EKS-ORN-00192

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00192

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	362.4	2.1E-108	56	317	262

Status

Unreviewed

Ensembl Protein

ENSONIP00000011257

UniProt Accession

I3JQW4;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB2

Gene Synonyms/Alias

RPS6KB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000008956	ENSONIP00000011258	ENSONIT00000011267
ENSONIG00000008956	ENSONIP00000011257	ENSONIT00000011266

Organism

Oreochromis niloticus

Functional Description

Protein Length

472

Protein Sequence
(FASTA)

MAGVFDIDLE TEDISDTEDD VCDFTVPEPE NAQTEEVELT SESVNRDRER VGPDCFELLT 60

VLGKGAYGKV FQVRKVQGAQ TGRIFAMKVL KKAKIVCNAK DTAHTRAERE ILETVRHPFI 120

VDLLYAFQTG GKLYLILECL SGGELFMQLE KEGIFMEDTA CFYLGEITLA LGHLHSNGII 180

YRDLKPENIM LNHQGHIKLT DFGLCKESIH DGSVTHTFCG TIEYMAPEIL TRSGHNRAVD 240

WWSLGALMYD MMTGSPPFTA ENRKKTIDKI LKCKLSLPPY LTIDARDLVK KLLKKNPAQR 300

LGSSKADCAD IQKHAFFKHV IWDDLLHRRV EPPYKPQLQS DEDVSQFDTR FTRQTPVDSP 360

DDTSLSHSAE LAFAGFTYVA PSVLESLKEG FSFEPRARNV RRHNSSPRTP ISPLKFSPAG 420

PFKSSIDGEP DPFSPMSPPT AAAPVSMPKE NGAASQPIKT PARNKKLKGH RR 472

Nucleotide Sequence
(FASTA)

ATGGCAGGAG TGTTCGACAT CGACTTGGAG ACTGAGGACA TCAGTGACAC AGAGGATGAT 60

GTGTGCGACT TCACTGTGCC AGAACCAGAA AATGCCCAGA CGGAGGAGGT GGAGCTGACC 120

AGTGAAAGTG TCAACAGGGA CCGTGAGAGA GTCGGACCGG ACTGCTTTGA GCTTCTTACA 180

GTGCTGGGAA AAGGAGCTTA TGGCAAAGTT TTCCAAGTGA GGAAGGTTCA AGGGGCTCAG 240

ACAGGGAGAA TTTTTGCCAT GAAGGTCCTG AAAAAGGCAA AGATAGTGTG CAACGCTAAA 300

GACACGGCCC ATACGCGAGC AGAGCGAGAG ATCCTGGAGA CGGTGAGGCA CCCGTTCATC 360

GTAGATCTCC TGTACGCCTT CCAGACTGGA GGAAAACTCT ACCTCATCTT GGAGTGTCTG 420

AGCGGAGGAG AGTTGTTCAT GCAGCTGGAG AAGGAAGGCA TCTTCATGGA GGACACTGCC 480

TGCTTCTATC TTGGAGAGAT CACTCTGGCC CTCGGTCACC TCCACTCTAA CGGGATTATT 540

TATCGGGACC TGAAACCTGA AAACATCATG CTCAATCACC AAGGACACAT CAAGCTGACT 600

GACTTTGGGC TCTGCAAAGA ATCGATTCAC GATGGATCCG TCACACACAC CTTCTGCGGC 660

ACCATCGAGT ACATGGCTCC AGAGATCCTG ACCAGGTCGG GTCACAACAG AGCGGTGGAC 720

TGGTGGAGCC TCGGGGCGCT CATGTACGAT ATGATGACTG GATCGCCTCC GTTCACGGCG 780

GAAAACAGGA AGAAGACCAT CGACAAGATC TTGAAGTGTA AACTCAGCCT GCCGCCGTAC 840

CTGACAATCG ATGCCAGAGA CCTCGTCAAA AAGCTGTTGA AGAAAAACCC AGCCCAAAGA 900

CTTGGCTCCA GTAAAGCAGA CTGTGCTGAC ATCCAGAAAC ACGCCTTCTT TAAACACGTT 960

ATCTGGGACG ACCTGCTGCA TAGGAGAGTG GAGCCGCCGT ATAAGCCACA GCTGCAGTCG 1020

GATGAGGATG TGAGCCAGTT TGACACCAGG TTTACCAGAC AGACGCCGGT GGACAGTCCA 1080

GATGACACTT CGCTCAGCCA CAGCGCAGAG CTCGCCTTCG CTGGTTTCAC ATACGTGGCT 1140

CCATCGGTCC TCGAGAGTCT AAAGGAAGGC TTCTCATTCG AACCCCGAGC GAGAAATGTA 1200

CGCCGACACA ACAGCAGCCC ACGCACGCCC ATCAGTCCTT TAAAATTTTC CCCCGCTGGG 1260

CCGTTCAAGT CCAGCATCGA CGGAGAGCCA GACCCTTTCT CTCCGATGTC TCCACCGACA 1320

GCGGCAGCTC CGGTTTCCAT GCCGAAGGAA AACGGAGCCG CCAGTCAGCC AATCAAAACC 1380

CCTGCGAGGA ACAAGAAGCT GAAAGGACAT CGGAGATGA 1419

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkGaygkvf+vrkv++ +tg+++a+Kvlkka++v   k++++t++ereiLe+v

Q: 56    FELLTVLGKGAYGKVFQVRKVQGAQTGRIFAMKVLKKAKIVCnaKDTAHTRAEREILETV  115

         89**************************************9999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+k+++f+e++a+f+l e++lal +lH

Q: 116   RHPFIVDLLYAFQTGGKLYLILECLSGGELFMQLEKEGIFMEDTACFYLGEITLALGHLH  175

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         s+g++yrDLkpeNi+l+++gh+kltDfgl+ke+i ++++ +++fcgT+ey+aPe+l+r+g

Q: 176   SNGIIYRDLKPENIMLNHQGHIKLTDFGLCKESI-HDGSVTHTFCGTIEYMAPEILTRSG  234

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+m+tG++Pft+e+rk+t+++ilk+k  l+lp +  l+ +a+dlvk

Q: 235   HNRAVDWWSLGALMYDMMTGSPPFTAENRKKTIDKILKCK--LSLPPY--LTIDARDLVK  290

         ****************************************..99****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         klLkk+pa+Rlg+   + ++i++h f+

Q: 291   KLLKKNPAQRLGSskaDCADIQKHAFF  317

         ************9999999******97

Domain Sequence
(FASTA)

FELLTVLGKG AYGKVFQVRK VQGAQTGRIF AMKVLKKAKI VCNAKDTAHT RAEREILETV 60

RHPFIVDLLY AFQTGGKLYL ILECLSGGEL FMQLEKEGIF MEDTACFYLG EITLALGHLH 120

SNGIIYRDLK PENIMLNHQG HIKLTDFGLC KESIHDGSVT HTFCGTIEYM APEILTRSGH 180

NRAVDWWSLG ALMYDMMTGS PPFTAENRKK TIDKILKCKL SLPPYLTIDA RDLVKKLLKK 240

NPAQRLGSSK ADCADIQKHA FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013