EKS-ORN-00353

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00353

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	465.3	9.3E-140	196	482	287

Status

Unreviewed

Ensembl Protein

ENSONIP00000012121

UniProt Accession

I3JTC6;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR1

Gene Synonyms/Alias

TGFBR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000009648	ENSONIP00000012121	ENSONIT00000012130

Organism

Oreochromis niloticus

Functional Description

Protein Length

493

Protein Sequence
(FASTA)

MFVEASACPG LHCYCDRCST NSSCTTDGIC FVAIQKSGSR MTIEQRQCVH ERDLIPRDRP 60

FICAPSTKDD SGIYPLCCTT DYCNKDPVTP TGPTATPSPL GPVALAAVIA GPVCVLCLLL 120

VLAFYVCHSH RGLGAGGAGA HHHHHHRVPN EEDPSMDHPF ITVGTTLKDL IYDMTTSGSG 180

SGLPLLVQRT IARTIILQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER SWFREAEIYQ 240

TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE GMIKLSLSTA 300

SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA DLGLAVRHDS ATDTIDIAPN 360

HRVGTKRYMA PEVLDDSINM KHFESFKRAD IYAMGLVFWE IASRCSMGGI HEDYQLPYYD 420

LVQSDPSVEE MRRVVCEQKL RPNIPNRWQS CEALRVMAKI MRECWYANGA ARLTALRIKK 480

TLSQLSQQEG IHM 493

Nucleotide Sequence
(FASTA)

ATGTTTGTAG AGGCGTCTGC ATGCCCAGGC CTTCATTGTT ACTGTGACCG CTGCAGTACC 60

AACTCCAGCT GCACGACAGA TGGTATCTGC TTTGTAGCCA TCCAAAAGTC GGGCAGCCGG 120

ATGACCATTG AGCAACGCCA GTGTGTGCAC GAACGTGACT TGATCCCACG AGACCGACCC 180

TTCATCTGTG CCCCATCTAC CAAAGATGAC AGTGGCATTT ACCCACTGTG CTGTACCACA 240

GACTACTGCA ACAAAGACCC GGTGACCCCC ACTGGCCCCA CAGCGACCCC TTCTCCTCTG 300

GGGCCGGTGG CCCTCGCTGC TGTCATTGCT GGCCCTGTAT GTGTGCTCTG CTTGCTGCTG 360

GTTTTGGCGT TCTATGTTTG CCACAGCCAC AGAGGCCTGG GCGCCGGGGG AGCCGGGGCT 420

CACCACCACC ACCACCATCG GGTGCCTAAT GAGGAGGACC CCTCCATGGA CCACCCTTTC 480

ATCACTGTGG GAACAACACT GAAGGACCTA ATCTATGACA TGACCACTTC AGGCTCTGGA 540

TCAGGTCTCC CACTGCTGGT CCAAAGAACA ATTGCCAGAA CTATCATCCT CCAGGAAAGC 600

ATTGGGAAGG GGCGTTTTGG TGAGGTTTGG CGCGGTAAAT GGCGCGGCGA GGAGGTGGCT 660

GTGAAGATTT TCTCTTCCCG AGAGGAGCGC TCCTGGTTCC GTGAGGCTGA GATCTACCAG 720

ACTGTGATGC TGAGGCATGA GAATATCCTG GGCTTCATTG CTGCTGACAA TAAAGATAAT 780

GGAACATGGA CTCAGCTGTG GCTGGTGTCG GACTACCATG AACACGGATC CCTGTTTGAC 840

TACCTGAACC GCTACACGGT CACAGTGGAG GGCATGATCA AACTGTCTCT GTCAACAGCC 900

AGCGGCCTCG CCCACCTTCA CATGGAGATT GTTGGCACGC AAGGAAAGCC AGCTATTGCC 960

CACAGAGACC TGAAGTCGAA GAACATCCTG GTGAAGAAAA ACGGGACGTG CTGCATCGCT 1020

GACCTGGGTC TGGCTGTGCG GCATGACTCT GCCACCGACA CCATCGACAT CGCTCCAAAC 1080

CACAGAGTAG GGACCAAAAG GTATATGGCT CCAGAGGTGC TGGACGACTC CATAAACATG 1140

AAGCATTTTG AGTCTTTCAA ACGAGCTGAC ATCTACGCCA TGGGCCTAGT CTTCTGGGAG 1200

ATCGCCAGTC GCTGCTCCAT GGGAGGCATT CATGAGGACT ACCAGCTGCC CTACTATGAC 1260

CTGGTCCAGT CAGATCCATC AGTGGAGGAG ATGAGAAGGG TGGTTTGTGA GCAGAAGCTT 1320

CGGCCCAACA TCCCCAATCG CTGGCAGAGC TGTGAGGCCT TGCGGGTGAT GGCAAAGATC 1380

ATGAGGGAGT GCTGGTACGC CAACGGAGCT GCACGACTCA CTGCTCTGCG AATCAAGAAA 1440

ACACTGTCTC AGCTCAGCCA GCAGGAGGGG ATCCATATG 1479

Domain Profile

S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaa  61

          l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fiaa

Q: 196   ILQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAA  255

         58899*******************************************************

S: 62    dkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtkg  121

         d+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++l ls+asGlahLH+eivgt+g

Q: 256   DNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLSLSTASGLAHLHMEIVGTQG  315

         ************************************************************

S: 122   kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPEv  181

           KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPEv

Q: 316   --KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEV  373

         ..**********************************************************

S: 182   leealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleemk  241

         l++++n+k+fe+fkraD+Y++gLv+WE+asRc++ ++++e+y+lp+++ v+sdPs+eem+

Q: 374   LDDSINMKHFESFKRADIYAMGLVFWEIASRCSM-GGIHEDYQLPYYDLVQSDPSVEEMR  432

         **********************************.*************************

S: 242   evvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 433   RVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  482

         ************************************************97

Domain Sequence
(FASTA)

ILQESIGKGR FGEVWRGKWR GEEVAVKIFS SREERSWFRE AEIYQTVMLR HENILGFIAA 60

DNKDNGTWTQ LWLVSDYHEH GSLFDYLNRY TVTVEGMIKL SLSTASGLAH LHMEIVGTQG 120

KPAIAHRDLK SKNILVKKNG TCCIADLGLA VRHDSATDTI DIAPNHRVGT KRYMAPEVLD 180

DSINMKHFES FKRADIYAMG LVFWEIASRC SMGGIHEDYQ LPYYDLVQSD PSVEEMRRVV 240

CEQKLRPNIP NRWQSCEALR VMAKIMRECW YANGAARLTA LRIKKTL 287

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013