EKS-ORN-00510

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00510

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	516.3	2.0E-155	505	769	265

Status

Unreviewed

Ensembl Protein

ENSONIP00000012420

UniProt Accession

I3JU75;

Protein Name

Protein Synonyms/Alias

Gene Name

MERTK

Gene Synonyms/Alias

MERTK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000009883	ENSONIP00000012420	ENSONIT00000012429

Organism

Oreochromis niloticus

Functional Description

Protein Length

796

Protein Sequence
(FASTA)

LVIPRVVSRM YLSPEELRKL RFKPTVGTIQ LSEGHEAKLN CSIDIPDTRL EPTILWVKDS 60

KELLPNIHVV MNELQSITDG VSTLLSTVII KHVQRVDAGE YRCRLSISNM LVESDPISIR 120

VEGLPTFVKQ PEDKNVTRYT PFTLSCEAVG PPGPVHIRWF RDGSPYTEVY SSPSNFSVTE 180

LTEIAGFTLI DFLLRLRVEA FTNRDKEIFG AQMATKYYRI LWTIRFTSHL RSFFSSKSNW 240

WKVPDFKPHG SVPKRVMDLQ LILYLITQAK LYINVNINLN CDSSVTWSNP KPVLVAFLVP 300

SIHPGNVTVQ LEGSSLVIRW KPPPSDKING ILRGYDVIVR HDTHQKKVSL SAIYEVNSTT 360

TWAHVAVEEF NKTYSVEVAA RTQAGSGMVS PRVELFVPED KSTVRPSSGP ETAVAHTNHV 420

VGIVICTIFV LLIILSGVLY FRNRVYDSCF GQRCRDEEML PPVIQYTQQR SYNRSAIGVT 480

LENLGISEEL QAKLQDVMVM RTLLSVGKVL GEGEFGSVVE GHFRQPDGTS EKVAVKTMKL 540

DSFSQREIEE FLNEAACMKD FNHPNVIKLL GVCLEVGSGH FPKPMVILPF MKHGDLHSFL 600

LRSRHRETPM FLPTQTLLKF MVDIASGMEY LSGRNFLHRD LAARNCMLRD DMTVCVADFG 660

LSKKIYSGDY YRQGRIAKMP VKWIALESLA DRVFTVKSDV WAFGVTMWEI ATRGMTPYPG 720

VQNHEIYDYL VEGHRLKQPP DCLDELYEIM YSCWRADPLD RPFFPQLREM LEKLAEKLPE 780

SSSRDDIIYI NTSFPE 796

Nucleotide Sequence
(FASTA)

CTTGTGATAC CTCGAGTTGT TTCTCGGATG TATCTGAGTC CAGAGGAGCT CAGGAAACTC 60

CGCTTTAAGC CCACCGTTGG CACCATTCAG CTGTCAGAGG GCCATGAAGC CAAACTGAAC 120

TGTTCCATTG ACATTCCTGA TACCAGACTG GAGCCCACCA TCCTGTGGGT GAAGGATAGT 180

AAGGAGCTGT TGCCAAACAT CCATGTGGTG ATGAATGAGC TCCAATCCAT CACAGATGGG 240

GTATCAACTC TCCTCTCCAC TGTCATCATT AAACATGTGC AGAGAGTGGA TGCTGGAGAG 300

TATCGTTGCC GACTGAGTAT CAGCAACATG TTGGTAGAGT CTGATCCGAT CAGCATTCGG 360

GTAGAAGGTC TGCCAACATT TGTCAAGCAA CCAGAGGACA AGAACGTAAC AAGATACACA 420

CCTTTCACCC TGTCCTGTGA AGCGGTGGGA CCACCAGGCC CTGTTCATAT CCGCTGGTTC 480

CGTGACGGAT CACCTTATAC TGAGGTTTAC AGCTCTCCCA GCAACTTCTC TGTAACAGAA 540

CTAACTGAAA TAGCTGGTTT TACTTTGATT GACTTCCTTT TGAGGCTAAG AGTGGAAGCA 600

TTTACCAACA GAGATAAAGA GATATTTGGC GCTCAGATGG CTACAAAATA TTATAGAATA 660

CTTTGGACCA TACGTTTCAC TTCTCATCTG AGAAGCTTCT TCAGTTCTAA GAGCAACTGG 720

TGGAAAGTCC CAGATTTTAA GCCCCATGGG AGTGTCCCCA AGAGGGTCAT GGACCTCCAA 780

TTGATCCTCT ACCTAATCAC ACAAGCCAAG CTGTACATTA ATGTTAACAT CAATCTTAAT 840

TGTGACAGCT CAGTAACCTG GAGCAATCCC AAACCGGTTC TCGTTGCATT CTTAGTGCCA 900

TCAATTCATC CCGGAAATGT CACAGTCCAG CTTGAAGGCT CAAGCCTGGT GATCAGGTGG 960

AAACCTCCGC CCAGTGATAA GATAAACGGG ATCCTACGTG GTTATGATGT CATTGTTAGA 1020

CATGACACAC ACCAGAAAAA GGTGAGCTTA TCTGCAATAT ATGAGGTCAA TAGTACTACC 1080

ACTTGGGCAC ATGTAGCTGT GGAGGAATTC AACAAAACCT ACAGTGTGGA GGTGGCCGCA 1140

CGCACGCAGG CAGGAAGCGG CATGGTCAGC CCACGAGTTG AATTGTTTGT GCCAGAGGAC 1200

AAATCCACCG TACGCCCTTC ATCCGGCCCT GAGACAGCGG TAGCACACAC AAACCATGTC 1260

GTGGGGATCG TGATTTGTAC CATCTTTGTC CTGCTGATCA TCCTCTCTGG GGTTCTCTAT 1320

TTTCGGAACA GGGTTTATGA CTCCTGTTTT GGGCAGCGTT GCAGAGATGA AGAAATGCTG 1380

CCGCCTGTCA TACAGTACAC ACAACAGAGG TCCTACAACC GATCGGCCAT AGGAGTCACT 1440

CTTGAGAACC TTGGGATCAG TGAGGAACTC CAGGCCAAAC TTCAGGATGT GATGGTAATG 1500

AGAACTCTGC TCTCAGTGGG GAAAGTTCTT GGAGAGGGTG AGTTTGGTTC AGTGGTGGAA 1560

GGTCATTTCA GACAACCAGA TGGCACTTCA GAAAAGGTTG CCGTGAAGAC AATGAAATTG 1620

GATAGTTTTT CTCAAAGGGA GATTGAAGAG TTCCTGAATG AGGCTGCTTG CATGAAAGAT 1680

TTCAACCATC CTAATGTCAT CAAACTGCTC GGTGTATGCT TGGAAGTAGG CTCAGGACAC 1740

TTTCCTAAAC CCATGGTAAT TCTGCCGTTT ATGAAACACG GAGATCTGCA TAGCTTCCTG 1800

CTGCGTTCAC GCCACAGAGA GACTCCAATG TTCTTGCCCA CTCAGACACT CCTGAAGTTC 1860

ATGGTTGACA TTGCTTCGGG TATGGAGTAT CTCAGTGGTC GTAACTTTCT GCATCGAGAC 1920

CTGGCGGCAC GCAACTGCAT GCTGCGTGAC GACATGACAG TGTGTGTAGC AGATTTTGGA 1980

TTATCTAAAA AGATCTACAG TGGTGACTAT TACAGGCAGG GAAGAATTGC GAAAATGCCT 2040

GTAAAATGGA TCGCATTAGA GAGTCTGGCA GACAGAGTTT TTACTGTAAA GAGTGACGTG 2100

TGGGCGTTTG GTGTCACCAT GTGGGAAATT GCTACAAGAG GCATGACGCC GTACCCTGGA 2160

GTCCAGAACC ATGAAATTTA TGATTATCTA GTTGAAGGAC ACAGACTGAA GCAGCCCCCA 2220

GACTGTTTGG ATGAACTGTA TGAAATCATG TACAGCTGCT GGAGAGCCGA TCCGCTAGAC 2280

CGACCCTTCT TTCCCCAGCT GCGAGAAATG TTGGAAAAGC TCGCCGAAAA GCTTCCAGAG 2340

TCTTCCAGCA GGGATGATAT CATTTATATC AACACCAGCT TTCCTGAG 2388

Domain Profile

S: 2     vlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdhp  61

          +gkvlgegefgsv+eg+++q dg++ kvavkt+kld ++++eieefl+eaacmk+f+hp

Q: 505   SVGKVLGEGEFGSVVEGHFRQPDGTSEKVAVKTMKLDSFSQREIEEFLNEAACMKDFNHP  564

         68**********************************************************

S: 62    nvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmvd  121

         nvi+l+gv+le+ +  ++pkp+vilpfmk+gdlh+fll sr  e p++lp+qtl+kfmvd

Q: 565   NVIKLLGVCLEVGSG-HFPKPMVILPFMKHGDLHSFLLRSRHRETPMFLPTQTLLKFMVD  623

         ***********9875.5*******************************************

S: 122   iasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvkw  181

         iasgmeyls rnf+hrdlaarncml++dmtvcvadfglskkiysgdyyrqgriak+pvkw

Q: 624   IASGMEYLSGRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKW  683

         ************************************************************

S: 182   iaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedcl  241

         ia+esladrv+t+ksdvwafgvtmweiatrg+tpy+gv+n+eiydyl++g+rlkqp+dcl

Q: 684   IALESLADRVFTVKSDVWAFGVTMWEIATRGMTPYPGVQNHEIYDYLVEGHRLKQPPDCL  743

         ************************************************************

S: 242   delydlmyrcweadpkdrpsfsvlre  267

         dely++my+cw+adp drp f +lre

Q: 744   DELYEIMYSCWRADPLDRPFFPQLRE  769

         *********************99985

Domain Sequence
(FASTA)

SVGKVLGEGE FGSVVEGHFR QPDGTSEKVA VKTMKLDSFS QREIEEFLNE AACMKDFNHP 60

NVIKLLGVCL EVGSGHFPKP MVILPFMKHG DLHSFLLRSR HRETPMFLPT QTLLKFMVDI 120

ASGMEYLSGR NFLHRDLAAR NCMLRDDMTV CVADFGLSKK IYSGDYYRQG RIAKMPVKWI 180

ALESLADRVF TVKSDVWAFG VTMWEIATRG MTPYPGVQNH EIYDYLVEGH RLKQPPDCLD 240

ELYEIMYSCW RADPLDRPFF PQLRE 265

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 1.
SM00409	; IG; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 1.
PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013