EKS-ORN-00240
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00240
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/CASK536.11.8E-16114278265
StatusUnreviewed
Ensembl ProteinENSONIP00000015246
UniProt AccessionI3K2A1;
Protein Name
Protein Synonyms/Alias
Gene NameCASK
Gene Synonyms/Alias CASK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000012112ENSONIP00000015247ENSONIT00000015260
ENSONIG00000012112ENSONIP00000015246ENSONIT00000015259
OrganismOreochromis niloticus
Functional Description
Protein Length935
Protein Sequence
(FASTA)
MTMADDDVLF EDVYELCEVI GKGPFSVVRR CINRDTGQQF AVKIVDVASF TSSPGLSTED 60
LKREASICHM LKHPHIVELL ETYSSDGMLY MVFEFMDGAD LCFEIVKRAD AGFVYSEAVA 120
SHYMRQILEA LRYCHDNNVI HRDVKPHCVL LASKENSAPV KLGGFGVAIQ LGESGLVAGG 180
RVGTPHFMAP EVVKREPYGK PVDVWGCGVI LFILLSGCLP FYGTKERLFE AIIKGKYKMN 240
PRQWAHISES AKDLVRRMLM LDPAERITVY EALNHPWLKE RDRYAYKIHL PETVEQLRKF 300
NARRKLKGAV LAAVSSHKFN SYYGDPPEEL HDFSDDPTSS GAVSQVLDSL EEIHALTDCS 360
EKDMDFLHSV FQDQHLHTLL DLYDKINTRS SPQIRNPPSD GVQRAKEVLE TISCYPENME 420
AKELRRILTQ PHFMALLQTH DVVAHEVYSD EALRVTPPPT SPYLNGDSPD STNGDMDLEN 480
VTRVRLVQFQ KNTDEPMGIT LKMNDLNHCI VARIMHGGMI HRQGTLHVGD EIREINGISV 540
ANQTVEQLQK MLREMRGSIT FKIVPSYRSQ SMSCEKESPD LSRQSPANGH ASVTSSILDL 600
PSTIQPKGRQ ICRPAIKDKL SIKIYVRAQF EYDPAKDDLI PCKEAGIRFR VGDIIQIISK 660
DDHNWWQGKL ENTKNGTAGL IPSPELQEWR VACIAMEKTK QEQQASCTWF GKKKKQYKDK 720
YLAKHNAVFD QLDLVTYEEV VKLPSFKRKT LVLLGAHGVG RRHIKNTLIT KHPDRFAYPI 780
PHTTRPPKKD EENGKNYYFV SHEQMMQDIS NNDYLEYGSH EDAMYGTRLE TIRQIHAQGM 840
ISILDVEPQA LKILRTAEFA PYVVFIAAPT ITPGMTEDES LQRLQKESEM LQQTYAHYFD 900
QTIINNEIDD TIRLLEEAVD LVSTTPQWVP VSWVY 935
Nucleotide Sequence
(FASTA)
ATGACCATGG CGGACGACGA CGTGCTGTTC GAGGATGTGT ACGAGTTGTG CGAGGTGATT 60
GGCAAGGGTC CCTTCAGTGT GGTGAGGCGC TGCATCAACA GGGACACCGG CCAGCAGTTT 120
GCTGTAAAGA TTGTTGATGT GGCCAGCTTT ACCTCCAGCC CTGGCCTCAG CACAGAAGAT 180
CTGAAGCGAG AGGCGAGCAT CTGCCACATG CTGAAACACC CCCACATCGT GGAGCTGCTG 240
GAGACTTACA GCTCCGATGG CATGCTCTAC ATGGTCTTTG AATTTATGGA TGGTGCGGAC 300
CTGTGTTTTG AAATCGTGAA GCGAGCTGAT GCTGGGTTTG TGTACAGCGA AGCAGTGGCC 360
AGCCACTACA TGAGGCAGAT TCTGGAGGCA CTTCGATACT GCCATGACAA CAATGTGATT 420
CACCGTGATG TAAAGCCTCA CTGTGTGCTG CTGGCCTCAA AGGAGAACTC TGCTCCAGTG 480
AAACTCGGAG GCTTCGGAGT GGCGATCCAG CTGGGAGAGT CTGGTTTAGT AGCCGGAGGT 540
CGAGTGGGCA CGCCCCACTT CATGGCCCCA GAGGTGGTGA AAAGGGAGCC TTATGGCAAA 600
CCGGTAGATG TGTGGGGATG TGGCGTGATC CTCTTCATTC TGCTGTCTGG CTGCCTGCCT 660
TTCTACGGCA CCAAGGAGCG ATTGTTTGAG GCTATCATCA AAGGGAAATA TAAGATGAAC 720
CCGCGCCAGT GGGCTCACAT CTCTGAAAGT GCCAAGGACC TGGTGAGGCG CATGCTGATG 780
CTTGACCCTG CTGAGAGAAT CACTGTCTAT GAGGCTCTCA ACCACCCCTG GCTGAAGGAG 840
AGGGACAGGT ATGCCTACAA GATCCACCTG CCCGAAACAG TTGAGCAGCT GAGAAAGTTC 900
AACGCCAGGA GGAAGCTGAA GGGTGCAGTG CTGGCTGCTG TTTCCAGCCA CAAGTTTAAT 960
TCCTACTATG GTGACCCCCC TGAGGAGCTC CATGACTTCT CAGATGATCC CACCTCCTCA 1020
GGGGCAGTAT CACAGGTTTT GGACAGTCTA GAGGAGATCC ATGCATTGAC AGACTGCAGT 1080
GAGAAAGATA TGGACTTCCT GCACAGCGTC TTCCAGGACC AGCACCTCCA CACTCTATTA 1140
GATCTTTATG ACAAAATCAA CACCAGGTCG TCCCCTCAGA TCAGAAATCC TCCAAGTGAT 1200
GGAGTGCAGA GAGCCAAAGA GGTACTGGAA ACCATCTCCT GTTACCCAGA GAATATGGAG 1260
GCCAAGGAGC TCAGGAGGAT CCTCACACAG CCACACTTCA TGGCTCTGCT GCAGACCCAC 1320
GATGTGGTGG CACACGAGGT GTACAGCGAC GAGGCGTTGA GGGTGACTCC CCCGCCTACT 1380
TCACCGTACC TGAACGGAGA CTCCCCGGAC AGCACCAACG GAGACATGGA CTTGGAAAAT 1440
GTCACCAGGG TTCGGCTGGT TCAGTTTCAG AAGAACACCG ATGAGCCCAT GGGCATTACT 1500
CTGAAAATGA ACGACCTCAA CCACTGCATT GTGGCCCGCA TCATGCATGG TGGAATGATC 1560
CATCGACAAG GGACTCTGCA TGTAGGAGAT GAGATCCGGG AGATTAATGG CATCAGCGTT 1620
GCTAATCAGA CGGTAGAACA GCTCCAGAAG ATGCTGAGAG AGATGAGGGG AAGCATCACC 1680
TTCAAGATTG TGCCCAGTTA CCGATCCCAG TCAATGTCTT GTGAGAAAGA GTCTCCGGAT 1740
TTATCTCGAC AGTCACCTGC AAATGGTCAT GCTAGTGTGA CCAGCTCCAT CCTGGACCTG 1800
CCATCGACTA TTCAGCCTAA AGGCCGTCAG ATCTGCAGAC CTGCTATCAA GGACAAATTG 1860
TCCATCAAGA TTTATGTACG CGCTCAGTTT GAGTACGACC CGGCAAAAGA CGACCTCATC 1920
CCGTGCAAAG AGGCCGGCAT CCGCTTCCGG GTAGGTGACA TCATTCAGAT CATCTCCAAG 1980
GATGACCACA ACTGGTGGCA AGGAAAGCTG GAGAACACCA AGAATGGCAC AGCAGGACTC 2040
ATCCCCTCAC CTGAACTGCA GGAATGGCGT GTGGCATGTA TAGCAATGGA GAAGACCAAA 2100
CAGGAACAGC AGGCCAGTTG TACCTGGTTT GGCAAGAAGA AGAAACAGTA CAAAGACAAA 2160
TACCTGGCCA AGCACAACGC AGTGTTTGAT CAACTAGATC TGGTGACATA TGAGGAGGTG 2220
GTTAAACTGC CGTCATTTAA GAGAAAAACA CTGGTTTTAC TTGGTGCACA CGGAGTTGGT 2280
CGGAGGCACA TCAAGAACAC GCTGATCACC AAACATCCCG ACCGCTTTGC CTACCCTATT 2340
CCTCACACAA CTCGGCCTCC CAAGAAAGAC GAGGAGAACG GAAAGAACTA CTACTTTGTT 2400
TCTCACGAGC AGATGATGCA GGACATCAGC AACAACGACT ACCTGGAGTA TGGCAGCCAT 2460
GAGGATGCCA TGTATGGAAC CAGGCTGGAG ACTATCAGGC AGATCCATGC CCAGGGCATG 2520
ATCTCCATCC TAGACGTCGA GCCACAGGCA CTAAAGATCC TCAGGACAGC TGAGTTTGCT 2580
CCATACGTCG TCTTCATCGC GGCTCCCACC ATCACCCCAG GCATGACTGA GGACGAATCT 2640
CTTCAGCGGC TACAGAAGGA GTCGGAGATG CTGCAGCAAA CCTACGCTCA CTACTTTGAC 2700
CAGACCATCA TCAACAACGA GATCGACGAC ACCATCCGCC TGCTGGAGGA GGCCGTGGAC 2760
CTGGTGTCCA CCACTCCTCA GTGGGTTCCC GTCTCCTGGG TCTACTGA 2808
Domain Profile
S: 1     yelcevigkGpfsvvrriihresnqkfavkivdvakftsspGlstedlkreasichmlkh  60
         yelcevigkGpfsvvrr+i+r+++q+favkivdva ftsspGlstedlkreasichmlkh
Q: 14    YELCEVIGKGPFSVVRRCINRDTGQQFAVKIVDVASFTSSPGLSTEDLKREASICHMLKH  73
         89**********************************************************
S: 61    pyivelletyssegmlylvfefmeGadlcfeivkrasaGfvyseavashymrqilealry  120
         p+ivelletyss+gmly+vfefm+Gadlcfeivkra+aGfvyseavashymrqilealry
Q: 74    PHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRY  133
         ************************************************************
S: 121   chdnkivhrdvrphcvllaskdnsapvklgGfGvaiqlseisglvagGrvGvphfmapev  180
         chdn+++hrdv+phcvllask+nsapvklgGfGvaiql+e sglvagGrvG+phfmapev
Q: 134   CHDNNVIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGE-SGLVAGGRVGTPHFMAPEV  192
         ****************************************.*******************
S: 181   vkrerygksvdvwgaGvvlfillsGrlpflGskerlfesiikgklkldarewssisesak  240
         vkre+ygk+vdvwg+Gv+lfillsG+lpf+G+kerlfe+iikgk+k+++r+w +isesak
Q: 193   VKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEAIIKGKYKMNPRQWAHISESAK  252
         ************************************************************
S: 241   dlvrrmlaadpakrisvkealnhewl  266
         dlvrrml++dpa+ri+v+ealnh+wl
Q: 253   DLVRRMLMLDPAERITVYEALNHPWL  278
         *************************7
Domain Sequence
(FASTA)
YELCEVIGKG PFSVVRRCIN RDTGQQFAVK IVDVASFTSS PGLSTEDLKR EASICHMLKH 60
PHIVELLETY SSDGMLYMVF EFMDGADLCF EIVKRADAGF VYSEAVASHY MRQILEALRY 120
CHDNNVIHRD VKPHCVLLAS KENSAPVKLG GFGVAIQLGE SGLVAGGRVG TPHFMAPEVV 180
KREPYGKPVD VWGCGVILFI LLSGCLPFYG TKERLFEAII KGKYKMNPRQ WAHISESAKD 240
LVRRMLMLDP AERITVYEAL NHPWL 265
KeywordComplete proteome; Reference proteome; SH3 domain.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00177
EKS-BOT-00189
EKS-CAE-00177
EKS-CAJ-00196
EKS-CAF-00195
EKS-CAP-00214
EKS-CII-00122
EKS-CIS-00227
EKS-DRM-00100
EKS-FEC-00177
EKS-GOG-00185
EKS-HOS-00194
EKS-LOA-00185
EKS-MAM-00189
EKS-MOD-00187
EKS-MUM-00191
EKS-MUP-00191
EKS-NOL-00178
EKS-ORC-00172
EKS-ORL-00226
EKS-OTG-00195
EKS-POA-00183
EKS-SUS-00162
EKS-TAR-00246
EKS-TEN-00240
EKS-XIM-00235
Gene Ontology
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
KEGG
InterPros
IPR008144; Guanylate_kin.
IPR008145; Guanylate_kin/L-typ_Ca_channel.
IPR020590; Guanylate_kinase_CS.
IPR011009; Kinase-like_dom.
IPR004172; L27.
IPR014775; L27_C.
IPR001478; PDZ.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR011511; SH3_2.
IPR001452; SH3_domain.
Pfam
PF00625; Guanylate_kin; 1.
PF02828; L27; 2.
PF00595; PDZ; 1.
PF00069; Pkinase; 1.
PF07653; SH3_2; 1.
SMARTs
SM00072; GuKc; 1.
SM00569; L27; 2.
SM00228; PDZ; 1.
SM00220; S_TKc; 1.
SM00326; SH3; 1.
Prosites
PS00856; GUANYLATE_KINASE_1; 1.
PS50052; GUANYLATE_KINASE_2; 1.
PS51022; L27; 2.
PS50106; PDZ; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50002; SH3; 1.
Prints
Created Date20-Feb-2013