EKS-ORN-00242

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00242

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	452.9	4.3E-136	361	630	270

Status

Unreviewed

Ensembl Protein

ENSONIP00000010230

UniProt Accession

I3JMY6;

Protein Name

Protein Synonyms/Alias

Gene Name

LIMK1 (1 of 2)

Gene Synonyms/Alias

LIMK1 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000008123	ENSONIP00000010230	ENSONIT00000010239

Organism

Oreochromis niloticus

Functional Description

Protein Length

675

Protein Sequence
(FASTA)

MRLMLLCCTW KDERMGEEEA GGSLPVCAGC KQRIYDEQYL QALNNDWHTV CFRCCECSAS 60

LSHWYYEKDG RLFCKKDYWA KFGELCHGCN DPITTGLIMV AGEQKYHPEC FTCLNCRSFI 120

GDGDTYALVE RSKLYCGHCY YQTIVTPVSL PDSPCSRIPH TVTLVSIPAS ADGNNGRKGR 180

GFSVAIDQPL SPTNGYSPEH GHTVRVSQVD ADCISPDVKN SIHVGDRILE INGTPIHNVP 240

LDEIDLLIQE TSRLLQLTIE HDPHSQSGQE GGSSEAEDQV DGPLSTPLSE GPSPILPITQ 300

PPNPDISNLK SRIITRSYST DKSPGSSNAA SPISQRKDIN RSESLRVVSN RTHRIFRPSD 360

LIHGEVLGKG CFGQAIKVTH RETGEVMVMK ELIRFDDETQ KTFLKEVKVM RCLDHPNVLK 420

FIGVLYKDKR LNFIAEYIKG GTLREIIKKM DSNYPWNQRV SFAKDIAAGM AYLHSMNIIH 480

RDLNSHNCLV RENNTVVVAD FGLARLMVDD KHGEKLTQGK LSGLKRPDRR KRYTVVGNPY 540

WMAPEMIHGK SYDERVDIFS FGIMLCEIIG RVNADPDYLP RATDFGLNIS GFLEHYCPPN 600

CPRAFFPMAA VCCDLDADKR PAFSKLEEWL ENLKMHLDIG LPLMSEVDQL HKAFWEHHSI 660

TRPENGLHTH PEQPE 675

Nucleotide Sequence
(FASTA)

ATGAGGTTGA TGCTGCTCTG TTGCACCTGG AAGGACGAAC GCATGGGAGA GGAGGAAGCA 60

GGAGGAAGTT TGCCCGTGTG CGCGGGATGC AAACAGAGGA TCTACGATGA GCAGTACCTC 120

CAGGCCCTTA ACAATGACTG GCATACCGTC TGCTTCAGGT GTTGTGAGTG CAGCGCCTCG 180

CTGTCCCACT GGTATTATGA AAAAGATGGC CGGCTCTTCT GCAAGAAGGA CTACTGGGCC 240

AAATTTGGGG AGCTGTGCCA TGGCTGCAAC GACCCGATCA CCACTGGCCT CATTATGGTC 300

GCAGGGGAAC AGAAATATCA TCCAGAATGC TTCACATGTC TGAACTGCCG ATCGTTCATC 360

GGTGATGGAG ACACATACGC TCTGGTGGAG AGATCTAAAC TGTACTGTGG TCACTGCTAC 420

TACCAGACCA TCGTGACCCC GGTGTCGCTG CCGGACTCGC CATGCTCACG GATCCCTCAC 480

ACAGTCACAC TGGTGTCCAT CCCGGCCTCC GCCGATGGCA ACAATGGCCG CAAAGGGCGC 540

GGTTTCTCCG TGGCGATTGA CCAGCCGCTA AGCCCGACCA ATGGCTACAG TCCCGAACAT 600

GGACATACCG TCAGAGTCTC CCAGGTGGAT GCCGACTGCA TCAGCCCAGA TGTGAAAAAT 660

TCCATTCATG TTGGAGACCG GATCTTAGAA ATTAATGGGA CGCCCATTCA CAACGTTCCT 720

CTGGATGAGA TTGACCTGCT GATCCAGGAA ACGAGCCGGC TGCTGCAGCT CACCATCGAA 780

CACGACCCTC ACAGCCAGTC GGGACAGGAG GGAGGCTCCT CAGAGGCTGA GGACCAGGTG 840

GACGGTCCGT TGTCCACCCC ACTGTCAGAA GGGCCCAGCC CCATCCTACC CATCACCCAG 900

CCCCCCAATC CAGACATCAG CAACCTGAAA TCCCGCATCA TCACGCGAAG TTACAGCACT 960

GATAAGTCGC CTGGATCCAG CAATGCTGCG TCACCAATCT CCCAGAGGAA GGACATCAAT 1020

CGGTCGGAGT CACTTCGGGT TGTCTCAAAC CGGACTCACC GTATCTTCCG CCCATCTGAC 1080

CTCATCCACG GAGAAGTGCT GGGGAAGGGA TGCTTTGGAC AAGCCATAAA GGTGACACAC 1140

AGGGAGACGG GTGAGGTGAT GGTGATGAAA GAGCTGATCC GCTTTGATGA CGAGACTCAA 1200

AAAACATTCC TCAAAGAGGT GAAAGTCATG CGATGCCTGG ATCACCCCAA TGTGCTCAAG 1260

TTTATCGGAG TCCTCTACAA AGACAAGAGA CTCAACTTCA TCGCAGAGTA CATCAAAGGA 1320

GGCACTTTGC GGGAAATCAT CAAAAAAATG GACTCAAACT ATCCCTGGAA CCAGCGGGTC 1380

AGTTTTGCTA AGGACATCGC TGCTGGGATG GCATATCTGC ACTCCATGAA CATTATTCAT 1440

CGGGACCTGA ACTCTCACAA CTGTCTAGTC CGAGAGAACA ACACAGTGGT GGTGGCAGAC 1500

TTCGGGCTGG CGCGACTCAT GGTGGACGAC AAGCACGGGG AAAAGCTGAC GCAGGGAAAG 1560

CTGTCTGGCC TCAAGAGGCC CGACCGCCGG AAGAGATACA CGGTGGTGGG AAACCCCTAC 1620

TGGATGGCTC CAGAGATGAT CCATGGGAAG AGCTACGATG AGAGAGTAGA CATCTTTTCC 1680

TTTGGTATCA TGCTCTGCGA GATCATTGGC AGGGTGAATG CTGACCCCGA CTACCTCCCC 1740

AGAGCGACGG ACTTTGGACT GAACATCTCG GGTTTCCTGG AGCACTACTG TCCCCCCAAC 1800

TGTCCCCGCG CCTTCTTCCC CATGGCTGCT GTGTGCTGTG ACCTTGATGC AGACAAACGG 1860

CCTGCTTTCT CCAAACTGGA GGAGTGGCTG GAGAACCTGA AGATGCACTT GGACATCGGT 1920

CTGCCCCTGA TGTCCGAAGT GGACCAGCTG CACAAGGCCT TCTGGGAGCA CCACAGCATA 1980

ACACGTCCTG AGAATGGCCT GCACACCCAC CCCGAGCAGC CAGAGTAG 2028

Domain Profile

S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60

         li+ge+lGkG+f++++kvthr++Gevmv+kelir+d+e++k++lkevk++r+l+hpnvlk

Q: 361   LIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDDETQKTFLKEVKVMRCLDHPNVLK  420

         689*********************************************************

S: 61    fiGvlvkdkklhllteyiegGtlkellkskes.lpwtqrvrlakdiasGlsylhskgiih  119

         fiGvl+kdk+l++++eyi+gGtl+e++k+++s +pw+qrv++akdia+G++ylhs++iih

Q: 421   FIGVLYKDKRLNFIAEYIKGGTLREIIKKMDSnYPWNQRVSFAKDIAAGMAYLHSMNIIH  480

         *******************************99***************************

S: 120   rdlnsknclvredksvvvadfGlarlvveerkks....eklrslkkkdrkkrltvvGsPy  175

         rdlns+nclvre+++vvvadfGlarl+v++++       kl  lk+ dr+kr+tvvG+Py

Q: 481   RDLNSHNCLVRENNTVVVADFGLARLMVDDKHGEkltqGKLSGLKRPDRRKRYTVVGNPY  540

         ****************************9887655555999*******************

S: 176   wmaPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaed  235

         wmaPe+++gksyde+vd+fsfGi+lceii+rv+adPdylPr++dfgl+++ f e++++ +

Q: 541   WMAPEMIHGKSYDERVDIFSFGIMLCEIIGRVNADPDYLPRATDFGLNISGFLEHYCPPN  600

         ************************************************************

S: 236   cPeaflklavvccdldpesrpsfeelekkl  265

         cP af+++a+vccdld+++rp+f++le++l

Q: 601   CPRAFFPMAAVCCDLDADKRPAFSKLEEWL  630

         ***************************997

Domain Sequence
(FASTA)

LIHGEVLGKG CFGQAIKVTH RETGEVMVMK ELIRFDDETQ KTFLKEVKVM RCLDHPNVLK 60

FIGVLYKDKR LNFIAEYIKG GTLREIIKKM DSNYPWNQRV SFAKDIAAGM AYLHSMNIIH 120

RDLNSHNCLV RENNTVVVAD FGLARLMVDD KHGEKLTQGK LSGLKRPDRR KRYTVVGNPY 180

WMAPEMIHGK SYDERVDIFS FGIMLCEIIG RVNADPDYLP RATDFGLNIS GFLEHYCPPN 240

CPRAFFPMAA VCCDLDADKR PAFSKLEEWL 270

Keyword

Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781	; Znf_LIM.

Pfam

PF00412	; LIM; 2.
PF00595	; PDZ; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00132	; LIM; 2.
SM00228	; PDZ; 1.

Prosites

PS00478	; LIM_DOMAIN_1; 2.
PS50023	; LIM_DOMAIN_2; 2.
PS50106	; PDZ; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013