EKS-ORN-00009
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00009
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph509.31.8E-153620877258
StatusUnreviewed
Ensembl ProteinENSONIP00000012932
UniProt AccessionI3JVN6;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA4 (2 of 2)
Gene Synonyms/Alias EPHA4 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000010283ENSONIP00000012931ENSONIT00000012941
ENSONIG00000010283ENSONIP00000012932ENSONIT00000012942
OrganismOreochromis niloticus
Functional Description
Protein Length984
Protein Sequence
(FASTA)
QRSFFSIIIF LRLGVLKWAD SRTRIYPPNE VTLLDTRTVP GELKWAASPS EGGWEEVSIM 60
DEKNIPIRTY QVCNVLEPNQ NNWLRTDWIP RSGAQRVYVE VKFTLRDCNS LPGVTGTCKE 120
TFNLYYHESN EDRESYIKES SFIKVDTVAA DESFTQVDVG DRIMKLNTEV RDVKVTTRKG 180
FYLAFQDVGA CIALVSVRVF YKTCPLTVRN LATFPDTITG ADTSSLVEVR GSCVNQSEER 240
EEPKMYCGAD GEWLVPIGGC LCNPGYEERG GACKACPAGF YKAKSTDPGC AKCPPHSHSL 300
RDGATICDCH AGFFRADTDP PSMACTQPPS APQQLISVVN ETSVVLEWTP PHRLGGRSDT 360
SYSLECLICQ TGSQVCVPCA SDVLFSPGQT GLKATRVVVS ELRAHTHYTF IVHARNGVSQ 420
ASGAGAAQSV SVSVTTNQAA PSPVSSIQAT DVTRHSLSLS WQQPDRPNGV ILEYEVKFYE 480
KDQRERSYRI MRTFSRSVDV TGLNPLTVYV FHVRARTAAG YGEFSAPFEF STNSDPFPLI 540
GEGVNSAFLL LSVSGVGILL LISAAVLCVI RRSKYSKTKQ DSEEEKHLNP GVKIYVDPFT 600
YEDPDQAIHE FAKEIDVSSI HIEKVIGMGE FGEVCSGRLR VQGKREIYVA IKSLKAGYSD 660
KQRRDFLSEA SIMGQFDHPN IIRLEGVVTR CKPLMIITEY MENGSLDAFL RKHDGQFTVI 720
QLVGMLRGIA SGMKYLSDMN YVHRDLAARN ILVNSNLVCK VSDFGLSRVL EDDPEAAYTT 780
RGGKIPIRWT APEAIAYRKF TTASDVWSYG IVMWEVVSYG ERPYWDMNNQ DVIKAIEEGY 840
RLPAPMDCPV VLHQLMLDCW ERDRAERPTF SQILNMLDKL IRNPGTLRRT GGERYRPTGT 900
ILESEMCVPE WSLCEWLQSI GLERYRDTLA AAGYTSLDSL LALTHQEMDR LGIITPSHQD 960
ILIASVQQEI FSQMQHMQHT MVPV 984
Nucleotide Sequence
(FASTA)
CAGCGTTCAT TTTTTTCCAT CATTATATTT CTCAGATTAG GTGTTTTAAA GTGGGCTGAT 60
TCGAGAACAA GGATTTATCC GCCAAATGAA GTGACCCTGC TGGATACCAG GACAGTGCCA 120
GGAGAGCTGA AATGGGCAGC CAGTCCTTCA GAGGGAGGGT GGGAAGAGGT GAGCATTATG 180
GATGAGAAGA ACATCCCCAT CAGGACGTAC CAGGTGTGCA ATGTCCTAGA GCCCAATCAA 240
AACAACTGGC TGAGGACAGA CTGGATCCCT CGGTCCGGAG CTCAGCGGGT CTACGTCGAA 300
GTCAAGTTCA CCCTGAGAGA CTGTAACAGC CTCCCAGGGG TCACCGGCAC CTGTAAGGAG 360
ACATTCAATC TGTACTACCA TGAGTCAAAC GAAGACAGAG AGAGCTACAT CAAAGAGAGC 420
AGCTTCATTA AGGTGGACAC GGTGGCAGCA GACGAAAGCT TCACCCAGGT GGATGTTGGA 480
GACCGCATCA TGAAACTGAA CACAGAGGTG CGAGATGTAA AAGTCACGAC CCGGAAGGGC 540
TTCTATCTAG CCTTTCAGGA TGTGGGCGCC TGCATTGCTT TGGTTTCTGT CAGAGTTTTC 600
TACAAAACCT GCCCGCTCAC CGTTCGTAAC CTGGCAACAT TTCCCGACAC CATTACCGGG 660
GCCGACACGT CCTCCTTAGT GGAGGTCCGG GGGTCCTGTG TCAACCAATC GGAAGAAAGA 720
GAGGAACCTA AAATGTACTG TGGTGCTGAT GGAGAGTGGT TGGTTCCTAT TGGTGGATGT 780
CTCTGTAACC CCGGATATGA GGAGAGGGGA GGTGCGTGTA AAGCCTGTCC TGCTGGTTTC 840
TACAAGGCCA AGTCTACAGA TCCAGGATGT GCCAAGTGTC CTCCACATAG CCACTCACTC 900
AGAGATGGGG CAACTATCTG TGATTGCCAT GCTGGATTCT TCCGTGCTGA TACTGACCCT 960
CCCTCCATGG CCTGTACCCA GCCACCATCA GCCCCACAGC AACTCATTTC AGTGGTGAAT 1020
GAGACCTCAG TGGTCTTGGA ATGGACCCCC CCTCATCGTT TGGGAGGAAG AAGTGACACA 1080
AGCTACAGTC TGGAGTGTCT CATCTGTCAG ACTGGCTCTC AAGTCTGCGT GCCCTGTGCC 1140
TCAGATGTGC TCTTCTCTCC CGGTCAGACG GGCCTCAAGG CCACCAGGGT GGTGGTGAGC 1200
GAGCTCAGGG CCCACACGCA CTACACCTTC ATTGTCCATG CGCGCAATGG GGTTTCCCAG 1260
GCCAGTGGTG CAGGGGCAGC ACAGAGCGTG TCTGTGAGCG TCACCACCAA CCAAGCTGCA 1320
CCCTCTCCAG TGTCGTCTAT CCAAGCCACT GATGTCACCA GGCACAGTTT GTCGTTGTCG 1380
TGGCAACAGC CGGATCGACC CAACGGGGTC ATCCTGGAGT ACGAGGTCAA GTTCTATGAA 1440
AAGGATCAGA GAGAGAGGTC GTACCGCATA ATGAGGACCT TCTCTCGGAG TGTCGATGTC 1500
ACGGGTCTCA ACCCCCTCAC TGTTTACGTG TTTCATGTGC GTGCTCGCAC AGCTGCTGGA 1560
TATGGAGAGT TCAGCGCTCC CTTCGAATTC TCCACAAATT CAGATCCCTT CCCTCTGATT 1620
GGAGAAGGAG TCAACTCTGC CTTCCTGCTG CTGTCTGTCA GCGGGGTTGG AATTTTACTG 1680
CTGATATCTG CAGCTGTCTT ATGTGTCATC AGGAGGAGCA AGTACAGTAA AACAAAGCAG 1740
GACTCGGAGG AAGAGAAACA TCTTAACCCA GGAGTGAAAA TCTATGTGGA CCCGTTCACC 1800
TATGAAGACC CTGATCAGGC CATCCACGAG TTTGCCAAAG AGATTGATGT CAGCAGTATT 1860
CACATTGAGA AGGTTATTGG CATGGGAGAG TTTGGGGAGG TGTGCAGCGG TCGGCTGCGT 1920
GTGCAGGGGA AGAGGGAGAT CTACGTGGCC ATCAAGAGTC TGAAGGCAGG ATACTCTGAC 1980
AAACAGAGGC GGGACTTCCT GTCTGAGGCA TCCATCATGG GACAGTTTGA CCACCCGAAC 2040
ATCATCAGGC TGGAGGGTGT TGTCACGAGA TGTAAACCAT TGATGATCAT CACAGAATAT 2100
ATGGAAAATG GATCTCTGGA TGCATTTCTT CGGAAACATG ACGGCCAGTT CACAGTGATC 2160
CAGCTGGTCG GCATGCTGCG CGGCATCGCC TCAGGTATGA AGTACCTGTC AGACATGAAC 2220
TACGTGCACA GAGACCTGGC AGCTCGAAAC ATCCTGGTGA ACAGCAACCT GGTGTGTAAG 2280
GTGTCCGACT TTGGCCTGAG CCGAGTTCTG GAGGACGACC CAGAGGCCGC CTACACTACA 2340
AGGGGGGGGA AAATCCCAAT CAGATGGACT GCTCCAGAAG CTATAGCCTA CAGGAAGTTC 2400
ACCACAGCCA GCGATGTGTG GAGTTATGGT ATCGTTATGT GGGAGGTGGT TTCATATGGA 2460
GAGAGACCCT ACTGGGACAT GAACAACCAA GATGTGATCA AAGCAATAGA AGAGGGCTAC 2520
CGACTGCCTG CGCCCATGGA CTGCCCTGTG GTGCTGCACC AGCTCATGTT GGACTGTTGG 2580
GAGAGGGATC GAGCAGAGAG ACCCACATTC AGCCAGATCC TCAACATGTT GGATAAACTC 2640
ATACGCAACC CTGGGACTTT GCGCCGGACA GGAGGGGAAA GATATAGACC CACAGGCACA 2700
ATACTGGAGT CAGAGATGTG TGTGCCCGAG TGGTCGCTGT GTGAGTGGCT GCAGTCCATT 2760
GGGTTGGAGA GGTACAGAGA CACCCTTGCA GCAGCGGGTT ACACCAGCCT TGACAGTCTT 2820
CTGGCTCTCA CACACCAGGA GATGGACAGA CTTGGAATAA TCACACCGTC ACATCAGGAC 2880
ATACTAATTG CTAGTGTGCA GCAAGAAATA TTCTCTCAAA TGCAACACAT GCAGCACACT 2940
ATGGTTCCAG TCTGA 2955
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++iekviG GefGevcsGrl+++gkrei+vaik+lkag+++kqrrdflseasi+Gqfdhp
Q: 620   IHIEKVIGMGEFGEVCSGRLRVQGKREIYVAIKSLKAGYSDKQRRDFLSEASIMGQFDHP  679
         78**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvt++kp+mi+teymeng+ld+flrk+dgqftviqlvgmlrGiasgmkylsdm
Q: 680   NIIRLEGVVTRCKPLMIITEYMENGSLDAFLRKHDGQFTVIQLVGMLRGIASGMKYLSDM  739
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         +yvhrdlaarnilvnsnlvckvsdfGlsrvledd+eaaytt+ggkipirwtapeaiayrk
Q: 740   NYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRK  799
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ft+asdvwsyGiv+wev+syGerpywdm+nqdvikaieegyrlp+pmdcp  l+qlmldc
Q: 800   FTTASDVWSYGIVMWEVVSYGERPYWDMNNQDVIKAIEEGYRLPAPMDCPVVLHQLMLDC  859
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         w++draerp+f+qi ++l
Q: 860   WERDRAERPTFSQILNML  877
         **************9875
Domain Sequence
(FASTA)
IHIEKVIGMG EFGEVCSGRL RVQGKREIYV AIKSLKAGYS DKQRRDFLSE ASIMGQFDHP 60
NIIRLEGVVT RCKPLMIITE YMENGSLDAF LRKHDGQFTV IQLVGMLRGI ASGMKYLSDM 120
NYVHRDLAAR NILVNSNLVC KVSDFGLSRV LEDDPEAAYT TRGGKIPIRW TAPEAIAYRK 180
FTTASDVWSY GIVMWEVVSY GERPYWDMNN QDVIKAIEEG YRLPAPMDCP VVLHQLMLDC 240
WERDRAERPT FSQILNML 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gasterosteus aculeatus"; ?>Oryzias latipes"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-GAA-00020
EKS-ORL-00009
EKS-TAR-00008
EKS-TEN-00006
EKS-XIM-00013
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013