EKS-ORN-00389
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00389
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR479.14.0E-144739996258
StatusUnreviewed
Ensembl ProteinENSONIP00000014529
UniProt AccessionI3K085;
Protein Name
Protein Synonyms/Alias
Gene NameERBB2
Gene Synonyms/Alias ERBB2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000011537ENSONIP00000014529ENSONIT00000014540
ENSONIG00000011537ENSONIP00000014530ENSONIT00000014541
OrganismOreochromis niloticus
Functional Description
Protein Length1212
Protein Sequence
(FASTA)
MRCKNFISVP PRWTRSAGSA QMEAARSLLF VGAVLLGVTG ASGREVCRGT DMKLALPSSL 60
ENHYETLRLL YTGCQVVHGN LEITHLHGNP DLSFLQGIVE VQGYVLVAHV SVSLLPLDSL 120
RIIRGSQLYN SSYALAVLDN THAGQGLRTL RLRSLTEILL GAVYIWGNPQ LCFPDPQNIN 180
LTDILDEQNG RAKEHQLQPR PPNCPSCSPA CGKRCWGETP QDCQILTRAK CASGCQRCKG 240
PLPNDCCHLQ CAAGCTGPKD SDCLACRHFN DSGVCKENCP LPTTYDPVTF QSLSNPHGKF 300
NFGATCVKTC PYNYLALEVA CTLSCPPNNQ EVVVTQPDGT ETQKCDKCEG DCPKVCFGPS 360
TDNNGVTDSS SSSIAVVTPS NVEEFNKCTK IFGSLAFRSE SFSWDPAKNT SGLTLEQLSA 420
FRTLEEITGY LYIDAWPEQW TNLSVFENLK VIRGTMLYKG VFSLAIQNLH IESLGLRSLR 480
SVSGGLVLIY NNTQLCYTNS VPWQNLLHPT QGPHRIVSHN QDPAVCEKER NVCHSLCKAG 540
CWGPGPSQCV SCQTFQRGTE CVEQCDLYQG PVREYIDGSK CVACDPQCRP LNGSESCHGP 600
GAQHCTECRN FQDGENCVDR CPSGVKGDLH TVWKYSNATG HCLPCKTNCT PPCTVKDERG 660
CPIDTRTGPG TSIAAAVGGV VLFIILLALL VFYLRRQKKL KRKETMRRIL QEHELVEPLT 720
PSGASPNQAQ MRILKETELK KLRVLGSGAF GTVYKGIWAP DGENVKIPVA IKVLRENTSP 780
KANKEILDEA YVMAGVASPY VCRLLGICLT STVQLVTQLM PYGCLLDYVR ENKDRIGSQF 840
LLNWCVQIAK GMSYLEEVRL VHRDLAARNV LVKNPNHVKI TDFGLARLLD IDETEYHADG 900
GKVPIKWMAL ESILHRRFTH QSDVWSYGVT VWELMTFGSK PYDTIPARDI PEVLEGGERL 960
PQPLICTIDV YMIMVKCWMI DPESRPRFKG LVNDFSAMAR DPPRYVVIQN DEEMSKCSPV 1020
DSEFYRMLLR EDENIGEMMD PEEYLVPNIR KGDEPQANGL SRHQSYRSRD HSLDMDPSNT 1080
AGPRNLHSSL TGISHTQYPT SPMAASASNS VWPQYPMLAR STSAGGQSDS VFLDAPTDGH 1140
SLAPASPGRY SKDPTFPNGS KDDLETDGCN GFPHPYLHHS LPRRSHAIQN HPLPGESVVF 1200
LKNEISVTPI VF 1212
Nucleotide Sequence
(FASTA)
ATGAGATGCA AAAACTTCAT CTCTGTTCCC CCCAGATGGA CTAGAAGCGC CGGGTCTGCG 60
CAGATGGAGG CGGCGAGAAG TTTGCTGTTT GTCGGGGCCG TGCTGCTCGG AGTGACGGGC 120
GCTTCAGGCA GAGAAGTCTG TCGGGGTACA GACATGAAGC TGGCCCTGCC CTCCAGCCTG 180
GAAAACCACT ATGAGACCCT GAGGCTGCTC TACACCGGTT GCCAGGTTGT TCATGGAAAC 240
TTGGAGATTA CACACCTCCA TGGAAACCCT GACCTCTCCT TCCTGCAGGG GATTGTGGAG 300
GTACAGGGTT ATGTACTCGT TGCTCATGTT TCTGTGAGCC TGTTGCCCTT AGACAGCCTT 360
CGGATCATAA GAGGCAGCCA GTTGTACAAC TCCAGCTACG CGCTGGCTGT GCTGGATAAC 420
ACTCACGCCG GTCAGGGGCT GAGGACGCTC CGGCTTCGTA GCCTCACAGA GATCCTGCTG 480
GGCGCAGTGT ATATTTGGGG GAACCCCCAG CTGTGCTTCC CAGACCCCCA GAACATCAAT 540
TTGACGGACA TCTTGGATGA GCAGAATGGC CGCGCCAAGG AACACCAACT GCAGCCTCGG 600
CCTCCTAACT GTCCAAGTTG TTCGCCTGCA TGCGGGAAAA GATGCTGGGG AGAGACTCCT 660
CAGGATTGCC AAATTCTGAC CCGAGCTAAA TGTGCGTCTG GCTGCCAGCG ATGTAAAGGT 720
CCTCTACCCA ACGACTGCTG TCACCTGCAG TGTGCAGCTG GATGCACTGG ACCCAAAGAC 780
TCAGACTGTC TGGCTTGTCG TCACTTCAAC GACAGCGGTG TATGTAAAGA GAACTGTCCA 840
CTGCCCACCA CCTATGACCC CGTCACGTTT CAGTCCCTAT CCAACCCACA TGGGAAGTTT 900
AACTTTGGAG CAACCTGTGT CAAGACGTGT CCTTATAACT ATCTGGCGTT GGAAGTGGCC 960
TGTACTTTAT CTTGCCCCCC AAACAACCAG GAAGTTGTCG TCACCCAACC TGATGGGACG 1020
GAGACGCAGA AATGTGATAA GTGTGAAGGA GACTGTCCCA AAGTGTGTTT CGGCCCGAGT 1080
ACAGACAACA ATGGTGTCAC CGACAGCAGC AGCAGCAGCA TCGCCGTGGT AACGCCTTCC 1140
AATGTGGAGG AGTTCAACAA GTGTACGAAG ATTTTCGGTA GCCTGGCCTT CCGCTCTGAG 1200
AGCTTCTCAT GGGATCCTGC GAAGAACACC TCAGGCCTGA CTTTGGAGCA GCTGAGTGCC 1260
TTCAGGACTC TGGAGGAGAT TACAGGTTAT CTCTACATTG ATGCCTGGCC AGAGCAGTGG 1320
ACCAACCTCA GTGTGTTTGA GAACCTGAAG GTGATCAGAG GCACGATGCT CTACAAGGGT 1380
GTGTTTTCAC TGGCCATCCA GAATCTGCAC ATCGAGTCTC TCGGGTTGCG GTCGCTGCGC 1440
AGCGTCAGTG GAGGTTTGGT CTTGATTTAC AACAACACAC AGCTGTGCTA CACCAACTCA 1500
GTGCCATGGC AGAATCTCCT CCATCCCACC CAGGGTCCGC ACCGCATCGT CAGCCACAAC 1560
CAGGACCCTG CAGTCTGTGA GAAAGAGAGG AATGTTTGTC ACTCGCTTTG TAAGGCGGGC 1620
TGTTGGGGTC CGGGGCCCAG CCAGTGCGTG TCCTGCCAAA CTTTCCAACG TGGCACCGAG 1680
TGTGTAGAGC AGTGTGATCT CTATCAGGGG CCCGTACGTG AATACATAGA TGGGTCTAAG 1740
TGTGTTGCCT GTGATCCACA GTGTCGACCC CTCAATGGCT CAGAGTCCTG CCACGGGCCG 1800
GGTGCTCAAC ATTGCACAGA GTGTCGGAAC TTCCAGGATG GCGAAAATTG CGTGGATCGG 1860
TGTCCCAGTG GCGTGAAGGG CGATCTGCAT ACTGTGTGGA AATACAGCAA CGCCACGGGA 1920
CACTGTCTGC CATGCAAGAC CAACTGCACG CCACCCTGCA CTGTGAAGGA TGAGCGAGGC 1980
TGCCCCATTG ATACCAGGAC AGGACCTGGC ACGTCTATCG CGGCTGCAGT GGGTGGGGTG 2040
GTGCTCTTCA TTATCCTGCT GGCTCTGCTG GTCTTTTACT TGAGGAGACA GAAGAAGCTA 2100
AAGAGGAAGG AGACAATGAG GAGGATCCTG CAGGAGCACG AGCTGGTGGA GCCTTTAACG 2160
CCGAGTGGTG CTTCACCCAA TCAAGCTCAG ATGCGTATAT TGAAAGAGAC CGAGCTGAAA 2220
AAACTCAGGG TGCTGGGTTC GGGGGCCTTT GGCACTGTTT ACAAGGGAAT TTGGGCTCCT 2280
GATGGGGAAA ATGTGAAAAT CCCAGTGGCC ATTAAGGTTT TGCGTGAGAA CACCTCACCA 2340
AAAGCCAACA AAGAAATCCT CGATGAGGCG TATGTGATGG CGGGCGTCGC CAGCCCGTAC 2400
GTGTGTCGTC TCCTGGGGAT TTGTCTCACC TCCACTGTGC AGCTGGTCAC TCAGCTGATG 2460
CCGTACGGCT GCCTCCTTGA CTACGTCAGA GAGAACAAGG ACCGCATTGG TTCGCAGTTC 2520
CTACTCAACT GGTGTGTCCA GATTGCCAAG GGGATGAGTT ATCTGGAGGA GGTCCGTTTG 2580
GTCCACAGAG ATTTGGCAGC CCGCAATGTC CTGGTGAAGA ACCCCAATCA CGTGAAGATC 2640
ACTGACTTTG GTCTGGCGCG TCTGCTTGAT ATAGACGAGA CTGAGTATCA CGCCGATGGA 2700
GGGAAGGTGC CAATCAAATG GATGGCCTTG GAGTCTATCC TGCACAGGAG GTTTACTCAC 2760
CAGAGTGATG TGTGGAGCTA CGGGGTAACT GTTTGGGAGC TGATGACATT TGGCTCTAAG 2820
CCCTACGACA CGATTCCAGC AAGAGATATC CCAGAGGTTT TAGAGGGGGG CGAGCGGCTT 2880
CCCCAACCCC TTATCTGCAC CATTGATGTC TACATGATCA TGGTCAAATG TTGGATGATT 2940
GATCCTGAGA GCAGGCCGAG ATTCAAAGGC CTGGTCAATG ATTTTAGTGC CATGGCTAGA 3000
GATCCACCTC GCTATGTAGT TATTCAGAAT GATGAAGAGA TGAGCAAGTG CAGCCCAGTG 3060
GACAGCGAGT TTTACAGGAT GCTTCTGAGG GAAGATGAAA ATATTGGGGA AATGATGGAT 3120
CCTGAGGAGT ACCTGGTGCC AAATATAAGG AAAGGGGACG AGCCCCAGGC CAATGGGCTA 3180
TCCAGACACC AGTCATACAG GAGCAGAGAT CATAGCTTAG ATATGGACCC TTCCAACACT 3240
GCTGGGCCTC GGAACCTTCA CTCCTCCCTG ACTGGAATCA GCCACACCCA GTACCCAACC 3300
TCACCGATGG CAGCAAGCGC CTCTAACAGT GTGTGGCCTC AGTATCCAAT GCTGGCTCGC 3360
AGCACCTCAG CTGGAGGTCA GTCTGACTCT GTCTTCCTGG ATGCACCTAC AGACGGCCAC 3420
TCCTTGGCAC CAGCCAGCCC CGGACGCTAC AGCAAAGACC CCACCTTCCC CAACGGGAGC 3480
AAGGATGACC TAGAAACTGA TGGGTGTAAT GGTTTTCCCC ATCCTTATCT TCACCACTCA 3540
CTACCCCGGC GGAGTCACGC CATTCAAAAT CATCCCCTGC CAGGTGAGTC GGTGGTCTTC 3600
TTAAAGAACG AAATATCCGT AACTCCGATT GTGTTCTGA 3639
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lkkl+vlGsGafGtvykGiw p+genvkipvaikvl+e+t++kanke+ldea+v+a + +
Q: 739   LKKLRVLGSGAFGTVYKGIWAPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVAS  798
         699*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+qlvtql+p+Gclldyvre+kd++Gsq llnwcvqiakGmsylee 
Q: 799   PYVCRLLGICLTSTVQLVTQLMPYGCLLDYVRENKDRIGSQFLLNWCVQIAKGMSYLEEV  858
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvk+pnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+r++
Q: 859   RLVHRDLAARNVLVKNPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILHRRF  918
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfG+kpyd+ipa++ip++le Gerl+qp ictidvym++vkcw
Q: 919   THQSDVWSYGVTVWELMTFGSKPYDTIPARDIPEVLEGGERLPQPLICTIDVYMIMVKCW  978
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mid+esrp+fk l+++fs
Q: 979   MIDPESRPRFKGLVNDFS  996
         ***************996
Domain Sequence
(FASTA)
LKKLRVLGSG AFGTVYKGIW APDGENVKIP VAIKVLRENT SPKANKEILD EAYVMAGVAS 60
PYVCRLLGIC LTSTVQLVTQ LMPYGCLLDY VRENKDRIGS QFLLNWCVQI AKGMSYLEEV 120
RLVHRDLAAR NVLVKNPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILHRRF 180
THQSDVWSYG VTVWELMTFG SKPYDTIPAR DIPEVLEGGE RLPQPLICTI DVYMIMVKCW 240
MIDPESRPRF KGLVNDFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00280
EKS-ANC-00289
EKS-BOT-00298
EKS-CAF-00305
EKS-CAP-00334
EKS-DAR-00646
EKS-EQC-00290
EKS-FEC-00284
EKS-GAA-00370
EKS-GOG-00296
EKS-ICT-00281
EKS-LAC-00310
EKS-LOA-00309
EKS-MOD-00293
EKS-MUM-00330
EKS-MUP-00296
EKS-MYL-00300
EKS-NOL-00275
EKS-ORC-00281
EKS-ORL-00360
EKS-OTG-00303
EKS-PAT-00284
EKS-RAN-00315
EKS-SAH-00280
EKS-SUS-00262
EKS-TAR-00391
EKS-TEN-00386
EKS-XET-00372
EKS-XIM-00379
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR021157; Cyt_c1_TM_anchor_C.
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 2.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 3.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013