EKS-ORN-00048

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00048

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	310.7	1.2E-92	876	1149	274

Status

Unreviewed

Ensembl Protein

ENSONIP00000011064

UniProt Accession

I3JQC0;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK1

Gene Synonyms/Alias

JAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000008800	ENSONIP00000011064	ENSONIT00000011073

Organism

Oreochromis niloticus

Functional Description

Protein Length

1159

Protein Sequence
(FASTA)

MPTLYMMELG RQLCLKMRKP RKPQTSSSPA SIKGLEIHFY RPDIDPLKYP KGHYTAENLC 60

VEAAKKCSIS PLCHNLFALY DELTDTWYPP NYEFEVTDET SIKLHYRMRF YFRNWHSSIE 120

GEPYVWRHCI SKLKGNSPQK IPEGTPLLDA DSLTYLFTQS QNDFQTGVVP LRSPQSEAEQ 180

HEIENECLGM AVLAITHYAM NEKMPLSTAS HEISYKRFIP DSLNRNIKQR NILTRIRINN 240

VFKKFLTEFN SRTVKDSNIT TYDLKIKYLA TLEGLVSSMG SEVFEPSSLS VIQEGDLCNA 300

FPMADSITAT EVLVTGTTGI SWRKKPATSS VACREKGKSK KNKHDAKQKT DKKKDANEGW 360

VVFCDFHEIT HTVIKEAMVT IYKQDNKKME LLMDTRAEAL SFAALVDGYF RLTVDAHHYL 420

CKEVAPASVV HNITNGCHGP ISTEYAVQKL RQEGNEEGAY ILRWSCTEYQ YIIITVVCSE 480

IDLRESRPVR QYKNFQIEVT PSSFTLHGTD TSQSTLKELL EHLEGQNLRS DNLQFQLVRC 540

CPPQPREISN LLVATKNRAT APKRHMPGNQ VSFPRILKED IEQEEHLGIG TKTNIYSGTL 600

KVKGEEEEDA GYTSFQEVKV VLKVLGSGHR DISMAFFETA SKMQQVSHKH IVLLYGVCVH 660

HQENIMVEEF VQLGPLDVFM RRQQTPLSTS WKFQVALQLA SALSYLEDKK LVHGFVCAKN 720

ILLARDGLGN DEGGPFIKLS DPGIPITVLT REECVHRIPW IAPECVRNAS SLGVAADKWG 780

FGTTLWEICY DGEVPLKDKK LTEKERFYET ECQLATPDCT ELAELMTHCM NYDPKKRPFF 840

RAIVREMDQL IEKNPSIKPQ PTPDVDPTMF EKRFLRKIRD LGEGHFGKVE LCRYDPRGDR 900

TGELVAVKSL KPENREEQSN NLSREIDILK DLYHENIVKY KGISQEEGGQ AIKLIMEYLP 960

LGSLKEYLPR NRARISIPTL LSYSVQICKG MDYLGSQNYI HRDLAARNVL MENETTVKIG 1020

DFGLTKSIKD NEGYYTVKDE NDSPVFWYAP ECLTLCKFYL ASDVWSFGVT MYELLTYCDS 1080

AKSPMTCFLE MIGKTHGQMT IIRLVKVLQE GKRLPCPKDC PDSVYELMRR CWEQSPERRI 1140

TFKRLIEELT TAQQLAQQQ 1159

Nucleotide Sequence
(FASTA)

ATGCCAACTT TGTACATGAT GGAGTTGGGC AGGCAACTCT GTTTGAAGAT GAGGAAACCT 60

AGGAAACCCC AGACTTCTTC CTCACCTGCT TCCATTAAAG GCCTGGAAAT CCACTTTTAC 120

AGACCCGACA TTGACCCACT GAAATACCCA AAAGGCCACT ATACTGCCGA GAACCTCTGT 180

GTGGAAGCTG CCAAGAAATG CTCTATCTCT CCCTTGTGCC ATAACCTATT TGCCCTGTAC 240

GATGAGCTCA CTGACACTTG GTATCCCCCA AACTACGAGT TCGAGGTCAC AGATGAAACC 300

AGTATCAAGT TGCACTATCG CATGAGGTTT TATTTCAGAA ACTGGCATAG CTCCATTGAA 360

GGAGAGCCAT ATGTCTGGAG GCACTGCATC AGTAAACTCA AAGGAAACAG CCCACAGAAA 420

ATACCAGAGG GAACACCGTT ACTGGATGCT GACTCCTTGA CTTACCTGTT TACTCAGAGC 480

CAAAATGACT TTCAGACTGG CGTAGTTCCA CTCAGGAGCC CCCAGTCAGA GGCAGAGCAA 540

CATGAGATAG AAAATGAGTG TTTGGGCATG GCTGTGCTTG CAATCACTCA CTACGCCATG 600

AACGAGAAAA TGCCTCTGTC CACTGCTTCC CATGAAATCA GCTACAAACG TTTCATCCCA 660

GATTCGCTGA ACCGCAACAT TAAGCAGCGT AACATTCTGA CACGGATCCG CATCAACAAC 720

GTGTTCAAGA AATTCCTCAC TGAATTCAAC AGTCGCACAG TGAAAGATAG CAACATCACG 780

ACATACGACC TGAAGATCAA GTACCTGGCC ACATTGGAGG GCCTGGTCAG CAGCATGGGC 840

AGTGAGGTTT TTGAGCCTTC TTCACTTAGT GTAATTCAGG AGGGAGACTT ATGCAATGCA 900

TTTCCTATGG CAGATAGCAT CACCGCCACA GAGGTCCTGG TTACCGGCAC CACTGGTATT 960

TCCTGGAGGA AGAAGCCCGC TACATCGTCC GTGGCCTGTA GAGAAAAAGG AAAGTCGAAG 1020

AAGAACAAAC ATGATGCAAA ACAGAAGACT GACAAAAAGA AAGATGCAAA CGAAGGCTGG 1080

GTGGTCTTCT GTGACTTCCA TGAGATCACG CATACTGTCA TCAAAGAGGC AATGGTCACC 1140

ATCTATAAAC AGGACAACAA GAAGATGGAG CTACTGATGG ATACAAGGGC AGAGGCTCTG 1200

TCCTTTGCAG CCCTTGTGGA CGGGTACTTC AGGCTGACCG TAGATGCCCA TCACTACCTG 1260

TGCAAGGAGG TGGCTCCGGC TTCAGTGGTA CACAACATCA CCAATGGTTG CCACGGACCC 1320

ATCAGTACGG AGTACGCTGT CCAAAAGCTG CGTCAGGAGG GCAATGAGGA GGGTGCCTAC 1380

ATCCTGCGCT GGAGCTGTAC TGAATACCAG TACATCATCA TCACTGTGGT TTGCAGTGAG 1440

ATTGACTTGA GGGAGTCTCG TCCTGTGCGC CAATACAAGA ACTTCCAGAT TGAGGTTACC 1500

CCCAGTTCCT TCACTCTACA CGGCACAGAT ACATCACAAT CCACTCTCAA GGAGCTGCTT 1560

GAGCACCTGG AGGGCCAGAA TCTGCGCAGC GATAACCTTC AGTTCCAGTT GGTTCGCTGC 1620

TGCCCCCCAC AGCCAAGAGA GATTTCGAAT CTCCTTGTGG CCACCAAAAA CAGAGCAACA 1680

GCCCCTAAGA GACACATGCC AGGCAATCAA GTCAGCTTCC CACGCATTCT CAAAGAGGAC 1740

ATTGAACAGG AGGAGCACCT AGGTATAGGT ACAAAAACCA ACATTTACTC GGGCACTCTG 1800

AAGGTGAAGG GTGAGGAGGA GGAGGATGCA GGATATACAT CCTTCCAGGA AGTCAAAGTG 1860

GTCCTAAAGG TGCTGGGCTC TGGACACAGG GACATCTCCA TGGCTTTCTT TGAAACGGCC 1920

AGTAAGATGC AACAAGTGTC CCATAAACAT ATTGTGCTGC TCTATGGAGT GTGTGTCCAC 1980

CACCAGGAGA ATATCATGGT GGAGGAGTTT GTCCAGCTAG GACCACTGGA TGTGTTTATG 2040

AGGAGACAAC AGACTCCACT CAGCACATCG TGGAAGTTCC AGGTGGCCTT GCAGTTGGCA 2100

TCAGCCCTCA GTTACTTGGA GGACAAAAAG CTGGTCCATG GCTTTGTGTG TGCTAAAAAC 2160

ATACTGCTGG CCAGAGACGG ACTCGGTAAC GATGAAGGAG GGCCATTCAT TAAGCTCAGC 2220

GACCCAGGAA TACCAATCAC AGTGCTCACT AGAGAGGAGT GTGTGCATCG TATCCCATGG 2280

ATCGCTCCAG AGTGTGTGAG GAATGCTTCG TCACTGGGTG TCGCAGCTGA CAAATGGGGA 2340

TTCGGTACCA CTCTGTGGGA GATCTGCTAT GATGGCGAGG TTCCACTCAA AGACAAGAAG 2400

CTCACAGAGA AGGAGAGATT TTATGAAACA GAGTGCCAAC TGGCCACCCC GGACTGCACA 2460

GAGCTAGCTG AACTCATGAC CCACTGCATG AACTATGACC CCAAGAAGAG ACCTTTCTTC 2520

AGGGCTATTG TCAGAGAGAT GGATCAGCTC ATAGAAAAAA ACCCTTCTAT CAAACCCCAG 2580

CCAACACCAG ATGTTGACCC AACCATGTTT GAAAAGAGAT TTCTCAGGAA GATCAGAGAT 2640

CTGGGAGAGG GTCACTTTGG TAAGGTGGAG CTATGCCGCT ATGACCCTAG GGGGGACCGA 2700

ACGGGCGAGC TGGTGGCTGT GAAGTCGCTG AAGCCTGAGA ACCGAGAAGA GCAGAGCAAC 2760

AACCTCTCCA GAGAGATCGA CATCCTGAAG GATCTCTACC ATGAAAACAT AGTCAAATAT 2820

AAGGGCATTT CCCAAGAAGA AGGTGGTCAG GCTATTAAGC TGATCATGGA GTATCTTCCA 2880

CTGGGCAGCT TGAAGGAGTA TCTGCCCAGA AACAGAGCCA GGATTAGCAT CCCCACCTTG 2940

CTCAGCTACT CTGTGCAGAT ATGCAAGGGA ATGGACTATT TGGGATCTCA AAATTACATC 3000

CACCGTGACC TGGCTGCCCG AAACGTGCTG ATGGAGAACG AGACGACTGT GAAGATTGGA 3060

GACTTTGGCC TCACGAAGAG CATCAAGGAT AACGAAGGTT ATTACACAGT CAAGGACGAG 3120

AATGACAGCC CTGTTTTCTG GTATGCTCCA GAGTGTCTGA CTCTCTGTAA GTTTTACCTT 3180

GCTTCAGACG TTTGGTCCTT TGGGGTGACG ATGTATGAAC TCCTCACTTA CTGCGACTCT 3240

GCCAAGAGCC CGATGACGTG CTTCCTTGAA ATGATTGGTA AAACTCATGG TCAGATGACT 3300

ATCATCCGAT TGGTGAAGGT GTTGCAAGAA GGAAAGAGGC TGCCATGTCC TAAGGACTGT 3360

CCTGACTCTG TGTATGAGCT GATGCGAAGA TGCTGGGAGC AGTCACCCGA GAGGAGGATC 3420

ACCTTCAAGC GCCTGATCGA GGAGCTCACC ACCGCTCAAC AGCTCGCCCA ACAGCAG 3477

Domain Profile

S: 2     kqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlshe  60

         ++i++Lg+g+f+kv+++r+d++gd t+e va+k Lk e  e++s+++ re++il+ l+he

Q: 876   RKIRDLGEGHFGKVELCRYDPRGDRTGELVAVKSLKpENREEQSNNLSREIDILKDLYHE  935

         6799********************************999999******************

S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118

         +ivk+kg++ +eg +  +l+mey++ GsL++yL+++++++s++ ll+++ q++k+m+YL+

Q: 936   NIVKYKGISQEEGGQaiKLIMEYLPLGSLKEYLPRNRARISIPTLLSYSVQICKGMDYLG  995

         ************9999********************************************

S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177

         +++++hrd+aarnvL+e+e        vk++d+gl+k ++ +  Yy+v++e ds+++w+a

Q: 996   SQNYIHRDLAARNVLMENETT------VKIGDFGLTKSIKDNeGYYTVKDENDSPVFWYA  1049

         *********************......************9999*****************

S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklell  225

         pecl+ +k +++asdvWsFgvt+yellt c++ +sp    l++++ +       r++++l

Q: 1050  PECLTLCK-FYLASDVWSFGVTMYELLTyCDSAKSPmtcfLEMIGKThgqmtiiRLVKVL  1108

         ********.***************************999988888778888888******

S: 226   eekerlpkpk.cpaelaelmtnclsyepsqrpsFrailedl  265

         +e++rlp+pk cp+ ++elm++c++++p++r++F+ ++e+l

Q: 1109  QEGKRLPCPKdCPDSVYELMRRCWEQSPERRITFKRLIEEL  1149

         *************************************9986

Domain Sequence
(FASTA)

RKIRDLGEGH FGKVELCRYD PRGDRTGELV AVKSLKPENR EEQSNNLSRE IDILKDLYHE 60

NIVKYKGISQ EEGGQAIKLI MEYLPLGSLK EYLPRNRARI SIPTLLSYSV QICKGMDYLG 120

SQNYIHRDLA ARNVLMENET TVKIGDFGLT KSIKDNEGYY TVKDENDSPV FWYAPECLTL 180

CKFYLASDVW SFGVTMYELL TYCDSAKSPM TCFLEMIGKT HGQMTIIRLV KVLQEGKRLP 240

CPKDCPDSVY ELMRRCWEQS PERRITFKRL IEEL 274

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776	; Tyr_kinase_non-rcpt_Jak1.

Pfam

PF07714	; Pkinase_Tyr; 2.
PF00017	; SH2; 1.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR01824	; JANUSKINASE1.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013