EKS-ORN-00438

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00438

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/DCAMKL	447.4	2.1E-134	413	670	258

Status

Unreviewed

Ensembl Protein

ENSONIP00000012619

UniProt Accession

I3JUS5;

Protein Name

Protein Synonyms/Alias

Gene Name

DCLK2 (2 of 2)

Gene Synonyms/Alias

DCLK2 (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000010034	ENSONIP00000012619	ENSONIT00000012629
ENSONIG00000010034	ENSONIP00000012620	ENSONIT00000012630

Organism

Oreochromis niloticus

Functional Description

Protein Length

718

Protein Sequence
(FASTA)

MSLSRSIEFE HFEERDKPHR PPRTNSGSGS QCGSRGNGLV PSPAHSAHCS FYRTRTLQSL 60

TSEKKARKVR FYRNGDKYFK GLVYAVSNDR FRSLDALLME LTRSLSDNVN LPQGVRTLYT 120

LDGGRKITSL DELVEGESYV CASNEPFRRV DYTKNVNPNW SVGSKTSTSR SLSSLFPLKS 180

ELQRESKDFI KPKLVTVIRS GVKPRKAVRI LLNKKTAHSF EQVLTDITDA IKLDSGAVRR 240

LYTLEGKQIT CLQDFFGDDD VFIACGPEKF RYAQDDFVLD HSGKASTAFT TECRVLKSSY 300

SRSATPNRTA KSPGVSRRSK SPGAARRPAH FSTTQSPVKS PVNGISTHKS TKSSTPSPTS 360

PRTTPSFKIP PSHHHSSPNI NGSLNNHQEQ TNQLSPEVNG NQHSHASSIC EKYRIGKVIG 420

DGNFAVVKDC VERSTGKEFA LKIIDKTKCS GKEHLIENEV AVLRKVKHPN IIMLIEEVDT 480

PSELYLVMEL VKGGDLFDAI TSSAKYTERD ASIMVYNLAG ALKYLHSLNI VHRDIKPENL 540

LVFEYPDGTK SLKLGDFGLA TVVEGPLYTV CGTPTYVAPE IIAESGYGLK VDIWAAGVIT 600

YILLCGFPPF RSENNQQEDL FDQILRGRLD FPSPYWDNIT DSAKELIGKM LQVNAEARYT 660

AQDVLSHPWV TDDAIMENNM KMEVTGKLKT HFNTAPKHST TTAGVSVIML QGNEHSAR 718

Nucleotide Sequence
(FASTA)

ATGTCGCTAA GCAGAAGTAT TGAATTTGAA CACTTTGAGG AACGAGACAA GCCTCACCGG 60

CCACCGAGGA CCAATTCGGG CTCCGGGTCT CAATGTGGCT CTAGAGGTAA CGGGCTGGTG 120

CCAAGCCCCG CGCACAGTGC GCATTGTAGT TTCTACCGCA CACGCACTCT CCAGTCCCTC 180

ACCTCCGAGA AAAAGGCCAG GAAGGTGCGC TTTTATCGCA ATGGTGACAA GTATTTCAAA 240

GGTTTGGTGT ACGCCGTGTC TAATGACCGC TTCAGATCCC TGGATGCCCT GCTCATGGAG 300

CTCACACGGT CCCTGTCAGA CAACGTCAAC CTTCCGCAAG GAGTCCGGAC GTTGTACACG 360

CTGGATGGGG GCAGGAAGAT CACCAGCCTG GATGAGTTAG TAGAGGGAGA GAGTTACGTG 420

TGCGCCTCAA ACGAACCCTT CCGACGTGTC GACTACACCA AGAACGTGAA CCCCAACTGG 480

TCAGTGGGCA GCAAGACCAG CACATCGCGC TCCCTCTCGT CTCTCTTCCC ACTGAAGAGT 540

GAGCTGCAGA GGGAATCTAA GGACTTCATC AAACCCAAGT TGGTCACAGT CATCCGCAGC 600

GGCGTCAAGC CCCGCAAGGC CGTTCGGATA CTGCTCAATA AGAAAACTGC ACACTCCTTT 660

GAGCAGGTGC TCACCGACAT CACAGACGCT ATCAAGTTGG ACTCTGGCGC AGTGAGGAGA 720

CTGTACACGC TGGAAGGCAA GCAGATCACC TGCCTGCAGG ACTTCTTCGG GGATGATGAT 780

GTCTTCATAG CGTGCGGACC AGAGAAGTTT CGCTATGCCC AAGACGACTT TGTGCTGGAT 840

CACAGTGGTA AGGCTTCCAC AGCCTTTACA ACCGAATGCA GAGTGCTAAA GTCGTCATAC 900

AGCCGCTCTG CTACTCCAAA CCGGACGGCT AAAAGCCCTG GAGTTTCACG GCGCAGCAAG 960

TCCCCCGGTG CAGCAAGGCG ACCTGCCCAC TTCTCCACCA CACAGTCCCC AGTCAAGTCC 1020

CCAGTAAATG GTATTTCAAC CCACAAGTCC ACCAAGTCCT CTACTCCATC CCCTACCAGC 1080

CCTCGAACCA CCCCCAGTTT TAAGATCCCT CCGTCACATC ACCACTCTTC CCCAAATATA 1140

AATGGCTCGT TGAACAATCA TCAGGAGCAA ACCAATCAGC TGAGTCCAGA AGTTAATGGG 1200

AACCAGCACT CGCATGCCTC AAGCATCTGT GAAAAATACA GGATTGGCAA AGTCATCGGA 1260

GATGGCAACT TTGCTGTGGT CAAAGATTGT GTGGAGAGGT CCACGGGGAA AGAGTTTGCC 1320

CTGAAGATTA TCGACAAGAC AAAGTGCAGC GGAAAGGAGC ACCTCATAGA GAATGAAGTC 1380

GCTGTGCTCC GGAAGGTGAA ACATCCCAAC ATCATCATGT TGATCGAGGA GGTGGACACT 1440

CCCTCTGAAC TATACCTGGT TATGGAGCTG GTGAAGGGAG GCGATTTATT TGACGCCATC 1500

ACCTCCTCGG CCAAATACAC AGAGAGAGAC GCCAGTATCA TGGTGTACAA CCTCGCCGGA 1560

GCGCTGAAGT ACCTACACAG CTTGAACATC GTCCACAGAG ACATTAAACC AGAGAATCTA 1620

CTGGTTTTCG AGTACCCAGA TGGCACCAAA TCACTGAAAC TTGGAGACTT CGGCCTAGCT 1680

ACAGTAGTCG AGGGCCCCTT GTATACTGTA TGTGGCACTC CTACATATGT GGCTCCAGAA 1740

ATCATCGCTG AGTCAGGTTA CGGCCTGAAG GTGGATATCT GGGCTGCAGG TGTCATCACC 1800

TACATCCTCC TGTGTGGATT CCCTCCTTTT AGAAGTGAGA ATAACCAGCA AGAGGACCTG 1860

TTTGACCAAA TCCTTCGAGG GCGACTGGAC TTTCCCAGTC CTTACTGGGA CAACATCACT 1920

GACTCGGCTA AGGAGCTGAT TGGAAAGATG CTGCAGGTCA ACGCTGAGGC TCGATACACA 1980

GCACAAGATG TCCTCTCACA TCCATGGGTC ACGGATGATG CAATCATGGA GAATAACATG 2040

AAGATGGAGG TGACAGGTAA ACTGAAGACG CACTTTAACA CCGCGCCAAA GCACAGCACC 2100

ACCACAGCCG GGGTGTCAGT CATCATGCTC CAAGGCAATG AACACAGCGC TAGATAA 2157

Domain Profile

S: 1     yeigrviGdGnfavvkevreretgkeyalkiidksklkGkehlidneveilkkvkhpniv  60

         y+ig+viGdGnfavvk+++er+tgke+alkiidk+k+ Gkehli+nev++l+kvkhpni+

Q: 413   YRIGKVIGDGNFAVVKDCVERSTGKEFALKIIDKTKCSGKEHLIENEVAVLRKVKHPNII  472

         99**********************************************************

S: 61    klieeletetelylvlelvkgGdlfdaitkstkleerdaaimilelakalkylhelnivh  120

         +liee++t +elylv+elvkgGdlfdait+s+k++erda+im+++la alkylh+lnivh

Q: 473   MLIEEVDTPSELYLVMELVKGGDLFDAITSSAKYTERDASIMVYNLAGALKYLHSLNIVH  532

         ************************************************************

S: 121   rdvkpenllvvekedgskslkladfGlaaevegplytvcGtPtyvaPeilaetGyglkvd  180

         rd+kpenllv e+ dg+kslkl+dfGla++vegplytvcGtPtyvaPei+ae Gyglkvd

Q: 533   RDIKPENLLVFEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAESGYGLKVD  592

         ************************************************************

S: 181   iWaaGvilyillvGfpPfrssdedqeelfdlilsgklefpsPyWdnisdkakdlvsrlle  240

         iWaaGvi+yill+GfpPfrs++++qe+lfd+il g+l+fpsPyWdni+d+ak+l+ ++l+

Q: 593   IWAAGVITYILLCGFPPFRSENNQQEDLFDQILRGRLDFPSPYWDNITDSAKELIGKMLQ  652

         ************************************************************

S: 241   vdeekrltaeqilehpwv  258

         v+ e+r+ta+++l+hpwv

Q: 653   VNAEARYTAQDVLSHPWV  670

         *****************8

Domain Sequence
(FASTA)

YRIGKVIGDG NFAVVKDCVE RSTGKEFALK IIDKTKCSGK EHLIENEVAV LRKVKHPNII 60

MLIEEVDTPS ELYLVMELVK GGDLFDAITS SAKYTERDAS IMVYNLAGAL KYLHSLNIVH 120

RDIKPENLLV FEYPDGTKSL KLGDFGLATV VEGPLYTVCG TPTYVAPEII AESGYGLKVD 180

IWAAGVITYI LLCGFPPFRS ENNQQEDLFD QILRGRLDFP SPYWDNITDS AKELIGKMLQ 240

VNAEARYTAQ DVLSHPWV 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR003533	; Doublecortin_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF03607	; DCX; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00537	; DCX; 2.
SM00220	; S_TKc; 1.

Prosites

PS50309	; DC; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013