EKS-ORN-00396
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00396
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/Alpha201.02.6E-5915761797222
StatusUnreviewed
Ensembl ProteinENSONIP00000013531
UniProt AccessionI3JXD6;
Protein Name
Protein Synonyms/Alias
Gene NameTRPM6
Gene Synonyms/Alias TRPM6;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000010763ENSONIP00000013531ENSONIT00000013541
OrganismOreochromis niloticus
Functional Description
Protein Length1809
Protein Sequence
(FASTA)
MSRKCWIEEA FSRRECVKFI PSSWDQHRCS PVCHVCQNLI RCCCGRLIGE HSWQDSLPPL 60
SLCPGPGQDV EEEWSMERHT RASPTNAYGT VDFEDTATRV CRAKYVRVAV DSKSEALLQL 120
MLREWQMERP KLLLSVHGGS ENFTLPPKVN QSFSKGLITA ALSTGAWIFT DGINTGVSKY 180
VGDAVKSFGS HDLRKRNTVG ITPWGVIDNN MDLIGRDVFR PYQPVGNPLS KRACLNGFHS 240
HFLLVDDGTL GKHGCQQGLR RKLEKHVQLQ KIHPRLNQGV PVVCVVVEGG PSVVSTVLDY 300
VSTVPPVPVF VFEGSGRAAD LLAFLHKQTA VDRPLEADIK ENFLTTIGDV FGMERTEATD 360
LYTLLLQCMD HRQSITIFDS ESDDQMAPDA AILTATLKGT KASPSEQLSM TLAWDRADIA 420
QKDVLVYGQH WQVGSLEQAM LDALVMDRVS FVKMLIDNGM TMSRFLTVDR LEELYNMAQG 480
PTARFLHHLV EDAKQTSLPA GYRLSIIDMG LVIEYLIGGA YRSTYTRKQF RAAYSRLHEK 540
NGRRDSSATF SKLRHGLMPS STRNRSLQDL HFFRTAQPYK RKEQDVSPST SEEVSTPGLD 600
DAPLLVPFNF NDLFVWAVLQ QRQQMALFLW QHGEEALARA TVACKLYRSM AFEARQSSLD 660
DNIIERFKTY SLEFGKLAVD VLDCAFRQNE QMAMKLLTYE MEEWSHFTCL QMAVSSCHRP 720
FVSHSCTQTL LTDLWTGPLN MRKNSFLKII LSLLLPPAIL LLEFKSKAEM CHVPQTHEAM 780
LFGLDSVNSS FFSFTLPMQG SHDAEKGLSF QDKRVGPVSE TMSSITVRCV SWITTLYDFY 840
TAPVVKFWFH TMSYLAFLML FSYVVLVKME DQPSVPEWLV IAYILSTAAE KTREILMSEA 900
TKLSQKLKIW FSEYWNISDF IAILLFVAGL AMRWHSDPYR TAGRLTYCLD IIFWFIRVMD 960
LLAVNQHAGP YLTMITKMTR NMFYIVVMMA IVLLSYGVSR KAVLSPDEEP SWSLARDIVF 1020
QPYWMIYGEV YASEIDPCEE DDSCPPASFL APFLQAVYMF VQYIIMVNIL IAFFNNVYFD 1080
MASTSNKLWK YNRYRYIMTY QVRPWLPPPL NLLSHMDLGL RAIYKKFSGD AEREERASGL 1140
KLYLGHEDRK KLHEFEEKCV EAYFHEKSEC PLNSQKNRIK VTAERTEEMC MMVGEVSEKV 1200
NFIQDNLSEL DSQLGHLQDL SALAVDTLTF LSASNNLHQE ETRLAQCRLI TASQHAIPHS 1260
IQRLVAKPYK STPPSLLKGY TLAGNRRESQ ECHVGVRGSR GGRYGHTGEP ERIIHVRISR 1320
ELLGQGLVCP SPTLTVENFL QLVSEIRHPR LGVTPFKILD FQEETSMEEE DEVEEEEEEK 1380
EEEKTQEELP NTDVHRASSS AFLFDPRDIS EGLTNPAFSH DDSQPTSRSR NSNQWRKPIK 1440
SPRWACLSRD RPYGYCRSLS SSMENMTFAG APLSPTRGSF PSLNESMNTE SLLGRGGLKN 1500
NTSLRCSKSQ GMITHGFENQ FCLYCACVLT AVERNNLMRL AQTIPFTPVS IMGGEEVSIY 1560
SLEEVASDAD PESSSVSSWS SRGLSAILQP LMSEEGSLDG GLRQGRRVLC TWAEQDVLRP 1620
GLVYVVKGFR PEVVRVCKKY FHGSTALQLC LREIQQQRAA QKMMQVFNQV KPDDLHHSPR 1680
FLDVSLVLWH SNGQWLTIER NMSGDFRKYN NNTGEEITPC CSLEEMLLAF SHWTYEYSRR 1740
ELLVLDIQGV GEELTDPTVI MAEDQSVSRG EMLFGPDNLG DAGINGFLQK HSCSACCHRL 1800
GLKGQKHTN 1809
Nucleotide Sequence
(FASTA)
ATGTCCAGAA AGTGTTGGAT TGAGGAAGCC TTCTCCAGGA GAGAGTGTGT GAAGTTCATC 60
CCTTCCTCTT GGGATCAGCA CAGATGTAGT CCAGTATGCC ACGTTTGCCA AAATTTGATA 120
AGATGTTGCT GCGGCCGCCT GATAGGGGAA CACTCTTGGC AAGACTCCCT TCCTCCATTG 180
TCCCTCTGTC CTGGTCCTGG ACAGGATGTG GAAGAGGAGT GGTCCATGGA GCGCCACACC 240
AGGGCCAGTC CCACCAATGC CTATGGCACC GTAGACTTTG AAGATACTGC CACACGTGTT 300
TGTCGAGCCA AGTATGTTCG TGTTGCTGTG GATTCCAAGT CAGAAGCATT ACTCCAGCTG 360
ATGTTGAGGG AATGGCAGAT GGAAAGACCC AAGCTACTAC TGAGTGTCCA CGGAGGCTCA 420
GAAAATTTTA CCTTGCCACC TAAAGTCAAC CAGTCCTTTA GCAAAGGGCT GATCACTGCT 480
GCCCTCAGCA CAGGGGCATG GATTTTCACC GATGGCATTA ATACAGGTGT GTCTAAATAT 540
GTAGGCGATG CAGTTAAATC CTTTGGAAGC CATGACCTGA GGAAGAGAAA CACAGTTGGC 600
ATCACACCCT GGGGAGTGAT TGACAACAAC ATGGACCTTA TAGGCAGAGA TGTGTTCAGG 660
CCCTACCAGC CTGTGGGAAA CCCTTTGAGC AAGAGAGCCT GTCTCAATGG TTTCCACTCC 720
CACTTCCTGT TGGTGGACGA TGGAACGCTG GGCAAGCATG GCTGTCAGCA AGGCCTCAGG 780
AGGAAGCTGG AGAAGCACGT ACAACTACAG AAGATACATC CCCGACTGAA CCAAGGAGTG 840
CCTGTGGTGT GTGTGGTGGT GGAGGGAGGT CCTTCTGTGG TGTCTACAGT GTTGGACTAC 900
GTCAGCACTG TGCCCCCTGT GCCAGTGTTT GTGTTTGAGG GATCAGGCAG GGCTGCTGAC 960
CTACTCGCCT TCTTACACAA GCAGACTGCT GTTGACAGAC CGTTGGAAGC TGACATTAAA 1020
GAGAACTTCC TCACCACGAT CGGAGATGTG TTTGGAATGG AGAGGACTGA AGCCACTGAC 1080
CTCTATACTC TCCTGCTGCA GTGTATGGAT CATAGACAGT CTATAACCAT CTTTGACTCA 1140
GAGTCAGATG ACCAGATGGC ACCAGATGCT GCCATTTTGA CTGCTACTCT CAAGGGCACA 1200
AAGGCCAGTC CGTCAGAGCA GCTGAGTATG ACTCTGGCGT GGGACAGGGC TGACATTGCA 1260
CAGAAAGACG TCCTTGTATA TGGACAGCAT TGGCAGGTGG GCTCCTTGGA GCAAGCCATG 1320
CTGGATGCTC TGGTGATGGA CCGTGTCAGT TTTGTCAAAA TGCTGATTGA TAACGGCATG 1380
ACTATGAGCC GCTTCCTCAC AGTCGATCGC CTTGAAGAGC TCTACAACAT GGCACAAGGG 1440
CCAACAGCCC GCTTCTTGCA CCACCTCGTT GAAGATGCAA AACAGACTTC CCTTCCTGCA 1500
GGTTATCGTC TTTCGATCAT TGACATGGGC TTGGTGATAG AATACCTCAT AGGAGGAGCA 1560
TACCGCAGCA CCTACACACG CAAACAATTC AGAGCTGCGT ACAGCCGATT GCACGAAAAA 1620
AATGGTAGAC GAGACAGTTC AGCCACCTTT TCTAAACTCA GACATGGACT GATGCCAAGC 1680
TCTACGAGGA ACAGGAGCCT CCAGGACCTG CATTTCTTTA GGACCGCCCA GCCTTACAAA 1740
CGCAAGGAGC AAGATGTGTC ACCCAGTACC AGTGAGGAGG TGTCTACACC AGGCCTTGAT 1800
GATGCTCCAC TGCTGGTTCC TTTCAACTTC AACGACTTGT TTGTGTGGGC AGTCCTTCAG 1860
CAAAGGCAGC AAATGGCACT GTTCCTGTGG CAACATGGAG AAGAAGCGCT GGCACGTGCA 1920
ACTGTGGCCT GCAAGCTTTA CCGCTCCATG GCCTTTGAAG CACGTCAAAG CAGCCTGGAT 1980
GATAACATTA TAGAGCGATT CAAGACGTAT TCACTTGAGT TTGGTAAGCT GGCGGTGGAT 2040
GTGTTAGATT GTGCGTTTCG TCAGAACGAG CAGATGGCCA TGAAGCTGTT GACTTATGAG 2100
ATGGAGGAAT GGAGCCACTT CACCTGTCTG CAGATGGCTG TCTCCTCATG TCACAGACCA 2160
TTCGTCTCAC ACTCCTGCAC CCAGACTCTC CTCACTGATC TCTGGACTGG TCCACTTAAC 2220
ATGAGAAAAA ACTCATTCTT GAAGATTATT TTGAGCCTTC TTCTGCCTCC TGCCATCCTA 2280
CTTCTGGAGT TTAAAAGCAA AGCTGAAATG TGTCACGTAC CACAGACACA CGAGGCAATG 2340
CTGTTTGGAC TCGACTCAGT CAATTCTTCT TTTTTTTCAT TTACTCTACC CATGCAGGGT 2400
AGTCATGATG CAGAGAAAGG ACTCTCTTTC CAAGACAAAC GTGTTGGTCC TGTGTCAGAA 2460
ACCATGTCCT CTATAACTGT GCGCTGTGTT TCCTGGATCA CAACACTCTA TGATTTCTAC 2520
ACAGCTCCTG TTGTCAAGTT TTGGTTTCAC ACGATGTCCT ACTTGGCCTT TCTGATGTTA 2580
TTCTCCTATG TTGTCCTGGT GAAGATGGAG GATCAACCCA GTGTTCCGGA GTGGCTGGTT 2640
ATAGCATACA TCTTGTCAAC TGCAGCAGAG AAAACCCGAG AGATATTAAT GTCTGAGGCA 2700
ACAAAACTGA GCCAGAAGCT GAAGATTTGG TTCTCAGAAT ACTGGAACAT ATCAGATTTC 2760
ATTGCCATCC TGCTTTTCGT GGCTGGACTG GCAATGCGTT GGCACTCTGA TCCCTACCGG 2820
ACAGCAGGAC GCCTCACATA CTGCCTGGAC ATCATCTTCT GGTTTATCAG GGTGATGGAT 2880
CTGCTGGCCG TTAATCAGCA TGCTGGCCCT TACCTCACCA TGATCACTAA GATGACCAGA 2940
AACATGTTTT ACATTGTGGT GATGATGGCA ATAGTGCTGC TGAGCTACGG AGTATCCAGG 3000
AAGGCTGTCC TGTCACCAGA CGAGGAGCCA TCATGGAGCC TGGCTCGAGA CATAGTCTTC 3060
CAGCCCTACT GGATGATCTA TGGAGAGGTC TATGCATCAG AGATAGACCC ATGTGAGGAA 3120
GATGATTCTT GTCCTCCTGC ATCCTTTCTT GCACCATTTC TCCAGGCTGT GTATATGTTT 3180
GTCCAGTATA TCATCATGGT CAACATCCTC ATCGCATTTT TCAACAATGT CTACTTTGAC 3240
ATGGCATCAA CATCCAACAA GCTGTGGAAG TACAACCGGT ACCGCTACAT AATGACCTAT 3300
CAAGTGAGAC CGTGGCTGCC ACCGCCCCTA AACCTCCTCA GTCACATGGA CCTGGGTTTG 3360
AGAGCTATTT ACAAGAAATT TAGTGGAGAC GCTGAGCGGG AAGAGAGAGC CTCTGGACTT 3420
AAGCTCTATC TGGGCCACGA GGATCGCAAG AAGCTGCATG AGTTTGAGGA GAAATGTGTG 3480
GAGGCCTATT TTCATGAGAA GAGCGAATGC CCGCTCAACA GTCAAAAGAA CAGGATCAAA 3540
GTCACAGCTG AGAGAACAGA AGAGATGTGC ATGATGGTGG GGGAGGTTTC AGAGAAGGTC 3600
AACTTCATTC AGGATAACCT GTCGGAGTTA GACTCTCAGC TCGGTCATCT CCAGGACCTC 3660
TCTGCACTGG CTGTGGACAC CCTCACATTT CTTTCTGCAT CCAACAACCT ACATCAGGAG 3720
GAGACGCGCC TGGCTCAGTG TCGACTCATT ACAGCATCCC AGCACGCCAT CCCTCACAGT 3780
ATACAACGAT TGGTGGCCAA GCCGTATAAA AGTACCCCGC CTTCATTGCT AAAGGGCTAC 3840
ACTTTGGCAG GGAATAGACG GGAATCACAG GAGTGCCATG TAGGAGTTAG GGGAAGCAGG 3900
GGAGGAAGAT ATGGACACAC AGGAGAACCA GAAAGGATCA TCCATGTGAG AATCAGCAGG 3960
GAGCTTCTGG GCCAGGGTCT TGTGTGTCCG TCTCCCACTT TAACAGTGGA GAATTTTCTT 4020
CAGTTGGTGT CAGAGATCAG ACACCCTAGG CTTGGAGTCA CTCCATTTAA GATTCTGGAC 4080
TTTCAGGAAG AAACATCCAT GGAAGAGGAG GATGAAGTAG AGGAAGAAGA AGAAGAGAAA 4140
GAGGAGGAAA AGACACAGGA AGAACTGCCT AATACAGACG TACACCGAGC CTCCAGCAGT 4200
GCTTTTCTGT TCGACCCACG AGACATCTCA GAGGGTTTGA CAAATCCTGC CTTTTCTCAT 4260
GATGATAGTC AGCCAACTTC TCGGTCCAGA AATTCCAACC AGTGGAGAAA ACCCATAAAA 4320
TCCCCCAGGT GGGCATGTTT GTCGAGGGAC CGTCCGTATG GCTACTGCAG ATCTTTGTCA 4380
TCCAGCATGG AAAATATGAC TTTCGCTGGA GCACCCCTCA GTCCAACCAG GGGATCCTTT 4440
CCCTCTCTCA ATGAATCAAT GAACACTGAG AGTTTGCTTG GTAGGGGGGG TTTAAAGAAC 4500
AACACATCAC TAAGATGCAG CAAGAGCCAA GGTATGATAA CGCATGGGTT TGAAAATCAA 4560
TTTTGCCTGT ATTGTGCCTG TGTGTTAACA GCCGTGGAGA GAAACAATTT GATGAGACTG 4620
GCTCAGACCA TCCCTTTCAC TCCCGTCTCA ATCATGGGAG GTGAAGAGGT GAGCATTTAC 4680
TCTCTGGAGG AAGTAGCCTC TGATGCTGAC CCTGAATCCA GCTCAGTCTC TTCCTGGTCA 4740
TCACGAGGCC TGTCTGCTAT CCTGCAGCCC CTCATGAGCG AAGAAGGCTC GTTGGATGGT 4800
GGCCTCCGGC AGGGCCGCCG GGTTCTCTGT ACATGGGCAG AACAGGATGT GCTCAGACCT 4860
GGTCTGGTAT ACGTGGTGAA AGGTTTCAGA CCAGAGGTGG TTCGTGTCTG TAAGAAGTAC 4920
TTCCATGGTA GCACAGCACT GCAGCTTTGT TTAAGGGAGA TACAGCAGCA GAGAGCAGCC 4980
CAGAAGATGA TGCAAGTGTT TAACCAAGTC AAACCTGATG ATTTGCACCA CTCACCAAGA 5040
TTTCTTGACG TGTCACTGGT CCTCTGGCAT TCTAATGGTC AGTGGCTGAC GATTGAAAGG 5100
AACATGTCTG GTGACTTCAG GAAATACAAC AACAACACGG GAGAAGAGAT CACCCCCTGC 5160
TGTTCACTGG AAGAAATGCT TCTAGCCTTT TCCCACTGGA CATACGAGTA CTCACGCAGA 5220
GAGCTGCTGG TGCTCGACAT ACAAGGAGTG GGAGAGGAGC TGACTGATCC GACAGTCATT 5280
ATGGCAGAGG ACCAGAGTGT TAGCAGGGGT GAGATGCTTT TTGGACCTGA TAATCTTGGA 5340
GATGCTGGCA TCAATGGTTT CCTGCAGAAA CACTCTTGCA GCGCCTGCTG CCACAGACTA 5400
GGTCTAAAAG GTCAGAAACA TACAAAT 5427
Domain Profile
S: 2     sesWsqqetivlikvlskeek..kGalRkalrv..........kkgslflvkeelkevvr  49
         ++sWs +++ ++++ l  ee+  +G+lR+  rv          ++g +++vk + +evvr
Q: 1576  VSSWSSRGLSAILQPLMSEEGslDGGLRQGRRVlctwaeqdvlRPGLVYVVKGFRPEVVR  1635
         689***********9988875348************************************
S: 50    yvakiykeqkvlhlylrdverqraaqklvtefnqvkPkkivyiprlievfLkdrtsknql  109
           +k ++ ++ l+l+lr++++qraaqk+++ fnqvkP  + ++pr++ v L   +s++q+
Q: 1636  VCKKYFHGSTALQLCLREIQQQRAAQKMMQVFNQVKPDDLHHSPRFLDVSLVLWHSNGQW  1695
         ************************************************************
S: 110   ltvEeyllGefvKynnnngdeikrenkleelmlafsHftyeytngellVvDlqGvgeklT  169
         lt+E+ + G+f+Kynnn+g+ei++   lee+ lafsH+tyey++ ellV+D+qGvge+lT
Q: 1696  LTIERNMSGDFRKYNNNTGEEITPCCSLEEMLLAFSHWTYEYSRRELLVLDIQGVGEELT  1755
         ************************************************************
S: 170   Dpqiat......ksrgtkfgkanlgeraiknFfakhhCNeiC  205
         Dp ++          ++ fg+ nlg ++i+ F +kh C ++C
Q: 1756  DPTVIMaedqsvSRGEMLFGPDNLGDAGINGFLQKHSCSACC  1797
         ****998887754556899***********************
Domain Sequence
(FASTA)
VSSWSSRGLS AILQPLMSEE GSLDGGLRQG RRVLCTWAEQ DVLRPGLVYV VKGFRPEVVR 60
VCKKYFHGST ALQLCLREIQ QQRAAQKMMQ VFNQVKPDDL HHSPRFLDVS LVLWHSNGQW 120
LTIERNMSGD FRKYNNNTGE EITPCCSLEE MLLAFSHWTY EYSRRELLVL DIQGVGEELT 180
DPTVIMAEDQ SVSRGEMLFG PDNLGDAGIN GFLQKHSCSA CC 222
KeywordComplete proteome; Ion transport; Ionic channel; Membrane; Reference proteome; Transmembrane; Transport.
Sequence SourceEnsembl
Orthology
Ortholog group
Gasterosteus aculeatus"; ?>Oryzias latipes"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-GAA-00378
EKS-ORL-00366
EKS-TAR-00398
EKS-TEN-00394
EKS-XIM-00386
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005216; F:ion channel activity
GO:0004674; F:protein serine/threonine kinase activity
KEGG
InterPros
IPR005821; Ion_trans_dom.
IPR011009; Kinase-like_dom.
IPR004166; MHCK_EF2_kinase.
Pfam
PF02816; Alpha_kinase; 1.
PF00520; Ion_trans; 1.
SMARTs
SM00811; Alpha_kinase; 1.
Prosites
PS51158; ALPHA_KINASE; 1.
Prints
Created Date20-Feb-2013