP SFSSIHSMAE QQQVLSDMTI LQRRIPPSFR DPASAPLRKL SVDLIKTYKH 60

INEVYYTKKK RRAQQVPPED SSTKKERKIY NDGYDDDNYD YIVKNGEKWL DRYEIDSLIG 120

KGSFGQVVKA YDHHEQEWVA IKIIKNKKAF LNQAQIELRL LELMNKHDTE MKYYIVHLKR 180

HFMFRNHLCL VFELLSYNLY DLLRNTNFRG VSLNLTRKFA QQLCTALLFL ATPELSIIHC 240

DLKPENILLC NPKRSAIKIV DFGSSCQLGQ RIYQYIQSRF YRSPEVLLGM PYDLAIDMWS 300

LGCILVEMHT GEPLFSGSNE HICGMLLLCV EVLGVPPSHM LDAAPKARKY FDKLSDGLWT 360

VKKNKDVKKE YKPPATRRLH EILGVETGGP GGRRAGEPGH APCDYLKFKD LILRMLDYDP 420

KSRITPFYAL QHNFFKKTTD EGTNTSSSTS TSPAMDHSHS ASTTSSVSSS GGSSGSSNDN 480

RNYRYSNRYY NSAVTHSDYE MTSPQAPSQQ QMRMWPGSDG GGGGQDPGYT QLLLHKPAAS 540

QQHQRHFLDP PHHPHPTYSH HGNGGRGLRQ GGQTGIGGGG GPQGSSPQMS DSMDVSVSLG 600

LHHLGAVSSM EASQFGSASL PLALPIGLSA FRTRTAPTAP GPQAQPPEDY YPASNNNNPT 660

GGGRG 665

Nucleotide Sequence
(FASTA)

ATGACCAGCC AGCACTCACA TACACACCCC TCCTTCAGCT CCATCCACTC CATGGCCGAG 60

CAGCAGCAGG TGCTGTCTGA TATGACCATA CTCCAGCGGA GAATTCCCCC TAGTTTCAGA 120

GACCCTGCCA GCGCTCCATT GAGAAAACTC TCTGTTGACC TCATCAAAAC TTATAAGCAC 180

ATCAATGAGG TGTACTATAC TAAGAAGAAG CGGCGGGCCC AGCAGGTCCC TCCTGAGGAC 240

AGCAGCACGA AGAAGGAGAG AAAAATCTAT AACGATGGCT ATGACGATGA CAATTATGAC 300

TACATTGTGA AAAATGGAGA AAAGTGGCTG GACCGCTACG AGATAGACTC ACTGATTGGG 360

AAAGGCTCTT TCGGACAGGT GGTAAAGGCC TACGACCACC ATGAGCAGGA GTGGGTTGCC 420

ATTAAGATCA TTAAGAACAA AAAGGCATTT TTGAACCAGG CACAGATAGA ACTACGCCTG 480

CTGGAGCTCA TGAACAAGCA TGACACTGAG ATGAAATATT ACATAGTCCA CCTGAAGCGT 540

CACTTTATGT TTAGGAACCA TCTCTGTTTG GTGTTTGAGT TGTTGAGCTA CAACCTGTAC 600

GATCTGCTGA GGAACACCAA TTTCAGAGGA GTTTCCCTCA ACCTCACCAG GAAATTTGCA 660

CAGCAGCTCT GTACAGCACT ATTATTCCTG GCCACTCCGG AGCTGTCAAT CATCCACTGC 720

GACCTGAAAC CAGAGAACAT ACTGCTGTGT AACCCCAAGA GATCAGCCAT CAAAATAGTC 780

GATTTTGGAT CCTCCTGCCA GCTTGGACAG AGAATCTATC AGTACATCCA GAGCAGGTTT 840

TACCGCTCTC CCGAGGTTCT GTTGGGAATG CCGTATGACC TGGCTATCGA CATGTGGTCT 900

CTGGGATGCA TCCTAGTGGA GATGCACACA GGGGAGCCTC TCTTCAGTGG CTCCAATGAG 960

CATATTTGTG GTATGCTCTT ACTTTGTGTG GAGGTTCTGG GAGTTCCACC CAGCCACATG 1020

CTGGATGCAG CTCCTAAAGC CAGGAAGTAT TTTGACAAGC TGTCAGATGG TCTGTGGACA 1080

GTGAAGAAGA ACAAGGATGT CAAGAAGGAG TATAAGCCCC CAGCCACACG GCGTCTACAT 1140

GAGATTTTGG GTGTTGAGAC TGGGGGTCCA GGGGGCCGGC GGGCAGGAGA ACCAGGACAC 1200

GCCCCTTGTG ACTACCTGAA GTTTAAAGAC CTGATCCTGC GCATGCTGGA CTACGACCCT 1260

AAAAGCCGTA TCACGCCATT CTATGCCCTG CAGCACAATT TCTTCAAGAA AACAACAGAT 1320

GAAGGAACCA ATACTAGTTC ATCTACATCC ACCTCTCCTG CCATGGACCA CTCTCATTCT 1380

GCCTCCACTA CTAGCTCTGT TTCTAGCTCT GGTGGCTCCA GTGGTTCTTC CAATGACAAC 1440

CGCAACTACC GCTACAGTAA TCGTTACTAC AACTCTGCTG TTACACATTC AGACTATGAG 1500

ATGACCAGCC CTCAGGCTCC CTCACAGCAG CAGATGAGAA TGTGGCCAGG CAGTGATGGC 1560

GGAGGTGGAG GTCAGGATCC AGGATACACC CAGTTGCTGC TCCATAAGCC AGCTGCCTCC 1620

CAACAACACC AGCGCCACTT CTTGGACCCG CCCCACCACC CACACCCAAC TTACTCCCAC 1680

CATGGGAATG GTGGCCGTGG CCTGAGGCAG GGTGGACAGA CAGGCATCGG CGGAGGTGGG 1740

GGCCCACAGG GATCCTCGCC CCAGATGAGT GACAGCATGG ATGTGAGTGT ATCCCTGGGG 1800

CTGCACCACC TGGGGGCGGT GTCTTCCATG GAGGCCTCTC AGTTTGGCTC TGCATCTCTG 1860

CCCCTCGCTC TGCCAATCGG ACTGTCTGCC TTCCGGACTC GGACGGCTCC CACCGCCCCA 1920

GGGCCACAAG CCCAGCCCCC TGAAGACTAC TACCCTGCCT CCAACAACAA TAACCCCACT 1980

GGGGGAGGCA GAGGG 1995

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         ye++++igkGsfgqVvka+d++++e+vaikiiknkk+f++qaq+E+++Le +nk+d+e+k

Q: 113   YEIDSLIGKGSFGQVVKAYDHHEQEWVAIKIIKNKKAFLNQAQIELRLLELMNKHDTEMK  172

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119

         y++v+l+++f+frnhlclvfells+nLy+ll++++f+g+sl+l+rk+aqq+++aL +L+

Q: 173   YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLAt  232

         **********************************************************99

S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++

Q: 233   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMP  291

         99*************************************.********************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenev..dqlalivevlglppekllekakkakkff  236

         yd aiDmWSlGc+l+E++tG+pLf+G+ne    +l l vevlg+pp+++l++a ka+k+f

Q: 292   YDLAIDMWSLGCILVEMHTGEPLFSGSNEHicGMLLLCVEVLGVPPSHMLDAAPKARKYF  351

         ****************************964479**************************

S: 237   tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedkl  287

         +k ++  +++k++          ++r+ +++l+v++ +     p+ +++ge+ +   d+l

Q: 352   DKLSDGLWTVKKNkdvkkeykpPATRRLHEILGVETGG-----PGGRRAGEPGHAPCDYL  406

         **********9986766666555555666666665555.....999**********9999

S: 288   .fkdllkrmleldpakRitpkealkhpfv  315

          fkdl+ rml++dp++Ritp +al+h+f+

Q: 407   kFKDLILRMLDYDPKSRITPFYALQHNFF  435

         9***************************7

Domain Sequence
(FASTA)

YEIDSLIGKG SFGQVVKAYD HHEQEWVAIK IIKNKKAFLN QAQIELRLLE LMNKHDTEMK 60

YYIVHLKRHF MFRNHLCLVF ELLSYNLYDL LRNTNFRGVS LNLTRKFAQQ LCTALLFLAT 120

PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY 180

DLAIDMWSLG CILVEMHTGE PLFSGSNEHI CGMLLLCVEV LGVPPSHMLD AAPKARKYFD 240

KLSDGLWTVK KNKDVKKEYK PPATRRLHEI LGVETGGPGG RRAGEPGHAP CDYLKFKDLI 300

LRMLDYDPKS RITPFYALQH NFF 323

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Gasterosteus aculeatus"; ?>Oryzias latipes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013