EPS-ORN-00076

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORN-00076

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/PTEN	256.0	3.2E-76	106	276	171

Status

Unreviewed

Ensembl Protein

ENSONIP00000011457

UniProt Accession

I3JRG3;

Protein Name

Protein Synonyms/Alias

Gene Name

TENC1 (1 of 2)

Gene Synonyms/Alias

TENC1 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000009111	ENSONIP00000011457	ENSONIT00000011466

Organism

Oreochromis niloticus

Functional Description

Protein Length

1381

Protein Sequence
(FASTA)

MRLTKAGKGE PHVFKEKTFK KKRQCSVCRQ SVDNVGSFCR VCKTAAHRKC EAKVTSACIP 60

APPNDLRRGT APSRHIQHLG STKSLTYTKQ RNTLPRSFSV DRVMERVMER NYDFDLTYIT 120

ERIISVFFPP KLEEQRYRLN LKEVAAMLKS KHQEKFLLLN LSERRHDITR LNPKVHDFGW 180

PDLHAPPLDK ICAICKAMEN WLNSDPQHVV VLHCKGNKGK TGVIIAAYMH YSKISAGADQ 240

ALSTLAMRKF CEDKVSSSLQ PSQNRYIYYF GGLLSGAIKM NSSPLFLHQV LIPSLPNFQG 300

EGGYYPFLKI YQSMQLVYTS GIYDLQGTGG RRLCVTIEPA LLLKGDIMVK CYHRRAQSAD 360

RDTVFRLQFH TCTIHGSQLW FGKGELDEAC TDERFPSDAT VEFVFSSGPE RIKGREYHKN 420

DPAVTVDYNT ADPVVRWDSY ENFNQRYQDS LEVDIAHTRG PLDGSLYAQI KKRRGPGSGS 480

LTSTNGSIAG GVVAEDRPDH RITQGSDSGL SAHSLHLNQS SIHPDHQEES NRPPPPTRQE 540

REELERLLGG IEGSRDGERE TAILDDGDSI QSERTGTLRL SRSCSCRDGY RSQRCAEPGC 600

DRTLLMPNGY CLDRAPGTNG HHGAPPSASP NPAGPPSHMD LCQHYSPHHH PHPHQKPATS 660

PTYHDIMLMD GLPPPGCPCR DCSMRREDSA AYHTLRMERG DSFHWDREAE LHQREVGLRR 720

TRHRRATVAS YGPQGQDLLA FTFDPLPSGH PAYPEASRSH AHSHLDMKYS SSSSGYQTPR 780

QVCPCSPYQP SPSESRGYAS GYQSESTSPL PPASAVMGHC GHSSGPDGLR SSGESVGWRD 840

HITHGSFKRV HRNGHAACST PSDMSGSPTP VHTSSPLCTQ ESPERQRSST ERLEPHTKEA 900

QSHTASPKQT ESTNQSPPPT NLPPAAPQQQ HCSSDMSSAH DSVNGSSPTR ESHAEVPKHT 960

STTNPTSSPA PSSPQPGPSS MDGSPVSDAP VPGFATLAVD TNKRPCYSPH TPQPHPASYS 1020

SYTTISIPLP HPQPPLPEKR HLPGHSGSPS DGVKPAHVPA STAAQHQHHV TFSPTVGEIA 1080

PPAGQNDQVE AEAANRVSVK FVQDSSKFWY KPSISREQAI AALKEREPGT FLIRDSNSFQ 1140

GAYGLALKVV TPPPNVSNHS NKVSDPLEQL VRHFLIETSP RGVKIKGCQN EPYFGSLSAL 1200

VYQHSITPIS LPCALKIPEK DLIGEVQEVQ PVSNISTAAD LLKQGAACNV LYLNSVETES 1260

LTGPQAIAKA TDATLGRSPR PAATVVQFKV TSQGITLTDN QRRVFFRRHY PVNSVTFSSI 1320

DPKDRRWTNS DNTTVKVFGF VAKKPGSTAE NVCHLFAELD PDQPASAIVN FINKVMLSQR 1380

R 1381

Nucleotide Sequence
(FASTA)

ATGAGACTTA CAAAGGCAGG CAAAGGAGAG CCCCACGTCT TCAAGGAGAA GACTTTCAAG 60

AAGAAGCGGC AGTGCAGTGT GTGTCGGCAG AGCGTCGATA ACGTGGGCTC CTTCTGCAGA 120

GTATGCAAAA CTGCCGCCCA CAGGAAGTGC GAGGCAAAGG TGACCTCTGC ATGCATCCCA 180

GCTCCCCCCA ATGATCTGCG TAGAGGGACG GCTCCTTCTC GACACATCCA GCACCTGGGA 240

TCCACCAAAT CTTTAACCTA CACCAAACAG AGAAACACCC TGCCAAGGAG CTTCAGCGTG 300

GACCGTGTGA TGGAGCGAGT GATGGAACGA AACTACGACT TCGACCTGAC CTACATCACT 360

GAGAGGATCA TCTCCGTCTT CTTCCCTCCG AAGCTGGAAG AGCAGAGATA CCGGCTGAAC 420

CTGAAGGAGG TGGCTGCCAT GCTCAAGTCC AAACACCAGG AAAAGTTTCT GCTCCTGAAT 480

CTCTCTGAAA GGCGCCACGA TATCACCCGA CTGAACCCAA AGGTCCACGA CTTTGGCTGG 540

CCCGACCTCC ACGCCCCACC GCTGGATAAG ATCTGTGCCA TATGCAAGGC CATGGAGAAC 600

TGGTTGAACT CTGACCCCCA GCACGTGGTG GTCTTACACT GCAAGGGGAA CAAAGGTAAA 660

ACAGGCGTCA TTATCGCAGC CTACATGCAC TACAGCAAGA TCTCTGCAGG GGCGGACCAG 720

GCTCTCAGTA CTCTTGCCAT GAGGAAGTTC TGTGAAGATA AGGTGTCCTC GTCCCTCCAG 780

CCGTCCCAAA ACAGGTATAT ATATTACTTT GGAGGCCTTC TGTCTGGGGC GATCAAGATG 840

AACAGCAGCC CTCTCTTCCT TCATCAAGTA CTCATCCCGT CGCTCCCCAA CTTCCAAGGG 900

GAAGGAGGTT ACTACCCCTT CTTGAAAATC TACCAGTCCA TGCAGTTGGT CTACACTTCA 960

GGCATATATG ACCTTCAAGG CACTGGAGGC AGAAGACTGT GTGTGACCAT TGAACCAGCA 1020

CTGCTGCTAA AGGGTGACAT CATGGTCAAG TGCTACCACA GGCGAGCTCA AAGTGCTGAC 1080

AGAGACACCG TGTTCAGACT GCAGTTCCAC ACCTGCACCA TCCACGGATC CCAGCTGTGG 1140

TTTGGCAAAG GGGAGCTGGA CGAAGCGTGT ACTGATGAGC GTTTCCCATC TGATGCCACA 1200

GTGGAGTTTG TCTTCTCCTC CGGACCAGAG CGGATCAAAG GCCGTGAATA TCACAAGAAT 1260

GACCCGGCTG TCACAGTGGA CTACAACACC GCTGACCCCG TGGTTCGCTG GGATTCCTAT 1320

GAGAATTTTA ACCAGCGATA CCAGGACAGC CTGGAAGTAG ATATTGCCCA CACCAGAGGT 1380

CCTCTGGATG GTAGCCTCTA CGCTCAGATA AAGAAGCGGC GAGGTCCAGG CTCTGGTTCC 1440

CTCACCTCAA CCAACGGCAG CATCGCAGGG GGAGTAGTTG CAGAAGACAG GCCCGATCAC 1500

CGCATCACCC AAGGCTCTGA CTCCGGCCTT TCAGCACATT CCCTCCATTT GAACCAGTCT 1560

TCTATCCATC CAGACCATCA GGAGGAGTCC AATCGTCCAC CGCCGCCCAC CAGACAGGAA 1620

AGGGAGGAGC TCGAACGTCT TCTCGGAGGC ATCGAGGGAA GCCGAGATGG AGAGCGAGAG 1680

ACCGCCATTT TGGATGATGG AGATTCTATT CAGTCGGAGA GAACGGGGAC ACTGAGGCTC 1740

AGTCGGTCAT GTTCCTGCCG GGATGGTTAC CGGTCACAGC GCTGTGCAGA GCCAGGATGC 1800

GACCGCACCC TTCTCATGCC TAATGGTTAC TGCCTCGATC GGGCTCCAGG GACCAACGGT 1860

CACCACGGGG CTCCTCCTTC GGCTAGCCCC AACCCCGCTG GTCCACCATC ACACATGGAT 1920

CTGTGCCAAC ACTATAGCCC CCACCACCAT CCCCACCCGC ACCAGAAACC AGCCACCAGC 1980

CCTACTTACC ATGACATCAT GCTAATGGAT GGTCTGCCGC CCCCTGGCTG TCCTTGCAGA 2040

GACTGCAGCA TGAGGAGAGA GGACTCGGCT GCCTATCACA CCCTCAGGAT GGAGCGTGGC 2100

GACAGCTTCC ATTGGGACAG AGAAGCGGAG CTTCATCAGA GAGAGGTGGG GCTTAGGAGA 2160

ACCAGGCACA GGAGAGCCAC CGTAGCCTCC TATGGCCCAC AGGGCCAAGA TCTTCTAGCC 2220

TTTACCTTTG ACCCCTTGCC ATCAGGTCAC CCAGCTTATC CAGAGGCATC GAGGTCCCAC 2280

GCTCATTCCC ACCTGGACAT GAAGTACAGC AGCAGCAGCA GTGGTTACCA GACACCACGT 2340

CAGGTGTGCC CCTGCTCACC TTACCAACCC TCACCGTCTG AGAGCAGGGG CTACGCATCA 2400

GGCTACCAGT CCGAGTCCAC GTCCCCGCTG CCTCCTGCTT CCGCTGTGAT GGGCCACTGC 2460

GGCCATAGCA GCGGACCAGA TGGCCTCCGT AGTTCTGGTG AAAGCGTGGG CTGGAGGGAT 2520

CACATTACCC ATGGTTCTTT TAAAAGGGTG CACAGAAACG GCCATGCCGC GTGTTCCACA 2580

CCATCCGACA TGTCTGGATC GCCCACTCCT GTTCACACCA GCAGTCCTCT ATGCACACAG 2640

GAATCACCGG AAAGGCAAAG AAGCAGCACA GAGCGCCTGG AGCCACACAC CAAAGAAGCA 2700

CAGTCACACA CAGCCTCACC AAAACAAACA GAATCCACCA ATCAGAGCCC TCCACCAACA 2760

AACCTGCCCC CAGCTGCTCC TCAACAGCAG CACTGTAGCT CAGATATGTC CTCAGCTCAT 2820

GATTCTGTTA ATGGATCCTC TCCAACCAGG GAATCTCACG CAGAGGTTCC TAAACACACC 2880

AGCACCACCA ACCCAACATC TTCTCCTGCA CCGTCATCCC CACAGCCTGG GCCCAGCAGC 2940

ATGGACGGCT CCCCTGTGTC TGATGCACCA GTTCCCGGAT TCGCTACCTT GGCTGTAGAC 3000

ACAAACAAGA GGCCCTGCTA CTCTCCTCAC ACCCCACAAC CTCACCCAGC CTCCTATTCC 3060

AGCTACACCA CAATCTCCAT CCCTCTTCCT CACCCCCAAC CCCCCTTGCC AGAGAAGCGC 3120

CATTTGCCTG GACATTCGGG TTCACCCAGT GATGGGGTGA AACCAGCTCA CGTGCCTGCC 3180

TCCACTGCTG CGCAGCATCA GCACCACGTC ACGTTTTCTC CCACGGTGGG GGAAATTGCA 3240

CCCCCTGCTG GCCAAAATGA CCAAGTAGAG GCAGAAGCTG CGAACAGGGT CAGTGTGAAG 3300

TTTGTCCAGG ATAGTTCCAA GTTTTGGTAT AAGCCCAGCA TCTCTAGAGA GCAAGCAATC 3360

GCAGCTCTGA AGGAAAGGGA GCCCGGCACT TTCCTAATCA GGGACAGTAA CTCGTTCCAG 3420

GGAGCCTATG GGCTGGCTCT GAAGGTGGTT ACACCTCCTC CCAATGTCAG CAACCACAGC 3480

AACAAAGTGA GCGACCCTCT GGAGCAGCTG GTGAGACATT TTCTCATTGA AACTAGTCCT 3540

CGAGGAGTGA AGATTAAAGG CTGTCAGAAC GAGCCCTACT TTGGGAGTCT GTCTGCACTC 3600

GTCTACCAGC ACTCCATCAC ACCCATCTCT TTGCCCTGCG CTCTTAAAAT CCCTGAAAAG 3660

GATCTCATAG GAGAGGTGCA GGAGGTTCAA CCAGTCAGTA ACATCAGCAC AGCTGCTGAC 3720

CTGCTGAAGC AGGGAGCGGC CTGTAACGTC CTCTATCTGA ACTCTGTGGA AACAGAGTCC 3780

CTGACGGGCC CCCAGGCCAT TGCCAAGGCA ACAGATGCCA CACTGGGTCG TAGCCCGCGT 3840

CCTGCTGCCA CAGTCGTCCA GTTCAAAGTG ACATCACAGG GTATCACGCT GACCGACAAC 3900

CAGCGCAGAG TTTTCTTCAG GAGACATTAC CCAGTGAACA GTGTGACCTT CAGCAGCATC 3960

GATCCAAAGG ACAGGAGGTG GACTAACTCA GACAACACAA CTGTTAAAGT GTTTGGTTTT 4020

GTAGCCAAGA AGCCCGGCAG CACGGCAGAG AACGTCTGCC ACTTATTCGC TGAGTTGGAC 4080

CCCGACCAGC CTGCTTCTGC CATCGTCAAC TTTATCAACA AGGTCATGCT GTCTCAGCGC 4140

CGATAG 4146

Domain Profile

S: 2     rltedgfdldltyvteriiavsfPaeareevyrnnlrevvrlldskhrnkyklynlcser  61

         r++e+++d+dlty+terii+v fP + +e++yr nl+ev+ +l+skh++k++l nl ser

Q: 106   RVMERNYDFDLTYITERIISVFFPPKLEEQRYRLNLKEVAAMLKSKHQEKFLLLNL-SER  164

         89******************************************************.***

S: 62    rydltklnakvaefgiedlnaPaleklvsickeldeWlseddenvvvlhckggkgrlGvi  121

         r+d+t+ln+kv++fg++dl+aP+l+k+++ick++++Wl+ d+++vvvlhckg+kg++Gvi

Q: 165   RHDITRLNPKVHDFGWPDLHAPPLDKICAICKAMENWLNSDPQHVVVLHCKGNKGKTGVI  224

         ************************************************************

S: 122   vcayllaseisakadealdtfgerrtredkvagvkqPsqrryvsyfsqllkg  173

         ++ay+++s+isa+ad+al t+++r+++edkv++  qPsq+ry++yf +ll+g

Q: 225   IAAYMHYSKISAGADQALSTLAMRKFCEDKVSSSLQPSQNRYIYYFGGLLSG  276

         *************************************************986

Domain Sequence
(FASTA)

RVMERNYDFD LTYITERIIS VFFPPKLEEQ RYRLNLKEVA AMLKSKHQEK FLLLNLSERR 60

HDITRLNPKV HDFGWPDLHA PPLDKICAIC KAMENWLNSD PQHVVVLHCK GNKGKTGVII 120

AAYMHYSKIS AGADQALSTL AMRKFCEDKV SSSLQPSQNR YIYYFGGLLS G 171

Keyword

Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0046872	; F:metal ion binding
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR011993	; PH_like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR013625	; PTB.
IPR006020	; PTyr_interaction_dom.
IPR000980	; SH2.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00130	; C1_1; 1.
PF08416	; PTB; 1.
PF10409	; PTEN_C2; 1.
PF00017	; SH2; 1.

SMARTs

SM00109	; C1; 1.
SM00462	; PTB; 1.
SM00252	; SH2; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS51181	; PPASE_TENSIN; 1.
PS50001	; SH2; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013