EKS-ORN-00199

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00199

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	484.6	8.2E-146	416	673	258

Status

Unreviewed

Ensembl Protein

ENSONIP00000010338

UniProt Accession

I3JN95;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA3

Gene Synonyms/Alias

RPS6KA3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000008212	ENSONIP00000010339	ENSONIT00000010348
ENSONIG00000008212	ENSONIP00000010338	ENSONIT00000010347

Organism

Oreochromis niloticus

Functional Description

Protein Length

734

Protein Sequence
(FASTA)

MPLAQLADPW QKMPLGRTAG EDAHHDPEDS VGEDDSMSVC TDDVPIKEIS ITHHVKEGSE 60

KADPRQFELR KVLGQGSFGK VFLVRKITGP DAGQLYAMKV LKKATLKVRD RVRTKMERDI 120

LVEVNHPFIV KLHYAFQTEG KLYLILDFLR GGDLFTRLSK EVMFTEEDVK FYLAELALAL 180

DHLHGLGIIY RDLKPENILL DEEGHIKLTD FGLSKESIDH ENKAYSFCGT VEYMAPEVVN 240

RRGHTHSADW WSYGVLMFEM LTGTLPFQGK DRKETMTMIL KAKLGMPQFL SSEAQSLLRN 300

LFKRNPGNRL GAGPDGVEEI KRHHFFSTID WNKLYRREIH PPFKPAAGRP DDTFYFDPEF 360

TAKTPRDSPG VPPSANAHQL FRGFSFVAIT EEETQPLPNA IVQQLHRSTS QFADAYEIKE 420

DIGVGSYSIC KRCIHKGTGM EYAVKIINKS KRDPTEEVEI LLRYGQHPNI ITLKDVYDDG 480

RSVFLVTELM KGGELLDKIL RQKFFSEREA SAVLYTITKT VEYLHVQGVV HRDLKPSNIL 540

YVDESGNAES IRICDFGFAK QLRAENGLLM TPCYTANFVA PEVLKKQGYD AACDIWSLGV 600

LLYTMLTGFT PFANGPEDTP EEILARIGSG KFSLSGGYWN SVSTEAKDLV SKMLHVDPHQ 660

RLTAGQVLRH PWVTHRDQLP KYTLNRQDAP HLVKGAMAAT YSALNRNVPP VLEPVGCSTL 720

AQRRGLKKIT STAL 734

Nucleotide Sequence
(FASTA)

ATGCCTCTGG CTCAGCTGGC GGATCCCTGG CAGAAGATGC CGCTGGGGAG GACGGCTGGA 60

GAGGATGCAC ATCATGATCC CGAGGACTCG GTGGGCGAGG ACGATTCGAT GTCTGTCTGC 120

ACGGATGACG TCCCGATTAA GGAGATCAGC ATCACTCACC ACGTGAAGGA AGGGTCGGAA 180

AAGGCCGACC CTCGGCAGTT CGAGCTGCGC AAAGTCCTGG GACAGGGCTC GTTTGGAAAG 240

GTGTTTCTGG TGAGGAAGAT CACAGGACCG GACGCTGGTC AGCTGTACGC CATGAAGGTG 300

TTGAAGAAAG CCACACTGAA AGTGCGTGAC CGGGTCAGGA CAAAGATGGA GAGAGACATC 360

CTGGTGGAGG TCAACCATCC CTTCATCGTC AAACTGCACT ACGCATTTCA GACGGAGGGG 420

AAGCTCTACC TGATCCTGGA TTTTCTCCGA GGAGGCGACC TCTTCACTCG TCTCTCTAAG 480

GAGGTAATGT TCACAGAGGA AGACGTGAAG TTCTACCTGG CAGAGCTCGC TCTGGCCCTC 540

GATCACCTCC ACGGGCTCGG CATCATTTAC AGAGACCTCA AACCTGAGAA CATCCTGCTC 600

GATGAGGAGG GACACATCAA GCTGACCGAC TTCGGCCTCA GCAAGGAGTC GATAGACCAC 660

GAGAACAAGG CCTACTCTTT CTGCGGCACG GTGGAGTACA TGGCTCCAGA GGTGGTGAAC 720

AGGCGGGGAC ACACGCACAG CGCCGACTGG TGGTCATACG GCGTTCTCAT GTTTGAGATG 780

CTGACGGGAA CGCTGCCGTT TCAAGGAAAA GACCGGAAAG AGACGATGAC CATGATCCTC 840

AAGGCCAAGC TGGGAATGCC GCAGTTTCTC AGCTCCGAAG CTCAGAGTCT CCTCAGGAAC 900

CTTTTCAAGC GAAACCCCGG CAACAGATTA GGAGCTGGGC CGGATGGAGT GGAGGAGATC 960

AAGAGGCATC ATTTCTTCAG CACCATCGAC TGGAATAAGC TGTACCGCAG AGAAATCCAC 1020

CCTCCTTTCA AGCCAGCAGC GGGGCGACCT GACGACACTT TCTATTTTGA TCCAGAGTTC 1080

ACAGCTAAAA CACCCAGAGA CTCGCCGGGG GTCCCGCCGA GCGCCAACGC CCATCAGCTG 1140

TTCAGAGGGT TCAGCTTTGT GGCCATAACG GAGGAGGAGA CGCAACCACT ACCCAACGCT 1200

ATTGTACAGC AACTTCACAG AAGCACGTCC CAGTTCGCAG ACGCCTACGA GATCAAAGAG 1260

GACATCGGAG TCGGCTCCTA CTCCATCTGC AAGCGCTGCA TACACAAAGG AACCGGCATG 1320

GAGTACGCAG TCAAGATTAT CAACAAGTCC AAGAGAGACC CGACGGAGGA GGTGGAGATC 1380

CTGCTGAGAT ACGGGCAGCA CCCCAACATC ATCACCCTCA AAGACGTGTA TGACGACGGC 1440

CGGTCGGTGT TCCTGGTGAC GGAGCTGATG AAGGGAGGCG AGCTGCTGGA CAAAATCCTC 1500

CGTCAGAAGT TTTTCTCCGA GCGGGAAGCC AGCGCTGTTC TCTACACCAT CACCAAGACG 1560

GTGGAGTACC TGCACGTGCA AGGGGTGGTG CACAGAGACC TGAAGCCCAG TAACATCCTG 1620

TACGTGGACG AGAGCGGGAA CGCCGAGTCC ATCAGGATCT GCGACTTTGG CTTCGCCAAG 1680

CAGCTGAGAG CGGAGAACGG CCTGCTCATG ACGCCGTGTT ACACCGCCAA CTTCGTCGCC 1740

CCTGAGGTGT TGAAGAAGCA GGGTTATGAC GCAGCCTGCG ACATCTGGAG TCTCGGAGTC 1800

CTGCTCTACA CGATGCTAAC AGGTTTCACT CCATTTGCTA ACGGTCCAGA GGACACCCCG 1860

GAGGAGATTT TGGCTCGGAT CGGCAGCGGG AAGTTCTCGC TCAGCGGAGG ATACTGGAAC 1920

TCTGTCTCAA CTGAAGCTAA GGACCTGGTG TCTAAGATGC TGCACGTCGA CCCCCACCAG 1980

CGGCTGACAG CAGGGCAGGT CCTCAGACAC CCGTGGGTGA CGCACAGAGA CCAGCTACCC 2040

AAATACACCC TCAACAGACA GGACGCACCA CACCTCGTCA AGGGTGCGAT GGCGGCCACC 2100

TACTCTGCCC TTAACAGGAA TGTCCCCCCG GTCCTAGAGC CGGTGGGCTG CTCCACTCTG 2160

GCCCAGCGGC GGGGGTTGAA GAAGATCACT TCCACCGCTC TGTGA 2205

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         ye+ked+GvGsys+ckrc+hk t++e+avkii+kskrd++ee+eillry+qhpni+tlkd

Q: 416   YEIKEDIGVGSYSICKRCIHKGTGMEYAVKIINKSKRDPTEEVEILLRYGQHPNIITLKD  475

         789*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyddg+ v+lv+el+kGGelld+i+++kffsereasa+l+t++k+veylh qGvvhrdlk

Q: 476   VYDDGRSVFLVTELMKGGELLDKILRQKFFSEREASAVLYTITKTVEYLHVQGVVHRDLK  535

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nilyvdes+naesi+i+dfGfak++raengll+tpcyt+nfvapevlk+qGyd+acd+

Q: 536   PSNILYVDESGNAESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKKQGYDAACDI  595

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslGvllytml+G++pfangpedt+eeila+i++GkfslsG++w+svs eakdlvsk+l+

Q: 596   WSLGVLLYTMLTGFTPFANGPEDTPEEILARIGSGKFSLSGGYWNSVSTEAKDLVSKMLH  655

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl++ q+l+h+w+

Q: 656   VDPHQRLTAGQVLRHPWV  673

         *****************7

Domain Sequence
(FASTA)

YEIKEDIGVG SYSICKRCIH KGTGMEYAVK IINKSKRDPT EEVEILLRYG QHPNIITLKD 60

VYDDGRSVFL VTELMKGGEL LDKILRQKFF SEREASAVLY TITKTVEYLH VQGVVHRDLK 120

PSNILYVDES GNAESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK KQGYDAACDI 180

WSLGVLLYTM LTGFTPFANG PEDTPEEILA RIGSGKFSLS GGYWNSVSTE AKDLVSKMLH 240

VDPHQRLTAG QVLRHPWV 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013