EKS-ORN-00386
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00386
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR496.32.2E-149630886257
StatusUnreviewed
Ensembl ProteinENSONIP00000011760
UniProt AccessionI3JSB5;
Protein Name
Protein Synonyms/Alias
Gene NameEGFR (1 of 2)
Gene Synonyms/Alias EGFR (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000009358ENSONIP00000011760ENSONIT00000011769
OrganismOreochromis niloticus
Functional Description
Protein Length1114
Protein Sequence
(FASTA)
VCQGVTNRLN LLGTKEDHYR NMVKTYSNCT VVLENLEITY MEDHRDLSFL RSIKEVGGYV 60
LIALNTVSRI PLENLRIIRG QSKTNLCAQS SNFFNLNMVV IGHQNQKQNK FIPGLGHSTQ 120
LLLLSSPVTK LNCAQQCSRR CKGPSPSDCC NEHCAAGCTG PRAEDCLACR DFQDNGVCKD 180
SCPGLHRYDP NLHQLVPNPH GKYSFGATCV KSCPRNYIIS DYGACVRTCN GNTYEVEVGG 240
IRKCAKCDGL CPKVCNGLGT GDLVHTLSIN ATNIGSFENC TKINGNIDII HTSIYGDKFT 300
KTPKMDPEQL NVFKTVKEIT GYLWIQTWPD TMSSLSPFEN LEIVQGRTKR GSRSLVVSGL 360
HITHLGLRSL REISDGDVFV SKNSELCYTD AKHWQKLFKS PHQTVNIEGN ANAATCALRN 420
DTCDKKCTAD GCWGPGPSMC ISCRDYKRDG SCVDSCNILE GEPRETAVNK TCIKCHPECQ 480
PMNGTATCSA PGSANCTKCA NFKDGLFCVS RCPQGVLGED DALVWKYADE QKVCQLCHKN 540
CTQGCIGPGL EGCHSKGPPG LSMVAAGVVG GLLAALIAGL SVFVLLRRRH IKRKRTMRRL 600
LQERELVEPL TPSGEAPNQA LLRILKEPEF KKIKVLGSGA FGTVYKGLWV PEGEDVKIPV 660
AIKVLREATS PKANKEILDE AYVMASVEHP HVCRLLGICL TSTVQLITQL MPYGCLLDYV 720
KENKDNIGSQ YLLNWCVQIA KGMNYLEERH LVHRDLAARN VLVKTPQHVK ITDFGLAKLL 780
KADEKEYHAD GGKVPIKWMA LESILNRTYT HQSDVWSYGV TVWELMTFGT KPYDGIPASE 840
IAGILEKGER LPQPPICTID VYMIMVKCWM IDADSRPRFR ELIAEFTKMA RDPPRYLVIQ 900
GDDRMHLPSP SDTKFYRSLI SGEDMEDAVD ADEYLVPQRG FFSSPSTSRT PLIHSTSLNS 960
SIGTCHSRTG LLNGFPSRDG SMALRYIPDP TDKFLDEAFQ PAPGYINQTP ISDVVNPIYQ 1020
HPGPPRTLLP TISSDHTETE YLNYFKNGAA GPEYLNEILS PAVLPLTSNG TVHSIEKYLP 1080
QQSIDNPDYQ QDFTPTFKTH TNGHIPAAEN AEYL 1114
Nucleotide Sequence
(FASTA)
GTGTGCCAAG GTGTAACCAA TCGTTTAAAC CTTCTGGGAA CTAAAGAGGA CCACTACAGG 60
AACATGGTGA AGACCTACAG CAACTGCACC GTAGTGTTGG AGAACCTGGA GATCACATAC 120
ATGGAGGATC ACCGTGACCT GTCCTTCCTC CGGTCAATCA AAGAAGTTGG TGGCTATGTC 180
CTGATCGCCC TCAATACAGT ATCCAGGATT CCTCTGGAGA ACCTGCGCAT CATTCGAGGC 240
CAAAGTAAAA CAAATCTGTG CGCACAATCC TCCAATTTTT TTAATTTGAA CATGGTGGTG 300
ATAGGGCATC AGAATCAAAA GCAGAACAAA TTCATTCCTG GGCTTGGACA CTCCACTCAA 360
CTTCTGCTGC TCTCATCTCC AGTGACAAAG CTGAACTGTG CCCAGCAGTG CTCTAGAAGG 420
TGCAAAGGAC CTTCACCGAG CGACTGTTGC AATGAGCATT GTGCCGCGGG GTGCACGGGA 480
CCCAGAGCTG AAGACTGTCT GGCCTGTCGG GACTTCCAGG ATAATGGGGT GTGTAAGGAC 540
TCCTGCCCAG GCCTTCATCG TTACGACCCC AACCTGCACC AGCTGGTTCC TAATCCGCAT 600
GGAAAGTACA GCTTCGGGGC CACCTGTGTC AAAAGCTGCC CACGTAATTA TATTATTTCT 660
GATTACGGCG CATGTGTGCG GACGTGCAAC GGTAACACAT ATGAGGTGGA GGTAGGAGGA 720
ATCAGGAAGT GCGCCAAGTG TGATGGGCTG TGTCCAAAAG TGTGTAATGG ACTTGGAACA 780
GGAGACTTGG TTCACACTCT GTCTATTAAT GCCACAAACA TCGGCTCCTT TGAAAACTGC 840
ACCAAAATCA ATGGAAACAT CGACATCATC CACACATCGA TTTATGGGGA TAAATTCACC 900
AAAACACCAA AGATGGATCC TGAGCAGCTT AATGTGTTCA AGACGGTTAA AGAAATTACT 960
GGGTACCTGT GGATTCAAAC ATGGCCAGAT ACCATGAGCT CACTGAGTCC TTTTGAGAAT 1020
CTGGAGATCG TTCAGGGGAG AACTAAACGC GGAAGCCGCA GTTTGGTTGT GTCTGGGCTC 1080
CATATCACCC ACCTGGGCCT GAGGTCCCTC AGAGAAATCA GTGATGGAGA TGTGTTTGTC 1140
TCTAAGAACT CTGAACTCTG TTACACCGAT GCAAAGCACT GGCAGAAGCT TTTCAAATCA 1200
CCACACCAAA CTGTTAATAT AGAGGGCAAT GCCAATGCTG CCACCTGCGC TCTGAGGAAC 1260
GACACTTGTG ACAAGAAGTG CACGGCGGAC GGCTGCTGGG GTCCGGGCCC CAGTATGTGC 1320
ATTTCGTGCC GCGACTACAA GCGCGACGGG AGCTGCGTCG ACTCCTGCAA CATCCTGGAG 1380
GGAGAGCCAC GCGAGACAGC TGTGAATAAA ACCTGCATCA AGTGCCACCC CGAGTGTCAG 1440
CCCATGAACG GGACCGCAAC CTGCAGCGCG CCTGGGTCTG CTAACTGCAC TAAATGTGCT 1500
AACTTCAAAG ATGGACTGTT CTGCGTGTCC CGCTGTCCCC AAGGCGTGCT GGGGGAGGAC 1560
GATGCGCTAG TGTGGAAATA CGCAGATGAG CAGAAAGTGT GCCAGCTATG CCACAAAAAC 1620
TGCACTCAGG GGTGCATTGG ACCTGGTCTT GAAGGCTGTC ACAGTAAAGG GCCCCCTGGT 1680
CTTTCCATGG TCGCGGCTGG TGTTGTTGGT GGGCTGCTGG CCGCTCTCAT CGCAGGCCTG 1740
TCTGTTTTTG TGTTGCTCCG CCGACGCCAC ATCAAGAGGA AGAGGACCAT GCGTAGACTG 1800
CTCCAAGAGA GAGAGCTGGT CGAACCCCTC ACTCCAAGTG GAGAGGCACC GAACCAGGCT 1860
CTGCTGCGGA TCCTGAAGGA ACCCGAGTTT AAGAAAATCA AGGTGCTGGG ATCAGGAGCT 1920
TTTGGTACTG TTTACAAGGG TCTGTGGGTC CCGGAGGGAG AGGACGTGAA AATCCCGGTC 1980
GCCATCAAGG TTTTGAGAGA GGCCACGTCC CCAAAAGCAA ACAAGGAGAT CTTGGATGAA 2040
GCTTATGTGA TGGCCAGTGT GGAGCACCCC CACGTGTGTC GTCTGTTGGG CATCTGCCTC 2100
ACCTCCACGG TGCAGCTCAT AACGCAGCTC ATGCCTTACG GCTGCCTGTT GGATTATGTC 2160
AAAGAGAACA AGGACAATAT TGGCTCCCAG TACCTGCTCA ACTGGTGTGT GCAGATAGCC 2220
AAGGGTATGA ACTACCTGGA GGAGCGCCAC TTAGTGCATC GTGACTTGGC AGCCAGAAAC 2280
GTCCTGGTGA AGACTCCTCA ACATGTCAAG ATCACTGACT TTGGTTTGGC CAAGCTGCTA 2340
AAGGCAGATG AGAAAGAGTA CCATGCAGAT GGAGGAAAGG TGCCAATAAA ATGGATGGCT 2400
CTTGAGTCGA TCCTTAACAG AACTTACACG CACCAGAGCG ACGTATGGAG TTATGGTGTA 2460
ACAGTTTGGG AGCTGATGAC ATTTGGGACC AAACCATACG ATGGGATTCC AGCCAGTGAA 2520
ATAGCTGGGA TACTGGAGAA GGGAGAACGC CTGCCTCAGC CACCAATCTG CACCATAGAT 2580
GTCTACATGA TCATGGTGAA ATGTTGGATG ATTGATGCAG ACAGCCGGCC TCGTTTCCGA 2640
GAACTCATAG CTGAGTTTAC AAAGATGGCT CGGGATCCAC CGCGTTATCT TGTCATCCAG 2700
GGGGATGACC GCATGCACCT ACCGAGTCCT TCAGACACTA AGTTCTACCG CAGCCTGATC 2760
AGCGGGGAGG ACATGGAGGA TGCTGTGGAC GCTGATGAAT ATCTGGTGCC ACAGCGTGGC 2820
TTCTTCAGCA GCCCGAGTAC CTCCCGCACC CCACTGATTC ACTCAACAAG CCTCAACAGC 2880
AGCATCGGGA CGTGCCACAG CAGAACTGGC TTACTGAACG GATTTCCGAG CAGAGATGGA 2940
AGCATGGCCC TGCGATATAT TCCAGACCCC ACAGACAAAT TTCTCGATGA GGCCTTCCAG 3000
CCCGCTCCAG GCTACATAAA CCAGACTCCC ATCTCAGATG TGGTGAATCC TATCTACCAG 3060
CATCCCGGTC CACCTCGCAC CCTTCTTCCC ACCATCTCCT CGGACCATAC GGAGACAGAG 3120
TACCTGAACT ACTTTAAGAA CGGGGCCGCC GGACCAGAAT ATCTCAATGA GATTCTGTCC 3180
CCGGCCGTCC TCCCGCTCAC GTCAAACGGC ACGGTCCACA GCATTGAGAA ATACCTGCCT 3240
CAGCAAAGCA TAGACAACCC CGACTACCAA CAGGATTTCA CTCCCACCTT CAAGACCCAC 3300
ACCAATGGAC ACATACCGGC AGCGGAGAAT GCAGAGTACC TG 3342
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         +kk+kvlGsGafGtvykG+w+pege+vkipvaikvl+e+t++kanke+ldea+v+as++h
Q: 630   FKKIKVLGSGAFGTVYKGLWVPEGEDVKIPVAIKVLREATSPKANKEILDEAYVMASVEH  689
         59**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+ql+tql+p+Gclldyv+e+kd++Gsq+llnwcvqiakGm+ylee+
Q: 690   PHVCRLLGICLTSTVQLITQLMPYGCLLDYVKENKDNIGSQYLLNWCVQIAKGMNYLEER  749
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         +lvhrdlaarnvlvk+p+hvkitdfGlakll+adeke++a+ggkvpikw+alesil+r+y
Q: 750   HLVHRDLAARNVLVKTPQHVKITDFGLAKLLKADEKEYHADGGKVPIKWMALESILNRTY  809
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfG+kpydgipa+ei  +lekGerl+qppictidvym++vkcw
Q: 810   THQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGILEKGERLPQPPICTIDVYMIMVKCW  869
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mida+srp+f+el++ef
Q: 870   MIDADSRPRFRELIAEF  886
         ***************99
Domain Sequence
(FASTA)
FKKIKVLGSG AFGTVYKGLW VPEGEDVKIP VAIKVLREAT SPKANKEILD EAYVMASVEH 60
PHVCRLLGIC LTSTVQLITQ LMPYGCLLDY VKENKDNIGS QYLLNWCVQI AKGMNYLEER 120
HLVHRDLAAR NVLVKTPQHV KITDFGLAKL LKADEKEYHA DGGKVPIKWM ALESILNRTY 180
THQSDVWSYG VTVWELMTFG TKPYDGIPAS EIAGILEKGE RLPQPPICTI DVYMIMVKCW 240
MIDADSRPRF RELIAEF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00297
EKS-CAF-00304
EKS-CAP-00333
EKS-CII-00174
EKS-CIS-00072
EKS-DAR-00652
EKS-EQC-00289
EKS-FEC-00283
EKS-GAA-00368
EKS-HOS-00304
EKS-ICT-00280
EKS-LOA-00308
EKS-MAM-00301
EKS-MUM-00329
EKS-MUP-00295
EKS-NOL-00274
EKS-ORA-00262
EKS-ORC-00280
EKS-ORL-00358
EKS-OTG-00304
EKS-PAT-00283
EKS-POA-00289
EKS-RAN-00314
EKS-SAH-00279
EKS-TAR-00390
EKS-TEN-00385
EKS-XIM-00378
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 4.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013