EKS-ORN-00480
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00480
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src425.48.6E-128239488250
StatusUnreviewed
Ensembl ProteinENSONIP00000010316
UniProt AccessionI3JN72;
Protein Name
Protein Synonyms/Alias
Gene NameLCK
Gene Synonyms/Alias LCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000008194ENSONIP00000010316ENSONIT00000010325
OrganismOreochromis niloticus
Functional Description
Protein Length501
Protein Sequence
(FASTA)
MGCNCSSDYS DSDWIENLDE ICEHCNCPIP PQSCNPYTDQ LIPYPSQMTP PTSPLPVNVV 60
VAIYSYEPTH DGDLGFDKGD KLKILNKDDP EWYLAESLTT GQQGYIPHNF VALSTVETEP 120
WFFRNISRNE AMRLLLAPGN TQGSFLIRES ETAKGSYSLS VRDLDHNTGE GVKHYRIRNM 180
DNGGFYITAK ISFNSLKELV QHHSRDADGL CTKLVKPCQS RAPQKPWWQD EWEIPRESLK 240
LERRLGAGQF GEVWMGVYNN DRKVAIKNLK MGTMSVEAFL AEANMMKNLQ HPRLVRLFAV 300
VTQEPIYIVT EYMENGSLVD YLKTTEGSNL PMNVLIEMSS QVADGMAFIE QKNYIHRDLR 360
AANILVSHEL ICKVADFGLA RLIEDNEYTA REGAKFPIKW TAPEAINYGT FSIKSDVWSF 420
GILLTEIVTY GRIPYPGMSN PEVIQNLERG YRMPQPDNCS DALYSIMCHC WKESPEERPT 480
FEYLRNVLED FFTSTERQYQ E 501
Nucleotide Sequence
(FASTA)
ATGGGCTGCA ACTGCAGTTC GGACTATTCA GACAGTGACT GGATCGAGAA CTTGGATGAA 60
ATCTGCGAAC ACTGCAACTG TCCCATACCG CCACAATCAT GCAACCCATA CACAGATCAG 120
CTGATTCCAT ATCCATCGCA GATGACACCT CCTACATCAC CTTTACCAGT CAACGTTGTG 180
GTGGCCATTT ACAGCTATGA GCCCACTCAT GACGGCGACC TCGGCTTCGA CAAAGGAGAC 240
AAACTCAAGA TCCTCAACAA GGATGATCCA GAATGGTATC TGGCAGAGTC TCTCACCACA 300
GGCCAGCAGG GCTACATCCC CCACAACTTT GTCGCATTGT CCACCGTGGA GACTGAACCG 360
TGGTTCTTCA GGAACATTTC GAGAAACGAA GCCATGAGGC TGCTCCTCGC TCCTGGGAAT 420
ACGCAGGGTT CCTTCCTGAT TCGAGAGAGT GAGACCGCTA AAGGATCATA CTCGTTATCA 480
GTGAGAGATC TGGACCATAA CACAGGTGAA GGAGTGAAGC ACTACAGGAT CCGCAACATG 540
GACAATGGTG GCTTCTACAT CACAGCGAAG ATATCCTTCA ACTCACTGAA GGAGCTCGTC 600
CAGCATCACT CACGTGATGC AGACGGGCTG TGCACAAAGC TGGTGAAACC ATGTCAGTCG 660
AGGGCACCGC AGAAGCCTTG GTGGCAGGAC GAGTGGGAGA TTCCTCGTGA GTCCCTGAAA 720
CTGGAGCGCA GGCTCGGAGC TGGGCAGTTT GGAGAAGTCT GGATGGGTGT CTACAACAAT 780
GACAGGAAAG TGGCAATCAA GAATCTGAAA ATGGGCACTA TGTCAGTGGA AGCTTTCTTG 840
GCAGAAGCCA ACATGATGAA GAACCTGCAG CATCCTCGCC TCGTCCGCCT CTTCGCTGTG 900
GTTACCCAGG AGCCAATCTA CATTGTCACC GAGTACATGG AAAATGGTAG CCTGGTGGAT 960
TACCTGAAAA CAACAGAGGG AAGCAATTTG CCCATGAACG TCCTGATAGA GATGTCATCT 1020
CAGGTGGCTG ACGGCATGGC ATTTATTGAG CAGAAAAATT ACATTCATCG AGATCTGCGA 1080
GCTGCCAATA TTCTCGTCTC TCATGAGCTC ATTTGCAAGG TTGCTGACTT TGGACTCGCC 1140
CGACTCATAG AGGACAACGA ATACACAGCC AGAGAGGGTG CAAAGTTCCC CATTAAATGG 1200
ACCGCCCCAG AAGCTATTAA CTATGGCACC TTCTCCATAA AATCTGATGT GTGGTCATTT 1260
GGGATCCTCC TTACAGAAAT AGTGACATAT GGACGCATTC CTTACCCTGG TATGTCTAAC 1320
CCAGAGGTTA TCCAGAACCT GGAGCGGGGC TACAGAATGC CACAGCCTGA CAACTGCTCC 1380
GATGCTCTTT ATAGCATCAT GTGTCACTGC TGGAAGGAGA GTCCGGAGGA GAGACCTACG 1440
TTTGAGTACC TGAGGAATGT TCTGGAGGAT TTCTTCACAT CCACAGAGAG GCAATACCAG 1500
GAATAG 1506
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lkl+++lG+GqfGevw+g +++  kva+k lk gt+s eafl+ea+++k+l+h++lv+l+
Q: 239   LKLERRLGAGQFGEVWMGVYNNDRKVAIKNLKMGTMSVEAFLAEANMMKNLQHPRLVRLF  298
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ ePiyivte+m++Gsl+d+lk++eg++l+++ l+++++qva+Gma++e+kn+ihr
Q: 299   AVVTQ-EPIYIVTEYMENGSLVDYLKTTEGSNLPMNVLIEMSSQVADGMAFIEQKNYIHR  357
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+++l++kvadfGlarlied+eyta+egak+PikWtaPeai++g+f+iksdv
Q: 358   DLRAANILVSHELICKVADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFSIKSDV  417
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillteivt+G++PypGm+n ev++++ergyr+p+p++c + ly+++++cwk++pee
Q: 418   WSFGILLTEIVTYGRIPYPGMSNPEVIQNLERGYRMPQPDNCSDALYSIMCHCWKESPEE  477
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe+l++vl
Q: 478   RPTFEYLRNVL  488
         *******9875
Domain Sequence
(FASTA)
LKLERRLGAG QFGEVWMGVY NNDRKVAIKN LKMGTMSVEA FLAEANMMKN LQHPRLVRLF 60
AVVTQEPIYI VTEYMENGSL VDYLKTTEGS NLPMNVLIEM SSQVADGMAF IEQKNYIHRD 120
LRAANILVSH ELICKVADFG LARLIEDNEY TAREGAKFPI KWTAPEAINY GTFSIKSDVW 180
SFGILLTEIV TYGRIPYPGM SNPEVIQNLE RGYRMPQPDN CSDALYSIMC HCWKESPEER 240
PTFEYLRNVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00347
EKS-BOT-00370
EKS-CAF-00371
EKS-CAP-00402
EKS-DAR-00750
EKS-DIO-00065
EKS-EQC-00361
EKS-ERE-00004
EKS-FEC-00358
EKS-GAM-00223
EKS-GAA-00453
EKS-GOG-00391
EKS-HOS-00376
EKS-ICT-00351
EKS-LAC-00385
EKS-LOA-00383
EKS-MEG-00303
EKS-MIM-00060
EKS-MOD-00357
EKS-MUM-00403
EKS-MUP-00365
EKS-MYL-00368
EKS-OCP-00080
EKS-ORC-00349
EKS-ORL-00441
EKS-OTG-00374
EKS-PES-00333
EKS-POA-00359
EKS-RAN-00384
EKS-SAH-00340
EKS-SOA-00006
EKS-SUS-00324
EKS-TAR-00475
EKS-TEN-00475
EKS-TUT-00115
EKS-XET-00485
EKS-XIM-00468
Gene Ontology
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013