EKS-ORN-00071
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00071
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/RAF394.53.5E-118320576257
StatusUnreviewed
Ensembl ProteinENSONIP00000013094
UniProt AccessionI3JW49;
Protein Name
Protein Synonyms/Alias
Gene NameARAF
Gene Synonyms/Alias ARAF;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000010417ENSONIP00000013094ENSONIT00000013104
OrganismOreochromis niloticus
Functional Description
Protein Length618
Protein Sequence
(FASTA)
LPSPNSLLPL TMSSTSSSYS SSGETSPEDP PRGGGTIRVY LPNKQRTVVN VRQGQTVHEI 60
LDKALKVRGL SQECCAVFRL LGGRKRLTDW DTDITPLVGE ELLVEVLDDI PLTMHNFVRK 120
TFFKLAYCDF CHKFLFNGFR CQTCGYKFHQ HCSSKVPTVC VDMDTIRERP CPDGYPQIIL 180
PENSPTQSNP ALTPEPSGMG HLSPSPSSTF HFPMSGGDGQ SLQRHRSTST PNVHMVSTLD 240
PASAMIIEEA LKFNNTIGPE PSPKPSTSPP SSFSSPGKKP PKSPSEPRER KPSSSDDKKK 300
VHRGGNRDSS YYWEVHSREV NIQKRIGSGS FGTVFKGKWH GDVAIKILKV KEPTPEQLQA 360
FKNEMQVLRK TRHVNILLFM GFMTKPNFAI ITQWCEGSSL YRHLHVLESK FDTVRRIDVA 420
RQTAQGMDYL HAKNIIHRDL KSNNIFLHEG WTVKIGDFGL ATVKARWTGS QQVEQPSGSI 480
LWMAPEVIRM QDTNPYTFQS DVYGYGVVLF ELMSGTLPYS NINNRDQIIF MVGRGYLSPD 540
LSKLYSTSPK AMKRLIVDCL KFKRDERPLF PQILVSIEQV QDLLPKIERS RSEPSLHRAV 600
HAEDLNPLLF HTTRLMPL 618
Nucleotide Sequence
(FASTA)
CTGCCCTCCC CCAATTCCCT CCTGCCTCTC ACCATGTCCT CCACCTCCTC CTCCTACTCC 60
TCCTCAGGGG AGACCAGTCC AGAGGATCCA CCCCGAGGTG GAGGAACCAT CCGAGTCTAC 120
CTCCCCAACA AACAGAGGAC AGTGGTGAAT GTCCGCCAAG GACAGACTGT GCATGAGATT 180
CTGGATAAAG CGCTCAAAGT GAGAGGCCTG AGCCAAGAGT GCTGTGCTGT ATTTCGCCTT 240
CTAGGAGGTC GAAAGAGACT GACAGACTGG GACACAGACA TAACTCCTCT AGTTGGAGAG 300
GAGCTTTTAG TTGAGGTCCT GGATGATATT CCCCTGACCA TGCACAACTT TGTACGCAAA 360
ACTTTCTTCA AGCTGGCTTA CTGTGATTTT TGCCACAAGT TCCTTTTCAA TGGCTTCAGA 420
TGTCAGACAT GTGGCTACAA GTTTCACCAA CACTGCAGTA GCAAGGTCCC CACCGTGTGT 480
GTGGACATGG ATACTATAAG AGAGCGTCCT TGCCCAGATG GATACCCACA GATAATATTG 540
CCAGAAAATT CCCCCACGCA GAGCAACCCA GCCTTAACCC CAGAGCCTTC TGGAATGGGC 600
CACCTGTCCC CGTCCCCGTC CTCAACCTTT CACTTCCCCA TGTCAGGCGG AGATGGTCAG 660
TCTCTACAGA GGCATCGCTC CACATCTACT CCCAATGTTC ATATGGTCAG CACATTGGAC 720
CCTGCTTCTG CCATGATTAT AGAGGAAGCA CTGAAGTTCA ACAACACAAT AGGTCCTGAA 780
CCCTCACCTA AGCCCTCCAC CAGCCCGCCC TCTTCTTTTA GCTCTCCAGG GAAGAAACCA 840
CCAAAGTCCC CTTCGGAACC CAGGGAGCGC AAGCCCTCGT CCTCTGATGA CAAAAAGAAA 900
GTGCACCGAG GAGGCAACAG AGATTCAAGT TACTACTGGG AGGTTCACTC TCGAGAAGTC 960
AACATCCAGA AGAGAATAGG TTCTGGCTCC TTTGGAACTG TCTTCAAGGG AAAGTGGCAT 1020
GGAGATGTGG CAATCAAGAT CCTCAAAGTC AAAGAGCCAA CGCCTGAGCA GTTACAAGCC 1080
TTTAAAAATG AAATGCAGGT GTTGCGGAAG ACCCGCCACG TCAACATCCT GCTGTTCATG 1140
GGCTTCATGA CTAAGCCCAA CTTTGCCATC ATCACACAAT GGTGTGAAGG CAGCAGCCTG 1200
TACCGCCATC TGCATGTCTT AGAGAGCAAG TTTGACACTG TGCGTCGCAT TGATGTGGCC 1260
AGACAGACAG CACAGGGCAT GGATTATCTT CATGCAAAGA ACATAATTCA TCGAGATCTA 1320
AAATCAAACA ATATTTTTCT CCATGAGGGC TGGACTGTTA AAATCGGTGA CTTTGGCTTG 1380
GCTACAGTAA AGGCTCGATG GACTGGCTCT CAGCAGGTAG AACAACCCAG CGGATCCATT 1440
CTCTGGATGG CTCCTGAGGT GATCCGCATG CAGGACACAA ACCCATACAC GTTCCAGTCA 1500
GACGTATATG GCTACGGAGT AGTTCTGTTT GAGCTGATGT CAGGAACCCT GCCTTACTCC 1560
AATATCAACA ACAGAGACCA GATAATCTTC ATGGTTGGAC GCGGTTACCT GTCTCCAGAC 1620
CTCAGTAAGC TGTATAGTAC CTCACCCAAA GCAATGAAGA GGCTGATCGT CGACTGCCTG 1680
AAGTTTAAAC GTGATGAAAG GCCCCTTTTT CCACAGATTC TGGTGTCCAT TGAGCAGGTG 1740
CAAGATTTGC TGCCGAAAAT CGAGCGGAGT CGCTCCGAGC CGTCGCTCCA TCGAGCTGTC 1800
CATGCTGAGG ACCTGAACCC CCTCCTGTTC CACACCACCA GGCTCATGCC CCTCTAA 1857
Domain Profile
S: 1     velaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLF  60
         v+++++iGsG+fGtv++gkwhGdva+k+l+v+e+++eql+aFk+e+++++ktRh+ni+LF
Q: 320   VNIQKRIGSGSFGTVFKGKWHGDVAIKILKVKEPTPEQLQAFKNEMQVLRKTRHVNILLF  379
         6799********************************************************
S: 61    mGyvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkD  120
         mG+++kp++ai+t++c+gssLy++lh+ e+k+d ++ id+arq+aqgmdYLhak+i+h+D
Q: 380   MGFMTKPNFAIITQWCEGSSLYRHLHVLESKFDTVRRIDVARQTAQGMDYLHAKNIIHRD  439
         ************************************************************
S: 121   lksknilleeglkvvitDFgllsvkrllsgrrekqleipkgwilylapeviralsidleq  180
         lks+ni+l+eg +v+i+DFgl++vk +++g  ++q+e+p+g+il++apevir+      q
Q: 440   LKSNNIFLHEGWTVKIGDFGLATVKARWTG--SQQVEQPSGSILWMAPEVIRM------Q  491
         ******************************..*********************......*
S: 181   delpfskesDvyafGivlyellarelpyke.esadqilfavgrG.lkpdlskvksklpke  238
         d++p++++sDvy +G+vl+el++++lpy++ +++dqi+f+vgrG l+pdlsk++s  pk+
Q: 492   DTNPYTFQSDVYGYGVVLFELMSGTLPYSNiNNRDQIIFMVGRGyLSPDLSKLYSTSPKA  551
         ************************************************************
S: 239   lkellleClkfekeeRPlftqilkk  263
         +k+l+++Clkf+++eRPlf+qil +
Q: 552   MKRLIVDCLKFKRDERPLFPQILVS  576
         **********************976
Domain Sequence
(FASTA)
VNIQKRIGSG SFGTVFKGKW HGDVAIKILK VKEPTPEQLQ AFKNEMQVLR KTRHVNILLF 60
MGFMTKPNFA IITQWCEGSS LYRHLHVLES KFDTVRRIDV ARQTAQGMDY LHAKNIIHRD 120
LKSNNIFLHE GWTVKIGDFG LATVKARWTG SQQVEQPSGS ILWMAPEVIR MQDTNPYTFQ 180
SDVYGYGVVL FELMSGTLPY SNINNRDQII FMVGRGYLSP DLSKLYSTSP KAMKRLIVDC 240
LKFKRDERPL FPQILVS 257
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00045
EKS-BOT-00052
EKS-CAE-00039
EKS-CAJ-00052
EKS-CAF-00053
EKS-CAP-00052
EKS-CIS-00058
EKS-DAR-00067
EKS-EQC-00051
EKS-FEC-00050
EKS-GAM-00023
EKS-GAA-00070
EKS-GOG-00051
EKS-HOS-00053
EKS-ICT-00049
EKS-LAC-00056
EKS-LOA-00052
EKS-MAE-00026
EKS-MUM-00053
EKS-MUP-00054
EKS-MYL-00054
EKS-ORC-00048
EKS-ORL-00065
EKS-OTG-00055
EKS-POA-00049
EKS-SAH-00049
EKS-SUS-00043
EKS-TAR-00072
EKS-TEN-00076
EKS-TUT-00052
EKS-XIM-00069
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005057; F:receptor signaling protein activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR003116; Raf-like_ras-bd.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF07714; Pkinase_Tyr; 1.
PF02196; RBD; 1.
SMARTs
SM00109; C1; 1.
SM00455; RBD; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50898; RBD; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013