EKS-ORN-00357

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00357

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	447.9	1.9E-134	384	671	288

Status

Unreviewed

Ensembl Protein

ENSONIP00000011261

UniProt Accession

I3JQW7;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1

Gene Synonyms/Alias

ACVR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000008959	ENSONIP00000011261	ENSONIT00000011270
ENSONIG00000008959	ENSONIP00000011262	ENSONIT00000011271

Organism

Oreochromis niloticus

Functional Description

Protein Length

685

Protein Sequence
(FASTA)

MTSVDMFLLV VITLVLPCSS LEGEGGVRNE CLCDGSSCSS GDRCFGQECF SSLAMINGTS 60

VVRKGCILGD EDRSLSCRST PTPQLVVKCC YGHLCNMNIS LNFPLKDVQL SAGRPVLRDQ 120

ECVCEGGVCE HGHRCTGQHC FAALKMIDGA AVQQKGCLRD DEEGKATCAM PPSSAHVVKC 180

CQGHLCNMNV TVQAPGKGTV VQSKSPSKEE HECVCEGHSC GTQNRCLGYQ CFSSLAVSGG 240

IIMSQKGCFK VLEQSTMTCK TPPSTDQIVY CCQGHLCNMN ITVELPVKAD EQSNYSVTTL 300

AVVIVAPIIV LIILSAVAIL VFRRIHHNQM ERLTSRDAEY GTIDGLIASN VGESTLADLL 360

DHSCTSGSGS GLPFLVQRTV ARQITLNECV GKGRYGEVWR GQWQGENVAV KIFSSRDEKS 420

WFRETEIYNT VLLRHENILG FIGSDMTSRN SSTQLWLITH FHEMGSLYDY LQLNTLDANS 480

CLRMALSIAS GLAHLHVEIF GTHGKPAIAH RDLKSKNILV KKNGQCSIAD LGLAVMHFQD 540

TNELDVGNNP KVGTKRYMAP EVLDDSIQMD CFESYKRVDI WALGLVLWEI ARRTVSNGIV 600

EDYKPPFHDV VPNDPSFEDM RKVVCVDQQR PNIPNRWFSD PTLTSMAKLM KECWYQNPSA 660

RLTALRIKKT LTKIDNSLDK IKTDI 685

Nucleotide Sequence
(FASTA)

ATGACGAGTG TGGACATGTT TCTGTTAGTT GTGATCACAC TGGTCCTCCC CTGTTCAAGC 60

TTAGAAGGTG AGGGCGGTGT GAGAAATGAA TGTTTATGTG ACGGATCATC CTGCAGCAGT 120

GGGGACCGAT GCTTTGGTCA GGAGTGCTTC AGCTCTCTCG CGATGATAAA CGGGACATCA 180

GTCGTTCGTA AAGGCTGCAT TTTGGGGGAC GAAGACCGAT CCTTGAGCTG CAGATCCACA 240

CCAACTCCTC AGCTGGTGGT GAAGTGCTGC TATGGGCATT TGTGTAATAT GAACATCTCC 300

CTTAACTTCC CACTAAAAGA TGTACAACTG TCTGCTGGCA GACCAGTCCT CAGAGACCAA 360

GAGTGTGTAT GCGAGGGCGG TGTGTGTGAG CATGGCCATC GCTGCACAGG CCAGCACTGT 420

TTCGCCGCTC TGAAGATGAT TGATGGGGCA GCCGTCCAAC AGAAGGGCTG CCTGAGGGAC 480

GACGAGGAGG GCAAAGCCAC CTGTGCCATG CCACCCTCAT CGGCCCATGT TGTCAAGTGC 540

TGCCAGGGCC ATCTGTGTAA CATGAACGTC ACTGTGCAAG CCCCAGGGAA AGGTACAGTA 600

GTCCAGAGTA AGTCCCCGAG CAAAGAGGAG CATGAGTGCG TGTGCGAGGG TCATTCATGT 660

GGAACACAGA ATCGCTGCTT GGGCTACCAG TGTTTCTCAT CTCTGGCAGT CAGTGGCGGC 720

ATCATAATGT CCCAAAAAGG CTGCTTTAAG GTCTTAGAAC AGAGCACGAT GACCTGCAAG 780

ACCCCGCCTT CCACAGACCA GATAGTCTAC TGCTGCCAGG GACACCTGTG TAATATGAAC 840

ATAACTGTGG AGCTCCCTGT CAAAGCTGAT GAGCAATCCA ACTACAGTGT GACCACACTA 900

GCTGTTGTCA TCGTGGCACC CATCATTGTC CTCATCATCC TCTCTGCTGT CGCTATCCTG 960

GTGTTCAGAA GGATCCACCA CAACCAAATG GAGAGGCTAA CCTCCCGAGA TGCTGAATAT 1020

GGAACTATTG ATGGCCTTAT AGCTTCTAAT GTGGGGGAGA GCACTCTAGC GGATTTGCTG 1080

GATCATTCCT GCACTTCAGG AAGTGGCTCA GGACTCCCTT TCCTTGTTCA GAGAACTGTT 1140

GCACGACAAA TCACACTAAA TGAGTGTGTG GGCAAGGGCC GTTATGGTGA AGTGTGGAGG 1200

GGCCAGTGGC AGGGAGAGAA TGTCGCAGTT AAAATTTTCT CCTCTCGAGA TGAAAAGTCT 1260

TGGTTCAGAG AGACTGAAAT CTACAACACT GTGCTGCTGA GACATGAAAA CATCTTGGGC 1320

TTCATCGGTT CAGACATGAC CTCGAGGAAC TCCAGCACCC AGCTGTGGCT CATCACTCAC 1380

TTTCACGAGA TGGGCTCCTT GTACGATTAC CTTCAGCTCA ACACCCTCGA CGCAAACAGC 1440

TGCCTCCGGA TGGCGCTCTC CATTGCGAGC GGTCTGGCGC ATTTACATGT CGAGATCTTT 1500

GGCACTCATG GCAAGCCAGC TATTGCCCAC CGAGACCTGA AGAGCAAAAA CATATTGGTG 1560

AAAAAGAACG GACAGTGCAG CATTGCTGAT CTCGGTCTGG CTGTCATGCA TTTTCAAGAC 1620

ACAAACGAGT TAGACGTGGG GAACAACCCT AAAGTTGGAA CAAAGCGCTA CATGGCCCCT 1680

GAAGTGCTCG ATGACTCCAT CCAGATGGAT TGCTTTGAGT CCTACAAGAG AGTGGACATT 1740

TGGGCCCTGG GCCTCGTCCT GTGGGAGATC GCCAGGAGGA CAGTCAGTAA TGGAATTGTA 1800

GAAGATTACA AGCCCCCTTT TCATGACGTG GTCCCAAATG ATCCGAGTTT TGAAGATATG 1860

AGGAAAGTTG TGTGTGTGGA TCAGCAGAGA CCCAACATCC CAAACAGATG GTTTTCAGAC 1920

CCAACTTTAA CCTCCATGGC TAAACTCATG AAGGAGTGCT GGTACCAGAA TCCGTCAGCC 1980

AGATTAACGG CGCTGCGCAT CAAAAAGACT CTCACAAAGA TCGACAACTC TCTGGATAAA 2040

ATAAAAACAG ACATTTGA 2058

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++l e++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+eiy+tvllrhenil+fi+

Q: 384   ITLNECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFIG  443

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t++he+gsL+dyL+ +tld++++lr+als+asGlahLH ei+gt+

Q: 444   SDMTSRNSSTQLWLITHFHEMGSLYDYLQLNTLDANSCLRMALSIASGLAHLHVEIFGTH  503

         ***********************************************************9

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk+++c iaDlGLa+++ ++++eld+ +n +vGtkRYmaPE

Q: 504   G--KPAIAHRDLKSKNILVKKNGQCSIADLGLAVMHFQDTNELDVGNNPKVGTKRYMAPE  561

         9..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++++++fe++kr+D+++lgLvlWE+a+R+ + +++ve+yk+pf++vv++dPs+e+m

Q: 562   VLDDSIQMDCFESYKRVDIWALGLVLWEIARRTVS-NGIVEDYKPPFHDVVPNDPSFEDM  620

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++++rP+ip++w ++++l++++kl++ecW+++p+aRltalr+kk+l

Q: 621   RKVVCVDQQRPNIPNRWFSDPTLTSMAKLMKECWYQNPSARLTALRIKKTL  671

         *************************************************97

Domain Sequence
(FASTA)

ITLNECVGKG RYGEVWRGQW QGENVAVKIF SSRDEKSWFR ETEIYNTVLL RHENILGFIG 60

SDMTSRNSST QLWLITHFHE MGSLYDYLQL NTLDANSCLR MALSIASGLA HLHVEIFGTH 120

GKPAIAHRDL KSKNILVKKN GQCSIADLGL AVMHFQDTNE LDVGNNPKVG TKRYMAPEVL 180

DDSIQMDCFE SYKRVDIWAL GLVLWEIARR TVSNGIVEDY KPPFHDVVPN DPSFEDMRKV 240

VCVDQQRPNI PNRWFSDPTL TSMAKLMKEC WYQNPSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 3.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013