EKS-ORN-00182

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00182

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	552.6	1.6E-166	474	750	277

Status

Unreviewed

Ensembl Protein

ENSONIP00000012815

UniProt Accession

I3JVC0;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR2

Gene Synonyms/Alias

FGFR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000010192	ENSONIP00000012815	ENSONIT00000012825

Organism

Oreochromis niloticus

Functional Description

Protein Length

814

Protein Sequence
(FASTA)

MASWAWLLAA VLLSLLTVSV ARPPLTATKE EATLEPEEAS NKYQISKPTV CSVHPGEVLK 60

LSCPLPVTGT ITWTKDGSSL GNNNRTLIEQ EVLQIRDATP KDSGLYACTS VGKDTVCFIV 120

NVTDAISSGD DEDDTERSED TGADGEQLSA PYWTSSAKME KKLHAVPAAN TVKFRCAAGG 180

NPKPKLRWLK NSKPFRQEDR MGGYKVRSQH WTLIMESVVP SDKGNYTCLV ENEYGSINHT 240

YTLDVVAERS PHRPILQAGL PANTTVHVGE DARFVCKVYS DAQPHIQWLK HISQNGSRYG 300

TDGHPYVRVL KTAGVNTTDK EIEVLYLPNV TFEDAGEYTC LAGNSIGISY HTAWLTVLPA 360

LEKTPESISP DYVEIAIYCA GVFLIACMVG IVVVCRMRNT AKKPDFGGQP AVHKLTKQIP 420

LRRQVTVSAD SSSSMNSSTP LVRITTRRSS AHDEPIPEYD LPEDPRWEFP RDRLTLGKPL 480

GEGCFGQVVM AEALGIDKDK PKEAVTVAVK MLKDDATEKD LSDLVSEMEM MKMIGKHKNI 540

INLLGACTQD GPLYVIVEYA SKGNLREYLR ARRPPGMEYS YDIARVSDEQ LTFKDLVSCT 600

YQVARGMEYL ASQKCIHRDL AARNVLVTES NIMKIADFGL ARDVHNIDYY KKTTNGRLPV 660

KWMAPEALFD RVYTHQSDVW SFGVLMWEIF TLGGSPYPGI PVEELFKLLK EGHRMDKPGN 720

CTNELYMMMK DCWHAISSQR PTFKQLVEDL DRILTLSTNE EYLDLCAPTE QYSPSFPDTR 780

SSCSSGDDSV FSHDPLPDEP CIPKYQHING NVKT 814

Nucleotide Sequence
(FASTA)

ATGGCCTCGT GGGCCTGGCT CCTGGCCGCT GTCCTGCTGT CCCTTTTGAC TGTCAGCGTG 60

GCCCGGCCGC CCCTTACTGC CACCAAGGAG GAGGCCACTC TGGAACCTGA AGAGGCGTCG 120

AACAAATACC AAATTTCTAA GCCCACGGTG TGCTCAGTGC ACCCGGGGGA AGTGCTGAAG 180

CTCAGCTGCC CTCTGCCAGT GACGGGGACC ATCACCTGGA CCAAAGATGG CAGCTCTCTG 240

GGCAACAACA ACCGCACGCT GATAGAGCAG GAGGTGCTGC AGATCCGTGA CGCCACGCCC 300

AAGGATTCGG GCCTGTACGC CTGCACCAGC GTGGGCAAAG ACACGGTCTG CTTCATAGTC 360

AATGTCACAG ATGCCATCTC GTCGGGGGAT GATGAGGACG ATACAGAGCG ATCGGAGGAC 420

ACTGGGGCGG ATGGAGAGCA GTTAAGCGCG CCGTATTGGA CCTCATCAGC AAAGATGGAG 480

AAGAAGCTGC ATGCGGTGCC AGCTGCCAAC ACAGTCAAGT TCCGCTGTGC TGCAGGAGGC 540

AACCCCAAGC CCAAGCTGCG CTGGCTTAAA AACAGCAAGC CTTTCCGCCA AGAGGACCGC 600

ATGGGAGGGT ATAAGGTGCG TAGCCAGCAC TGGACCCTGA TCATGGAGAG CGTGGTGCCG 660

TCCGACAAAG GCAACTACAC CTGTTTGGTG GAGAACGAGT ATGGATCCAT CAACCATACC 720

TACACCCTGG ACGTAGTGGC AGAGCGGTCT CCTCATCGGC CTATTCTTCA GGCCGGCCTC 780

CCGGCCAACA CCACTGTCCA CGTAGGAGAG GATGCCCGTT TCGTTTGCAA GGTCTACAGT 840

GATGCCCAAC CTCACATCCA GTGGCTAAAA CATATCAGTC AGAACGGCAG CCGCTACGGC 900

ACAGATGGAC ACCCCTATGT CAGAGTGTTA AAGACCGCAG GTGTTAACAC CACAGATAAG 960

GAGATAGAAG TTCTCTACTT GCCCAATGTA ACATTTGAAG ATGCTGGGGA GTATACGTGC 1020

TTGGCGGGTA ATTCTATTGG GATCTCCTAT CACACTGCTT GGTTGACGGT GCTTCCAGCG 1080

CTTGAGAAGA CTCCCGAGTC CATTTCCCCA GACTACGTGG AGATCGCGAT ATACTGCGCG 1140

GGCGTCTTCC TCATTGCCTG CATGGTGGGC ATTGTGGTGG TGTGCCGTAT GAGGAACACT 1200

GCAAAGAAGC CCGACTTTGG TGGCCAGCCA GCGGTTCACA AACTGACCAA GCAGATCCCC 1260

CTGCGCCGCC AGGTAACAGT CTCAGCAGAC TCGAGTTCTT CCATGAACTC TAGCACGCCT 1320

CTGGTGCGCA TCACGACACG GCGGAGCTCT GCACACGATG AGCCAATCCC AGAGTACGAC 1380

CTTCCTGAGG ATCCGCGGTG GGAGTTTCCT AGAGACAGGT TGACCCTGGG CAAACCCCTC 1440

GGTGAGGGCT GTTTTGGCCA AGTCGTAATG GCAGAGGCGC TGGGCATCGA TAAGGACAAA 1500

CCCAAGGAGG CTGTAACTGT TGCAGTCAAG ATGCTGAAAG ATGACGCCAC CGAGAAAGAC 1560

CTGTCTGACC TGGTGTCAGA GATGGAGATG ATGAAGATGA TTGGCAAGCA TAAGAACATC 1620

ATTAACCTTT TGGGGGCCTG TACACAAGAT GGCCCCCTCT ATGTCATAGT CGAGTATGCC 1680

TCCAAAGGTA ACCTCAGGGA GTACCTCCGA GCCCGCCGGC CACCCGGCAT GGAATACTCC 1740

TACGACATCG CCCGTGTCTC AGATGAACAG CTCACGTTCA AAGATCTGGT CTCCTGCACT 1800

TATCAGGTGG CGCGGGGCAT GGAGTACCTA GCATCGCAGA AGTGTATACA CAGAGACCTG 1860

GCAGCGAGGA ACGTCCTGGT CACAGAGAGC AACATCATGA AGATCGCCGA CTTCGGTCTG 1920

GCCAGGGATG TCCACAACAT CGACTACTAT AAAAAGACGA CCAATGGTCG TCTCCCGGTG 1980

AAGTGGATGG CTCCAGAGGC ACTCTTCGAC CGGGTCTACA CACACCAGAG TGATGTCTGG 2040

TCATTTGGGG TGCTGATGTG GGAGATCTTC ACCCTAGGGG GCTCACCCTA CCCTGGTATC 2100

CCCGTTGAGG AGCTCTTCAA GTTGCTTAAA GAGGGCCATC GCATGGACAA GCCCGGAAAC 2160

TGCACCAACG AGCTGTACAT GATGATGAAA GATTGCTGGC ATGCCATCTC ATCCCAGAGA 2220

CCCACCTTCA AGCAGCTAGT AGAGGATCTG GATCGCATCC TAACCCTGAG CACCAATGAG 2280

GAGTATCTGG ACCTGTGCGC CCCAACAGAG CAGTATTCCC CCAGCTTCCC CGACACTCGG 2340

AGTTCCTGCT CCTCCGGCGA CGACTCCGTG TTTTCCCACG ACCCATTACC GGACGAGCCC 2400

TGCATCCCCA AGTACCAGCA CATCAACGGG AATGTCAAAA CATGA 2445

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aea+g+dkdk+k++vtvavkmlk+dat+kdl+dlvseme++k+

Q: 474   LTLGKPLGEGCFGQVVMAEALGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  533

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+s+d +++s+eqlt+

Q: 534   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDIARVSDEQLTF  593

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs++yqvarGmeylas+kcihrdlaarnvlvte n++kiadfGlardvh+idyykkt

Q: 594   KDLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNIMKIADFGLARDVHNIDYYKKT  653

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh

Q: 654   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  713

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp +ct+ely++m++cwha +s+rptfkqlvedl

Q: 714   RMDKPGNCTNELYMMMKDCWHAISSQRPTFKQLVEDL  750

         ***********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA LGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI ARVSDEQLTF 120

KDLVSCTYQV ARGMEYLASQ KCIHRDLAAR NVLVTESNIM KIADFGLARD VHNIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPGNCTN ELYMMMKDCW HAISSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR013151	; Immunoglobulin.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF00047	; ig; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013