EKS-ORN-00196

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00196

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	605.2	2.0E-182	410	688	279

Status

Unreviewed

Ensembl Protein

ENSONIP00000011004

UniProt Accession

I3JQ59;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK1 (1 of 2)

Gene Synonyms/Alias

TLK1 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000008753	ENSONIP00000011003	ENSONIT00000011012
ENSONIG00000008753	ENSONIP00000011004	ENSONIT00000011013

Organism

Oreochromis niloticus

Functional Description

Protein Length

718

Protein Sequence
(FASTA)

PGTMEELHSL DPRRQELLEA RFMGGVSGST GGSTGSASGG TKGLTNNECS NHSFGSLGSS 60

SDKESETPEK KQTETTRGRK RKPEIQSESS QGKSSVRGPK ISDYFDFQGG NGSSPVRGPP 120

PVIRSPQNSH SHSTQGTSVR QNSSSPISLS FGDHMAHPKQ LAVKFVQTDL TVLKLAALES 180

TKNLDLEKKE GRIDDLLRAN CDLRRQIDEQ QKLLEKYKER LNKCITMSKK LLIEKSTQEK 240

QACREKSMQD RLRLGHFTTV RHGASFTEQW TDGYAFQNLV KQQEWINQQR EDIERQRKLL 300

AKRKPPSSNN SQTPTTNSEP KQRKTKAVNG AENDPFLKPS LPQLLTLAEY HEQEEIFKLR 360

LGHLKKEEAE IQAELERLER VRNLHIRELK RINNEDSSQF KDHPTLNERY LLLHLLGRGG 420

FSEVYKAFDL IEQRYAAVKI HQLNKNWREE KKENYHKHAC REYRIHKELD HPRIVKLYDY 480

FSLDTDTFCT VMEYCEGNDL DFYLKQHKLM SEKEARSIVM QIVNALKYLN EIKPPIIHYD 540

LKPGNILLVD GTACGEIKIT DFGLSKIMDD DNYGVDGMDL TSQGAGTYWY LPPECFVVGK 600

EPPKISNKVD VWSVGVIFFQ CLYGRKPFGH NQSQQDILQE NTILKATDVQ FPVKPVSSNE 660

AKAFIRRCLA YRKEDRIDVH QLGSDPYLLP HIRRSSSSGN LQMSAAVSSP ASSSNISY 718

Nucleotide Sequence
(FASTA)

CCAGGCACCA TGGAGGAGCT GCACAGCCTG GACCCCCGGA GACAGGAGCT GCTGGAGGCT 60

CGTTTTATGG GCGGAGTCAG CGGCAGCACA GGGGGCAGCA CTGGCAGCGC AAGCGGGGGA 120

ACCAAAGGCT TGACCAATAA TGAATGTTCA AATCACAGTT TTGGAAGTCT AGGATCTTCA 180

AGTGACAAGG AGTCGGAGAC CCCAGAGAAG AAACAGACTG AAACAACTAG AGGCAGAAAA 240

AGGAAACCTG AGATCCAGTC AGAGAGCAGC CAAGGAAAAT CATCTGTGCG AGGACCCAAA 300

ATAAGTGATT ATTTCGACTT CCAGGGAGGA AATGGGTCCA GTCCTGTGAG AGGTCCCCCA 360

CCAGTGATTC GTTCGCCCCA GAATTCACAT TCCCACTCGA CTCAGGGCAC TTCTGTTAGA 420

CAAAATAGCT CATCTCCTAT TAGTCTGTCT TTTGGGGACC ATATGGCACA TCCAAAGCAA 480

CTAGCAGTCA AATTTGTTCA GACTGACCTT ACAGTGTTAA AATTGGCTGC CCTTGAAAGC 540

ACCAAGAATC TAGACCTTGA AAAGAAGGAG GGCAGGATAG ATGACCTGTT AAGGGCAAAC 600

TGTGATCTCA GGAGACAGAT AGATGAACAG CAAAAATTAC TCGAGAAATA CAAGGAACGC 660

TTGAATAAGT GCATCACCAT GAGCAAGAAG TTACTTATAG AAAAGAGCAC CCAGGAGAAG 720

CAGGCCTGTC GGGAGAAGAG CATGCAGGAT AGACTACGTT TAGGCCACTT TACTACAGTG 780

AGACATGGGG CCTCATTCAC AGAGCAGTGG ACAGATGGCT ATGCCTTCCA AAACCTTGTC 840

AAGCAGCAGG AGTGGATAAA CCAACAGAGA GAAGACATTG AGAGGCAGAG GAAACTTCTT 900

GCCAAGAGGA AACCTCCATC TTCCAACAAC TCCCAAACAC CAACCACAAA TTCTGAGCCA 960

AAGCAACGGA AAACCAAGGC GGTGAATGGA GCAGAAAACG ATCCCTTTCT AAAACCCAGC 1020

CTACCTCAGC TGCTGACATT AGCAGAGTAC CACGAACAGG AAGAGATCTT CAAACTGCGA 1080

CTTGGACATC TGAAAAAGGA AGAAGCTGAG ATCCAGGCAG AGCTCGAGCG TCTGGAGAGA 1140

GTGCGCAACC TTCACATTCG GGAACTGAAG AGAATAAATA ACGAAGACAG CTCACAATTT 1200

AAAGATCACC CAACGTTGAA TGAAAGATAC CTGCTCCTGC ATCTTCTGGG TAGAGGAGGC 1260

TTTAGTGAAG TTTACAAGGC TTTTGACTTG ATTGAACAAC GATACGCTGC TGTGAAAATC 1320

CACCAACTTA ACAAAAACTG GAGAGAAGAA AAAAAAGAGA ACTATCACAA GCATGCATGT 1380

CGAGAGTACA GAATACACAA GGAGTTGGAC CATCCCAGGA TTGTGAAACT TTATGACTAC 1440

TTCTCACTGG ACACAGACAC GTTTTGCACC GTTATGGAGT ACTGCGAGGG CAACGACCTG 1500

GATTTCTACT TGAAGCAGCA TAAATTAATG TCTGAGAAGG AGGCACGGTC CATAGTCATG 1560

CAGATTGTAA ATGCACTAAA ATACCTGAAT GAAATCAAAC CTCCCATCAT CCATTATGAC 1620

CTTAAACCAG GTAATATCTT GTTGGTGGAT GGCACAGCCT GTGGGGAAAT TAAAATCACT 1680

GACTTTGGCC TTTCCAAAAT TATGGATGAT GACAACTACG GCGTAGATGG GATGGACCTG 1740

ACATCACAGG GTGCAGGAAC CTACTGGTAC TTGCCTCCTG AGTGTTTTGT GGTTGGTAAA 1800

GAACCTCCAA AGATCTCCAA CAAGGTGGAT GTGTGGTCTG TGGGTGTCAT CTTTTTCCAG 1860

TGTCTGTATG GAAGGAAGCC TTTTGGCCAC AATCAGTCAC AACAAGATAT CCTGCAGGAG 1920

AACACCATAC TCAAAGCTAC CGACGTTCAG TTCCCTGTGA AGCCAGTTTC CAGTAACGAA 1980

GCAAAGGCTT TCATACGGCG GTGCCTGGCA TACAGGAAGG AGGACCGGAT TGACGTTCAC 2040

CAGCTGGGAA GTGACCCCTA CTTGCTCCCT CACATCCGGA GATCAAGCTC CTCTGGAAAT 2100

CTGCAAATGA GTGCTGCGGT CTCAAGTCCA GCCTCCTCCA GCAACATCTC ATATTGA 2157

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl eqry+avkihqlnk+w++ekkeny+kha+reyrihkel

Q: 410   YLLLHLLGRGGFSEVYKAFDLIEQRYAAVKIHQLNKNWREEKKENYHKHACREYRIHKEL  469

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtd+fctv+ey+egndldfylkqhkl+sekearsi+mqiv+alkyl

Q: 470   DHPRIVKLYDYFSLDTDTFCTVMEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALKYL  529

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimddd+y++d g++ltsqgagty

Q: 530   NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDNYGVD-GMDLTSQGAGTY  588

         *********************************************99.************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvif+qclyg+kpfghnqsqqdil+entilkat+

Q: 589   WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATD  648

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpv s+eakafirrclayrkedridv+ql +d+yl

Q: 649   VQFPVKPVSSNEAKAFIRRCLAYRKEDRIDVHQLGSDPYL  688

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LIEQRYAAVK IHQLNKNWRE EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDTFC TVMEYCEGND LDFYLKQHKL MSEKEARSIV MQIVNALKYL 120

NEIKPPIIHY DLKPGNILLV DGTACGEIKI TDFGLSKIMD DDNYGVDGMD LTSQGAGTYW 180

YLPPECFVVG KEPPKISNKV DVWSVGVIFF QCLYGRKPFG HNQSQQDILQ ENTILKATDV 240

QFPVKPVSSN EAKAFIRRCL AYRKEDRIDV HQLGSDPYL 279

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013