EKS-ORN-00355

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00355

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	453.6	3.4E-136	201	488	288

Status

Unreviewed

Ensembl Protein

ENSONIP00000015261

UniProt Accession

I3K2B7;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1B (1 of 2)

Gene Synonyms/Alias

ACVR1B (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000012123	ENSONIP00000015262	ENSONIT00000015275
ENSONIG00000012123	ENSONIP00000015261	ENSONIT00000015274

Organism

Oreochromis niloticus

Functional Description

Protein Length

499

Protein Sequence
(FASTA)

MALKQIAPTL LALLGLVAVG NALRCNCTNC EKTGYECETD GACMASTYYV SGKEEHVRVC 60

INQDSLVPPG QPFYCLSAEG FFNTHCCYVD YCNSIDLKVP VPTKGGEWST QVSNWGPVEL 120

VAVIAGPVFL LCVLLMVGVF LFQYHQRAYS HRQRLEVEDP SCDHLYLAKD KTLQDLIYDM 180

STSGSGSGLP LFVQRTVART IVLQEIIGKG RFGEVWRGKW RGGDVAVKIF SSREERSWFR 240

EAEIYQTIML RHENILGFIA ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YSVTIEGMIK 300

LALSAASGLA HLHMEILGTQ GKPGIAHRDL KSKNILVKKN GTCAIADLGL AVRHESITDT 360

IDIAPNQRVG TKRYMAPEVL DETINMKHFD SFKCADIYAL GLVYWEIARR CNTGGIHEEY 420

QLPYYDLVPS DPSIEEMRKV VCDQKLRPNV PNWWQSYESL RVMGKIMREC WYANGAARLT 480

ALRIKKTLSQ LSVEEDVKM 499

Nucleotide Sequence
(FASTA)

ATGGCTCTAA AACAAATTGC CCCAACGCTG CTGGCCCTGC TCGGGCTGGT GGCCGTCGGT 60

AATGCTTTAC GTTGCAACTG CACAAACTGT GAGAAGACGG GCTATGAGTG CGAGACAGAC 120

GGTGCCTGCA TGGCTTCAAC TTACTATGTC AGTGGGAAGG AGGAACACGT ACGTGTCTGC 180

ATCAACCAGG ACAGCCTGGT TCCCCCTGGG CAACCGTTCT ACTGTTTGAG TGCTGAAGGC 240

TTCTTCAATA CTCACTGCTG CTATGTAGAT TACTGCAACA GTATTGACCT GAAAGTCCCA 300

GTCCCAACCA AAGGGGGGGA ATGGTCAACC CAAGTGAGCA ACTGGGGGCC AGTGGAGCTG 360

GTGGCAGTGA TTGCAGGGCC CGTGTTCCTG CTCTGTGTGT TGCTGATGGT CGGGGTGTTC 420

CTGTTCCAGT ATCACCAGAG GGCCTATAGC CACAGACAAA GACTGGAGGT AGAAGATCCC 480

TCCTGTGACC ATCTATACTT GGCCAAGGAT AAGACGCTCC AGGACCTAAT CTATGACATG 540

TCCACCTCTG GATCAGGCTC TGGTTTGCCC CTGTTTGTGC AGCGGACTGT GGCCAGGACT 600

ATTGTGCTGC AGGAAATAAT AGGAAAAGGT CGCTTTGGGG AGGTGTGGCG CGGGAAGTGG 660

AGGGGAGGCG ATGTAGCAGT GAAAATCTTC TCATCCAGAG AGGAGCGCTC CTGGTTCAGA 720

GAGGCTGAAA TCTACCAGAC AATCATGTTA CGGCATGAAA ATATCCTAGG ATTTATCGCA 780

GCAGACAATA AAGACAATGG CACTTGGACT CAACTCTGGC TGGTGTCAGA CTATCATGAG 840

CATGGCTCAC TTTTTGACTA CCTGAATCGC TACTCTGTCA CCATTGAGGG GATGATAAAA 900

TTGGCGCTAT CAGCTGCCAG CGGCTTGGCA CACCTGCACA TGGAGATCCT AGGCACTCAG 960

GGTAAACCTG GCATTGCTCA CCGTGACCTC AAGTCCAAAA ATATTCTGGT TAAGAAGAAC 1020

GGCACGTGTG CTATAGCTGA CCTTGGTCTG GCAGTCCGCC ATGAGTCTAT CACAGACACG 1080

ATCGATATAG CACCGAACCA GCGCGTGGGC ACTAAGAGGT ATATGGCTCC AGAAGTCCTG 1140

GATGAAACCA TAAACATGAA ACACTTTGAC TCCTTCAAGT GCGCTGACAT TTACGCACTA 1200

GGCCTGGTGT ATTGGGAGAT TGCGCGTCGC TGCAACACAG GAGGTATCCA CGAGGAGTAC 1260

CAGCTACCCT ACTATGACCT TGTGCCCTCT GACCCGTCCA TAGAAGAGAT GAGGAAGGTG 1320

GTGTGTGACC AGAAACTGAG GCCCAATGTG CCCAATTGGT GGCAGAGCTA TGAGTCACTG 1380

CGCGTGATGG GGAAGATCAT GAGGGAGTGC TGGTATGCCA ACGGAGCAGC CAGACTGACA 1440

GCTCTGCGCA TCAAGAAGAC TCTGTCTCAG CTCAGCGTGG AGGAGGACGT GAAGATGTGA 1500

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++k+rg +vAvKifs+++e+sw+rE+eiyqt++lrhenil+fia

Q: 201   IVLQEIIGKGRFGEVWRGKWRGGDVAVKIFSSREERSWFREAEIYQTIMLRHENILGFIA  260

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+ +++e +++lals+asGlahLH+ei gt+

Q: 261   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYSVTIEGMIKLALSAASGLAHLHMEILGTQ  320

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaHRDlkskNilvkk++tc+iaDlGLa+++e+ ++++d+a n++vGtkRYmaPE

Q: 321   G--KPGIAHRDLKSKNILVKKNGTCAIADLGLAVRHESITDTIDIAPNQRVGTKRYMAPE  378

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp+++ v+sdPs+eem

Q: 379   VLDETINMKHFDSFKCADIYALGLVYWEIARRCNT-GGIHEEYQLPYYDLVPSDPSIEEM  437

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++klrP++p+ w++ e l+++ k+++ecW+a+++aRltalr+kk+l

Q: 438   RKVVCDQKLRPNVPNWWQSYESLRVMGKIMRECWYANGAARLTALRIKKTL  488

         *************************************************97

Domain Sequence
(FASTA)

IVLQEIIGKG RFGEVWRGKW RGGDVAVKIF SSREERSWFR EAEIYQTIML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YSVTIEGMIK LALSAASGLA HLHMEILGTQ 120

GKPGIAHRDL KSKNILVKKN GTCAIADLGL AVRHESITDT IDIAPNQRVG TKRYMAPEVL 180

DETINMKHFD SFKCADIYAL GLVYWEIARR CNTGGIHEEY QLPYYDLVPS DPSIEEMRKV 240

VCDQKLRPNV PNWWQSYESL RVMGKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013