EKS-ORN-00183
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00183
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR543.97.1E-164468744277
StatusUnreviewed
Ensembl ProteinENSONIP00000013857
UniProt AccessionI3JYB1;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR1 (1 of 2)
Gene Synonyms/Alias FGFR1 (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000011012ENSONIP00000013856ENSONIT00000013866
ENSONIG00000011012ENSONIP00000013857ENSONIT00000013867
OrganismOreochromis niloticus
Functional Description
Protein Length812
Protein Sequence
(FASTA)
MLMRPSILLF LALFAQVLRT QCRPANADEV SVETQAELYT LSIGDRLDLS CCAKDYLHAV 60
NWTKDHVAVV DGEHTRIRNG QLEIESVELT DSGLYTCTTF GNHSIFFNVT VHISASSEDD 120
DDGEESSSEE NKLLGSQKLM PMAPQWAHPE KMEKKLHAVP ASKTVKFKCQ ASGNPTPTLK 180
WYKNGKEFKR DHRIGGFKVR DHMWTIIMES VVPSDKGNYT CVVENKYGSI NHTYQLDVVE 240
RSPHRPILQA GLPANRTVVV GSDVEFECKV FSDPQPHIQW LKHIEVNGNR TGPDGLPYVR 300
VLKHSGVNSS DAQVLTLYNV TEEESGEYIC KVSNYIGEVS QSAWLTVIRY EPTAPPHYSP 360
ASHTYLEVVI YCVGFFFIAI MIAIAIIVKI RTTSSKKSDF NSQLAVHKLA KSIPLRRQVS 420
VDSSSSIHSG VMLVRPSRLS SSGSPMLSGV SECELPQDPR WELPRDRLVL GKPLGEGCFG 480
QVVMGEAVGL DKEKPNRVTK VAVKMLKADA TEKDLSDLIS EMEMMKIIGK HKNIINLLGA 540
CTQDGPLYVI VEYASKGNLR EYLRARRPPG MEYCSNPDQV PVENVSIKDL VSFAYQVARG 600
MEYLASKKCI HRDLAARNVL VTDDSVMKIA DFGLARDIHH IDYYKKTTNG RLPVKWMAPE 660
ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD KPSTCTHELY 720
MMMRDCWHAV PSQRPTFKQL VEDLDRALAM TSNQEYLELS VPLDQYSPSY PDTRSSTCSS 780
GEDSVFSHDA GAEEPCLPKF PPHSNGAAIK KR 812
Nucleotide Sequence
(FASTA)
ATGCTGATGA GGCCAAGTAT ACTTCTGTTT CTGGCTTTAT TTGCTCAAGT TTTAAGGACC 60
CAGTGCCGGC CTGCCAACGC TGATGAAGTA TCTGTGGAAA CGCAAGCCGA GCTGTACACC 120
CTTTCCATTG GGGATCGTCT CGATCTCAGT TGCTGTGCCA AGGACTACCT CCATGCTGTC 180
AACTGGACCA AAGACCATGT AGCTGTAGTG GATGGAGAAC ATACACGTAT CCGCAATGGC 240
CAGCTGGAGA TCGAGTCTGT GGAGCTTACT GACTCCGGCC TGTACACATG CACTACCTTT 300
GGCAACCACA GCATCTTCTT CAACGTGACA GTTCATATCT CGGCTTCATC TGAGGATGAT 360
GACGATGGTG AGGAGTCGTC ATCGGAGGAA AACAAACTGC TGGGCAGTCA AAAGCTGATG 420
CCAATGGCTC CACAATGGGC TCATCCAGAA AAAATGGAAA AGAAGCTTCA TGCCGTTCCA 480
GCCAGCAAAA CTGTAAAGTT TAAATGCCAG GCCAGTGGCA ACCCAACTCC GACTTTGAAA 540
TGGTACAAAA ATGGGAAGGA GTTCAAAAGG GACCATCGTA TTGGAGGGTT CAAGGTCCGT 600
GACCATATGT GGACCATCAT CATGGAATCT GTAGTGCCCT CTGACAAGGG AAACTATACC 660
TGTGTGGTGG AAAACAAGTA TGGCAGCATT AATCACACCT ATCAGCTAGA TGTAGTCGAG 720
CGCTCTCCAC ACAGGCCCAT CCTGCAGGCT GGCCTGCCAG CTAATCGCAC TGTAGTAGTA 780
GGAAGTGATG TGGAGTTTGA GTGCAAGGTG TTCAGCGACC CTCAGCCCCA CATTCAGTGG 840
TTAAAGCACA TCGAGGTCAA TGGGAACCGT ACTGGTCCAG ATGGGTTACC TTACGTTCGC 900
GTCCTCAAGC ATTCTGGGGT CAATAGCTCG GACGCTCAAG TGCTGACCCT CTACAATGTG 960
ACAGAGGAGG AGAGCGGAGA GTATATATGT AAAGTGTCCA ATTATATAGG AGAGGTCAGT 1020
CAGTCGGCCT GGCTGACTGT CATCAGATAT GAACCCACAG CACCCCCACA CTACTCTCCA 1080
GCCAGCCACA CCTACCTGGA GGTGGTCATC TACTGTGTGG GCTTCTTTTT CATAGCCATT 1140
ATGATTGCAA TTGCAATTAT TGTCAAGATT CGCACCACCT CCTCAAAGAA GAGTGACTTC 1200
AACAGTCAGC TAGCCGTCCA CAAGCTGGCC AAAAGCATCC CTCTGCGCAG ACAGGTGTCT 1260
GTGGACTCAA GTTCTTCCAT CCACTCTGGA GTGATGCTAG TCCGTCCCTC CCGCCTCTCT 1320
TCCAGTGGTT CTCCGATGTT GTCTGGAGTG TCCGAGTGTG AGCTGCCGCA AGATCCTCGC 1380
TGGGAGCTTC CTCGGGACAG ACTTGTTCTT GGGAAGCCCC TGGGAGAAGG ATGCTTTGGC 1440
CAGGTGGTGA TGGGGGAAGC GGTTGGTCTG GACAAAGAAA AGCCAAACCG TGTTACCAAG 1500
GTTGCAGTCA AAATGTTGAA AGCTGATGCA ACAGAGAAAG ACCTGTCAGA CCTCATTTCA 1560
GAGATGGAGA TGATGAAGAT CATTGGGAAG CACAAGAACA TCATTAATCT GCTGGGAGCC 1620
TGCACACAGG ATGGTCCTCT ATATGTGATA GTTGAATATG CATCCAAGGG CAACTTGCGA 1680
GAGTATCTAC GAGCTCGCCG CCCGCCGGGT ATGGAGTACT GCTCCAACCC TGACCAAGTT 1740
CCTGTGGAGA ATGTGTCTAT CAAAGATCTG GTGTCCTTCG CTTACCAAGT GGCCCGGGGC 1800
ATGGAGTATT TGGCCTCCAA AAAGTGCATC CACAGAGACC TTGCAGCTCG CAATGTTTTG 1860
GTAACGGATG ACAGTGTGAT GAAAATAGCT GACTTTGGCC TAGCAAGAGA TATCCACCAC 1920
ATCGACTATT ATAAGAAGAC CACCAATGGT CGTTTGCCAG TGAAGTGGAT GGCTCCAGAG 1980
GCTCTGTTTG ACCGGATATA CACACACCAA AGTGATGTCT GGTCATTTGG GGTGCTGCTT 2040
TGGGAGATCT TCACGCTAGG AGGCTCTCCA TATCCTGGCG TTCCAGTGGA AGAGCTGTTC 2100
AAGCTGCTGA AGGAAGGTCA CCGTATGGAC AAGCCTTCAA CATGTACACA TGAGCTGTAT 2160
ATGATGATGA GGGATTGCTG GCATGCTGTG CCTTCTCAGA GACCCACATT CAAACAGCTA 2220
GTAGAGGACC TGGATCGTGC TCTAGCCATG ACATCCAACC AGGAGTATTT GGAGCTTTCA 2280
GTACCTTTGG ACCAATATTC ACCCAGCTAC CCGGATACCC GGAGCTCCAC CTGCTCGTCC 2340
GGAGAGGACT CGGTTTTCTC GCATGATGCC GGAGCAGAGG AGCCATGCCT GCCTAAGTTC 2400
CCTCCTCACT CCAATGGGGC AGCCATCAAG AAACGCTGA 2439
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         lvlgk+lGeG+fGqvv+ ea+gldk+k+++ ++vavkmlk dat+kdl+dl+seme++k+
Q: 468   LVLGKPLGEGCFGQVVMGEAVGLDKEKPNRVTKVAVKMLKADATEKDLSDLISEMEMMKI  527
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+++++ +++ e+++ 
Q: 528   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYCSNPDQVPVENVSI  587
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvsfayqvarGmeylaskkcihrdlaarnvlvt+d+v+kiadfGlard+h+idyykkt
Q: 588   KDLVSFAYQVARGMEYLASKKCIHRDLAARNVLVTDDSVMKIADFGLARDIHHIDYYKKT  647
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh
Q: 648   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  707
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl
Q: 708   RMDKPSTCTHELYMMMRDCWHAVPSQRPTFKQLVEDL  744
         ***********************************97
Domain Sequence
(FASTA)
LVLGKPLGEG CFGQVVMGEA VGLDKEKPNR VTKVAVKMLK ADATEKDLSD LISEMEMMKI 60
IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYCSNP DQVPVENVSI 120
KDLVSFAYQV ARGMEYLASK KCIHRDLAAR NVLVTDDSVM KIADFGLARD IHHIDYYKKT 180
TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240
RMDKPSTCTH ELYMMMRDCW HAVPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Callithrix jacchus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oryzias latipes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-CAJ-00152
EKS-CIS-00182
EKS-DAR-00434
EKS-GAM-00076
EKS-GAA-00173
EKS-HOS-00154
EKS-ICT-00142
EKS-LAC-00157
EKS-MAM-00145
EKS-MOD-00148
EKS-MUM-00153
EKS-MUP-00152
EKS-ORL-00171
EKS-RAN-00147
EKS-SAH-00143
EKS-SUS-00129
EKS-TAG-00177
EKS-TAR-00192
EKS-TEN-00184
EKS-XET-00136
EKS-XIM-00177
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008284; P:positive regulation of cell proliferation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 2.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013