EPS-ORN-00039

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORN-00039

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	193.4	7.9E-57	1025	1270	246

Status

Unreviewed

Ensembl Protein

ENSONIP00000012120

UniProt Accession

I3JTC4;

Protein Name

Protein Synonyms/Alias

Gene Name

PHLPP1 (1 of 2)

Gene Synonyms/Alias

PHLPP1 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000009647	ENSONIP00000012120	ENSONIT00000012129
ENSONIG00000009647	ENSONIP00000012119	ENSONIT00000012128

Organism

Oreochromis niloticus

Functional Description

Protein Length

1543

Protein Sequence
(FASTA)

SSSLLLRRRR LKRNLSAAAA ATTTTSAVTA ACGAKMNSAL SSASLHTRSL DRKTLMKHRQ 60

NMQLQSADRE WVRADLHRGA IHVHDRLTPS YPRPVLCTMD TTAGEVALRL SKLSSKSSSV 120

MRIFCKDASK TDQNLNSNSN MDTPNDDDSE HRNGVDSYGL NSGSDVESSA FDDLSSGARL 180

SEHRDSLSDD MILGTEASIL SPSFDSATEG HDMYGSSSDE LELDCPASSS SMDPISQHHT 240

NGITAVTANY KQCNVGHLSD VGPDSRLSPH SLGSLPPSSS SGSLSRAGST GNTPDIQDPD 300

CSQGAVKTGL TAHQNGDSYN SSPTLYVQLH GEAVRRLSPD ERPLQIQNDF LFKLGFKNPW 360

RVQEEGLNTE IGSLLRFYAG KPQSIESSER VQLSGTYNVR KGKLQLPVNR WTRRQVILCG 420

TCLIVSSVKE SQTGKMHILP LIGGKVEEVK KHNHCLAFSS AGPQSQTYYV SFDSFTEHLR 480

WQRHAAKMVS QRIHSVDLSC CSLEHLPPNL FYSHDLTHLN LKHNFLPADQ RLQQLQRFSR 540

LRSLNLSNNH LGQFPLAICD IPTLTEVNLS CNYLASVPSS VGAMTNLQTF LLDGNSLNEL 600

PNELGSLQRL SYLGLSFNQF NHVPQVLERL SSMEKLCMAG NHLETLTLQN FRLLHVKHID 660

LRLNKISIMV PDEPDLLRHV TQLDVRDNRL TELDASVFPR LEVLHCERNH ITSLKAKGSL 720

LKGIYASNNE LRQLDVSPVP SNLSYMDISR NHMESLPDWL CEAKKLEVLD ASHNLIAELP 780

ARLLCSNSLR KLSAGHNQLQ KLPERVERPL LEVLDVQHNQ LVELPCNLFL KSDSLRCVNA 840

SANKLEHLPP SSLSEESHSI LQEFYLTNNR LTDKCVPMLT GHTHLRVLHM AYNHLQTFPA 900

SKMAKLEELE EVDLSGNMLK TVPTTIMNCR RMHTLIAHSN AIEVFPEVMQ LMEMKCVDLS 960

CNELSEITLP ENLPPKLQEL DLTGNPRLNL DHKTLEQLNN IRCFRIDPPP TFSSSEASGG 1020

PAVWSHGYTE ASGVKNKLCV AALSVNSFCG SREALYGVFD GDRNVEVPYL LQCTMNDVLA 1080

EEIHKTKSEE DYMTNTFLVM QRKLGTAGQK LGGSAALCHI RHDPTDPGGC FTLTAANVGK 1140

CQAILCRDGK PLSLSLLHNV GLEEEYRRIR QHKAIITEDN KVNGVTDSTR IMGYSFLYPS 1200

VIPCPYVQTV TLTPQDEFFI LGSRGLWDAV SPTEAVEAVR NVPDGLAAAK KLCTLAQGYG 1260

CTDSLSAVVV QLNVSEDCCS CCCSDPPQPP PSPGLGPYPP SSSAIKERPS DGSLPVPPSS 1320

CSEISSEIST SEMSSEVGST ASSDEPPQSS LVLGSELPSS RSCCALHPAC LAHSFQRQLS 1380

SATFSSALSD NGLDSEDEEP IAGVFSNGSR VEVEADVHCL KAQSCLSSSP KTPVPLSSSQ 1440

EGIDISQGET ENGLERDESW PGAGVGCGDG GKLAGKRRVN GSVAQQEKSH NLIEVAADAP 1500

SKKSGGYFTA PAQPDPDDQF IIPPELEEEV KEIMKQHQQK QQK 1543

Nucleotide Sequence
(FASTA)

TCCAGCTCGC TCTTGTTGAG ACGGAGGCGC TTGAAGAGGA ACCTCTCAGC CGCAGCTGCA 60

GCCACCACTA CCACCTCAGC TGTCACAGCC GCTTGCGGCG CGAAGATGAA CTCGGCCCTG 120

TCCTCTGCGT CTTTACATAC TCGAAGTCTG GATAGGAAGA CTCTGATGAA GCACCGACAG 180

AACATGCAGC TGCAGTCCGC AGATCGCGAG TGGGTGAGAG CAGATCTCCA CCGGGGCGCC 240

ATACATGTCC ACGACAGACT GACGCCCTCG TATCCCAGGC CGGTGCTTTG CACTATGGAC 300

ACCACAGCCG GCGAGGTGGC CCTCCGACTG AGTAAACTCT CCAGCAAGTC GAGCTCTGTA 360

ATGCGTATTT TTTGTAAAGA CGCCTCCAAG ACGGACCAAA ACTTGAATTC TAACTCTAAC 420

ATGGATACCC CCAATGACGA TGATTCGGAG CACAGGAACG GTGTGGACAG TTATGGATTA 480

AACTCTGGCT CAGATGTAGA AAGCAGTGCA TTTGACGACC TGAGCTCCGG GGCCCGGCTC 540

AGTGAACACA GGGACTCCCT GAGTGATGAC ATGATCCTGG GAACTGAAGC ATCCATCCTC 600

AGTCCCTCCT TTGATAGTGC CACAGAGGGC CATGACATGT ACGGGAGCTC CTCAGACGAA 660

CTGGAACTCG ACTGCCCAGC ATCGAGCTCA AGCATGGACC CCATCTCCCA GCATCATACT 720

AATGGCATCA CTGCTGTCAC TGCCAACTAC AAGCAGTGCA ACGTGGGACA TTTAAGCGAC 780

GTGGGGCCAG ATAGCAGACT CAGCCCACAC AGTCTGGGCA GCCTCCCACC CAGCAGTAGT 840

TCCGGCTCAT TGTCAAGAGC TGGTTCTACA GGTAACACAC CTGACATCCA AGATCCGGAC 900

TGTAGCCAGG GGGCCGTAAA AACAGGGCTC ACAGCACACC AGAATGGAGA TTCTTATAAT 960

TCCAGCCCCA CACTGTATGT TCAGCTGCAT GGTGAAGCTG TTAGGAGGCT TAGCCCAGAT 1020

GAGAGGCCTC TGCAGATCCA GAATGACTTT CTCTTTAAGC TTGGATTTAA GAACCCGTGG 1080

AGAGTTCAAG AGGAGGGGCT TAACACAGAA ATTGGCTCCT TGTTACGTTT TTATGCAGGG 1140

AAGCCCCAGA GCATTGAGAG CTCAGAGAGG GTCCAGCTGT CTGGAACCTA CAACGTTCGG 1200

AAAGGGAAGC TTCAACTACC AGTCAACCGC TGGACCAGAC GCCAGGTCAT CCTGTGCGGC 1260

ACTTGCCTCA TCGTCTCCTC TGTGAAGGAG AGCCAGACAG GGAAGATGCA CATCCTGCCC 1320

CTCATTGGAG GAAAAGTGGA GGAGGTGAAG AAGCACAATC ATTGTTTGGC CTTCAGCTCA 1380

GCAGGGCCTC AGAGTCAAAC CTACTATGTC AGCTTTGACA GCTTCACGGA GCACCTGCGC 1440

TGGCAAAGAC ACGCTGCCAA GATGGTGTCC CAGAGAATCC ACTCAGTTGA TTTGTCCTGC 1500

TGCAGTCTGG AGCATCTTCC TCCCAATCTC TTTTATAGCC ACGACCTGAC CCACCTCAAC 1560

CTAAAACACA ACTTCCTGCC TGCAGATCAG CGGCTGCAGC AGCTGCAGAG ATTTTCTCGT 1620

CTTCGGAGCC TCAATCTGTC CAACAACCAC CTTGGCCAGT TCCCCCTGGC TATCTGTGAC 1680

ATACCCACTC TGACAGAGGT CAACCTCAGC TGTAACTACT TGGCCTCTGT CCCCAGCTCT 1740

GTGGGTGCCA TGACCAATTT GCAGACATTC CTACTGGATG GAAACAGCTT AAATGAACTG 1800

CCCAATGAGC TGGGTTCCTT GCAGAGGCTG AGTTACTTGG GCCTTTCCTT CAACCAGTTC 1860

AACCACGTGC CCCAGGTGCT GGAGCGGCTG TCCTCCATGG AGAAGCTCTG CATGGCTGGC 1920

AACCACCTAG AAACTCTTAC CCTGCAGAAT TTCAGACTGC TCCATGTCAA ACACATCGAT 1980

CTAAGGTTGA ATAAAATCTC CATCATGGTG CCGGACGAGC CTGACCTACT GAGGCACGTG 2040

ACCCAGCTGG ACGTGAGGGA TAACAGGCTG ACGGAGCTGG ACGCCTCGGT CTTCCCCAGG 2100

CTGGAGGTGC TTCACTGCGA GAGGAACCAC ATCACCAGCC TGAAGGCTAA GGGCTCCTTG 2160

CTCAAAGGCA TCTACGCCTC CAACAATGAG CTCCGACAGC TGGATGTCAG CCCTGTGCCC 2220

TCCAATCTGA GTTACATGGA TATCTCGAGG AACCATATGG AGTCCTTGCC AGACTGGCTA 2280

TGTGAAGCTA AGAAACTGGA AGTCCTGGAC GCGAGCCACA ACCTCATTGC TGAGCTACCA 2340

GCACGGTTGT TGTGCAGCAA CAGTCTGAGG AAGCTCAGTG CTGGACATAA CCAGCTGCAG 2400

AAGCTGCCTG AAAGAGTTGA GCGCCCTCTG CTGGAGGTTT TGGATGTACA GCACAATCAA 2460

CTGGTTGAGT TGCCCTGCAA CCTGTTCCTC AAATCTGACA GCTTACGATG CGTAAATGCA 2520

TCAGCTAATA AGCTGGAGCA CCTGCCACCA TCCAGTCTGT CAGAGGAAAG CCACAGCATT 2580

CTGCAGGAAT TCTACCTGAC CAATAACCGA CTAACAGACA AGTGTGTACC CATGCTAACA 2640

GGCCATACAC ACCTACGAGT TTTGCACATG GCCTACAACC ATCTCCAGAC CTTCCCGGCC 2700

AGTAAAATGG CTAAGCTGGA GGAGCTGGAG GAGGTGGATC TGAGTGGCAA CATGCTGAAG 2760

ACTGTCCCCA CCACCATTAT GAACTGCCGG CGAATGCACA CACTCATTGC CCACTCTAAT 2820

GCCATTGAAG TATTTCCTGA GGTCATGCAG CTGATGGAGA TGAAATGTGT GGACCTGAGC 2880

TGTAATGAGC TGAGTGAGAT CACTCTACCA GAGAATCTGC CCCCAAAGCT CCAGGAGCTG 2940

GACCTCACTG GAAACCCTCG ACTAAACCTT GACCACAAGA CCCTCGAGCA GCTCAACAAT 3000

ATTCGCTGCT TCCGTATCGA TCCACCTCCG ACCTTTTCAT CGAGTGAGGC GTCTGGTGGG 3060

CCCGCTGTGT GGAGTCATGG TTACACAGAG GCCTCGGGCG TCAAGAACAA ACTCTGTGTT 3120

GCTGCCCTTT CGGTAAACAG CTTTTGTGGG AGTCGTGAAG CTCTGTATGG TGTGTTTGAT 3180

GGAGACAGGA ATGTGGAAGT GCCCTACCTT CTGCAGTGCA CAATGAATGA TGTGCTGGCG 3240

GAAGAAATTC ACAAGACGAA GAGCGAAGAG GACTACATGA CCAACACCTT CCTTGTCATG 3300

CAAAGGAAGC TTGGAACTGC AGGACAGAAA CTGGGTGGCT CGGCAGCTCT GTGTCACATT 3360

CGCCATGACC CCACTGACCC TGGTGGCTGC TTCACCCTCA CGGCTGCTAA TGTGGGAAAG 3420

TGCCAGGCCA TTCTGTGCCG TGATGGAAAG CCGTTGTCCC TGTCACTCCT TCACAATGTA 3480

GGGCTGGAGG AGGAATACCG CAGGATCAGG CAGCACAAAG CTATCATCAC TGAGGACAAC 3540

AAAGTGAACG GTGTAACTGA TTCTACACGA ATCATGGGCT ACTCCTTCCT CTACCCTTCT 3600

GTCATCCCTT GTCCCTATGT GCAGACAGTC ACTCTCACCC CTCAGGATGA GTTCTTCATT 3660

CTCGGTAGCC GTGGCCTGTG GGATGCTGTG TCCCCCACAG AGGCTGTGGA GGCTGTTCGG 3720

AACGTCCCAG ATGGCCTGGC TGCTGCTAAA AAGCTTTGCA CATTGGCGCA GGGCTACGGC 3780

TGCACCGACA GCCTCAGCGC CGTCGTTGTG CAGCTCAATG TGAGTGAAGA CTGCTGTTCC 3840

TGCTGTTGTT CTGACCCTCC CCAGCCACCA CCCAGTCCAG GCTTGGGTCC TTATCCTCCG 3900

TCGTCCTCTG CCATCAAGGA GAGACCCTCA GATGGCTCCC TACCTGTTCC TCCCTCCTCC 3960

TGTAGTGAAA TTAGCAGTGA GATTAGCACC AGTGAGATGA GCAGCGAGGT GGGCTCTACC 4020

GCCTCATCGG ACGAACCTCC ACAGAGCTCC TTGGTCCTAG GTTCAGAGCT GCCTTCATCC 4080

CGAAGCTGCT GTGCTCTCCA CCCTGCCTGC TTAGCACACT CCTTTCAGAG GCAGCTCTCT 4140

AGTGCCACTT TCTCCAGCGC CCTGTCTGAC AACGGGCTGG ACAGCGAGGA TGAAGAGCCC 4200

ATCGCTGGGG TTTTCTCTAA CGGTAGCCGT GTGGAGGTAG AGGCAGATGT TCACTGCCTG 4260

AAAGCACAGT CCTGCTTGTC CTCATCACCC AAAACACCGG TACCCTTATC CTCCAGTCAG 4320

GAAGGGATTG ACATTAGCCA AGGAGAGACT GAGAACGGGC TTGAAAGGGA TGAGTCATGG 4380

CCGGGAGCTG GAGTGGGATG CGGGGATGGA GGGAAGCTAG CAGGCAAGAG AAGGGTTAAT 4440

GGGTCCGTGG CACAGCAGGA AAAGAGCCAC AACCTTATTG AAGTGGCTGC TGATGCTCCC 4500

TCCAAGAAGT CCGGGGGTTA CTTCACAGCT CCAGCCCAAC CTGACCCGGA CGACCAGTTC 4560

ATCATCCCAC CCGAGCTGGA GGAAGAGGTG AAGGAAATCA TGAAGCAGCA TCAGCAGAAA 4620

CAGCAGAAG 4629

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g+++ +g +n+++ a+ s+++f+ s+e+     ++gv+DG+++ ev + +++++ ++l

Q: 1025  SHGYTEASGVKNKLCVAALSVNSFCGSREA-----LYGVFDGDRNVEVPYLLQCTMNDVL  1079

         689***********************9885.....9************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

         aee+     +++  +++++++Fl ++++l       ++ +k G +a +++i+++

Q: 1080  AEEIH----KTKSEEDYMTNTFLVMQRKL------GTAGQKLGGSAALCHIRHDptdpgg  1129

         ***99....8999999*************......99***********************

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLa  173

           +l+ anvG+++a+Lcr+gk+++ls  H++  e+E++Ri+++++ +++++  +v+Gv+

Q: 1130  cfTLTAANVGKCQAILCRDGKPLSLSLLHNVGLEEEYRRIRQHKAIITEDN--KVNGVTD  1187

         ********************************************9999998..*******

S: 174   vsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekke  233

          +R +G  +l+p v+p P v+ ++lt++def+iL+s Glwd vs+ eav++vr+v +

Q: 1188  STRIMGYSFLYPSVIPCPYVQTVTLTPQDEFFILGSRGLWDAVSPTEAVEAVRNVPD---  1244

         *********************************************************...

S: 234   aeqeaakkLvklalargskdnvsaivv  260

            +aakkL++la+ +g++d++sa+vv

Q: 1245  -GLAAAKKLCTLAQGYGCTDSLSAVVV  1270

         .************************97

Domain Sequence
(FASTA)

SHGYTEASGV KNKLCVAALS VNSFCGSREA LYGVFDGDRN VEVPYLLQCT MNDVLAEEIH 60

KTKSEEDYMT NTFLVMQRKL GTAGQKLGGS AALCHIRHDP TDPGGCFTLT AANVGKCQAI 120

LCRDGKPLSL SLLHNVGLEE EYRRIRQHKA IITEDNKVNG VTDSTRIMGY SFLYPSVIPC 180

PYVQTVTLTP QDEFFILGSR GLWDAVSPTE AVEAVRNVPD GLAAAKKLCT LAQGYGCTDS 240

LSAVVV 246

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>