EKS-ORN-00477

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00477

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	436.4	4.0E-131	246	496	251

Status

Unreviewed

Ensembl Protein

ENSONIP00000011363

UniProt Accession

I3JR69;

Protein Name

Protein Synonyms/Alias

Gene Name

LYN

Gene Synonyms/Alias

LYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000009035	ENSONIP00000011363	ENSONIT00000011372

Organism

Oreochromis niloticus

Functional Description

Protein Length

511

Protein Sequence
(FASTA)

MGCMKSTLNQ GLSGGVDQKM GQHAVHSEQS RYVRDPTFNP KVNTNNSLLP GQVFQKMEEQ 60

KGVGKIVIAL FPYEAAHPDD LGFKKGEKMK ILEEHGEWWK AKSLVNNKEG FIPSNYVAQA 120

DTMETEDWFF KDITRKDAER QLLAPANRPG AYLIRESETS KGSYSLSIRD VDAQGTESVK 180

HYKIRMLDNG GCYISPKISF RDISSMIKHY HNKSDGLCRK LERPCAKPKA QKPWDKDAWE 240

ISKDSIKMVK KLGAGQFGEV WMAFYNNTTK VAVKTLKPGT MTAEAFLDEA NVMKTLQHDR 300

LVRLYAVVTK IEPIYIITEF MANGSLLDFL KSDTGCRLQL PKLIDFSAQI AEGMAYIEKK 360

NYIHRDLRAA NVLVSESLLC KIADFGLARI IEDNEYSARE GAKFPIKWTA PEAINYGTFT 420

IKSDMWSFGV LLYEIITYGK IPYPGMTKGE VMSSIQRGYR MPQPDNCPTE LYDIMMSCWK 480

NRPEDRPTFD YLQSVLDDFY TATEGQYQQQ P 511

Nucleotide Sequence
(FASTA)

ATGGGCTGCA TGAAATCCAC GCTAAATCAA GGTCTGAGTG GAGGTGTGGA CCAAAAAATG 60

GGCCAACACG CTGTGCATTC TGAACAGTCA CGCTATGTTA GAGACCCCAC CTTTAATCCA 120

AAAGTAAACA CGAATAACTC CCTGTTACCG GGTCAGGTGT TCCAAAAAAT GGAGGAACAA 180

AAGGGGGTGG GTAAAATAGT GATTGCCCTT TTCCCATATG AAGCTGCACA TCCTGATGAC 240

TTAGGATTCA AGAAGGGAGA AAAAATGAAA ATTCTAGAAG AACATGGTGA GTGGTGGAAA 300

GCAAAGTCTC TGGTAAACAA CAAAGAGGGA TTCATCCCAT CCAACTATGT GGCCCAAGCT 360

GACACCATGG AGACAGAGGA TTGGTTTTTC AAGGACATCA CAAGGAAGGA TGCAGAGAGG 420

CAGCTGCTGG CACCAGCGAA CAGGCCAGGC GCTTATCTAA TCAGAGAAAG TGAAACATCA 480

AAAGGGAGTT ACTCGTTGTC CATCAGAGAT GTGGACGCCC AGGGAACAGA GTCGGTGAAA 540

CATTACAAGA TCAGGATGCT GGATAATGGC GGCTGCTACA TCTCTCCTAA AATCTCCTTT 600

CGGGATATTA GCAGCATGAT TAAACACTAT CACAACAAAT CGGATGGCCT GTGCCGTAAA 660

CTTGAACGTC CTTGTGCAAA ACCCAAAGCT CAGAAACCTT GGGATAAGGA TGCCTGGGAG 720

ATATCCAAAG ACTCTATTAA GATGGTGAAG AAACTTGGAG CAGGCCAGTT TGGAGAAGTC 780

TGGATGGCAT TCTACAACAA CACAACCAAA GTGGCAGTGA AGACGCTGAA GCCGGGAACC 840

ATGACGGCTG AAGCTTTTTT GGACGAAGCC AACGTGATGA AGACTCTGCA GCACGACAGG 900

CTGGTGCGGC TCTACGCTGT TGTCACCAAG ATAGAACCCA TCTACATCAT CACTGAATTC 960

ATGGCAAATG GGAGCCTGCT AGACTTTTTA AAGAGCGACA CAGGATGCAG ACTGCAGCTG 1020

CCCAAGCTCA TTGATTTCTC TGCACAGATA GCAGAGGGCA TGGCGTACAT TGAGAAGAAG 1080

AATTATATTC ACAGAGACCT CAGGGCAGCT AATGTCCTGG TGTCTGAAAG CCTGCTCTGT 1140

AAAATAGCAG ATTTTGGCTT GGCGAGAATC ATTGAGGATA ACGAGTACTC TGCCAGAGAG 1200

GGAGCCAAAT TCCCCATAAA GTGGACTGCT CCAGAGGCTA TTAACTATGG CACCTTCACC 1260

ATCAAATCTG ACATGTGGTC ATTCGGAGTC CTGCTCTATG AGATTATCAC CTATGGGAAA 1320

ATCCCTTACC CAGGCATGAC TAAAGGAGAG GTGATGTCCT CGATACAGCG CGGCTACAGG 1380

ATGCCTCAGC CCGACAACTG TCCCACTGAG CTGTATGATA TCATGATGTC CTGTTGGAAG 1440

AACAGACCTG AAGACAGGCC CACATTTGAC TACCTACAGA GTGTCCTGGA TGACTTCTAC 1500

ACCGCCACAG AGGGACAGTA CCAGCAACAG CCGTAG 1536

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         +k+vkklG+GqfGevw++ +++++kvavktlk+gt++ eafl+ea+++k+l+h++lv+ly

Q: 246   IKMVKKLGAGQFGEVWMAFYNNTTKVAVKTLKPGTMTAEAFLDEANVMKTLQHDRLVRLY  305

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ ePiyi+te+ma+Gslldflk+++g +l+lpkl+d++aq+aeGmay+e+kn+ihr

Q: 306   AVVTKIEPIYIITEFMANGSLLDFLKSDTGCRLQLPKLIDFSAQIAEGMAYIEKKNYIHR  365

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+nvlv+esl++k+adfGlar+ied+ey+a+egak+PikWtaPeai++g+ftiksd+

Q: 366   DLRAANVLVSESLLCKIADFGLARIIEDNEYSAREGAKFPIKWTAPEAINYGTFTIKSDM  425

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfG+ll+ei+t+Gk+PypGmt+ ev+++++rgyr+p+p++cp+ely+++++cwk++pe+

Q: 426   WSFGVLLYEIITYGKIPYPGMTKGEVMSSIQRGYRMPQPDNCPTELYDIMMSCWKNRPED  485

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtf++lq+vl

Q: 486   RPTFDYLQSVL  496

         ********986

Domain Sequence
(FASTA)

IKMVKKLGAG QFGEVWMAFY NNTTKVAVKT LKPGTMTAEA FLDEANVMKT LQHDRLVRLY 60

AVVTKIEPIY IITEFMANGS LLDFLKSDTG CRLQLPKLID FSAQIAEGMA YIEKKNYIHR 120

DLRAANVLVS ESLLCKIADF GLARIIEDNE YSAREGAKFP IKWTAPEAIN YGTFTIKSDM 180

WSFGVLLYEI ITYGKIPYPG MTKGEVMSSI QRGYRMPQPD NCPTELYDIM MSCWKNRPED 240

RPTFDYLQSV L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013