EKS-ORN-00131

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00131

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	457.4	1.5E-137	380	629	250

Status

Unreviewed

Ensembl Protein

ENSONIP00000014647

UniProt Accession

I3K0K2;

Protein Name

Protein Synonyms/Alias

Gene Name

TEC

Gene Synonyms/Alias

TEC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000011633	ENSONIP00000014647	ENSONIT00000014659

Organism

Oreochromis niloticus

Functional Description

Protein Length

641

Protein Sequence
(FASTA)

MSADLLLEEL LIKRSQQKKR TSPLNYKERL FVLTKSRLTY YDGKAEKKFK RGSIELSRIR 60

CVEVVKNGGG VIPCQNKYPF QVVYDSNTLY VFAPSHDSRS RWVQSLKDEI KDNPEVLVKF 120

HPQFWQDGLW LCCRQAEKQA LGCEQYNPLE DISRKPLPPI PGEKYKKRRN PPPAPPTPQG 180

EDEDDEEDEE EEVVVAMYDF PGMEPHDLSL VKGEEYVIVD KCDVNWYRAR NKYNEEGYIP 240

SNYVTEKKSG NLVQYVWYNK NVNRNKAEEL LRKEDKEGAF IIRNSSTPGT YTVSLYTKSS 300

GDGGAAIKHY HIKETQTLPK QFYLAEKHLF SSIPDLIEYH KHNAAGLVAR LRYPVGKQDK 360

SAPSTAGFSY EKWEIDPNEL TFMKELGCGQ FGVVRLGKWR AQHKVAIKAL KEGAMYEEDF 420

IEEAKVMMRL SHPKLVQLYG VCSQQRPIYI VTEFMEQGCL LNYLRQRRGS FNQGCLLSIC 480

LDVCEGMAHL EANGFIHRDL AARNCLVNDS LVVKVSDFGM ARYVLDDQYT SSSGAKFPVK 540

WSPPEVFNFC KYSSKSDVWS YGVLMWEVFT EGRMPFEQSP NHEVVTLVTQ GHRLYRPKMA 600

KPVIYDIMQM CWYERPEDRP SFASLCVMIS DALEDDEATL N 641

Nucleotide Sequence
(FASTA)

ATGAGTGCGG ATCTGCTGTT GGAGGAGTTG CTGATCAAGC GTTCGCAGCA GAAGAAGAGG 60

ACGTCGCCGC TTAACTACAA GGAGAGGCTG TTCGTCCTCA CCAAGAGCCG GCTGACATAC 120

TATGATGGAA AAGCTGAGAA GAAGTTCAAG AGGGGCTCCA TCGAACTGAG TCGCATCAGA 180

TGTGTGGAGG TCGTCAAGAA TGGAGGAGGG GTCATCCCCT GCCAGAACAA ATACCCCTTT 240

CAGGTGGTGT ATGATAGCAA CACCCTCTAT GTATTTGCTC CAAGTCACGA CAGCAGAAGC 300

CGATGGGTCC AGAGCCTCAA AGATGAGATC AAAGACAACC CAGAGGTCTT GGTGAAATTT 360

CACCCTCAGT TCTGGCAGGA TGGGCTGTGG CTCTGCTGCC GCCAGGCAGA AAAACAAGCA 420

CTGGGGTGTG AGCAGTACAA CCCGTTAGAA GACATTTCCA GAAAACCTCT GCCCCCGATT 480

CCTGGAGAGA AGTATAAAAA ACGTCGGAAT CCTCCTCCCG CCCCCCCGAC CCCCCAGGGT 540

GAGGACGAGG ACGATGAGGA GGATGAGGAA GAGGAGGTGG TGGTGGCTAT GTACGACTTC 600

CCCGGCATGG AGCCTCATGA TCTGAGTCTG GTGAAAGGGG AAGAGTATGT TATCGTGGAT 660

AAGTGTGATG TCAACTGGTA CAGGGCACGC AACAAGTATA ATGAGGAAGG ATACATTCCA 720

AGTAACTATG TAACGGAGAA AAAATCCGGA AACTTGGTCC AATATGTCTG GTACAATAAA 780

AATGTCAACA GGAATAAAGC TGAGGAGCTG CTAAGGAAGG AGGATAAAGA AGGAGCCTTC 840

ATTATTAGAA ACTCCAGCAC CCCAGGAACC TACACTGTTT CGCTCTACAC CAAGTCTTCA 900

GGGGATGGAG GTGCAGCTAT TAAACATTAC CACATCAAGG AGACGCAAAC CTTACCAAAG 960

CAGTTCTACC TGGCTGAAAA ACACCTCTTC AGCTCCATCC CGGACCTGAT TGAATACCAC 1020

AAACATAATG CAGCAGGTCT TGTAGCCAGG TTGAGATATC CTGTTGGAAA ACAAGACAAA 1080

TCAGCTCCAT CCACTGCTGG CTTCAGCTAT GAAAAGTGGG AGATCGACCC CAATGAGCTA 1140

ACCTTCATGA AGGAGCTGGG CTGCGGTCAG TTCGGAGTAG TGAGGCTCGG CAAGTGGAGA 1200

GCTCAACACA AAGTGGCCAT CAAGGCATTA AAGGAGGGAG CCATGTATGA GGAGGACTTC 1260

ATAGAGGAGG CCAAGGTCAT GATGAGACTG TCCCACCCCA AACTGGTGCA GTTGTATGGG 1320

GTGTGCAGCC AGCAGCGGCC AATCTACATT GTCACTGAGT TCATGGAGCA GGGCTGCCTG 1380

TTGAACTACC TCAGGCAGCG GCGGGGCAGC TTTAACCAGG GATGCTTGCT GAGTATCTGT 1440

TTGGATGTCT GCGAGGGCAT GGCGCACCTG GAAGCCAACG GCTTCATCCA CAGAGACTTG 1500

GCAGCCAGAA ACTGTCTGGT AAACGACTCT CTGGTGGTGA AAGTGTCTGA CTTTGGCATG 1560

GCCAGATACG TGTTAGATGA TCAGTACACC AGCTCATCAG GCGCCAAGTT TCCTGTGAAG 1620

TGGTCACCTC CTGAAGTCTT TAACTTTTGC AAATACAGCA GCAAGTCGGA CGTCTGGTCA 1680

TACGGTGTGT TGATGTGGGA GGTCTTCACA GAGGGTCGGA TGCCATTTGA GCAAAGTCCC 1740

AACCATGAGG TGGTGACATT AGTTACACAG GGTCATCGAC TGTACAGGCC CAAAATGGCC 1800

AAGCCCGTCA TCTATGATAT CATGCAGATG TGCTGGTATG AGAGGCCAGA GGACCGTCCA 1860

TCATTCGCCA GTCTTTGTGT AATGATCTCT GATGCTCTGG AGGACGACGA GGCAACTCTA 1920

AACTGA 1926

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt++kelg gqfgvv+lgkwra+++vaika+kegam eedfieeakvmm+lshpklvqly

Q: 380   LTFMKELGCGQFGVVRLGKWRAQHKVAIKALKEGAMYEEDFIEEAKVMMRLSHPKLVQLY  439

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvc++q+piyivte++e+gcllnylr++++++++  ll++c dvcegm++le + fihrd

Q: 440   GVCSQQRPIYIVTEFMEQGCLLNYLRQRRGSFNQGCLLSICLDVCEGMAHLEANGFIHRD  499

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+++lvvkvsdfg+aryvlddqy+ss+gakfpvkwsppev+++ kyssksdvw

Q: 500   LAARNCLVNDSLVVKVSDFGMARYVLDDQYTSSSGAKFPVKWSPPEVFNFCKYSSKSDVW  559

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         ++gvlmwevf+eg++p+e+  n+evv+ v++g+rlyrpk+a   +y++m+ cw e+pe+r

Q: 560   SYGVLMWEVFTEGRMPFEQSPNHEVVTLVTQGHRLYRPKMAKPVIYDIMQMCWYERPEDR  619

         ************************************************************

S: 241   ptfkellsal  250

         p+f++l   +

Q: 620   PSFASLCVMI  629

         ****998766

Domain Sequence
(FASTA)

LTFMKELGCG QFGVVRLGKW RAQHKVAIKA LKEGAMYEED FIEEAKVMMR LSHPKLVQLY 60

GVCSQQRPIY IVTEFMEQGC LLNYLRQRRG SFNQGCLLSI CLDVCEGMAH LEANGFIHRD 120

LAARNCLVND SLVVKVSDFG MARYVLDDQY TSSSGAKFPV KWSPPEVFNF CKYSSKSDVW 180

SYGVLMWEVF TEGRMPFEQS PNHEVVTLVT QGHRLYRPKM AKPVIYDIMQ MCWYERPEDR 240

PSFASLCVMI 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013