EKS-ORN-00087

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00087

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	369.6	1.3E-110	40	324	285

Status

Unreviewed

Ensembl Protein

ENSONIP00000013766

UniProt Accession

I3JY21;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK10

Gene Synonyms/Alias

CDK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000010942	ENSONIP00000013766	ENSONIT00000013776

Organism

Oreochromis niloticus

Functional Description

Protein Length

360

Protein Sequence
(FASTA)

MDAAGEDEPD PIKLKSVKDN KTFTVPQNYR FGSCRSVREF EKLNRIGEGT YGIVYRARDT 60

KSDEIVALKK VRMDAEKDGV PISSLREITL LLRLRHPNIV ELKEVVVGTQ LESLFLVMSY 120

CEQDLASLLE NMQTPFSEAQ VKCIVLQLLR GLEYLHHNFI IHRDLKVSNL LMTDKGCVKI 180

ADFGLARMYG IPQQPMTPRV VTLWYRAPEL LLGTKTQTTA LDMWAVGCIL AELLAHKPLL 240

PGTSEIQQVD LIVQLLGTPN ENIWPGFSQL PLIGQYSLRK QPYNNLKNKF TWLSDAGHRL 300

LNLLFMYNPQ RRATAKDCLE SSYFKEKPLP CEPELMPTFP HHRNKRAAPP AESHSKRSKV 360

Nucleotide Sequence
(FASTA)

ATGGACGCGG CTGGAGAGGA CGAACCGGAC CCCATAAAGC TGAAGTCTGT TAAGGACAAT 60

AAAACTTTCA CAGTGCCTCA AAATTACAGG TTTGGGAGCT GCAGAAGTGT CAGAGAGTTT 120

GAGAAACTCA ACCGAATAGG AGAAGGAACC TACGGCATTG TGTACCGCGC CCGCGACACC 180

AAGTCAGATG AGATTGTAGC CCTGAAAAAG GTGCGAATGG ACGCAGAGAA AGATGGGGTC 240

CCCATCAGCA GCCTCAGAGA GATCACCCTG CTGCTGAGGC TGAGACATCC CAACATAGTG 300

GAGCTGAAAG AGGTGGTTGT CGGCACTCAG CTAGAAAGCC TCTTTCTGGT GATGAGTTAC 360

TGTGAACAAG ATCTGGCCAG TCTGCTGGAG AACATGCAGA CACCATTCTC AGAGGCGCAG 420

GTTAAGTGCA TCGTTCTTCA GTTGCTCAGA GGTTTGGAGT ATCTCCACCA CAACTTCATT 480

ATTCACAGAG ACCTGAAGGT GTCTAATCTG CTGATGACAG ACAAAGGCTG CGTAAAGATT 540

GCTGATTTCG GTCTGGCCCG GATGTACGGC ATTCCTCAGC AACCCATGAC ACCTCGAGTA 600

GTTACGCTGT GGTATAGAGC ACCAGAGCTC CTCCTAGGGA CGAAGACTCA GACTACGGCT 660

CTGGACATGT GGGCAGTGGG CTGTATCCTG GCTGAGCTGC TAGCCCACAA ACCTCTGCTG 720

CCTGGAACCT CTGAGATCCA GCAGGTCGAC CTGATCGTTC AGCTGCTGGG AACACCCAAT 780

GAAAACATCT GGCCGGGTTT CTCTCAGCTT CCCCTCATCG GTCAGTACAG CCTGAGGAAG 840

CAGCCGTACA ACAACCTGAA GAATAAATTC ACCTGGCTGT CTGATGCTGG ACACAGACTG 900

CTTAACCTGC TCTTCATGTA CAACCCCCAG CGCAGAGCTA CTGCTAAAGA TTGCTTGGAG 960

AGTTCGTACT TCAAAGAGAA ACCTCTACCC TGCGAACCAG AGCTGATGCC AACATTCCCT 1020

CACCATCGCA ACAAGCGAGC GGCTCCTCCA GCAGAGAGCC ACTCGAAGAG GAGCAAAGTG 1080

TGA 1083

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         +ekl++igeGtyg vy+a+d++++e+vAlKk+r++ ek+gvpi++lrEi+ll +l+h+ni

Q: 40    FEKLNRIGEGTYGIVYRARDTKSDEIVALKKVRMDAEKDGVPISSLREITLLLRLRHPNI  99

         89**********************************************************

S: 61    vkLlevva.kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsn  119

         v+L+evv+ ++ ++l+Lv+ ++eqdL++ll+++++  +s+++vk ++lqll+gl+ylH+n

Q: 100   VELKEVVVgTQLESLFLVMSYCEQDLASLLENMQT-PFSEAQVKCIVLQLLRGLEYLHHN  158

         ********4555**********************9.************************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

          i+HRDlK +NlL++++g++k+aDfGlar ++ p++ +t++vvTlwYraPelLlg+k+ +

Q: 159   FIIHRDLKVSNLLMTDKGCVKIADFGLARMYGIPQQPMTPRVVTLWYRAPELLLGTKTQT  218

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksf  238

         ta+D+W+vgcilaell++kpl++g+sei+q++ i++llgtp+e++wp++s+lp +  +s+

Q: 219   TALDMWAVGCILAELLAHKPLLPGTSEIQQVDLIVQLLGTPNENIWPGFSQLPLIGqYSL  278

         *******************************************************988**

S: 239   pkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +k+++++lk+k++ l++++ +ll+ l++++p++R +ak++l+++yf

Q: 279   RKQPYNNLKNKFTWLSDAGHRLLNLLFMYNPQRRATAKDCLESSYF  324

         *********************************************8

Domain Sequence
(FASTA)

FEKLNRIGEG TYGIVYRARD TKSDEIVALK KVRMDAEKDG VPISSLREIT LLLRLRHPNI 60

VELKEVVVGT QLESLFLVMS YCEQDLASLL ENMQTPFSEA QVKCIVLQLL RGLEYLHHNF 120

IIHRDLKVSN LLMTDKGCVK IADFGLARMY GIPQQPMTPR VVTLWYRAPE LLLGTKTQTT 180

ALDMWAVGCI LAELLAHKPL LPGTSEIQQV DLIVQLLGTP NENIWPGFSQ LPLIGQYSLR 240

KQPYNNLKNK FTWLSDAGHR LLNLLFMYNP QRRATAKDCL ESSYF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013