EKS-ORN-00390
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00390
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR415.31.2E-124686942257
StatusUnreviewed
Ensembl ProteinENSONIP00000015298
UniProt AccessionI3K2F2;
Protein Name
Protein Synonyms/Alias
Gene NameERBB3 (2 of 2)
Gene Synonyms/Alias ERBB3 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000012148ENSONIP00000015298ENSONIT00000015311
ENSONIG00000012148ENSONIP00000015297ENSONIT00000015310
OrganismOreochromis niloticus
Functional Description
Protein Length1410
Protein Sequence
(FASTA)
EVCPGTQNGL SSTGSQENQY NLIRNRYYGC EIVMGNLEIT QIESNWDFSF LKRIREVTGY 60
VLIAMNHFQE IPLGQLRVIR GNSLYERRFA LSIFLNYPKD GSNGLQQLGL ANLTEILEGG 120
VQIINNKYLS YGPWIFWQDI VRDSSAPIDI KYNGKKGPCH KSCGDYCWGP NEKQCQILTK 180
TVCAPQCNGR CFGTSPRDCC HIECAAGCKG PQDVDCFACR HFNDSGACVP QCPRALIYNK 240
QTFQMETNPN AKYQYGSICV SQCPTHFVVD GSSCVSACPS DKMEVEKEGQ RKCELCSGLC 300
PKVCEGTGAE DRQTVDSSNI NSFINCTKIQ GSLHFLVTGI MGDDFKNIPP LDAKNLEVFR 360
TVREITDFLN IQSWPKELND LSVFSSLTTI QGRTLYNNES HFSLTVMCVP TLTSLGLRSL 420
KEISDGSMYI SLNSNLCYHH TVNWTQLFRG RRVRGGNLSN NKPLAECVAE GHVCDQLCSD 480
AGCWGPGPEQ CLSCRNYSRD GTCVHSCHFY NGAPREFAGP DGECTACHSE CKAQSGKVTC 540
TGPGSDDCVA CASFQDGPFC MSSCPTGIND GQKGLIFKYP NRKGHCQPCH HNCTQGCIGP 600
GLKDCLETAR LAVSSGQITG IALGVPAGLI FCLVLFFLGM LYHRGLAIRR KRAMRRYLES 660
GESFEPLGPG EKGTKVHARL LRPSELKKAK SLGVGVFGTV HKGFWTPEGE TVKIPVAIKT 720
IQDSSGRQTF TEITDHMLSM GSLDHPYIVR LLGICPGASL QLVTQLSPQG SLLEHIRQKK 780
NSLDPQLLLN WCVQIAKGMY YLEEHCMVHR NLAARNILLK NDYQVQISDY GVADLLYPDD 840
KKYVYTDTKT PIKWMALESI LFRRYTHQSD VWSYGVTVWE IMSFGAEPYA SVSPQEVPGL 900
LEKGERLSQP HICTIDVYMV MVKCWMIDEN IRPTFKELAS DFTRMARDPP RYLVIKLEGE 960
EPVSDATHRR ESERGLLDAG LEEQDEEGLE DGLVTPPLQH SPSWSVSRSR INSCRSGTYQ 1020
PGPIGYLPMT TSPADSFRQL WFHRSRLSSV RTLPERLEVR GISREAEVHE EGLRTGSLHR 1080
ARIDSESQQR KLSTASSPPS YKVWTAEEEE EVDSYGYVLP GSPSTPERVQ VSRISHSGQR 1140
NSRLKDNLLF MVINPTKEYE IMNTEESAPP RLASSISRQE DDPTVGICCK TPPLPSPTFR 1200
ALLPIEDIAH KETLPPASAV RKNTVHEACE GSVEERINSA EKHPLTSDIT SDIRAVDDPG 1260
EPAQGNGRYE YMDIRHSDST EGDESSQERR GSQTSAKSAA EEQEIHQTVE VLKKEHKEPD 1320
VLKAGGEKVE EYEEMNRFGV VPSRCKEAEY QNLPVKGRVI CEEMGSGRCT EIGEYIKVCA 1380
GVGEPASNTS FDNPDYWHSR LFLKPDAVRI 1410
Nucleotide Sequence
(FASTA)
GAAGTGTGTC CAGGGACGCA GAATGGACTC AGTTCCACGG GCTCTCAGGA GAACCAGTAC 60
AATCTGATTA GAAACCGGTA TTATGGCTGT GAGATTGTAA TGGGAAACCT GGAGATCACA 120
CAGATTGAGA GTAACTGGGA CTTCTCCTTC CTCAAGAGAA TCCGTGAGGT GACTGGCTAT 180
GTCCTCATTG CTATGAACCA CTTTCAAGAG ATTCCTCTGG GCCAACTGCG CGTCATCAGA 240
GGAAACAGCC TGTATGAAAG ACGTTTTGCT CTATCGATCT TCCTCAACTA CCCCAAGGAC 300
GGCTCCAACG GCCTACAACA GCTGGGACTC GCAAACCTGA CGGAGATTCT GGAGGGAGGG 360
GTGCAGATTA TCAATAACAA ATACCTGAGT TATGGTCCCT GGATCTTCTG GCAGGATATT 420
GTCCGGGACA GCAGCGCTCC TATTGATATC AAATACAATG GAAAGAAAGG CCCATGCCAT 480
AAATCTTGCG GAGATTATTG CTGGGGACCA AACGAAAAGC AATGCCAGAT CTTGACTAAG 540
ACGGTGTGCG CTCCACAGTG TAACGGCCGC TGCTTTGGCA CAAGCCCGAG GGACTGCTGT 600
CACATAGAGT GTGCAGCAGG ATGTAAAGGC CCCCAAGATG TGGACTGTTT TGCATGTCGT 660
CATTTCAATG ACTCCGGAGC CTGTGTGCCA CAATGTCCCC GGGCTCTGAT CTATAACAAG 720
CAGACGTTTC AAATGGAAAC CAACCCTAAT GCCAAGTACC AATACGGATC CATCTGTGTG 780
TCTCAGTGCC CCACTCATTT TGTGGTGGAT GGTAGCTCCT GCGTGAGCGC CTGTCCGTCA 840
GACAAGATGG AGGTAGAGAA AGAAGGCCAG AGGAAGTGTG AGCTCTGCAG CGGACTTTGC 900
CCAAAAGTGT GTGAAGGCAC TGGTGCTGAA GACAGGCAGA CTGTGGACTC AAGCAACATC 960
AACAGCTTCA TCAACTGCAC CAAGATTCAG GGCAGCCTTC ACTTCCTGGT CACGGGGATT 1020
ATGGGAGATG ATTTTAAAAA CATCCCACCA CTTGATGCCA AAAATTTGGA AGTGTTCCGC 1080
ACAGTCAGGG AAATAACAGA TTTCTTAAAC ATCCAGTCCT GGCCCAAAGA GCTGAATGAT 1140
CTGTCTGTTT TTTCGAGCCT CACTACCATT CAAGGGAGGA CGCTCTACAA CAACGAAAGC 1200
CATTTTTCTC TGACGGTCAT GTGCGTCCCC ACTCTTACCT CACTGGGTCT GCGCTCTCTG 1260
AAAGAAATCA GTGACGGCAG CATGTACATC AGTCTGAACA GCAATCTCTG CTACCACCAC 1320
ACTGTAAACT GGACGCAGCT GTTCAGAGGC CGCCGAGTTC GAGGCGGCAA CCTCAGCAAC 1380
AACAAGCCAT TGGCAGAGTG TGTTGCAGAA GGCCACGTGT GTGATCAGCT ATGTTCAGAC 1440
GCAGGATGCT GGGGCCCGGG GCCTGAACAG TGTCTTTCCT GTAGGAACTA CAGTCGAGAC 1500
GGCACATGTG TGCACAGCTG TCATTTTTAC AACGGGGCAC CAAGGGAATT TGCAGGTCCG 1560
GATGGCGAGT GTACCGCCTG TCATTCAGAA TGCAAGGCTC AGAGTGGGAA AGTCACCTGT 1620
ACTGGACCGG GTTCAGATGA TTGTGTGGCT TGTGCCAGCT TTCAAGATGG TCCTTTCTGC 1680
ATGTCCTCTT GTCCCACTGG GATAAATGAT GGACAGAAGG GACTCATTTT CAAATACCCC 1740
AACAGGAAGG GTCATTGTCA ACCGTGTCAC CACAACTGCA CACAGGGATG CATTGGCCCG 1800
GGATTAAAGG ACTGTTTAGA GACAGCCAGA CTGGCAGTTA GTAGTGGTCA GATCACAGGC 1860
ATAGCCTTGG GTGTCCCAGC TGGCTTAATT TTCTGCCTGG TGTTGTTTTT CCTGGGCATG 1920
CTTTACCACA GAGGACTTGC CATCCGTCGC AAGAGGGCTA TGAGGAGGTA CCTGGAGAGC 1980
GGAGAGAGCT TTGAGCCGCT GGGTCCTGGA GAGAAAGGCA CCAAGGTTCA TGCCCGCCTT 2040
CTGAGGCCCT CAGAGCTGAA AAAAGCCAAA TCCCTTGGCG TTGGTGTTTT TGGCACTGTG 2100
CACAAGGGCT TTTGGACTCC AGAAGGAGAG ACGGTAAAAA TACCCGTTGC CATTAAGACA 2160
ATCCAGGATA GCTCCGGTCG ACAAACTTTC ACTGAAATTA CTGATCATAT GCTCTCCATG 2220
GGCAGCTTGG ACCACCCTTA CATCGTTAGG CTGCTGGGCA TCTGCCCAGG TGCCAGTCTG 2280
CAACTGGTAA CCCAGCTCAG TCCACAAGGT TCACTGCTGG AGCACATCAG GCAAAAGAAG 2340
AACAGCCTGG ACCCCCAGCT CCTGCTCAAC TGGTGTGTGC AGATTGCAAA GGGCATGTAC 2400
TATCTGGAAG AGCACTGCAT GGTCCACAGG AATCTGGCTG CACGCAACAT CTTACTGAAA 2460
AATGACTATC AGGTCCAGAT CTCTGACTAC GGCGTCGCAG ACCTCCTTTA CCCTGATGAC 2520
AAGAAATACG TCTACACAGA CACAAAGACA CCAATAAAAT GGATGGCACT CGAAAGCATC 2580
TTGTTTCGAA GATATACTCA TCAGAGTGAT GTCTGGAGTT ATGGGGTGAC AGTGTGGGAG 2640
ATTATGTCAT TTGGGGCGGA GCCATATGCA TCCGTGTCGC CTCAGGAAGT GCCAGGTCTG 2700
CTGGAGAAGG GCGAGCGTCT GTCACAGCCC CACATCTGTA CTATAGATGT CTACATGGTC 2760
ATGGTGAAAT GCTGGATGAT TGATGAAAAT ATAAGGCCGA CCTTCAAAGA ACTGGCCAGT 2820
GACTTCACTC GCATGGCGAG GGACCCACCA AGATACCTTG TCATCAAGCT GGAAGGAGAA 2880
GAACCTGTCT CAGATGCAAC CCATCGAAGG GAGTCAGAGC GAGGACTTCT GGATGCAGGT 2940
TTAGAAGAGC AAGATGAGGA GGGACTGGAG GATGGTCTGG TTACACCTCC TCTTCAGCAC 3000
TCGCCGTCTT GGAGTGTGTC TCGTTCTCGG ATTAATTCGT GCAGGAGTGG CACATATCAG 3060
CCGGGACCTA TAGGATACCT GCCAATGACC ACAAGCCCAG CAGACAGCTT CCGCCAGCTG 3120
TGGTTTCACA GGTCTCGTCT GAGCTCAGTC CGGACTCTGC CTGAGAGGTT AGAGGTCAGG 3180
GGGATTAGCA GAGAGGCAGA GGTGCATGAG GAAGGCTTAC GGACGGGGAG TCTTCACAGG 3240
GCCAGGATTG ACTCAGAGAG CCAACAAAGG AAACTTTCAA CAGCCTCCAG TCCACCCTCG 3300
TACAAGGTGT GGACGGCAGA GGAAGAGGAG GAGGTGGACA GCTATGGCTA TGTCCTACCT 3360
GGCTCACCTA GTACACCAGA AAGAGTTCAA GTCTCTAGAA TTTCTCATTC TGGCCAAAGA 3420
AACTCAAGGC TCAAGGATAA CCTGCTTTTT ATGGTGATAA ATCCCACCAA GGAATATGAA 3480
ATCATGAACA CGGAGGAGAG CGCTCCTCCT CGCTTGGCCA GCAGCATTTC AAGACAGGAA 3540
GATGACCCCA CTGTGGGGAT TTGCTGCAAA ACCCCACCCT TACCCTCCCC AACATTCAGG 3600
GCTCTGTTAC CCATAGAGGA CATAGCACAC AAAGAAACTC TGCCACCAGC CTCAGCTGTA 3660
AGGAAGAATA CAGTTCATGA GGCTTGTGAA GGAAGTGTAG AAGAGCGAAT AAACTCAGCA 3720
GAGAAACATC CACTCACTAG TGACATCACT AGTGATATCA GAGCTGTGGA TGACCCAGGA 3780
GAGCCAGCCC AAGGGAATGG CAGGTATGAA TACATGGACA TCAGGCACTC TGACTCTACA 3840
GAGGGAGATG AATCATCACA GGAGAGACGT GGGAGTCAAA CATCTGCAAA GAGTGCAGCA 3900
GAAGAACAGG AAATACACCA AACAGTGGAG GTGTTGAAAA AGGAGCACAA AGAGCCAGAT 3960
GTGCTGAAAG CTGGGGGAGA AAAGGTGGAG GAGTATGAGG AGATGAACAG ATTTGGGGTG 4020
GTGCCCAGCA GATGTAAGGA AGCAGAATAC CAGAACCTCC CAGTAAAGGG GAGGGTTATT 4080
TGTGAGGAGA TGGGCAGTGG CAGGTGCACA GAGATTGGGG AATATATCAA GGTGTGCGCT 4140
GGTGTGGGGG AACCTGCAAG CAACACATCA TTCGACAACC CAGACTACTG GCACAGCAGG 4200
CTGTTCCTCA AACCAGATGC TGTGCGCATC TAA 4233
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lkk k lG G+fGtv+kG w pege+vkipvaik +++++g+++++e++d++l ++sldh
Q: 686   LKKAKSLGVGVFGTVHKGFWTPEGETVKIPVAIKTIQDSSGRQTFTEITDHMLSMGSLDH  745
         699*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         +++vrllg+c   +lqlvtql p G+ll+++r++k++l +q llnwcvqiakGm+ylee+
Q: 746   PYIVRLLGICPGASLQLVTQLSPQGSLLEHIRQKKNSLDPQLLLNWCVQIAKGMYYLEEH  805
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
          +vhr+laarn+l+k+  +v+i+d+G+a+ll  d+k++ + ++k+pikw+alesil+r+y
Q: 806   CMVHRNLAARNILLKNDYQVQISDYGVADLLYPDDKKYVYTDTKTPIKWMALESILFRRY  865
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwe+++fGa+py++++ +e+p llekGerl+qp+ictidvymv+vkcw
Q: 866   THQSDVWSYGVTVWEIMSFGAEPYASVSPQEVPGLLEKGERLSQPHICTIDVYMVMVKCW  925
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mid+++rp+fkela++f
Q: 926   MIDENIRPTFKELASDF  942
         **************998
Domain Sequence
(FASTA)
LKKAKSLGVG VFGTVHKGFW TPEGETVKIP VAIKTIQDSS GRQTFTEITD HMLSMGSLDH 60
PYIVRLLGIC PGASLQLVTQ LSPQGSLLEH IRQKKNSLDP QLLLNWCVQI AKGMYYLEEH 120
CMVHRNLAAR NILLKNDYQV QISDYGVADL LYPDDKKYVY TDTKTPIKWM ALESILFRRY 180
THQSDVWSYG VTVWEIMSFG AEPYASVSPQ EVPGLLEKGE RLSQPHICTI DVYMVMVKCW 240
MIDENIRPTF KELASDF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00281
EKS-CAJ-00306
EKS-CAP-00335
EKS-DAR-00648
EKS-EQC-00291
EKS-FEC-00285
EKS-GAM-00190
EKS-GAA-00372
EKS-ICT-00282
EKS-LOA-00310
EKS-MAM-00303
EKS-MOD-00294
EKS-MUM-00331
EKS-MUP-00297
EKS-MYL-00301
EKS-NOL-00276
EKS-OCP-00048
EKS-ORC-00282
EKS-ORL-00361
EKS-OTG-00305
EKS-POA-00291
EKS-RAN-00316
EKS-SAH-00281
EKS-TAR-00393
EKS-TEN-00389
EKS-TUT-00065
EKS-XIM-00380
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 4.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013