EKS-ORN-00339

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00339

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	413.8	3.6E-124	65	317	253

Status

Unreviewed

Ensembl Protein

ENSONIP00000012473

UniProt Accession

I3JUC7;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK3

Gene Synonyms/Alias

PLK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000009923	ENSONIP00000012472	ENSONIT00000012481
ENSONIG00000009923	ENSONIP00000012473	ENSONIT00000012482

Organism

Oreochromis niloticus

Functional Description

Protein Length

667

Protein Sequence
(FASTA)

MSTGCFTAAQ RISCHTMNAD LFKPAPERGG PQQTSAPAKN SRNKHDQPKP ELAQVVTDLK 60

TGRSYIKGKL LGKGGFARCY EMTDLSNNKM YAVKVIPQSR VSKPHQRDKI TNEIELHRTL 120

SHKHVVKFSH YFEDQENIYI FLELCSRKSL AHIWKARHTL TEPEVRYYLR QIISGLKYLH 180

SRGILHRDLK LGNFFINENM ELRLGDFGLA AKLETVEQRK KTICGTPNYL APEVLNRQGH 240

GTESDVWSLG CVMYTLMCGN PPFETLDLKE TYKCIKEVRY NLPSTLSPAA QKLISGILQK 300

NPSDRLTLDQ ILNHEFFKGF TPDKLPPSSC TMVPELHPPS PAKKFFTKMA KSLFGKKKAK 360

VEKIPCEDKE DKDISKLVSG IVKCSINRQI SYKTVGPNEV QSPTGQLVSS VPLEQTPAEE 420

ESRKSISRSF KGTMASSTEP CEDVLTPAAV ADSALKVLTN CLATMPAANR NPPCLSSPQS 480

FLWVTKWVDY SNKYGFGYQL SNQNVGVLFN EGTHLSLCDQ RKTVHYCLTN NKHFSFPANS 540

LPEQLRNQKQ IVELMANYME ENLMEGGDLH CEEHVSAPPP LLLQWVKTDH ALVMLFNNGT 600

LQVNFYTDHT KIILCKSSDD AYLLTYISRE RASCTYLLSM LNEMGCTSEL RHRLRYVVQL 660

LQHHTDA 667

Nucleotide Sequence
(FASTA)

ATGAGTACCG GCTGTTTCAC CGCGGCTCAG CGGATTTCGT GCCACACCAT GAATGCGGAT 60

TTATTTAAGC CTGCTCCGGA GCGTGGTGGA CCCCAACAGA CTTCTGCCCC GGCGAAAAAC 120

AGCAGGAATA AACACGACCA ACCCAAACCG GAGCTGGCTC AGGTTGTGAC GGATCTCAAG 180

ACGGGGAGGT CCTACATTAA AGGGAAGCTT TTGGGAAAGG GCGGCTTTGC TCGATGCTAT 240

GAGATGACAG ACCTGTCCAA CAACAAAATG TATGCAGTGA AGGTGATCCC ACAGAGCAGG 300

GTGTCCAAAC CACACCAGAG AGACAAGATT ACGAACGAGA TCGAGCTGCA CAGAACGCTG 360

TCACACAAGC ATGTGGTGAA ATTCTCCCAC TATTTCGAGG ACCAAGAAAA CATCTACATC 420

TTCCTCGAGC TGTGCAGTCG GAAGTCCCTG GCACACATTT GGAAGGCGAG ACACACACTC 480

ACAGAGCCTG AAGTGCGCTA TTACCTCAGA CAGATCATAT CCGGCCTCAA GTACCTCCAC 540

AGCAGAGGAA TCCTGCACAG GGATCTCAAA CTAGGGAACT TTTTCATCAA TGAGAACATG 600

GAGTTGCGGC TGGGAGACTT TGGCCTCGCT GCCAAGCTGG AGACAGTTGA ACAAAGAAAA 660

AAAACAATCT GCGGGACTCC TAATTACTTG GCTCCTGAGG TGCTCAACAG ACAGGGCCAC 720

GGCACAGAGT CTGACGTGTG GTCCCTCGGA TGTGTCATGT ACACACTGAT GTGTGGAAAC 780

CCTCCTTTTG AGACACTCGA CTTGAAAGAG ACGTACAAGT GTATTAAAGA AGTTCGCTAC 840

AACCTTCCCT CCACGCTTTC CCCTGCTGCT CAGAAACTCA TCTCAGGCAT CCTACAGAAG 900

AATCCCAGTG ACAGACTCAC GCTGGATCAG ATCCTCAACC ACGAGTTCTT CAAAGGTTTC 960

ACTCCTGACA AACTTCCTCC CAGCAGCTGT ACAATGGTGC CAGAGCTACA CCCTCCCAGC 1020

CCTGCCAAGA AATTCTTCAC TAAAATGGCC AAAAGCCTAT TTGGAAAGAA GAAAGCAAAA 1080

GTGGAAAAAA TTCCATGCGA GGACAAAGAG GACAAGGATA TTTCCAAGCT GGTGTCGGGC 1140

ATCGTTAAAT GTTCCATCAA CCGGCAGATC AGCTACAAAA CAGTGGGACC CAATGAGGTG 1200

CAGTCTCCCA CCGGTCAGCT GGTGAGCTCT GTGCCTCTGG AGCAGACTCC TGCTGAGGAG 1260

GAATCCAGGA AGTCCATTTC CAGGTCCTTT AAGGGCACCA TGGCCAGCAG CACTGAACCA 1320

TGTGAGGATG TGCTGACCCC TGCAGCTGTC GCTGACTCTG CGCTGAAAGT TCTCACGAAC 1380

TGCCTGGCCA CCATGCCTGC AGCCAATAGG AATCCACCCT GCCTGTCCAG TCCGCAGTCC 1440

TTCCTGTGGG TGACTAAATG GGTTGACTAC TCCAACAAGT ATGGCTTTGG CTACCAGCTC 1500

TCGAACCAAA ACGTAGGCGT GCTCTTCAAT GAGGGAACAC ATCTCAGTCT TTGTGACCAG 1560

CGCAAGACAG TCCACTACTG CTTGACCAAC AACAAACACT TCAGCTTCCC TGCAAACTCT 1620

CTACCTGAGC AGCTGCGCAA CCAGAAACAA ATAGTCGAAC TAATGGCTAA CTACATGGAG 1680

GAGAACCTAA TGGAGGGTGG AGATCTGCAT TGTGAGGAAC ATGTCTCAGC TCCTCCTCCT 1740

CTGCTCCTCC AGTGGGTGAA GACTGACCAT GCTCTTGTCA TGCTCTTCAA CAATGGCACT 1800

CTACAGGTTA ACTTCTACAC AGACCACACC AAAATCATCC TGTGCAAGTC TTCTGACGAC 1860

GCCTACCTGC TTACCTATAT CAGTCGGGAA CGTGCCTCGT GCACGTACCT CCTCAGCATG 1920

CTGAATGAAA TGGGCTGCAC ATCTGAGCTA CGACACCGCC TTAGATATGT GGTCCAGCTT 1980

CTCCAGCACC ACACTGATGC CTGA 2004

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y +gkllGkGgfa+cye++dl++++++avkv+p+s++ k++qr+k+++eie+hr+l+hk+

Q: 65    YIKGKLLGKGGFARCYEMTDLSNNKMYAVKVIPQSRVSKPHQRDKITNEIELHRTLSHKH  124

         889*********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +vk++++fed+en+y++lelcsr+sla+++k+r++ltepevryylrqi+sglkylh++ i

Q: 125   VVKFSHYFEDQENIYIFLELCSRKSLAHIWKARHTLTEPEVRYYLRQIISGLKYLHSRGI  184

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f+ne++e+++gdfGla++le+ e+rkkt+cGtPny+aPevl+++gh++e+

Q: 185   LHRDLKLGNFFINENMELRLGDFGLAAKLETVEQRKKTICGTPNYLAPEVLNRQGHGTES  244

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+WslGc++ytl++G+PPfet +lkety++ik+ +y+lPs+ls++a++li+ +l+k+P++

Q: 245   DVWSLGCVMYTLMCGNPPFETLDLKETYKCIKEVRYNLPSTLSPAAQKLISGILQKNPSD  304

         ************************************************************

S: 241   rpsleevlkdefl  253

         r++l+++l++ef+

Q: 305   RLTLDQILNHEFF  317

         ************8

Domain Sequence
(FASTA)

YIKGKLLGKG GFARCYEMTD LSNNKMYAVK VIPQSRVSKP HQRDKITNEI ELHRTLSHKH 60

VVKFSHYFED QENIYIFLEL CSRKSLAHIW KARHTLTEPE VRYYLRQIIS GLKYLHSRGI 120

LHRDLKLGNF FINENMELRL GDFGLAAKLE TVEQRKKTIC GTPNYLAPEV LNRQGHGTES 180

DVWSLGCVMY TLMCGNPPFE TLDLKETYKC IKEVRYNLPS TLSPAAQKLI SGILQKNPSD 240

RLTLDQILNH EFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR020658	; Ser/Thr_kinase_Plk3.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013