EKS-ORN-00481

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00481

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	415.6	8.8E-125	205	458	254

Status

Unreviewed

Ensembl Protein

ENSONIP00000014280

UniProt Accession

I3JZI4;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000011345	ENSONIP00000014280	ENSONIT00000014291
ENSONIG00000011345	ENSONIP00000014279	ENSONIT00000014290

Organism

Oreochromis niloticus

Functional Description

Protein Length

475

Protein Sequence
(FASTA)

EKSTVIKNLG AADKDEPSFH YYVALYDYSA RTEEDLSFNA GDTLEALDKS AGDWWFAKAL 60

TGVSASKQGY IPANYVAPVE SINAEPWYFP DTKRQDAEKM LMAGGNEHGA FLIRNCESQK 120

GDLSLSVLDS GRVKHYKLRK LDNGHYYVSR TKSFQTLKEL VEHYSRQSDG LCARLGEPCK 180

KIEVPQTYGL SYNTVDQWEI NRSSIKLLKK LGAGQFGEVF EGLWNETTSV AVKTLKPGTM 240

DAEDFLREAQ IMKRLRHPKL IQLYAVCTLE EPIYIITELM TNGSLLEYLQ KDKGRTLRIS 300

DQIEMAAQVA SGMAFLELQN YIHRDLAARN VLVGENNICK VADFGLARVF MKESENVYEA 360

KEGTKFPVKW TAPEAIHDNR FTIKSDVWSF GILLYEIVTF GQMPYPAMTN FQVVQKLAEG 420

YRMPCPANCP KVLYDIMKDC WKENEQTRPT FETLQWKLED YFEQDVTSYD DATRY 475

Nucleotide Sequence
(FASTA)

GAAAAATCGA CGGTTATTAA AAACTTGGGC GCTGCTGACA AAGACGAACC GAGCTTTCAT 60

TATTATGTCG CCCTGTATGA TTACTCTGCT CGCACAGAAG AGGATCTTAG CTTCAACGCC 120

GGGGATACTT TAGAGGCCCT GGACAAAAGT GCCGGTGATT GGTGGTTCGC TAAAGCCCTC 180

ACTGGGGTTT CAGCCTCCAA ACAGGGATAC ATCCCTGCTA ACTATGTGGC GCCTGTGGAG 240

AGCATTAATG CCGAACCATG GTATTTCCCT GACACCAAGA GGCAGGATGC TGAGAAGATG 300

CTAATGGCTG GAGGGAACGA GCATGGAGCC TTTCTCATCA GAAACTGTGA AAGTCAGAAA 360

GGAGATCTCT CACTGTCAGT GCTTGACAGT GGGAGGGTGA AGCATTACAA GCTGAGAAAA 420

CTGGACAATG GCCACTACTA CGTGTCAAGG ACCAAATCCT TTCAAACACT GAAGGAGTTA 480

GTGGAACATT ACTCCCGACA GTCTGATGGC CTCTGCGCAC GTCTGGGTGA GCCATGCAAA 540

AAGATAGAAG TTCCACAGAC TTATGGTCTG TCCTACAACA CAGTGGATCA ATGGGAAATC 600

AATCGTAGCT CCATCAAGCT ACTGAAAAAG CTTGGAGCGG GACAGTTTGG TGAGGTCTTT 660

GAAGGATTAT GGAATGAAAC CACATCAGTT GCCGTGAAGA CTCTCAAACC AGGCACCATG 720

GATGCCGAGG ACTTCCTGAG AGAGGCTCAG ATCATGAAGA GGCTGCGGCA CCCCAAGCTG 780

ATTCAGCTGT ATGCCGTTTG CACCTTGGAG GAGCCCATCT ACATAATCAC AGAGCTGATG 840

ACAAATGGCA GCCTATTGGA ATACCTTCAA AAGGATAAAG GTAGAACACT GCGTATCTCA 900

GATCAAATTG AGATGGCTGC ACAGGTGGCA TCAGGCATGG CTTTTCTGGA GTTACAGAAC 960

TACATCCACA GAGACCTGGC AGCCAGAAAT GTCCTAGTGG GCGAGAACAA CATCTGCAAG 1020

GTGGCTGACT TTGGCCTGGC CAGGGTTTTC ATGAAAGAAA GCGAAAATGT GTATGAAGCC 1080

AAAGAAGGAA CTAAATTCCC TGTAAAATGG ACCGCTCCAG AGGCCATTCA TGACAACAGG 1140

TTCACTATCA AATCTGATGT TTGGTCCTTT GGAATTTTGC TGTATGAGAT TGTGACATTT 1200

GGCCAGATGC CGTACCCAGC AATGACAAAC TTTCAGGTGG TCCAGAAACT GGCTGAGGGC 1260

TACAGAATGC CATGCCCTGC AAACTGCCCC AAAGTCTTGT ATGACATTAT GAAGGACTGC 1320

TGGAAGGAAA ACGAACAGAC CCGGCCTACA TTTGAGACCC TGCAGTGGAA GCTGGAGGAC 1380

TACTTTGAAC AGGATGTGAC GTCCTATGAT GATGCCACTC GTTATTAG 1428

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         +kl+kklG+GqfGev++g+w+++++vavktlk+gt++ e+fl+eaqi+k+lrh+kl++ly

Q: 205   IKLLKKLGAGQFGEVFEGLWNETTSVAVKTLKPGTMDAEDFLREAQIMKRLRHPKLIQLY  264

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ eePiyi+telm++Gsll++l++++g++l++++++++aaqva+Gma+le +n+ihr

Q: 265   AVCTLEEPIYIITELMTNGSLLEYLQKDKGRTLRISDQIEMAAQVASGMAFLELQNYIHR  324

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++++kvadfGlar++    ++ y+akeg+k+P+kWtaPeai+ ++ftik

Q: 325   DLAARNVLVGENNICKVADFGLARVFMkesENVYEAKEGTKFPVKWTAPEAIHDNRFTIK  384

         ************************765467999***************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGill+eivt G++Pyp mtn +v++++ +gyr+p+p++cp+ ly++++ cwk++

Q: 385   SDVWSFGILLYEIVTFGQMPYPAMTNFQVVQKLAEGYRMPCPANCPKVLYDIMKDCWKEN  444

         ************************************************************

S: 238   peerPtfetlqevl  251

          + rPtfetlq++l

Q: 445   EQTRPTFETLQWKL  458

         ***********986

Domain Sequence
(FASTA)

IKLLKKLGAG QFGEVFEGLW NETTSVAVKT LKPGTMDAED FLREAQIMKR LRHPKLIQLY 60

AVCTLEEPIY IITELMTNGS LLEYLQKDKG RTLRISDQIE MAAQVASGMA FLELQNYIHR 120

DLAARNVLVG ENNICKVADF GLARVFMKES ENVYEAKEGT KFPVKWTAPE AIHDNRFTIK 180

SDVWSFGILL YEIVTFGQMP YPAMTNFQVV QKLAEGYRMP CPANCPKVLY DIMKDCWKEN 240

EQTRPTFETL QWKL 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013